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| NCT ID | NCT02467270 |
| Title | Ponatinib in Patients With Resistant Chronic Phase Chronic Myeloid Leukemia (CML) to Characterize the Efficacy and Safety of a Range of Doses |
| Acronym | OPTIC |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase II |
| Variant Requirements | No |
| Sponsors | Ariad Pharmaceuticals |
| Indications | |
| Therapies | |
| Age Groups: | adult |
| Covered Countries | USA | SWE | POL | ITA | GBR | FRA | ESP | DNK | DEU | CZE | CHE | CAN | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Emory University Winship Cancer Institute | Atlanta | Georgia | 30322 | United States | Details | |
| Indiana Blood & Marrow Transplantation | Indianapolis | Indiana | 46237 | United States | Details | |
| University of Maryland Medical Center | Baltimore | Maryland | 21201 | United States | Details | |
| Michigan Medicine | Ann Arbor | Michigan | 48109 | United States | Details | |
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201 | United States | Details | |
| University of Minnesota Medical School | Minneapolis | Minnesota | 55455 | United States | Details | |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | United States | Details | |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | United States | Details | |
| Memorial Sloan-Kettering Cancer Center - New York | New York | New York | 10065 | United States | Details | |
| NewYork-Presbyterian Weill Cornell Medical Center | New York | New York | 10065 | United States | Details | |
| Duke University Medical Center | Durham | North Carolina | 27710 | United States | Details | |
| Cleveland Clinic Taussig Cancer Institute Main Campus | Cleveland | Ohio | 44195 | United States | Details | |
| Oregon Health and Science University | Portland | Oregon | 97239 | United States | Details | |
| Abramson Cancer Center | Philadelphia | Pennsylvania | 19104 | United States | Details | |
| MD Anderson Cancer Center | Houston | Texas | 77030 | United States | Details | |
| University of Utah Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | United States | Details | |
| Fundaleu | Ciudad Autonoma de Buenos Aires | Buenos Aires | C1114AAN | Argentina | Details | |
| Hospital General de Agudo Jose Maria Ramos Mejia | Ciudad Autonoma de Buenos Aires | Buenos Aires | C1221ADC | Argentina | Details | |
| Hospital Italiano La Plata | La Plata | Buenos Aires | B1900AXI | Argentina | Details | |
| Royal North Shore Hospital | Saint Leonards | New South Wales | 2065 | Australia | Details | |
| Royal Adelaide Hospital | Adelaide | South Australia | 5000 | Australia | Details | |
| Princess Margaret Hospital - Toronto | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| Jewish General Hospital | Montreal | Quebec | H3T 1E2 | Canada | Details | |
| Saskatchewan Cancer Agency | Regina | Saskatchewan | S4T 7T1 | Canada | Details | |
| Hospital del Salvador | Providencia | Santiago | 7500922 | Chile | Details | |
| Centro de Investigaciones Clinicas Vina del Mar | Vina del Mar | Valparaiso | 2540364 | Chile | Details | |
| Ustav Hematologie a Krevni Transfuze Praha | Prague | Praha | 12820 | Czechia | Details | |
| Fakultni Nemocnice Olomouc | Olomouc | 772 00 | Czechia | Details | ||
| Aarhus University Hospital | Aarhus C | \Aarhus | DK-8000 | Denmark | Details | |
| Centre de Lutte Contre le Cancer - Institut Bergonie | Bordeaux | Aquitaine | 33076 | France | Details | |
| Centre Hospitalier Universitaire de Nancy Hopital de Brabois | Vandoeuvre les Nancy | Lorraine | 54511 | France | Details | |
| Institut Universitaire du Cancer de Toulouse Oncopole | Toulouse Cedex 9 | Midi-pyrenees | 31059 | France | Details | |
| Centre Hospitalier Regional Universitaire de Lille | Lille cedex | NORD Pas-de-calais | 59037 | France | Details | |
| Center Hospitalier Universitaire d'Angers | Angers Cedex 9 | PAYS DE LA Loire | 49933 | France | Details | |
| Centre Hospitalier Universitaire de Nantes Hotel Dieu | Nantes Cedex 1 | PAYS DE LA Loire | 44093 | France | Details | |
| Centre Hospitalier Universitaire de Poitiers | Poitiers Cedex | Poitou-charentes | 86021 | France | Details | |
| Centre Hospitalier Universitaire de Nice Hopital l'Archet | Nice Cedex 3 | Provence Alpes COTE D'azur | 06202 | France | Details | |
| Universitaetsklinikum Heidelberg | Mannheim | Baden-wuerttemberg | 68169 | Germany | Details | |
| Universitatsklinikum Ulm | Ulm | Baden-wuerttemberg | 89081 | Germany | Details | |
| Universitatsmedizin Rostock | Rostock | Mecklenburg-vorpommern | 18057 | Germany | Details | |
| Uniklinik RWTH Aachen | Aachen | Nordrhein-westfalen | 52074 | Germany | Details | |
| Universitaetsklinikum Essen | Essen | Nordrhein-westfalen | 45147 | Germany | Details | |
| Universitatsklinikum Jena | Jena | Thuringen | 07747 | Germany | Details | |
| Charite Universitatsmedizin Berlin | Berlin | 13353 | Germany | Details | ||
| Universitatsklinikum Hamburg-Eppendorf | Hamburg | 20246 | Germany | Details | ||
| Queen Mary Hospital | Hong Kong | 852 | Hong Kong | Details | ||
| Azienda Ospedaliera San Gerardo di Monza | Monza | Monza E Brianza | 20090 | Italy | Details | |
| Azienda Ospedaliera Ospedali Riuniti Marche Nord | Pesaro | Pesaro E Urbino | 61100 | Italy | Details | |
| Azienda Ospedaliero - Universitaria Policlinico - Vittorio Emanuele | Catania | 95124 | Italy | Details | ||
| Azienda Ospedaliera Universitaria San Martino | Genova | 16132 | Italy | Details | ||
| Azienda Sanitaria Locale di Pescara Ospedale Civile Dello Spirito Santo | Pescara | 65124 | Italy | Details | ||
| Sapienza Universita Di Roma | Roma | 00161 | Italy | Details | ||
| AOUI - Ospedale Policlinico "Giambattista Rossi" di Borgo Roma | Verona | 37134 | Italy | Details | ||
| The Catholic University of Korea, Seoul St. Mary's Hospital | Seoul | 6591 | Korea, Republic of | Details | ||
| Samodzielny Publiczny Szpital Kliniczny Nr 1 we Wroclawiu | Wroclaw | Dolnoslaskie | 50-367 | Poland | Details | |
| Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi | Lodz | Lodzkie | 93-510 | Poland | Details | |
| Malopolskie Centrum Medyczne | Krakow | Malopolskie | 30-510 | Poland | Details | |
| Instytut Hematologii i Transfuzjologii | Warszawa | Mazowieckie | 02-776 | Poland | Details | |
| Uniwersyteckie Centrum Kliniczne | Gdansk | Pomorskie | 80-952 | Poland | Details | |
| Instituto Portugues de Oncologia de Lisboa Francisco Gentil | Lisboa | 1090-023 | Portugal | Details | ||
| Centro Hospitalar Sao Joao | Porto | 4200-319 | Portugal | Details | ||
| Rostov State Medical University | Rostov-na-Donu | Rostov | 344022 | Russian Federation | Details | |
| Chelyabinsk Regional Clinical Hospital | Chelyabinsk | 454076 | Russian Federation | Details | ||
| Kemerovo Regional Clinical Hospital | Kemerovo | 650066 | Russian Federation | Details | ||
| GBUZ Moscow Clinical Scientific Center DZM | Moscow | 111123 | Russian Federation | Details | ||
| Russian Academy of Medical Science | Moscow | 125167 | Russian Federation | Details | ||
| FGU Russian Scientific Research Institute of Hematology and Transfusiology | Saint Petersburg | 191024 | Russian Federation | Details | ||
| Almazov Federal North-West Medical Research Centre of Department of Health of Russian Federation | Saint Petersburg | 197341 | Russian Federation | Details | ||
| Samara State Medical University | Samara | 443099 | Russian Federation | Details | ||
| Saratov State Medical University | Saratov | 355018 | Russian Federation | Details | ||
| Singapore General Hospital | Singapore | 169856 | Singapore | Details | ||
| Hospital Regional Universitario Carlos Haya | Malaga | Andalucia | 29010 | Spain | Details | |
| Hospital Universitario de Gran Canaria Doctor Nergrin | Las Palmas de Gran Canaria | LAS Palmas | 35010 | Spain | Details | |
| Hospital Clinic i Provincial de Barcelona | Barcelona | 08036 | Spain | Details | ||
| Hospital Universitario de La Princesa | Madrid | 28006 | Spain | Details | ||
| Hospital Universitario Ramon Y Cajal | Madrid | 28034 | Spain | Details | ||
| Hospital Clinico Universitario de Valencia | Valencia | 46010 | Spain | Details | ||
| Akademiska Sjukhuset | Uppsala | 751 85 | Sweden | Details | ||
| University Hospital Zurich | Zurich | 8091 | Switzerland | Details | ||
| National Taiwan University Hospital | Taipei | 100 | Taiwan | Details | ||
| Royal Liverpool University Hospital NHS Trust | Liverpool | England | L7 8XP | United Kingdom | Details | |
| King's College Hospital NHS Foundation Trust | London | England | SE5 9RS | United Kingdom | Details | |
| Imperial College Healthcare NHS Trust | London | England | W12 0NN | United Kingdom | Details | |
| Nottingham City Hospital NHS Trust | Nottingham | England | NG5 1PB | United Kingdom | Details | |
| Churchill Hospital | Oxford | England | OX3 7LE | United Kingdom | Details | |
| Beatson West of Scotland Cancer Centre | Glasgow | Scotland | G12 0YN | United Kingdom | Details |