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BRAF L597V - Gene Variant Detail

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Gene BRAF
Variant L597V
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions BRAF L597V lies within the protein kinase domain of the Braf protein (UniProt.org). L597V results in activation of Braf as indicated by increased phosphorylation of Mek and Erk in cell culture (PMID: 22798288) and and induces cell proliferation and cell viability in culture (PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF act mut BRAF L597V

BRAF mutant BRAF L597X BRAF L597V

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Transcript NM_004333.6
gDNA chr7:g.140753346G>C
cDNA c.1789C>G
Protein p.L597V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333 chr7:g.140753346G>C c.1789C>G p.L597V RefSeq GRCh38/hg38
NM_001378473.1 chr7:g.140749334A>C c.1789T>G p.L597V RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753346G>C c.1789C>G p.L597V RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753346G>C c.1789C>G p.L597V RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753346G>C c.1789C>G p.L597V RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753346G>C c.1789C>G p.L597V RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753346G>C c.1789C>G p.L597V RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753346G>C c.1789C>G p.L597V RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753346G>C c.1789C>G p.L597V RefSeq GRCh38/hg38
NM_001378472.1 chr7:g.140749334A>C c.1789T>G p.L597V RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF L597V NRAS Q61K lung non-small cell carcinoma sensitive AZ628 Preclinical - Cell culture Actionable In a preclinical study, AZ628 inhibited proliferation of non-small cell lung cancer cells harboring both BRAF L597V and NRAS Q61K in culture (PMID: 27523909). 27523909
BRAF L597V NRAS Q61K lung non-small cell carcinoma sensitive TAK-632 Preclinical - Cell culture Actionable In a preclinical study, TAK-632 inhibited proliferation of non-small cell lung cancer cells harboring both BRAF L597V and NRAS Q61K in culture (PMID: 27523909). 27523909
BRAF L597V NRAS Q61K lung non-small cell carcinoma decreased response PLX7904 Preclinical - Cell culture Actionable In a preclinical study, non-small cell lung cancer cells harboring both BRAF L597V and NRAS Q61K demonstrated decreased sensitivity to PLX7904 in culture (PMID: 27523909). 27523909
BRAF L597V NRAS Q61K lung non-small cell carcinoma decreased response Vemurafenib Preclinical - Cell culture Actionable In a preclinical study, non-small cell lung cancer cells harboring both BRAF L597V and NRAS Q61K demonstrated decreased sensitivity to Zelboraf (vemurafenib) in culture (PMID: 27523909). 27523909
BRAF L597V NRAS Q61K lung non-small cell carcinoma decreased response Dabrafenib Preclinical - Cell culture Actionable In a preclinical study, non-small cell lung cancer cells harboring both BRAF L597V and NRAS Q61K demonstrated decreased sensitivity to Tafinlar (dabrafenib) in culture (PMID: 27523909). 27523909
BRAF L597V NRAS Q61K lung non-small cell carcinoma sensitive IHMT-RAF-128 Preclinical - Cell culture Actionable In a preclinical study, IHMT-RAF-128 inhibited proliferation in a non-small cell lung cancer cell line harboring NRAS Q61K and BRAF L597V in culture (PMID: 37164118). 37164118