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Molecular Profile Detail

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Profile Name APC T1556Nfs*3
Gene Variant Detail

APC T1556Nfs*3 (loss of function)

Relevant Treatment Approaches CTNNB1 Inhibitor Tankyrase Inhibitor

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC E853* APC T1556Nfs*3 colorectal cancer sensitive STP1002 Preclinical - Cell culture Actionable In a preclinical study, STP1002 inhibited Wnt/beta-catenin signaling and colony formation in a colorectal cancer cell line harboring APC E853* and APC T1556Nfs*3 in culture (PMID: 35849876). 35849876
APC V830Gfs*12 APC T1556Nfs*3 colorectal cancer resistant G007-LK Preclinical - Cell culture Actionable In a preclinical study, a patient-derived colorectal cancer cell line harboring APC V830Gfs*12 and T1556Nfs*3, along with PIK3CA E542K, was resistant to G007-LK treatment, as demonstrated by failure to inhibit viability in culture (PMID: 37968472). 37968472
APC S1465Wfs*3 APC T1556Nfs*3 colorectal cancer sensitive G007-LK Preclinical - Cell culture Actionable In a preclinical study, G007-LK inhibited viability of a patient-derived colorectal cancer cell line harboring APC S1465Wfs*3 and T1556Nfs*3 in culture (PMID: 37968472). 37968472