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ALK V1545I - Gene Variant Detail

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Gene ALK
Variant V1545I
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions ALK V1545I lies within the cytoplasmic domain of the Alk protein (UniProt.org). V1545I has not been biochemically characterized, but results in similar cell proliferation and viability levels to wild-type Alk in cultured cells (PMID: 29533785), and therefore, is predicted to have no effect on Alk protein function.
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK V1545I

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Transcript NM_004304.5
gDNA chr2:g.29193454C>T
cDNA c.4633G>A
Protein p.V1545I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29193454C>T c.4633G>A p.V1545I RefSeq GRCh38/hg38
NM_004304 chr2:g.29193454C>T c.4633G>A p.V1545I RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29193454C>T c.4633G>A p.V1545I RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References