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RET I590_G607del - Gene Variant Detail

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Gene RET
Variant I590_G607del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions RET I590_G607del results in the deletion of 18 amino acids in the extracellular domain of the Ret protein from amino acids 590 to 607 (UniProt.org). I590_G607del has been identified in the scientific literature (PMID: 35616103), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Jan 2025).
Associated Drug Resistance
Category Variants Paths

RET mutant RET I590_G607del

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Transcript NM_020975.6
gDNA chr10:g.43113565_43113618del54
cDNA c.1769_1822del54
Protein p.I590_G607del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.7 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References