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RET A883T - Gene Variant Detail

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Gene RET
Variant A883T
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions RET A883T lies within the protein kinase domain of the Ret protein (UniProt.org). A883T results in increased cell proliferation and foci formation in culture (PMID: 21810974), and therefore, is predicted to lead to a gain of Ret protein function.
Associated Drug Resistance
Category Variants Paths

RET mutant RET A883X RET A883T

RET mutant RET act mut RET A883T

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Transcript NM_020975.6
gDNA chr10:g.43120120G>A
cDNA c.2647G>A
Protein p.A883T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975 chr10:g.43120120G>A c.2647G>A p.A883T RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43120120G>A c.2647G>A p.A883T RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43120120G>A c.2647G>A p.A883T RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43120120G>A c.2647G>A p.A883T RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43120120G>A c.2647G>A p.A883T RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43120120G>A c.2647G>A p.A883T RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43120120G>A c.2647G>A p.A883T RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43120120G>A c.2647G>A p.A883T RefSeq GRCh38/hg38
NM_020630 chr10:g.43120120G>A c.2647G>A p.A883T RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43120120G>A c.2647G>A p.A883T RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
HRAS A59T RET A883F RET A883T medullary thyroid carcinoma predicted - resistant Pralsetinib Case Reports/Case Series Actionable In a retrospective analysis, a medullary thyroid carcinoma patient harboring RET A883T progressed on treatment with Gavreto (pralsetinib) and was found to have acquired RET A883F and HRAS A59T (PMID: 38127829; NCT03157128, NCT03037385, NCT03780517). 38127829