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| NCT ID | NCT02352948 |
| Title | A Global Study to Assess the Effects of MEDI4736 (Durvalumab), Given as Monotherapy or in Combination With Tremelimumab Determined by PD-L1 Expression Versus Standard of Care in Patients With Locally Advanced or Metastatic Non Small Cell Lung Cancer (ARCTIC) |
| Acronym | ARCTIC |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | AstraZeneca |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | ROU | POL | NLD | ITA | ISR | HUN | GRC | GBR | FRA | ESP | DEU | CZE | CAN | BGR | BEL | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Research Site | Chandler | Arizona | 85224 | United States | Details | |
| Research Site | Anaheim | California | 92801 | United States | Details | |
| Research Site | Duarte | California | 91010 | United States | Details | |
| Research Site | La Jolla | California | 92093 | United States | Details | |
| Research Site | San Diego | California | 92123 | United States | Details | |
| Research Site | Aurora | Colorado | 80045 | United States | Details | |
| Research Site | Fort Myers | Florida | 33901 | United States | Details | |
| Research Site | Orlando | Florida | 32804 | United States | Details | |
| Research Site | Port Saint Lucie | Florida | 34952 | United States | Details | |
| Research Site | Saint Petersburg | Florida | 33705 | United States | Details | |
| Research Site | Athens | Georgia | 30607 | United States | Details | |
| Research Site | Atlanta | Georgia | 30322 | United States | Details | |
| Research Site | Lawrenceville | Georgia | 30046 | United States | Details | |
| Research Site | Chicago | Illinois | 60612 | United States | Details | |
| Research Site | Waterloo | Iowa | 50701 | United States | Details | |
| Research Site | Ashland | Kentucky | 41101 | United States | Details | |
| Research Site | Rockville | Maryland | 20850 | United States | Details | |
| Research Site | Battle Creek | Michigan | 49017 | United States | Details | |
| Research Site | Saint Louis | Missouri | 63156 | United States | Details | |
| Research Site | Lincoln | Nebraska | 68506 | United States | Details | |
| Research Site | Bronx | New York | 10461-2375 | United States | Details | |
| Research Site | Mineola | New York | 11501 | United States | Details | |
| Research Site | New York | New York | 10011 | United States | Details | |
| Research Site | New York | New York | 10029 | United States | Details | |
| Research Site | Charlotte | North Carolina | 28204 | United States | Details | |
| Research Site | Pinehurst | North Carolina | 28374 | United States | Details | |
| Research Site | Cincinnati | Ohio | 45242 | United States | Details | |
| Research Site | West Chester | Ohio | 45069 | United States | Details | |
| Research Site | Chattanooga | Tennessee | 37404 | United States | Details | |
| Research Site | Germantown | Tennessee | 38138 | United States | Details | |
| Research Site | Nashville | Tennessee | 37203 | United States | Details | |
| Research Site | Salt Lake City | Utah | 84106 | United States | Details | |
| Research Site | Spokane | Washington | 99208 | United States | Details | |
| Research Site | Murdoch | 6150 | Australia | Details | ||
| Research Site | Port Macquarie | 2444 | Australia | Details | ||
| Research Site | Charleroi | 6000 | Belgium | Details | ||
| Research Site | Gent | 9000 | Belgium | Details | ||
| Research Site | Libramont-Chevigny | 6800 | Belgium | Details | ||
| Research Site | Mons | 7000 | Belgium | Details | ||
| Research Site | Roeselare | 8800 | Belgium | Details | ||
| Research Site | Yvoir | 5530 | Belgium | Details | ||
| Research Site | Pleven | 5800 | Bulgaria | Details | ||
| Research Site | Sofia | 1330 | Bulgaria | Details | ||
| Research Site | Sofia | 1407 | Bulgaria | Details | ||
| Research Site | Varna | 9010 | Bulgaria | Details | ||
| Research Site | Moncton | New Brunswick | E1C 6Z8 | Canada | Details | |
| Research Site | Saint John | New Brunswick | E2L 4L2 | Canada | Details | |
| Research Site | Santiago | 7500000 | Chile | Details | ||
| Research Site | Santiago | 8420383 | Chile | Details | ||
| Research Site | Temuco | 4810469 | Chile | Details | ||
| Research Site | Nova Ves pod Plesi | 262 04 | Czechia | Details | ||
| Research Site | Praha 2 | 128 08 | Czechia | Details | ||
| Research Site | Praha 5 | 150 06 | Czechia | Details | ||
| Research Site | Avignon Cedex 9 | 84918 | France | Details | ||
| Research Site | Bayonne | 64100 | France | Details | ||
| Research Site | Brest Cedex | 29609 | France | Details | ||
| Research Site | Creteil | 94010 | France | Details | ||
| Research Site | Le Mans | 72000 | France | Details | ||
| Research Site | Marseille Cedex 20 | 13915 | France | Details | ||
| Research Site | Montpellier Cedex | 34295 | France | Details | ||
| Research Site | Nice | 06100 | France | Details | ||
| Research Site | Pau Cedex | 64046 | France | Details | ||
| Research Site | Saint Herblain | 44805 | France | Details | ||
| Research Site | Toulon | 83100 | France | Details | ||
| Research Site | Villejuif | 94800 | France | Details | ||
| Research Site | Berlin | 10117 | Germany | Details | ||
| Research Site | Berlin | 10967 | Germany | Details | ||
| Research Site | Berlin | 12351 | Germany | Details | ||
| Research Site | Dresden | 01307 | Germany | Details | ||
| Research Site | Gauting | 82131 | Germany | Details | ||
| Research Site | Halle | 06120 | Germany | Details | ||
| Research Site | Hamburg | 22081 | Germany | Details | ||
| Research Site | Hannover | 30625 | Germany | Details | ||
| Research Site | Homburg | 66421 | Germany | Details | ||
| Research Site | Köln | 51109 | Germany | Details | ||
| Research Site | Löwenstein | 74245 | Germany | Details | ||
| Research Site | Regensburg | 93053 | Germany | Details | ||
| Research Site | Trier | 54290 | Germany | Details | ||
| Research Site | Ulm | 89081 | Germany | Details | ||
| Research Site | Villingen-Schwenningen | 78052 | Germany | Details | ||
| Research Site | Athens | 11527 | Greece | Details | ||
| Research Site | Thessaloniki | 54645 | Greece | Details | ||
| Research Site | Thessaloniki | 57010 | Greece | Details | ||
| Research Site | Hong Kong | Hong Kong | Details | |||
| Research Site | Miskolc | 3529 | Hungary | Details | ||
| Research Site | Törökbálint | 2045 | Hungary | Details | ||
| Research Site | Zalaegerszeg | 8000 | Hungary | Details | ||
| Research Site | Zalaegerszeg | 8900 | Hungary | Details | ||
| Research Site | Tel Hashomer | 52621 | Israel | Details | ||
| Research Site | Aviano | 33081 | Italy | Details | ||
| Research Site | Candiolo | 10060 | Italy | Details | ||
| Research Site | Catania | 95123 | Italy | Details | ||
| Research Site | Cremona | 26100 | Italy | Details | ||
| Research Site | Genova | 16100 | Italy | Details | ||
| Research Site | Lucca | 55100 | Italy | Details | ||
| Research Site | Milano | 20132 | Italy | Details | ||
| Research Site | Milano | 20133 | Italy | Details | ||
| Research Site | Milano | 20141 | Italy | Details | ||
| Research Site | Monza | 20900 | Italy | Details | ||
| Research Site | Napoli | 80131 | Italy | Details | ||
| Research Site | Orbassano | 10043 | Italy | Details | ||
| Research Site | Parma | 43100 | Italy | Details | ||
| Research Site | Pisa | 56124 | Italy | Details | ||
| Research Site | Rimini | 47900 | Italy | Details | ||
| Research Site | Terni | 05100 | Italy | Details | ||
| Research Site | Fukuoka-shi | 812-8582 | Japan | Details | ||
| Research Site | Habikino-shi | 583-8588 | Japan | Details | ||
| Research Site | Hidaka-shi | 350-1298 | Japan | Details | ||
| Research Site | Hirakata-shi | 573-1191 | Japan | Details | ||
| Research Site | Hirosaki-shi | 036-8545 | Japan | Details | ||
| Research Site | Hiroshima-shi | 730-8518 | Japan | Details | ||
| Research Site | Kanazawa | 920-8641 | Japan | Details | ||
| Research Site | Kobe-shi | 650-0047 | Japan | Details | ||
| Research Site | Kurume-shi | 830-0011 | Japan | Details | ||
| Research Site | Matsuyama-shi | 791-0280 | Japan | Details | ||
| Research Site | Nagoya-shi | 460-0001 | Japan | Details | ||
| Research Site | Nagoya-shi | 464-8681 | Japan | Details | ||
| Research Site | Nagoya-shi | 466-8560 | Japan | Details | ||
| Research Site | Natori-shi | 981-1293 | Japan | Details | ||
| Research Site | Okayama-shi | 700-8558 | Japan | Details | ||
| Research Site | Osaka-shi | 541-8567 | Japan | Details | ||
| Research Site | Osakasayama | 589-8511 | Japan | Details | ||
| Research Site | Sakai-shi | 591-8555 | Japan | Details | ||
| Research Site | Sapporo-shi | 003-0804 | Japan | Details | ||
| Research Site | Sapporo-shi | 060-8648 | Japan | Details | ||
| Research Site | Sendai-shi | 980-0873 | Japan | Details | ||
| Research Site | Shinjuku-ku | 160-0023 | Japan | Details | ||
| Research Site | Shinjuku-ku | 162-8655 | Japan | Details | ||
| Research Site | Sunto-gun | 411-8777 | Japan | Details | ||
| Research Site | Takatsuki-shi | 569-8686 | Japan | Details | ||
| Research Site | Wakayama-shi | 641-8510 | Japan | Details | ||
| Research Site | Yokohama-shi | 221-0855 | Japan | Details | ||
| Research Site | Yokohama-shi | 236-0024 | Japan | Details | ||
| Research Site | Busan | 49201 | Korea, Republic of | Details | ||
| Research Site | Cheongju-si | 28644 | Korea, Republic of | Details | ||
| Research Site | Incheon | 405-760 | Korea, Republic of | Details | ||
| Research Site | Jeonnam | 58128 | Korea, Republic of | Details | ||
| Research Site | Seongnam-si | 13620 | Korea, Republic of | Details | ||
| Research Site | Seoul | 02841 | Korea, Republic of | Details | ||
| Research Site | Seoul | 05505 | Korea, Republic of | Details | ||
| Research Site | Seoul | 06351 | Korea, Republic of | Details | ||
| Research Site | Amsterdam | 1081 HV | Netherlands | Details | ||
| Research Site | Lublin | 20-362 | Poland | Details | ||
| Research Site | Poznań | 60-569 | Poland | Details | ||
| Research Site | Warszawa | 02-781 | Poland | Details | ||
| Research Site | Alba Iulia | 510077 | Romania | Details | ||
| Research Site | Baia Mare | 430031 | Romania | Details | ||
| Research Site | Cluj Napoca | 400349 | Romania | Details | ||
| Research Site | Cluj-Napoca | 400132 | Romania | Details | ||
| Research Site | Onesti | 601048 | Romania | Details | ||
| Research Site | Oradea | 410469 | Romania | Details | ||
| Research Site | Timisoara | 300210 | Romania | Details | ||
| Research Site | Arkhangelsk | 163045 | Russian Federation | Details | ||
| Research Site | Omsk | 644013 | Russian Federation | Details | ||
| Research Site | Saint Petersburg | 197758 | Russian Federation | Details | ||
| Research Site | St. Petersburg | 197002 | Russian Federation | Details | ||
| Research Site | St. Petersburg | 197022 | Russian Federation | Details | ||
| Research Site | St. Petersburg | 197758 | Russian Federation | Details | ||
| Research Site | Belgrade | 11000 | Serbia | Details | ||
| Research Site | Belgrad | 11000 | Serbia | Details | ||
| Research Site | Gornji Matejevac | 18204 | Serbia | Details | ||
| Research Site | Kragujevac | 34000 | Serbia | Details | ||
| Research Site | Sremska Kamenica | 21204 | Serbia | Details | ||
| Research Site | Singapore | 119074 | Singapore | Details | ||
| Research Site | Singapore | 169610 | Singapore | Details | ||
| Research Site | Singapore | 308433 | Singapore | Details | ||
| Research Site | A Coruña | 15006 | Spain | Details | ||
| Research Site | Alicante | 03010 | Spain | Details | ||
| Research Site | Barcelona | 08003 | Spain | Details | ||
| Research Site | Barcelona | 08025 | Spain | Details | ||
| Research Site | Girona | 17007 | Spain | Details | ||
| Research Site | Jaén | 23007 | Spain | Details | ||
| Research Site | Lleida | 25198 | Spain | Details | ||
| Research Site | Madrid | 08035 | Spain | Details | ||
| Research Site | Madrid | 28005 | Spain | Details | ||
| Research Site | Madrid | 28007 | Spain | Details | ||
| Research Site | Madrid | 28033 | Spain | Details | ||
| Research Site | Madrid | 28046 | Spain | Details | ||
| Research Site | Madrid | 28050 | Spain | Details | ||
| Research Site | San Sebastian | 20014 | Spain | Details | ||
| Research Site | Sevilla | 41013 | Spain | Details | ||
| Research Site | Sevilla | 41071 | Spain | Details | ||
| Research Site | Valencia | 46014 | Spain | Details | ||
| Research Site | Valencia | 46026 | Spain | Details | ||
| Research Site | Taichung | 40447 | Taiwan | Details | ||
| Research Site | Taichung | 40705 | Taiwan | Details | ||
| Research Site | Tainan | 704 | Taiwan | Details | ||
| Research Site | Taipei City | 110 | Taiwan | Details | ||
| Research Site | Taipei | 10002 | Taiwan | Details | ||
| Research Site | Taipei | 112 | Taiwan | Details | ||
| Research Site | Taipei | 116 | Taiwan | Details | ||
| Research Site | Taipei | 235 | Taiwan | Details | ||
| Research Site | Bangkok | 10330 | Thailand | Details | ||
| Research Site | Muang | 50200 | Thailand | Details | ||
| Research Site | Phitsanulok | 65000 | Thailand | Details | ||
| Research Site | Songkla | 90110 | Thailand | Details | ||
| Research Site | Birmingham | B15 2WB | United Kingdom | Details | ||
| Research Site | London | EC1A 7BE | United Kingdom | Details | ||
| Research Site | London | W1G 6AD | United Kingdom | Details | ||
| Research Site | Southampton | SO16 6YD | United Kingdom | Details | ||
| Research Site | Stevenage | SG1 4AB | United Kingdom | Details | ||
| Research Site | Truro | TR1 3LJ | United Kingdom | Details | ||
| Research Site | Wolverhampton | WV10 0QP | United Kingdom | Details |