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NCT ID NCT02477826
Title An Open-Label, Trial of Nivolumab and Nivolumab Plus Ipilimumab Versus Platinum Doublet Chemotherapy in Subjects With Stage IV Non-Small Cell Lung Cancer (NSCLC)
Acronym CheckMate 227
Recruitment Completed
Gender both
Phase Phase III
Variant Requirements No
Sponsors Bristol-Myers Squibb
Indications
Therapies
Age Groups: adult
Covered Countries USA | ROU | POL | NLD | LBN | ITA | ISR | IRL | HUN | GRC | GBR | FRA | FIN | ESP | DEU | CZE | CHE | CAN | BRA | BEL | AUT | AUS | ARG

Facility Status City State Zip Country Details
Southern Cancer Center, Inc. Mobile Alabama 36608 United States Details
Local Institution - 0017 San Francisco California 94115 United States Details
Local Institution - 0021 New Haven Connecticut 06520 United States Details
Local Institution - 0001 Atlanta Georgia 30322 United States Details
Local Institution - 0013 Marietta Georgia 30060 United States Details
Local Institution - 0004 Lexington Kentucky 40503 United States Details
Local Institution - 0115 Saint Louis Missouri 63110 United States Details
Local Institution - 0005 Buffalo New York 14263 United States Details
Local Institution - 0019 New York New York 10065 United States Details
Local Institution - 0014 Cleveland Ohio 44106 United States Details
Local Institution - 0009 Columbus Ohio 43210 United States Details
Local Institution - 0007 Allentown Pennsylvania 18103 United States Details
Local Institution - 0075 Langhorne Pennsylvania 19047 United States Details
Local Institution - 0299 Philadelphia Pennsylvania 19107 United States Details
Local Institution - 0012 Philadelphia Pennsylvania 19111-2412 United States Details
Local Institution - 0015 Sayre Pennsylvania 18840 United States Details
Local Institution - 0008 Charleston South Carolina 29425 United States Details
Local Institution - 0080 Greenville South Carolina 29605 United States Details
Local Institution - 0010 Greenville South Carolina 29607 United States Details
Local Institution - 0020 Nashville Tennessee 37232 United States Details
Local Institution - 0306 Dallas Texas 75390-8852 United States Details
Local Institution - 0003 Dallas Texas 75390 United States Details
Local Institution - 0102 Houston Texas 77030 United States Details
Local Institution - 0011 Salt Lake City Utah 84108 United States Details
Local Institution - 0074 Kennewick Washington 99336 United States Details
Local Institution - 0170 Berazategui Buenos Aires 1880 Argentina Details
Local Institution - 0171 Capital Federal Buenos Aires 1426 Argentina Details
Local Institution - 0172 Ciudad Autonoma De Buenos Aire Buenos Aires 1181 Argentina Details
Local Institution - 0176 Ciudad de Buenos Aires Buenos Aires 1025 Argentina Details
Local Institution - 0296 Mar Del Plata Buenos Aires 7600 Argentina Details
Local Institution - 0177 Viedma RIO Negro 8500 Argentina Details
Local Institution - 0130 San Miguel de Tucuman Tucuman 4000 Argentina Details
Local Institution - 0268 Cordoba 5000 Argentina Details
Local Institution - 0272 Córdoba 5016 Argentina Details
Local Institution - 0297 Córdoba X50004FHP Argentina Details
Local Institution - 0182 Garran Australian Capital Territory 2605 Australia Details
Local Institution - 0301 Blacktown New South Wales 2148 Australia Details
Local Institution - 0300 Gosford New South Wales 2250 Australia Details
Local Institution - 0045 Brisbane Queensland 4102 Australia Details
Local Institution - 0046 Elizabeth Vale South Australia 5112 Australia Details
Local Institution - 0043 Clayton Victoria 3168 Australia Details
Local Institution - 0042 Fitzroy Victoria 3065 Australia Details
Local Institution - 0180 Perth Western Australia 6150 Australia Details
Local Institution - 0040 Murdoch 6150 Australia Details
Local Institution - 0183 North Tamworth 2340 Australia Details
Local Institution - 0241 Graz 8036 Austria Details
Local Institution - 0240 Vienna 1090 Austria Details
Local Institution - 0239 Wels 4600 Austria Details
Local Institution - 0121 Roeselare West-Vlaanderen 8800 Belgium Details
Local Institution - 0030 Edegem 2650 Belgium Details
Local Institution - 0031 Gent 9000 Belgium Details
Local Institution - 0034 Gilly 6060 Belgium Details
Local Institution - 0117 Hasselt 3500 Belgium Details
Local Institution - 0033 Sint Niklaas 9100 Belgium Details
Local Institution - 0125 Salvador Bahia 40170-110 Brazil Details
Local Institution - 0124 Ijui RIO Grande DO SUL 98700-000 Brazil Details
Local Institution - 0123 Porto Alegre Rio Grande Do Sul 90610-000 Brazil Details
Local Institution - 0127 Barretos Sao Paulo 14784-400 Brazil Details
Local Institution - 0129 Rio De Janeiro 20231-050 Brazil Details
Local Institution - 0144 Sao Paulo 01321-001 Brazil Details
Local Institution - 0126 Sao Paulo 01509-010 Brazil Details
Local Institution - 0128 Sao Paulo 05403-010 Brazil Details
Local Institution - 0103 Edmonton Alberta T6G 1Z2 Canada Details
Local Institution - 0290 St. John's Newfoundland and Labrador A1B 3V6 Canada Details
Local Institution - 0104 London Ontario N6A 5W9 Canada Details
Local Institution - 0122 Montreal Quebec H3T 1E2 Canada Details
Local Institution - 0106 Quebec City Quebec G1J 1Z4 Canada Details
Local Institution - 0107 Rimouski Quebec G5L 5T1 Canada Details
Local Institution - 0291 Sherbrooke Quebec J1H 5N4 Canada Details
Local Institution - 0292 Trois-Rivieres Quebec G8Z 3R9 Canada Details
Local Institution - 0302 Quebec G1V 4G5 Canada Details
Local Institution - 0173 Santiago Metropolitana 7500921 Chile Details
Local Institution - 0131 Santiago Región Metropolitana De Santiago 8420383 Chile Details
Local Institution - 0174 Vina Del Mar Valparaiso 254 0364 Chile Details
Local Institution - 0380 Hefei Anhui 230001 China Details
Local Institution - 0313 Beijing Beijing 100001 China Details
Local Institution - 0315 Beijing Beijing 100021 China Details
Local Institution - 0316 Beijing Beijing 100021 China Details
Local Institution - 0314 Beijing Beijing 100032 China Details
Local Institution - 0365 Chongqing Chongqing 400037 China Details
Local Institution - 0364 Chongqing Chongqing 400038 China Details
Local Institution - 0378 Chongqing Chongqing 400042 China Details
Local Institution - 0322 Guangzhou Guangdong 510060 China Details
Local Institution - 0372 Guangzhou Guangdong 510095 China Details
Local Institution - 0319 Guanzhou Guangdong 510080 China Details
Local Institution - 0323 Haikou Hainan 570311 China Details
Local Institution - 0325 Haerbin Heilongjiang 150081 China Details
Local Institution - 0324 Zhengzhou Henan 0 China Details
Local Institution - 0379 Zhengzhou Henan 450052 China Details
Local Institution - 0375 Wuhan Hubei 430024 China Details
Local Institution - 0362 Changsha Hunan 410013 China Details
Local Institution - 0347 Nanchang Jiangxi 0 China Details
Local Institution - 0329 Changchun Jilin 130012 China Details
Local Institution - 0361 Changchun Jilin 130021 China Details
Local Institution - 0359 Shenyang Liaoning 110000 China Details
Local Institution - 0371 Xi'an Shaanxi 710061 China Details
Local Institution - 0333 Xi'an Shan3xi 710038 China Details
Local Institution - 0360 Qingdao Shandong 266061 China Details
Local Institution - 0334 Shanghai Shanghai 200032 China Details
Local Institution - 0376 Chengdu Sichuan 610041 China Details
Local Institution - 0373 Tianjin Tianjin 300060 China Details
Local Institution - 0340 Urumqi Xinjiang 830011 China Details
Local Institution - 0343 Hangzhou Zhejiang 310003 China Details
Local Institution - 0370 Hangzhou Zhejiang 310009 China Details
Local Institution - 0342 Hangzhou Zhejiang 310022 China Details
Local Institution - 0328 Changsha 0 China Details
Local Institution - 0341 Hangzhou 310016 China Details
Local Institution - 0345 Kunming 0 China Details
Local Institution - 0336 Shanghai 200030 China Details
Local Institution - 0337 Shanghai 200030 China Details
Local Institution - 0374 Shantou 0 China Details
Local Institution - 0273 Pereira Risaralda 0 Colombia Details
Local Institution - 0237 Bogota 0 Colombia Details
Local Institution - 0238 Bogota 0 Colombia Details
Local Institution - 0282 Medellin 050034 Colombia Details
Local Institution - 0112 Hradec Kralove 500 05 Czechia Details
Local Institution - 0113 Olomouc 779 00 Czechia Details
Local Institution - 0111 Praha 4 140 59 Czechia Details
Local Institution - 0232 Pribram 261 01 Czechia Details
Local Institution - 0270 Oulu 90029 Finland Details
Local Institution - 0271 Turku 20520 Finland Details
Local Institution - 0222 Bron Rhône 69677 France Details
Local Institution - 0216 ANGERS Cedex 2 49055 France Details
Local Institution - 0229 Besançon Cedex 0 France Details
Local Institution - 0283 Caen 14076 France Details
Local Institution - 0218 Creteil 94010 France Details
Local Institution - 0228 Limoges 87042 France Details
Local Institution - 0215 Marseille Cedex 20 13915 France Details
Local Institution - 0230 Paris 75018 France Details
Local Institution - 0227 Pessac 33604 France Details
Local Institution - 0223 Rennes 350330 France Details
Local Institution - 0225 Rouen 76000 France Details
Local Institution - 0221 Saint Priest En Jarez 42271 France Details
Local Institution - 0217 Saint-herblain Cedex 44805 France Details
Local Institution - 0224 Strasbourg 67000 France Details
Local Institution - 0226 Toulon 83056 France Details
Local Institution - 0231 Magdeburg Sachsen-Anhalt 39120 Germany Details
Local Institution - 0213 Bad Berka 99437 Germany Details
Local Institution - 0208 Berlin 13125 Germany Details
Local Institution - 0205 Essen 45147 Germany Details
Local Institution - 0210 Frankfurt 60590 Germany Details
Local Institution - 0211 Gera 07548 Germany Details
Local Institution - 0203 Grosshansdorf 22927 Germany Details
Local Institution - 0209 Halle 06120 Germany Details
Local Institution - 0202 Heidelberg 69126 Germany Details
Local Institution - 0214 Hemer 58675 Germany Details
Local Institution - 0206 Immenstadt 87509 Germany Details
Local Institution - 0204 Muenchen 81925 Germany Details
Local Institution - 0201 Stuttgart 70376 Germany Details
Local Institution - 0212 Wiesbaden 65199 Germany Details
Local Institution - 0094 Athens Attikí 115 27 Greece Details
Local Institution - 0095 Heraklion 711 10 Greece Details
Local Institution - 0190 Neo Faliro 18547 Greece Details
Local Institution - 0101 Thessaloniki 54007 Greece Details
Local Institution - 0025 Budapest 1083 Hungary Details
Local Institution - 0024 Budapest 1121 Hungary Details
Local Institution - 0026 Matrahaza 3233 Hungary Details
Local Institution - 0054 Dublin 8 Dublin Ireland Details
Local Institution - 0053 Beaumont Dublin 9 Ireland Details
Local Institution - 0055 Galway 0 Ireland Details
Local Institution - 0100 Limerick 0 Ireland Details
Local Institution - 0187 Jerusalem 91120 Israel Details
Local Institution - 0186 Kfar-saba 44281 Israel Details
Local Institution - 0185 Petach Tikva 49100 Israel Details
Local Institution - 0184 Tel-hashomer 52621 Israel Details
Local Institution - 0188 Zerifin 70300 Israel Details
Local Institution - 0083 Milan Lombardia 20141 Italy Details
Azienda Ospedaliera Moscati Avellino 83024 Italy Details
Local Institution - 0179 Bergamo 24127 Italy Details
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola Bologna 40138 Italy Details
Local Institution - 0084 Livorno 57124 Italy Details
Policlinico G. Martino Messina 98125 Italy Details
Fondazione IRCCS Istituto Nazionale dei Tumori Milan 20133 Italy Details
Istituto Nazionale Tumori Fondazione Pascale Napoli 80131 Italy Details
Local Institution - 0087 Perugia 06132 Italy Details
Ospedale Santa Maria delle Croci Ravenna 48121 Italy Details
Ifo-Istituto Regina Elena Roma 00144 Italy Details
Local Institution - 0089 Roma 00161 Italy Details
Local Institution - 0085 Terni 05100 Italy Details
Local Institution - 0153 Nagoya-shi Aichi 4600001 Japan Details
Local Institution - 0152 Nagoya Aichi 4648681 Japan Details
Local Institution - 0148 Kashiwa-shi Chiba 2778577 Japan Details
Local Institution - 0159 Matsuyama Ehime 791-0280 Japan Details
Local Institution - 0160 Fukuoka-shi Fukuoka 8120054 Japan Details
Local Institution - 0259 Kurume-shi Fukuoka 8300011 Japan Details
Local Institution - 0255 Ota-shi Gunma 3730828 Japan Details
Local Institution - 0258 Hiroshima-shi Hiroshima 7308518 Japan Details
Local Institution - 0163 Sapporo-shi Hokkaido 0030804 Japan Details
Local Institution - 0253 Sapporo-shi Hokkaido 0608648 Japan Details
Local Institution - 0252 Akashi-shi Hyogo 6738558 Japan Details
Local Institution - 0156 Kobe-shi Hyogo 6500047 Japan Details
Local Institution - 0146 Kanazawa-shi Ishikawa 9208641 Japan Details
Local Institution - 0161 Yokohama-shi Kanagawa 2210855 Japan Details
Local Institution - 0150 Yokohama-Shi Kanagawa 2360051 Japan Details
Local Institution - 0275 Natori-shi Miyagi 9811293 Japan Details
Local Institution - 0254 Sendai-shi Miyagi 9800873 Japan Details
Local Institution - 0145 Sendai-shi Miyagi 9808574 Japan Details
Local Institution - 0164 Niigata-shi Niigata 9518566 Japan Details
Local Institution - 0158 Kurashiki-shi Okayama 7100052 Japan Details
Local Institution - 0155 Hirakata-shi Osaka 5731191 Japan Details
Local Institution - 0154 Osaka-shi Osaka 5340021 Japan Details
Local Institution - 0251 Osakasayama-shi Osaka 5890014 Japan Details
Local Institution - 0257 Takatsuki-shi Osaka 5698686 Japan Details
Local Institution - 0353 Hidaka-shi Saitama 3501298 Japan Details
Local Institution - 0256 Kitaadachi-gun Saitama 3620806 Japan Details
Local Institution - 0151 Sunto-gun Shizuoka 4118777 Japan Details
Local Institution - 0147 Chuo-ku Tokyo 1040045 Japan Details
Local Institution - 0149 Koto-ku Tokyo 1358550 Japan Details
Local Institution - 0278 Shinjuku-ku Tokyo 1600023 Japan Details
Local Institution - 0157 Wakayama-shi Wakayama 641-8510 Japan Details
Local Institution - 0354 Ube-shi Yamaguchi 7550241 Japan Details
Local Institution - 0260 Chiba 260-8677 Japan Details
Local Institution - 0165 Okayama 700-8558 Japan Details
Local Institution - 0162 Tokyo 113-8603 Japan Details
Local Institution - 0136 Seongnam-si Kyǒnggi-do 436-707 Korea, Republic of Details
Local Institution - 0249 Cheongju-si 28644 Korea, Republic of Details
Local Institution - 0133 Gangnam-gu 06351 Korea, Republic of Details
Local Institution - 0132 Seoul 05505 Korea, Republic of Details
Local Institution - 0135 Seoul 06591 Korea, Republic of Details
Local Institution - 0287 Beirut 00961 Lebanon Details
Local Institution - 0286 Beirut 166830 Lebanon Details
Local Institution - 0196 Df Distrito Federal 06720 Mexico Details
Local Institution - 0193 Mexico Distrito Federal 14080 Mexico Details
Local Institution - 0198 Cuautitlan Estado DE Mexico 54769 Mexico Details
Local Institution - 0197 Guadalajara Jalisco 44270 Mexico Details
Local Institution - 0191 Zapopan Jalisco 44280 Mexico Details
Local Institution - 0267 Morelia Michoacan 58000 Mexico Details
Local Institution - 0277 Monterrey Nuevo Leon 64060 Mexico Details
Local Institution - 0303 Merida Yucatán 97070 Mexico Details
Local Institution - 0192 Chihuahua 31217 Mexico Details
Local Institution - 0195 San Luis Potosi 78200 Mexico Details
Local Institution - 0236 San Luis Potosi 78213 Mexico Details
Local Institution - 0194 Toluca 50180 Mexico Details
Local Institution - 0036 Amsterdam 1066 CX Netherlands Details
Local Institution - 0189 Amsterdam 1081 HV Netherlands Details
Local Institution - 0169 Breda 4818 CK Netherlands Details
Local Institution - 0037 Rotterdam 3014 GD Netherlands Details
Local Institution - 0039 Veldhoven 5504 DB Netherlands Details
Local Institution - 0262 Lima 0 Peru Details
Local Institution - 0263 Lima 0 Peru Details
Local Institution - 0350 Lima 27 Peru Details
Local Institution - 0261 Lima 34 Peru Details
Local Institution - 0351 Lima Lima 41 Peru Details
Local Institution - 0060 Bydgoszcz 85-796 Poland Details
Local Institution - 0058 Gdansk 80-19 Poland Details
Local Institution - 0063 Gdynia 81-519 Poland Details
Local Institution - 0072 Gliwice 44-101 Poland Details
Local Institution - 0057 Lodz 93-513 Poland Details
Local Institution - 0059 Warszawa 02-781 Poland Details
Local Institution - 0070 Wroclaw 52-229 Poland Details
Local Institution - 0167 Craiova 200542 Romania Details
Local Institution - 0250 Floresti 407280 Romania Details
Local Institution - 0166 Romania 400015 Romania Details
Local Institution - 0284 Sector 2 022328 Romania Details
Local Institution - 0137 Chelyabinsk 454048 Russian Federation Details
Local Institution - 0142 Kazan 420029 Russian Federation Details
Local Institution - 0022 Moscow 115478 Russian Federation Details
Local Institution - 0049 Saint-Petersburg 197758 Russian Federation Details
Local Institution - 0028 St. Petersburg 194291 Russian Federation Details
Local Institution - 0027 St. Petersburg 198255 Russian Federation Details
Local Institution - 0143 Ufa 450054 Russian Federation Details
Local Institution - 0264 Pretoria Gauteng 0002 South Africa Details
Local Institution - 0234 Sandton Gauteng 2196 South Africa Details
Local Institution - 0233 Saxonwold, Johannesburg Gauteng 2196 South Africa Details
Local Institution - 0305 Vereeniging 1936 South Africa Details
Local Institution - 0064 Majadahonda Madrid 28222 Spain Details
Local Institution - 0066 Barcelona 08035 Spain Details
Local Institution - 0067 Barcelona 08916 Spain Details
Local Institution - 0065 Madrid 28041 Spain Details
Local Institution - 0069 Sevilla 41013 Spain Details
Local Institution - 0068 Valencia 46014 Spain Details
Local Institution - 0243 Basel 4031 Switzerland Details
Local Institution - 0246 Chur 7000 Switzerland Details
Local Institution - 0244 Lausanne 1011 Switzerland Details
Local Institution - 0245 Winterthur 8401 Switzerland Details
Local Institution - 0139 Taichung 407 Taiwan Details
Local Institution - 0138 Taipei 100 Taiwan Details
Local Institution - 0140 Taipei 112 Taiwan Details
Local Institution - 0310 Taipei 235 Taiwan Details
Local Institution - 0141 Taoyuan city 333 Taiwan Details
Local Institution - 0266 Middlesborough Cleveland TS4 3BW United Kingdom Details
Local Institution - 0098 London Greater London SW3 6JJ United Kingdom Details
Local Institution - 0099 Southampton Hampshire SO16 0YD United Kingdom Details
Local Institution - 0118 Leicester Leicestershire LE1 5WW United Kingdom Details
Local Institution - 0265 Birmingham B4 6DHH United Kingdom Details
Local Institution - 0051 Cambridgeshire CB2 2QQ United Kingdom Details
Local Institution - 0109 Edinburgh EH4 2XU United Kingdom Details
Local Institution - 0097 London N18 1QX United Kingdom Details
Local Institution - 0050 London SE1 9RT United Kingdom Details
Local Institution - 0119 Surrey SM2 5PT United Kingdom Details
*Shaded cells indicate that there was no data available from clinicaltrials.gov for the field