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Gene | RET |
Variant | D631_L633delinsS |
Impact List | indel |
Protein Effect | unknown |
Gene Variant Descriptions | RET D631_L633delinsS results in a deletion of three amino acids in the extracellular domain of the Ret protein from amino acids 631 to 633, combined with the insertion of one serine (S) at the same site (UniProt.org). D631_L633delinsS has been identified in the scientific literature (PMID: 35616103), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Apr 2024). |
Associated Drug Resistance | |
Category Variants Paths |
RET mutant RET D631_L633delinsS |
Transcript | NM_020975.6 |
gDNA | chr10:g.43114491_43114499delinsAGC |
cDNA | c.1891_1899delinsAGC |
Protein | p.D631_L633delinsS |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_020630.7 | chr10:g.43114491_43114499delinsAGC | c.1891_1899delinsAGC | p.D631_L633delinsS | RefSeq | GRCh38/hg38 |
NM_020975.6 | chr10:g.43114491_43114499delinsAGC | c.1891_1899delinsAGC | p.D631_L633delinsS | RefSeq | GRCh38/hg38 |
NM_020630.5 | chr10:g.43114491_43114499delinsAGC | c.1891_1899delinsAGC | p.D631_L633delinsS | RefSeq | GRCh38/hg38 |
NM_020975.5 | chr10:g.43114491_43114499delinsAGC | c.1891_1899delinsAGC | p.D631_L633delinsS | RefSeq | GRCh38/hg38 |
NM_001406743.1 | chr10:g.43114491_43114499delinsAGC | c.1891_1899delinsAGC | p.D631_L633delinsS | RefSeq | GRCh38/hg38 |
NM_001406760.1 | chr10:g.43114491_43114499delinsAGC | c.1891_1899delinsAGC | p.D631_L633delinsS | RefSeq | GRCh38/hg38 |
NM_001406744.1 | chr10:g.43114491_43114499delinsAGC | c.1891_1899delinsAGC | p.D631_L633delinsS | RefSeq | GRCh38/hg38 |
NM_001406759.1 | chr10:g.43114491_43114499delinsAGC | c.1891_1899delinsAGC | p.D631_L633delinsS | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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