Molecular Profile Detail

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
ATM I2629fs ATM neg	endometrial clear cell adenocarcinoma	predicted - sensitive	Elimusertib	Case Reports/Case Series	Actionable	In a Phase I trial, Elimusertib (BAY1895344) treatment resulted in a partial response with a 53% decrease in tumor size in a patient with clear cell endometrial cancer harboring ATM I2629fs with ATM protein loss, treatment was ongoing at 433 days (PMID: 32988960; NCT03188965).	32988960
ATM T2333fs ATM neg	Her2-receptor negative breast cancer	predicted - sensitive	Elimusertib	Case Reports/Case Series	Actionable	In a Phase I trial, Elimusertib (BAY1895344) treatment resulted in a partial response with a 54% decrease in tumor size in a patient with heavily treated, hormone receptor-positive, ERBB2 (HER2)-negative breast cancer harboring ATM T2333fs and ATM protein loss, who remained on treatment for 349 days (PMID: 32988960; NCT03188965).	32988960

Profile Name	ATM negative
Gene Variant Detail	ATM negative (loss of function)
Relevant Treatment Approaches	Olaparib