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| NCT ID | NCT01885195 |
| Title | MEK162 for Patients With RAS/RAF/MEK Activated Tumors |
| Acronym | SIGNATURE |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase II |
| Variant Requirements | Yes |
| Sponsors | Novartis Pharmaceuticals |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| University of South Alabama / Mitchell Cancer Institute Univ South Alabama | Mobile | Alabama | 36688 | United States | Details | |
| Alaska Oncology and Hematology AOH (2) | Anchorage | Alaska | 99508 | United States | Details | |
| Arizona Oncology Associates AZ Oncology Assoc. | Phoenix | Arizona | United States | Details | ||
| Arizona Oncology Associates HOPE Division | Phoenix | Arizona | United States | Details | ||
| Arizona Oncology Associates PC- NAHOA | Sedona | Arizona | 86336 | United States | Details | |
| Highlands Oncology Group Highlands Oncology Group (22) | Fayetteville | Arkansas | 72703 | United States | Details | |
| PCR Oncology | Pismo Beach | California | 93449 | United States | Details | |
| University of California Davis Cancer Center UC Davis Cancer (3) | Sacramento | California | 95817 | United States | Details | |
| Rocky Mountain Cancer Centers USOR | Boulder | Colorado | 80304 | United States | Details | |
| Yale University School of Medicine Yale Cancer Center | New Haven | Connecticut | 06511 | United States | Details | |
| Whittingham Cancer Center Norwalk Hospital | Norwalk | Connecticut | 06856 | United States | Details | |
| Eastern Connecticut Hematology & Oncology Associates Dept. of ECHO | Norwich | Connecticut | 06360 | United States | Details | |
| Hematology Oncology PC Stamford Hospital | Stamford | Connecticut | 06902 | United States | Details | |
| Florida Cancer Specialists Florida Cancer Specialists (31 | Fort Myers | Florida | 33901 | United States | Details | |
| Memorial Cancer Institute Memorial Healthcare System | Hollywood | Florida | 33021 | United States | Details | |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32256 | United States | Details | |
| Mt. Sinai Comprehensive Cancer Center | Miami Beach | Florida | 33140 | United States | Details | |
| Ocala Oncology Center Dept. of Ocala Oncology Center | Ocala | Florida | 34474 | United States | Details | |
| Cancer Centers of Florida PA Cancer Centers of FL-Orlando-4 | Ocoee | Florida | United States | Details | ||
| University Cancer & Blood Center, LLC | Athens | Georgia | 30607 | United States | Details | |
| Lurie Children's Hospital of Chicago Developmental Therapeutics | Chicago | Illinois | 60611 | United States | Details | |
| Oncology Specialists, SC Onc Specialists | Park Ridge | Illinois | 60068-0736 | United States | Details | |
| Illinois Cancer Care IL. Cancer Care | Peoria | Illinois | 61615-7828 | United States | Details | |
| Indiana University Indiana Univ. - Purdue Univ. | Indianapolis | Indiana | 46202 | United States | Details | |
| University of Iowa Hospitals & Clinics Regulatory Contact 2 | Iowa City | Iowa | 52242 | United States | Details | |
| Maryland Oncology Hematology, P.A. Oncology Hematology | Rockville | Maryland | 20850 | United States | Details | |
| Cancer and Hematology Centers of West Michigan Dept. of Oncology | Grand Rapids | Michigan | 49546 | United States | Details | |
| Metro MN CCOP - Coon Rapids | Coon Rapids | Minnesota | 55433 | United States | Details | |
| Research Medical Center Research Med Center (2) | Kansas City | Missouri | 64132 | United States | Details | |
| Washington University School of Medicine Washington University (16) | Saint Louis | Missouri | 63110 | United States | Details | |
| Glacier View Research Institute - Cancer Oncology Dept | Kalispell | Montana | 59901 | United States | Details | |
| Comprehensive Cancer Centers of Nevada CCC of Nevada (21) | Las Vegas | Nevada | 89109 | United States | Details | |
| Cancer Institute of New Jersey CINJ | New Brunswick | New Jersey | 08901 | United States | Details | |
| New Mexico Cancer Care Alliance Oncology Dept | Albuquerque | New Mexico | 87106 | United States | Details | |
| New York Oncology Hematology, P.C. NYOH Latham | Troy | New York | 12180 | United States | Details | |
| University of North Carolina Chapel Hill Physician Office Building | Chapel Hill | North Carolina | 27514 | United States | Details | |
| Duke University Medical Center Seeley G. Mudd Bldg. | Durham | North Carolina | 27710 | United States | Details | |
| Sanford Research/USD-Fargo Sanford Hematology Oncology | Fargo | North Dakota | 58122 | United States | Details | |
| Cleveland Clinic Foundation Cleveland Clinic (19) | Cleveland | Ohio | 44195 | United States | Details | |
| Ohio State University Medical Center Comprehensive Cancer Center | Columbus | Ohio | 43221 | United States | Details | |
| St. Charles Cancer Center | Bend | Oregon | 97701 | United States | Details | |
| Willamette Valley Clinical Studies Cancer Institute & Res. Ctr. | Eugene | Oregon | 97404 | United States | Details | |
| Northwest Cancer Specialists Vancouver Cancer Center | Portland | Oregon | 97210 | United States | Details | |
| Oregon Health & Science University Oregon Health & Science U (56) | Portland | Oregon | 97239 | United States | Details | |
| St. Luke's Hospital and Health Network St Luke's (2) | Bethlehem | Pennsylvania | United States | Details | ||
| West Penn Allegheny Oncology Network | Natrona Heights | Pennsylvania | 15065 | United States | Details | |
| Abington Hematology Oncology Associates, Inc Abington Hem Onc Assoc (5) | Willow Grove | Pennsylvania | 19090 | United States | Details | |
| Chattanooga Oncology and Hematology Assoicates, PC Chattanooga Oncology | Chattanooga | Tennessee | 37404 | United States | Details | |
| The West Clinic Dept. of the West Clinic | Memphis | Tennessee | 38120 | United States | Details | |
| Sarah Cannon Research Institute Sarah Cannon Research Inst (51 | Nashville | Tennessee | 37203 | United States | Details | |
| Texas Oncology Presbyterian Hospital (3) | Dallas | Texas | 75246 | United States | Details | |
| Texas Oncology Texas Oncology - Denton | Dallas | Texas | 75246 | United States | Details | |
| Texas Oncology Austin Midtown | Dallas | Texas | 75251 | United States | Details | |
| Texas Oncology Texas Oncology - Midland | Dallas | Texas | 75251 | United States | Details | |
| Sammons Cancer Center - Texas Oncology Sammons Cancer Center (10) | Dallas | Texas | 78246 | United States | Details | |
| Oncology Consultants Oncology Group | Houston | Texas | 77024 | United States | Details | |
| MD Anderson Cancer Center/University of Texas MD Anderson Cancer Center (3) | Houston | Texas | 77030 | United States | Details | |
| Cancer Care Centers of South Texas / HOAST CCC of So. TX-San Antonio (3) | San Antonio | Texas | 78229 | United States | Details | |
| Tyler Cancer Center Dept.ofTylerCancerCtr. (2) | Tyler | Texas | 75702 | United States | Details | |
| Deke Slayton Cancer Center Deke Slayton Cancer Center (2) | Webster | Texas | 77598 | United States | Details | |
| Intermountain Medical Center Intermountain Healthcare | Murray | Utah | 84157 | United States | Details | |
| Virginia Cancer Specialists, PC Virginia Cancer Specialists | Fairfax | Virginia | 22031 | United States | Details | |
| Medical Oncology & Hematology Associates of Northern VA Med Onc Hem Northern VA | Reston | Virginia | 20190 | United States | Details | |
| Kadlec Clinic Hematology and Oncology Kadlec Clinic Hematology & Onc | Kennewick | Washington | 99336 | United States | Details | |
| Providence Regional Cancer System | Lacey | Washington | 98503 | United States | Details | |
| MultiCare Health System Institute for Research & Innovation MultiCare | Tacoma | Washington | 98405 | United States | Details | |
| Northwest Medical Specialties NW Medical Specialties | Tacoma | Washington | 98405 | United States | Details | |
| Medical College of Wisconsin Cancer Center | Milwaukee | Wisconsin | 53226 | United States | Details |