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| NCT ID | NCT01667419 |
| Title | BRIM8: A Study of Vemurafenib Adjuvant Therapy in Patients With Resected Cutaneous BRAF Mutant Melanoma |
| Acronym | BRIM8 |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Hoffmann-La Roche |
| Indications | |
| Therapies | |
| Age Groups: | adult |
| Covered Countries | USA | SWE | POL | NZL | NOR | NLD | ITA | ISR | IRL | HRV | GBR | FRA | EST | ESP | DEU | CZE | CHE | CAN | BRA | BEL | AUT | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| A.O.U. Senese Policlinico Santa Maria Alle Scotte | Siena | Toscana | 53100 | Italy | Details | |
| Addenbrooke's Hospital | Cambridge | CB2 0QQ | United Kingdom | Details | ||
| Alfred Hospital | Melbourne | Victoria | 3004 | Australia | Details | |
| Asst Degli Spedali Civili Di Brescia | Brescia | Lombardia | 25100 | Italy | Details | |
| Atlantic Health Systems; Pediatrics | Randolph | New Jersey | 07869 | United States | Details | |
| AZ Groeninge, Apotheek | Kortrijk | 8500 | Belgium | Details | ||
| Azienda Ospedaliera Universitaria Policlinico Tor Vergata | Roma | Lazio | 00133 | Italy | Details | |
| Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni XXIII) | Bergamo | Lombardia | 24127 | Italy | Details | |
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201 | United States | Details | |
| BC Cancer Agency Vancouver Centre - PARENT; BC Cancer Agency | Vancouver | British Columbia | V5Z 4E6 | Canada | Details | |
| Border Medical Oncology | Wodonga | New South Wales | 3690 | Australia | Details | |
| Box Hill Hospital | Box Hill | Victoria | 3128 | Australia | Details | |
| Bristol Haematology and Oncology Centre | Bristol | BS2 8ED | United Kingdom | Details | ||
| Cairns Base Hospital | Cairns | Queensland | 4870 | Australia | Details | |
| Calvary Mater Newcastle | Waratah | New South Wales | 2298 | Australia | Details | |
| Cancer Center Of Santa Barbara; Network Clinical Research Specialist | Los Angeles | California | 90095 | United States | Details | |
| Centrallasarettet Växjö | Växjö | 351 85 | Sweden | Details | ||
| Centre Hospitalier Lyon Sud | Pierre Benite | 69495 | France | Details | ||
| Centro de Investigacion Pergamino SA | Pergamino | B2700CPM | Argentina | Details | ||
| Centro Oncologico Belenus | Cuernavaca | 62290 | Mexico | Details | ||
| Centro Regiomontano de Investigación Clínica | Monterrey | 64710 | Mexico | Details | ||
| Centrum Onkologii- Instytut; im. M.Skłodowskiej-Curie | Warszawa | 02-781 | Poland | Details | ||
| Chaim Sheba Medical Center | Ramat Gan | 5265601 | Israel | Details | ||
| Chris O'Brien Lifehouse | Camperdown | New South Wales | 2050 | Australia | Details | |
| Christchurch Hospital NZ | Christchurch | 8011 | New Zealand | Details | ||
| CHU Besançon - Hôpital Jean Minjoz | Besançon Cedex | 25030 | France | Details | ||
| CHU de Rouen Hopital; Service de Neurologie | Rouen | 76031 | France | Details | ||
| CHU de Toulouse - Hôpital Larrey | Toulouse | 31059 | France | Details | ||
| CHU NANTES - Hôtel Dieu; Pharmacy | Nantes | 44093 | France | Details | ||
| CHU Nice - Hopital de l'Archet 2 | Nice | 06202 | France | Details | ||
| CHUM Hôpital Notre-Dame | Montreal | Quebec | H2L 4M1 | Canada | Details | |
| CHUQ - Hôtel-Dieu de Québec | Ste-Foy | Quebec | G1V 4G2 | Canada | Details | |
| Churchill Hospital | Oxford | OX3 7LJ | United Kingdom | Details | ||
| CHUV; Departement d'Oncologie | Lausanne | 1011 | Switzerland | Details | ||
| CI Dnipropetrovsk CMCH 4 of Dnipropetrovsk RC Dept of Chemotherapy SI Dnipropetrovsk MA of MOHU | Dnipropetrovsk | 49102 | Ukraine | Details | ||
| CITO - Centro Integrado de Terapia Onco-Hematológica - Hospital da Cidade de Passo Fundo | Passo Fundo | RS | 99010-260 | Brazil | Details | |
| Clinica de Oncologia de Porto Alegre - CliniOnco | Porto Alegre | RS | 90430-090 | Brazil | Details | |
| Clinical Center Bezanijska Kosa | Belgrade | 11070 | Serbia | Details | ||
| Clinical Hospital Center Sestre Milosrdnice | Zagreb | 10000 | Croatia | Details | ||
| Clinical Hospital Centre Zagreb | Zagreb | 10000 | Croatia | Details | ||
| Coastal Integrative Cancer Care | San Luis Obispo | California | 93401 | United States | Details | |
| Cork University Hospital | Cork | Ireland | Details | |||
| Dolnoslaskie Centrum Onkologii | Wroclaw | 53-439 | Poland | Details | ||
| Duke University Medical Center; Oncology | Durham | North Carolina | 27710 | United States | Details | |
| East Tallinn Central Hospital; Clinic of Internal Medicine | Tallinn | 11312 | Estonia | Details | ||
| Elbekliniken Buxtehude GmbH | Buxtehude | 21614 | Germany | Details | ||
| Fachklinik Hornheide | Muenster | 48157 | Germany | Details | ||
| Fakultni nemocnice Hradec Kralove | Hradec Kralove | 500 05 | Czechia | Details | ||
| Fakultni nemocnice Kralovske Vinohrady | Praha | 100 34 | Czechia | Details | ||
| Fakultni nemocnice Ostrava | Ostrava - Poruba | 708 52 | Czechia | Details | ||
| Fakultní nemocnice Olomouc | Olomouc | 775 20 | Czechia | Details | ||
| Fiona Stanley Hospital | Murdoch | Western Australia | 6150 | Australia | Details | |
| Florida Cancer Specialists - Broadway | Fort Myers | Florida | 33901 | United States | Details | |
| FSBSI "Russian Oncological Scientific Center n.a. N.N. Blokhin" | Moscow | 115478 | Russian Federation | Details | ||
| Fundación CIDEA | Buenos Aires | C1425DTG | Argentina | Details | ||
| General Hospital Pula | Pula | 52100 | Croatia | Details | ||
| General Hospital Varazdin | Varazdin | 42000 | Croatia | Details | ||
| Groote Schuur Hospital Radiation Oncology Department; Department of Radiation Oncology | Observatory | 7925 | South Africa | Details | ||
| Groupe Hospitalier Saint André - Hôpital Saint André | Bordeaux | 33075 | France | Details | ||
| GulfCoast Oncology | Sarasota | Florida | 34232 | United States | Details | |
| Guys and St Thomas NHS Foundation Trust, Guys Hospital | London | SE1 9RT | United Kingdom | Details | ||
| GVI Rondebosch Oncology Centre | Cape Town | 7700 | South Africa | Details | ||
| Hadassah University Hospital - Ein Kerem | Jerusalem | 9112001 | Israel | Details | ||
| Hopital Claude Huriez - CHU Lille | Lille | 59037 | France | Details | ||
| Hopital de la Timone | Marseille | 13005 | France | Details | ||
| Hospital Britanico de Buenos Aires | Ciudad Autonoma Buenos Aires | C1284AEB | Argentina | Details | ||
| Hospital Civil de Guadalajara Fray Antonio Alcalde | Guadalajara | 44280 | Mexico | Details | ||
| Hospital Clinico Universitario de Santiago | Santiago de Compostela | LA Coruña | 15706 | Spain | Details | |
| Hospital Costa del Sol; Servicio de Oncologia | Marbella | Malaga | 29600 | Spain | Details | |
| Hospital das Clinicas - UFRGS | Porto Alegre | RS | 90035-003 | Brazil | Details | |
| Hospital de Caridade de Ijuí | Ijuí | RO | 98700-000 | Brazil | Details | |
| Hospital de la Santa Creu; i Sant Pau | Barcelona | 08025 | Spain | Details | ||
| Hospital de Santa Maria; Servico de Oncologia Medica | Lisboa | 1649-035 | Portugal | Details | ||
| Hospital do Espirito Santo; Servico de Oncologia Medica | Evora | 7000-811 | Portugal | Details | ||
| Hospital General Universitario Gregorio Marañon | Madrid | 28007 | Spain | Details | ||
| Hospital Sírio-Libanês | Sao Paulo | SP | 01308-050 | Brazil | Details | |
| Hospital Universitari i Politecnic La Fe | Valencia | 46026 | Spain | Details | ||
| Hospital Universitario Austral | Derqui-Pilar | B1629ODT | Argentina | Details | ||
| Hôpital Ambroise Paré - Boulogne-Billancourt; Respiratory | Boulogne Billancourt | 92104 | France | Details | ||
| Hôpital Saint-Louis | Paris | 75475 | France | Details | ||
| IDI-Istituto Dermopatico dell'Immacolata IRCCS | Roma | Lazio | 00167 | Italy | Details | |
| Indiana University Department of Medicine; Division of Infectious Diseases | Indianapolis | Indiana | 46202 | United States | Details | |
| Indiana University Health; Goshen Center for Cancer Care | Goshen | Indiana | 46526 | United States | Details | |
| Institut Catala d Oncologia Hospital Duran i Reynals | Barcelona | 08908 | Spain | Details | ||
| Institut Jules Bordet | Brussels | 1000 | Belgium | Details | ||
| Institute for oncology of Vojvodina | Sremska Kamenica | 21204 | Serbia | Details | ||
| Institute of Oncology and Radiology of Serbia | Belgrade | 11000 | Serbia | Details | ||
| Instituto de Oncología de Rosario | Rosario | S2000KZE | Argentina | Details | ||
| Instituto Medico Especializado Alexander Fleming | Ciudad Autonoma Buenos Aires | 1426 | Argentina | Details | ||
| IOV - Istituto Oncologico Veneto IRCCS | Padova | Veneto | 35128 | Italy | Details | |
| IPO de Coimbra; Servico de Oncologia Medica | Coimbra | 3000-075 | Portugal | Details | ||
| IPO do Porto; Servico de Oncologia Medica | Porto | 4200-072 | Portugal | Details | ||
| IRCCS Istituto Clinico Humanitas; Farmacia | Rozzano | Lombardia | 20089 | Italy | Details | |
| ISIS Clinica Especializada | Santa Fe | S3000 | Argentina | Details | ||
| Istituto Europeo Di Oncologia | Milano | Lombardia | 20141 | Italy | Details | |
| Istituto Nazionale per la Ricerca sul Cancro di Genova | Genova | Liguria | 16132 | Italy | Details | |
| Istituto Nazionale Tumori Fondazione G. Pascale | Napoli | Campania | 80131 | Italy | Details | |
| Istituto Nazionale Tumori Regina Elena IRCCS | Roma | Lazio | 00144 | Italy | Details | |
| Istituto Tumori Giovanni Paolo II IRCSS; Ospedale Oncologico Bari | Bari | Puglia | 70126 | Italy | Details | |
| Jessa Zkh (Campus Virga Jesse) | Hasselt | 3500 | Belgium | Details | ||
| K. Permanente - San Jose | San Jose | California | 95119 | United States | Details | |
| Kaiser Foundation Hospital - Oakland (W. MacArthur) | Oakland | California | 94611 | United States | Details | |
| Kaiser Permanente | San Francisco | California | 94115 | United States | Details | |
| Kaiser Permanente - Hayward | Hayward | California | 94545 | United States | Details | |
| Kaiser Permanente - Oakland | Oakland | California | 94611 | United States | Details | |
| Kaiser Permanente - Roseville | Roseville | California | 95661 | United States | Details | |
| Kaiser Permanente - Santa Clara | Santa Clara | California | 95051 | United States | Details | |
| Kaiser Permanente - South San Francisco | South San Francisco | California | 94080 | United States | Details | |
| Kaiser Permanente - Vallejo | Vallejo | California | 94589 | United States | Details | |
| Kaiser Permanente - Walnut Creek | Walnut Creek | California | 94596 | United States | Details | |
| Kaiser Permanente Sacramento Medical Center | Sacramento | California | 95814 | United States | Details | |
| Klinikum Mannheim GmbH Universitätsklinikum | Mannheim | 68167 | Germany | Details | ||
| Klinikum Wels-Grieskirchen | Wels | 4600 | Austria | Details | ||
| Krankenanstalt Rudolfstiftung Wien | Wien | 1030 | Austria | Details | ||
| Krasnodar City Oncology Center | Krasnodar | 350040 | Russian Federation | Details | ||
| Launceston General Hospital; Gastroenterology Research | Launceston | Tasmania | 7250 | Australia | Details | |
| Leids Universitair Medisch Centrum; Cardiology | Leiden | 2333 ZA | Netherlands | Details | ||
| LHSC - Victoria Hospital; Department of Pediatrics | London | Ontario | N6A 4G5 | Canada | Details | |
| Lviv State Oncological Regional Treatment and Diagnostic Center | Lviv | 79031 | Ukraine | Details | ||
| Länssjukhuset Ryhov | Jönköping | 551 85 | Sweden | Details | ||
| Mary Babb Randolph Cancer Center | Morgantown | West Virginia | 26506 | United States | Details | |
| Mary Potter Oncology Centre | Groenkloof | 0181 | South Africa | Details | ||
| Masarykuv onkologicky ustav | Brno | 656 53 | Czechia | Details | ||
| Mater Private Hospital | Dublin | 7 | Ireland | Details | ||
| Mcgill University - Royal Victoria Hospital; Oncology | Montreal | Quebec | H3A 1A1 | Canada | Details | |
| MD Anderson Cancer Center | Houston | Texas | 77030 | United States | Details | |
| Medizinische Universität Innsbruck | Innsbruck | 6020 | Austria | Details | ||
| Medizinische Universität Wien | Wien | 1090 | Austria | Details | ||
| Melanoma Institute Australia | North Sydney | New South Wales | 2060 | Australia | Details | |
| Memorial Healthcare System | Hollywood | Florida | 33021 | United States | Details | |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | United States | Details | |
| Military Medical Academy | Belgrade | 11040 | Serbia | Details | ||
| Moscow City Oncology Hospital #62 | Moscovskaya Oblast | Moskovskaja Oblast | 143423 | Russian Federation | Details | |
| MUSC Hollings Cancer Center/cannon Park Place; Attn: Tamara Saunders | Charleston | South Carolina | 29425 | United States | Details | |
| Nemocnice Na Bulovce | Prague | 180 01 | Czechia | Details | ||
| New Cross Hospital | Wolverhampton | WV10 0QP | United Kingdom | Details | ||
| New York University Medical Center PRIME; NYU Clinical Cancer Center | New York | New York | 10016 | United States | Details | |
| Norrlands Universitetssjukhus | Umea | 901 850 | Sweden | Details | ||
| North Estonia Medical Centre Foundation | Tallinn | 13419 | Estonia | Details | ||
| Nottingham University Hospitals City Campus | Nottingham | NG5 1PB | United Kingdom | Details | ||
| Oncology Specialists, S.C. | Park Ridge | Illinois | 60068 | United States | Details | |
| Ospedale San Raffaele | Milano | Lombardia | 20132 | Italy | Details | |
| Peninsula Oncology Centre; Frankston Private | Frankston | Victoria | 3199 | Australia | Details | |
| Peter Maccallum Cancer Centre | Melbourne | Victoria | 3000 | Australia | Details | |
| Princess Margaret Hospital; Department of Med Oncology | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| Przychodnia Med-Polonia Sp. z o.o. | Poznan | 60-693 | Poland | Details | ||
| Queen Elizabeth Hospital | Woodville | South Australia | 5011 | Australia | Details | |
| Queen Elizabeth Hospital | Kings Lynn | PE30 4ET | United Kingdom | Details | ||
| Rabin Medical Center-Beilinson Campus | Petach Tikva | 4941492 | Israel | Details | ||
| Rambam Health Care Campus | Haifa | 3109600 | Israel | Details | ||
| Royal Adelaide Hospital; Hepatology | Adelaide | South Australia | 5000 | Australia | Details | |
| Royal Cornwall Hospital | Truro | TR1 3LQ | United Kingdom | Details | ||
| Saint Boniface General Hospital; Section of Nephrology BG 007 | Winnipeg | Manitoba | R2H 2A6 | Canada | Details | |
| Saint John Regional Hospital; Department of Oncology | Saint John | New Brunswick | E2L 4L2 | Canada | Details | |
| Sanatorio la Luz | Morelia | 58260 | Mexico | Details | ||
| Sandton Oncology Medical Group | Sandton | 2196 | South Africa | Details | ||
| Scientific Research Oncology Institute named after N.N. Petrov | St. Petersburg | 197758 | Russian Federation | Details | ||
| Soroka Medical Center | Beer Sheva | 8410101 | Israel | Details | ||
| Southern Medical Day Care Centre | Wollongong | New South Wales | 2500 | Australia | Details | |
| SPZOZ MSW zWarmińsko-MazurskimCen.Onko.wOlsztynie | Olsztyn | 10-228 | Poland | Details | ||
| St. Josef-Hospital Universitaetsklinikum | Bochum | 44791 | Germany | Details | ||
| St. Luke's Hospital | Kansas City | Missouri | 64111 | United States | Details | |
| St. Mary's Hospital Regional Cancer Center | Grand Junction | Colorado | 81501 | United States | Details | |
| Stanford University School of Medicine; Stanford Hospital Pharmacy | Stanford | California | 94305 | United States | Details | |
| Stavanger Universitetssykehus, Helse Stavanger HF | Stavanger | 4011 | Norway | Details | ||
| Tartu University Hospital; Clinic of Hematology and Oncology | Tartu | 50406 | Estonia | Details | ||
| Tel-Aviv Sourasky Medical Center | Tel Aviv | 6423906 | Israel | Details | ||
| Tennessee Oncology PLLC - Nashville (20th Ave) | Nashville | Tennessee | 37203 | United States | Details | |
| The Angeles Clinic and Research Institute - W LA Office | Los Angeles | California | 90025 | United States | Details | |
| The Mater Misericordiae Hospital | Dublin | 7 | Ireland | Details | ||
| The Ottawa Hospital Cancer Center; General Campus | Ottawa | Ontario | K1H 1C4 | Canada | Details | |
| The Townsville Hospital; Townsville Cancer Centre | Townsville | Queensland | 4812 | Australia | Details | |
| Toronto Sunnybrook Hospital | Toronto | Ontario | M4N3M50 | Canada | Details | |
| TRIO-US Network Administration; Network Clinical Research Specialist | Los Angeles | California | 90095 | United States | Details | |
| Trymed Clinical Research | Belo Horizonte | MG | 30150-281 | Brazil | Details | |
| U of L - Physicians Pulmonology; Dept of Neuroradiology and Dept of Diagnostic Radiology | Louisville | Kentucky | 40202 | United States | Details | |
| UCLA Cancer Center Hema/Oncol | Valencia | California | 91355 | United States | Details | |
| UCLA Department of Medicine; Division of Hematology / Oncology | California City | California | 90095 | United States | Details | |
| UCLA Healthcare/Pasadena Oncology | Pasadena | California | 91105 | United States | Details | |
| UCLA Hematology Oncology - Irvine | Irvine | California | 92604 | United States | Details | |
| UCLA Hematology Oncology - Westlake | Westlake Village | California | 91361 | United States | Details | |
| UCSD Moores Cancer Center | La Jolla | California | 92093 | United States | Details | |
| Universitaetsklinikum Frankfurt | Frankfurt | 60528 | Germany | Details | ||
| Universitaetsklinikum Schleswig-Holstein - Campus Kiel; Klinik fuer Allgemeine Innere Medizin | Kiel | 24105 | Germany | Details | ||
| Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz; Apotheke | Mainz | 55131 | Germany | Details | ||
| Universitair Medisch Centrum Groningen | Groningen | 9713 GZ | Netherlands | Details | ||
| University College Hospital | Galway | Ireland | Details | |||
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | United States | Details | |
| University Of Colorado | Aurora | Colorado | 80045 | United States | Details | |
| University of Kansas Medical Center; Cancer Center | Kansas City | Missouri | 64131 | United States | Details | |
| University of Pennsylvania Health System | Philadelphia | Pennsylvania | 19104 | United States | Details | |
| University of Pretoria Oncology Department | Pretoria | 0001 | South Africa | Details | ||
| Universitätsklinikum Essen | Essen | 45147 | Germany | Details | ||
| Universitätsklinikum Heidelberg | Heidelberg | 69120 | Germany | Details | ||
| Universitätsklinikum Koeln | Koeln | 50937 | Germany | Details | ||
| Universitätsklinikum Tübingen | Tuebingen | 72076 | Germany | Details | ||
| Universitätsklinikum Wurzburg | Würzburg | 97080 | Germany | Details | ||
| UZ Antwerpen | Edegem | 2650 | Belgium | Details | ||
| UZ Gent | Gent | 9000 | Belgium | Details | ||
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | United States | Details | |
| Velindre Cancer Centre | Cardiff | CF14 2TL | United Kingdom | Details | ||
| Vseobecna fakultni nemocnice v Praze | Praha 2 | 128 08 | Czechia | Details | ||
| Washington University; Dept of Medicine/Div of Medical Oncology | Saint Louis | Missouri | 63110 | United States | Details | |
| Wellington Hospital | Wellington | 6012 | New Zealand | Details | ||
| West Clinic | Germantown | Tennessee | 38138 | United States | Details | |
| Western General Hospital | Edinburgh | EH4 2XU | United Kingdom | Details | ||
| ZNA Middelheim | Antwerpen | 2020 | Belgium | Details |
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