CKB is a dynamic digital resource for interpreting complex cancer genomic profiles in the context of protein impact, therapies, and clinical trials. CKB CORE is the public access version we have been providing to the community since 2016. CKB CORE contains all the content associated with 50 genes that are commonly found on cancer hotspot panels. New and updated content is pushed out daily and viewable genes are available on a quarterly rotating schedule.
News
Apr 13, 2026
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Attention CKB CORE users: our latest quarterly gene update has arrived! This quarter focuses on DNA repair genes. If you have any questions or feedback regarding CKB, please contact our team at ckbsupport@genomenon.com!
Jan 15, 2026
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Did you know CKB includes thousands of efficacy evidence annotations related to clinical case reports? Check out the latest blog on our recent publication, "Leveraging oncology clinical case report data through the Cancer Knowledgebase (CKB)", and learn how CKB can be used to identify actionable content for patients with rare tumor types, childhood cancer, or resistance to therapies through case study evidence.
Jan 12, 2026
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CKB CORE update! It's that time again, and this quarter we are highlighting genes related to immuno-oncology. If you have any questions or comments, please reach out to us at ckbsupport@genomenon.com!
Explore the Mastermind Genomic Intelligence Platform
Access article information on over 26 million variants, as well as curated germline variant content,
and discover valuable gene and variant summary information to streamline your analysis and deepen your insights.
Comparison of CKB Offerings
KEY FEATURES
CKB BOOSTTM
Access 50 genes & related content
Access 2200+ genes & related content
Scalable & flexible content integration for 2200+ genes
Genes
(50 Genes)
(2200+ Genes)
Gene Variants
Therapies
Limited
Global Drug Approvals
Drug Classes
Limited
Clinical Trials
Limited
Efficacy Evidence
Variant Tier Coding
(AMP/CAP/ASCO)
(AMP/CAP/ASCO)
Advanced Search Capability
System Integration
More about our plans
The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a
select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via
gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2200
cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes
while enabling a robust browse-like feature when the desired content is unknown.
Downloadable data from CKB is available using the FLEX version. CKB FLEX delivers CKB content as a
flat file or JSON, enabling CKB data integration.
Visit
CKB BOOST
for more information.
Contact: ckbsupport@genomenon.com
CKB BOOST
for more information.
Contact: ckbsupport@genomenon.com