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Gene Symbol

RAD51C

Synonyms

BROVCA3 | FANCO | R51H3 | RAD51L2

Gene Description

RAD51C, RAD51 paralog C, functions in homologous recombination in DNA repair and plays a role in cell cycle checkpoint signaling in response to DNA damage (PMID: 21821141). Germline mutations in RAD51C are associated with increased susceptibility to breast and ovarian cancers (PMID: 21821141, PMID: 31446535) and overexpression of Rad51c has been observed in ovarian cancer (PMID: 32055267).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
5889	17	17q22	NM_058216	Unknown

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Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance
inact mut	unknown	loss of function	RAD51C inact mut indicates that this variant results in a loss of function of the Rad51c protein. However, the specific amino acid change has not been identified.
mutant	unknown	unknown	RAD51C mutant indicates an unspecified mutation in the RAD51C gene.