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| NCT ID | NCT02008227 |
| Title | A Randomized Phase 3 Study of MPDL3280A (an Engineered Anti-PDL1 Antibody) Compared to Docetaxel in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Failed Platinum Therapy - OAK |
| Acronym | OAK |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Hoffmann-La Roche |
| Indications | |
| Therapies | |
| Age Groups: | adult |
| Covered Countries | USA | TUR | SWE | POL | NZL | NOR | NLD | ITA | HUN | GRC | GBR | FRA | FIN | ESP | DEU | CHE | CAN | BRA | AUT | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| A.O. Universitaria Pisana-Ospedale Cisanello; Dipartimento Cardio Toracico-Pneumologia Ii | Pisa | Toscana | 56124 | Italy | Details | |
| A.O.U. Integrata Verona - Policlinico G.B. Rossi; Oncologia Medica - Dip. di Medicina | Verona | Veneto | 37134 | Italy | Details | |
| Aichi Cancer Center Hospital; Respiratory Medicine | Aichi | 464-8681 | Japan | Details | ||
| AMPM Research Clinic | Miami | Florida | 33145 | United States | Details | |
| Antonius Ziekenhuis; Dept of Lung Diseases | Nieuwegein | 3435 CM | Netherlands | Details | ||
| Asklepios-Fachkliniken Muenchen-Gauting; Onkologie | Gauting | 82131 | Germany | Details | ||
| ASST DI MONZA; Oncologia Medica | Monza | Lombardia | 20900 | Italy | Details | |
| Auckland city hospital; Auckland Regional Cancer Centre and Blood Service | Auckland | 1023 | New Zealand | Details | ||
| Aurora Health Care; Patient Centered Research | Milwaukee | Wisconsin | 53215 | United States | Details | |
| Azienda Ospedaliera San Giuseppe Moscati | Avellino | Campania | 83100 | Italy | Details | |
| Azienda Ospedaliera Univ Parma; Dept Oncologia Medica | Parma | Emilia-Romagna | 43100 | Italy | Details | |
| Azienda Ospedaliero-Uni Ria Di Udine; Dept. Di Oncologia - Padiglione Pennato | Udine | Friuli-Venezia Giulia | 33100 | Italy | Details | |
| Billings Clinic; Research Center | Billings | Montana | 59101 | United States | Details | |
| Blue Ridge Cancer Care | Roanoke | Virginia | 24014 | United States | Details | |
| Bradford Hill Centro de Investigaciones Clinicas; Bradford Hill Centro de Investigaciones Clinicas | Recoleta | 8420383 | Chile | Details | ||
| Cancer Specialists; North Florida ;Jacksonville (AC Skinner Pkwy) | Jacksonville | Florida | 32256 | United States | Details | |
| Cancer Treatment Centers of America-Tulsa | Tulsa | Oklahoma | 74133 | United States | Details | |
| Catharina Ziekenhuis; Dept of Lung Diseases | Eindhoven | 5623 EJ | Netherlands | Details | ||
| Central Coast Medical Oncology | Santa Maria | California | 93454 | United States | Details | |
| Centre Francois Baclesse | Caen | 14076 | France | Details | ||
| Centre Hospitalier Intercommunal; Service de Pneumologie | Creteil | 94010 | France | Details | ||
| Centre Hospitalier Lyon Sud; Pneumologie | Pierre Benite | 69495 | France | Details | ||
| Centre Jean Bernard; Radiotherapie Chimiotherapie | Le Mans | 72000 | France | Details | ||
| Centre Oscar Lambret | Lille | 59020 | France | Details | ||
| Centre Paul Strauss; Oncologie Medicale | Strasbourg | 67065 | France | Details | ||
| Centro Hemato Oncologico Panama | Panama | 0832 | Panama | Details | ||
| Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie Klinika Nowotworów Piersi i Chirurgii | Warszawa | 02-781 | Poland | Details | ||
| CH de la region d Annecy | Pringy | 74374 | France | Details | ||
| Chang Gung Medical Foundation - Linkou; Division of Hematology- Oncology | Taoyuan | 333 | Taiwan | Details | ||
| Charing Cross Hospital | London | W6 8RF | United Kingdom | Details | ||
| China Medical University Hospital | Taichung | 40447 | Taiwan | Details | ||
| Christie Hospital NHS Trust | Manchester | M20 4BX | United Kingdom | Details | ||
| Chu Grenoble - Hopital Albert Michallon; Departement de Cancero-Hematologie | Grenoble | 38043 | France | Details | ||
| Chulalongkorn Hospital; Medical Oncology | Bangkok | 10330 | Thailand | Details | ||
| Cite de La Sante de Laval; Hemato-Oncologie | Laval | Quebec | H7M 3L9 | Canada | Details | |
| City Clinical Onc. | Saint-Petersburg | 198255 | Russian Federation | Details | ||
| Clinic for Pulmonology, Clinical Center of Serbia | Belgrade | 11000 | Serbia | Details | ||
| Coastal Integrative Cancer Care | San Luis Obispo | California | 93401 | United States | Details | |
| COIBA | Provincia De Buenos Aires | B1884BBF | Argentina | Details | ||
| Complejo Hospitalario Universitario A Coruña (CHUAC, Materno Infantil), Oncología | La Coruña | 15006 | Spain | Details | ||
| Comprehensive Blood/Cancer Ctr | Bakersfield | California | 93309 | United States | Details | |
| Comprehensive Cancer Centers of Nevada | Henderson | Nevada | 89014 | United States | Details | |
| Comprehensive Cancer Centers of Nevada - Eastern Avenue | Las Vegas | Nevada | 89169 | United States | Details | |
| Cross Cancer Institute | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| Diana Princess of Wales Hosp. | Grimsby | DN33 2BA | United Kingdom | Details | ||
| Dunedin Hospital | Dunedin | New Zealand | Details | |||
| Fachklinik für Lungenerkrankungen | Immenhausen | 34376 | Germany | Details | ||
| Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology | Bangkok | 10700 | Thailand | Details | ||
| Fundacion Jimenez Diaz; Servicio de Oncologia | Madrid | 28040 | Spain | Details | ||
| Georgia Cancer Specialists | Atlanta | Georgia | 30341 | United States | Details | |
| GH Paris Saint Joseph; Pneumologie | Paris | 75674 | France | Details | ||
| Grupo Angeles | Guatemala City | 01015 | Guatemala | Details | ||
| Guys and St Thomas NHS Foundation Trust, Guys Hospital | London | SE1 9RT | United Kingdom | Details | ||
| Helios Klinikum Emil von Behring GmbH | Berlin | 14165 | Germany | Details | ||
| Helsinki University Central Hospital; Dep. of Pulmonary Medicine | Helsinki | 00290 | Finland | Details | ||
| Hematology-Oncology; Associates of the Quad Cities | Bettendorf | Iowa | 52722 | United States | Details | |
| Hia Sainte Anne; Pneumologie | Toulon | 83041 | France | Details | ||
| Hopital Cochin; Unite Fonctionnelle D Oncologie | Paris | 75014 | France | Details | ||
| Hopital de Pontchaillou; Service de Pneumologie | Rennes | 35033 | France | Details | ||
| Hopital Emile Muller;Pneumologie | Mulhouse | 68070 | France | Details | ||
| Hopital Foch; Pneumologie | Suresnes | 92151 | France | Details | ||
| Hopital Jean Minjoz; Pneumologie | Besancon | 25030 | France | Details | ||
| Hopital Larrey; Pneumologie | Toulouse | 31059 | France | Details | ||
| Hopital Nord; Service d'Oncologie Multidisciplinaire et Innovation Thérapeutique | Marseille | 13915 | France | Details | ||
| Hopital Saint Louis; Oncologie Medicale | Paris | 75475 | France | Details | ||
| Hopital Tenon;Pneumologie | Paris | 75970 | France | Details | ||
| Hospital das Clinicas - UFRGS | Porto Alegre | RS | 90035-903 | Brazil | Details | |
| Hospital Geral; Servico de Pneumologia | Coimbra | 3041-801 | Portugal | Details | ||
| Hospital Pulido Valente; Servico de Pneumologia | Lisboa | 1796-001 | Portugal | Details | ||
| Hospital Ramon y Cajal; Servicio de Oncologia | Madrid | 28034 | Spain | Details | ||
| Hospital Regional Universitario Carlos Haya; Servicio de Oncologia | Malaga | 29010 | Spain | Details | ||
| Hospital Universitario 12 de Octubre; Servicio de Oncologia | Madrid | 28041 | Spain | Details | ||
| Hospital Universitario Clínico San Carlos; Servicio de Oncologia | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario La Paz; Servicio de Oncologia | Madrid | 28046 | Spain | Details | ||
| Hospital Universitario Materno Infantil de Gran Canaria; Servicio de Oncologia | Las Palmas de Gran Canaria | LAS Palmas | 35016 | Spain | Details | |
| Hospital Universitario Miguel Servet; Servicio Oncologia | Zaragoza | 50009 | Spain | Details | ||
| Hospital Universitario Puerta de Hierro; Servicio de Oncologia | Majadahonda | Madrid | 28222 | Spain | Details | |
| HUG; Oncologie | Geneve | 1211 | Switzerland | Details | ||
| Hyogo Cancer Center; Thoracic Oncology | Hyogo | 673-8558 | Japan | Details | ||
| Illinois Cancer Care | Peoria | Illinois | 61615 | United States | Details | |
| Ingalls Memorial Hospital | Harvey | Illinois | 60426 | United States | Details | |
| Institut Sainte Catherine | Avignon | 84918 | France | Details | ||
| Institute for pulmonary diseases of Vojvodina | Sremska Kamenica | 21204 | Serbia | Details | ||
| Instituto de Oncología de Rosario | Rosario | S2000KZE | Argentina | Details | ||
| Instituto Medico Rio Cuarto | Córdoba | Argentina | Details | |||
| IPO do Porto; Servico de Oncologia Medica | Porto | 4200-072 | Portugal | Details | ||
| Irccs Centro Di Riferimento Oncologico (CRO); Dipartimento Di Oncologia Medica | Aviano | Friuli-Venezia Giulia | 33081 | Italy | Details | |
| Irccs Ist. Tumori Giovanni Paolo Ii; Dipartimento Oncologia Medica | Bari | Puglia | 70124 | Italy | Details | |
| IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Seconda | Padova | Veneto | 35128 | Italy | Details | |
| Irccs Ospedale San Raffaele;Oncologia Medica | Milano | Lombardia | 20132 | Italy | Details | |
| Istanbul Uni Cerrahpasa Medical Faculty Hospital; Medical Oncology | Istanbul | 34300 | Turkey | Details | ||
| Istituto Europeo Di Oncologia | Milano | Lombardia | 20141 | Italy | Details | |
| Istituto Nazionale per la Ricerca sul Cancro di Genova | Genova | Liguria | 16132 | Italy | Details | |
| Izmir Suat Seren Chest Diseases and Surgery Research Hospital | Izmir | 35110 | Turkey | Details | ||
| Jeroen Bosch Ziekenhuis | 'S Hertogenbosch | 5223 GZ | Netherlands | Details | ||
| K. Permanente - S. San Fran | South San Francisco | California | 94080 | United States | Details | |
| K. Permanente - San Jose | San Jose | California | 95119 | United States | Details | |
| K. Permanente - Santa Clara | Santa Clara | California | 95051 | United States | Details | |
| K. Permanente - Walnut Creek | Walnut Creek | California | 94596 | United States | Details | |
| Kaiser Permanente - Franklin; Kaiser Permanente - Lone Tree | Lone Tree | Colorado | United States | Details | ||
| Kaiser Permanente - Hayward | Hayward | California | 94545 | United States | Details | |
| Kaiser Permanente - Oakland | Oakland | California | 94611 | United States | Details | |
| Kaiser Permanente - Roseville | Roseville | California | 95661 | United States | Details | |
| Kaiser Permanente - San Francisco (2238 Geary) | San Francisco | California | 94115 | United States | Details | |
| Kaiser Permanente - San Marcos | San Marcos | California | 92069 | United States | Details | |
| Kaiser Permanente - Vallejo | Vallejo | California | 94589 | United States | Details | |
| Kaiser Permanente Sacramento Medical Center | Sacramento | California | 95814 | United States | Details | |
| Kantonsspital Baden; Medizinische Klinik, Onkologie | Baden | 5404 | Switzerland | Details | ||
| Karkiv Regional Oncology Center | Kharkiv | 61070 | Ukraine | Details | ||
| Karmanos Cancer Inst. ; Hudson Webber; Cancer Research Building | Detroit | Michigan | 48201 | United States | Details | |
| Karolinska Universitetssjukhuset, Solna; Lung Allergikliniken N10:02 | Stockholm | 171 76 | Sweden | Details | ||
| Kindai University Hospital; Medical Oncology | Osaka | 589-8511 | Japan | Details | ||
| Kings Mill Hospital | Sutton in Ashfield | NG17 4JL | United Kingdom | Details | ||
| Kobe City Medical Center General Hospital; Respiratory Medicine | Hyogo | 650-0047 | Japan | Details | ||
| Krankenhaus Martha-Maria Halle-Doelau gGmbH; Klinik fuer Innere Medizin II | Halle | 06120 | Germany | Details | ||
| Krankenhaus Merheim Lungenklinik | Köln | 51109 | Germany | Details | ||
| Krankenhaus Nordwest; Klinik f. Onkologie und Hämatologie | Frankfurt | 60488 | Germany | Details | ||
| Lkh innsbruck - univ. Klinikum innsbruck - Tiroler landeskrankenanstalten ges.m.b.h.; Innere Medizin | Innsbruck | 6020 | Austria | Details | ||
| Lkh Salzburg - Univ. Klinikum Salzburg; Iii. Medizinische Abt. | Salzburg | 5020 | Austria | Details | ||
| Lkh Vöcklabruck; I. Abt. Für Innere Medizin | Vöcklabruck | 4840 | Austria | Details | ||
| Luckow Pavillion, Valley Hosp; Office of Clinical Trials | Paramus | New Jersey | 07652 | United States | Details | |
| Lungenklinik Hemer | Hemer | 58675 | Germany | Details | ||
| Luzerner Kantonsspital; Medizinische Onkologie | Luzern | 6004 | Switzerland | Details | ||
| Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy; Oddzial Iii | Otwock | 05-400 | Poland | Details | ||
| McGill University; Sir Mortimer B Davis Jewish General Hospital; Oncology | Montreal | Quebec | H3T 1E2 | Canada | Details | |
| Med.-Polonia Sp. z o.o. NSZOZ | Poznan | 60-693 | Poland | Details | ||
| Medical University of Gdansk | Gdansk | 80-952 | Poland | Details | ||
| Mid Ohio Onc Hematology Inc | Columbus | Ohio | 43219 | United States | Details | |
| Miyagi Cancer Center; Respiratory Medicine | Miyagi | 981-1293 | Japan | Details | ||
| Montana Cancer Specialists | Missoula | Montana | 59802 | United States | Details | |
| N.N.Burdenko Main Military Clinical Hospital; Oncology Dept | Moscow | 105229 | Russian Federation | Details | ||
| National Cancer Center Hospital East; Thoracic Oncology | Chiba | 277-8577 | Japan | Details | ||
| National Cancer Center Hospital; Thoracic Medical Oncology | Tokyo | 104-0045 | Japan | Details | ||
| National Cancer Center; Medical Oncology | Gyeonggi-do | 410-769 | Korea, Republic of | Details | ||
| National Hospital Organization Kinki-Chuo Chest Medical Center; Internal Medicine | Osaka | 591-8555 | Japan | Details | ||
| National Hospital Organization Kyushu Cancer Center, Thoracic Oncology | Fukuoka | 811-1395 | Japan | Details | ||
| National Hospital Organization Shikoku Cancer Center; Internal Medicine | Ehime | 791-0280 | Japan | Details | ||
| National Hospital Organization, Yamaguchi - Ube Medical Center; Oncology Medicine | Yamaguchi | 755-0241 | Japan | Details | ||
| National Taiwan Uni Hospital; Internal Medicine | Taipei | 100 | Taiwan | Details | ||
| New England Cancer Specialists | Scarborough | Maine | 04074 | United States | Details | |
| New York Oncology Hematology PC - Latham | Clifton Park | New York | 12065 | United States | Details | |
| North Valley Hem Onc Med Grp; Thomas&Dorothy Leavey Can Ctr | Northridge | California | 91328 | United States | Details | |
| Northwest Cancer Specialists - Vancouver | Vancouver | Washington | 98684 | United States | Details | |
| Northwest Medical Specialties | Tacoma | Washington | 98405 | United States | Details | |
| Okayama University Hospital; Respiratory and Allergy Medicine | Okayama | 700-8558 | Japan | Details | ||
| ONCOCENTRO APYS; Oncología | Vina Del Mar | 2520598 | Chile | Details | ||
| Oncology Hematology West Midwest | Omaha | Nebraska | 68130 | United States | Details | |
| Orlando Health Inc. | Orlando | Florida | 32806 | United States | Details | |
| Oslo Universitetssykehus HF; Radiumhospitalet | Oslo | 0310 | Norway | Details | ||
| Ospedale San Luca; Oncologia | Lucca | Toscana | 55100 | Italy | Details | |
| Oulu University Hospital; Oncology | Oulu | 90029 | Finland | Details | ||
| Pacific Shores Medical Group | Long Beach | California | 90813 | United States | Details | |
| POLICLINICO RODOLICO, U.O. di Oncologia Medica | Catania | Sicilia | 95100 | Italy | Details | |
| Polyclinique Bordeaux Nord Aquitaine; Chimiotherapie Radiotherapie | Bordeaux | 33077 | France | Details | ||
| Quincy Medical Group | Quincy | Illinois | 62301 | United States | Details | |
| Ramathibodi Hospital; Dept of Med.-Div. of Med. Onc | Bangkok | 10400 | Thailand | Details | ||
| Rhode Island Hospital | Providence | Rhode Island | 02903 | United States | Details | |
| Roswell Park Cancer Inst. | Buffalo | New York | 14263 | United States | Details | |
| Roy & Patricia Disney Family Cancer Center | Burbank | California | 91505 | United States | Details | |
| Royal Free Hospital | London | NW3 2QS | United Kingdom | Details | ||
| Sahlgrenska Universitetssjukhuset, Lungmedicinkliniken | Goeteborg | 41345 | Sweden | Details | ||
| Saitama Cancer Center; Thoracic Oncology | Saitama | 362-0806 | Japan | Details | ||
| Samsung Medical Center; Gastroenterology | Seoul | 135-710 | Korea, Republic of | Details | ||
| San Juan Oncology Associates | Farmington | New Mexico | 87401 | United States | Details | |
| SBI of Healthcare Samara Regional Clinical Oncology Dispensary | Samara | 443031 | Russian Federation | Details | ||
| Scripps Clinic; Hematology & Oncology | La Jolla | California | 92037-1027 | United States | Details | |
| Seconda Universita' Degli Studi; Divsione Di Oncologia Medica | Napoli | Campania | 80131 | Italy | Details | |
| Semmelweis Egyetem X; Pulmonologiai Klinika | Budapest | 1083 | Hungary | Details | ||
| Seoul National Uni Hospital; Internal Medicine | Seoul | 03080 | Korea, Republic of | Details | ||
| Seoul National University Bundang Hospital; Hematology Medical Oncology | Gyeonggi-do | 463-707 | Korea, Republic of | Details | ||
| Seoul St.Mary's Hospital; Medical Oncology | Seoul | 137-807 | Korea, Republic of | Details | ||
| Shizuoka Cancer Center; Thoracic Oncology | Shizuoka | 411-8777 | Japan | Details | ||
| Sociedad de Investigaciones Medicas Ltda (SIM) | Temuco | 4810469 | Chile | Details | ||
| St George's Hospital | London | SW17 0QT | United Kingdom | Details | ||
| St. Jude Heritage Healthcare; Virgiia K.Crosson Can Ctr | Fullerton | California | 92835 | United States | Details | |
| St. Mary's Hospital Regional Cancer Center | Grand Junction | Colorado | 81501 | United States | Details | |
| State Medical Academy; Oncology | Dnipropetrovsk | 43102 | Ukraine | Details | ||
| Summit Medical Center | Florham Park | New Jersey | 07932 | United States | Details | |
| Taipei Veterans General Hospital; Chest Dept , Section of Thoracic Oncology | Taipei | 112 | Taiwan | Details | ||
| Tampere University Hospital; Dept of Oncology | Tampere | 33520 | Finland | Details | ||
| Texas Onc-Central Austin CA Ct | Austin | Texas | 78731 | United States | Details | |
| Texas Oncology, P.A. - Tyler; Tyler Cancer Center | Tyler | Texas | 75702 | United States | Details | |
| The Cancer Institute Hospital of JFCR, Respiratory Medicine | Tokyo | 135-8550 | Japan | Details | ||
| The Methodist Cancer Center | Houston | Texas | 77030 | United States | Details | |
| Thermi Clinic; Oncology Clinic | Thermi Thessalonikis | 570 01 | Greece | Details | ||
| Thoraxklinik Heidelberg gGmbH | Heidelberg | 69126 | Germany | Details | ||
| TMPN/ Cancer Care Associates | Redondo Beach | California | 90277 | United States | Details | |
| Tokyo Medical University Hospital; Dept of Surgery | Tokyo | 160-0023 | Japan | Details | ||
| Tudogyogyintezet Torokbalint | Torokbalint | 2045 | Hungary | Details | ||
| UC Davis; Comprehensive Cancer Center | Sacramento | California | 95817 | United States | Details | |
| Uni Cattolica Policlinico Gemelli; Oncologia Medica Ist. Medicina Interna | Roma | Lazio | 00168 | Italy | Details | |
| Univ of Calif, Los Angeles; Hematology/Oncology | Los Angeles | California | 90095 | United States | Details | |
| Universitetssjukhuset Linköping; Lungmedicinkliniken | Linköping | 581 85 | Sweden | Details | ||
| University College London Hospital | London | NW1 - 2PG | United Kingdom | Details | ||
| University Hospital of Patras Medical Oncology | Patras | 265 04 | Greece | Details | ||
| University of Minnesota | Minneapolis | Minnesota | 55455 | United States | Details | |
| University of Pecs, I st Dept of Internal Medicine | Pecs | 7624 | Hungary | Details | ||
| Universitätsklinikum Regensburg; Klinik und Poliklinik für Innere Medizin II, Pneumologie | Regensburg | 93053 | Germany | Details | ||
| Uoa Sotiria Hospital; Oncology | Athens | 115 27 | Greece | Details | ||
| US Oncology Research at Minnesota Oncology | Minneapolis | Minnesota | 55404 | United States | Details | |
| Uzhgorod Nat. University Central Municip Hosp; Onc Center | Uzhgorod | 88000 | Ukraine | Details | ||
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | United States | Details | |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | United States | Details | |
| Waikato Hospital; Dept of Medical Oncology | Hamilton | 3240 | New Zealand | Details | ||
| Willamette Valley Cancer Ctr - 520 Country Club | Eugene | Oregon | 97401-8122 | United States | Details | |
| Windsor Regional Cancer Centre | Windsor | Ontario | N8W 2X3 | Canada | Details | |
| Woj.Wielospecjalistyczne Centrum Onkologii i Traumatologii; Oddz.Hematologii Pododz.Chemioterapii | Lodz | 93-513 | Poland | Details | ||
| Yonsei University Severance Hospital; Medical Oncology | Seoul | 120-752 | Korea, Republic of | Details |
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