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| NCT ID | NCT02492711 |
| Title | Margetuximab Plus Chemotherapy vs Trastuzumab Plus Chemotherapy in the Treatment of HER2+ Metastatic Breast Cancer |
| Acronym | SOPHIA |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | MacroGenics |
| Indications | |
| Therapies | |
| Age Groups: | adult |
| Covered Countries | USA | POL | NLD | ITA | ISR | GBR | FRA | FIN | ESP | DNK | DEU | CZE | CAN | BEL | AUT |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Aarhus Universitetshospital | Aarhus C | Central Jutland | 8000 | Denmark | Details | |
| AO G.Rummo | Benevento | 82100 | Italy | Details | ||
| AO S.Andrea, Università degli Studi di Roma La Sapienza | Roma | 00189 | Italy | Details | ||
| AOU di Parma | Parma | 43126 | Italy | Details | ||
| AOU Policlinico di Modena | Modena | 41122 | Italy | Details | ||
| Arcispedale S.Anna, AOU di Ferrara | Ferrara | 44124 | Italy | Details | ||
| ARH Cancer Clinic | Hazard | Kentucky | 41701 | United States | Details | |
| Asan Medical Center | Seoul | Seoul Teugbyeolsi | 05505 | Korea, Republic of | Details | |
| ASST Papa Giovanni XXIII - Oncologia-Bergamo | Bergamo | 24127 | Italy | Details | ||
| Austin Cancer Center | Austin | Texas | 78758 | United States | Details | |
| AZ Damiaan | Oostende | West-Vlaanderen | 8400 | Belgium | Details | |
| AZ Groeninge - Campus Loofstraat | Kortrijk | West-Vlaanderen | 8500 | Belgium | Details | |
| AZ Nikolaas - Campus Sint-Niklaas Moerland | Sint-Niklaas | Oost-Vlaanderen | 9100 | Belgium | Details | |
| AZ Sint-Jan Brugge - Oostende - Campus Sint-Jan | Brugge | West-Vlaanderen | 8000 | Belgium | Details | |
| Azienda Ospedaliera Fatebenefratelli e Oftalmico | Milano | 20121 | Italy | Details | ||
| Azienda Ospedaliero Universitaria Senese Universita degli St | Siena | Toscana | 53100 | Italy | Details | |
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | United States | Details | |
| Cancer Care Northwest, PS | Spokane | Washington | 99202 | United States | Details | |
| Carle Cancer Center | Urbana | Illinois | 61801 | United States | Details | |
| Castle Hill Hospital (Hull) | Hull | East Riding Of Yorkshire | HU16 5JQ | United Kingdom | Details | |
| Center de Lutte Contre le Cancer (CLCC) | Nice | Alpes-Martitimes | 06189 | France | Details | |
| Center de Lutte Contre le Cancer (CLCC) | Caen cedex 05 | Calvados | 14076 | France | Details | |
| Centre de Lutte Contre le Cancer (CLCC) - Institut de Cancer | St Herblain | Loire-Atlantique | 44805 | France | Details | |
| Centre Georges-François Lecler | Dijon | Côte-d'Or | 21079 | France | Details | |
| Centre Jean Perrin | Clermont-Ferrand | Puy-de-Dôme | 63011 | France | Details | |
| Centre Léon Bérard | Lyon Cedex 08 | Rhône-Alpes | 69373 | France | Details | |
| Centro Clínico Champalimaud/Fundação Champalimaud | Lisbon | Lisboa | 1400-038 | Portugal | Details | |
| Centrum Onkologii Ziemi Lubelskiej im. Sw. Jana z Dukli | Lublin | 20-090 | Poland | Details | ||
| Chc - Clinique Saint-Joseph | Liège | 4000 | Belgium | Details | ||
| Clalit Health Services - Lin Medical Center | Haifa | 35152 | Israel | Details | ||
| Clinique Saint-Pierre Ottignies | Ottignies | Brabant Wallon | 1340 | Belgium | Details | |
| Clinique Sainte Elisabeth | Namur | 5000 | Belgium | Details | ||
| Cliniques universitaires Saint-Luc | Brussels | Brussels Capital Region | 1200 | Belgium | Details | |
| CTCA - Eastern Regional Medical Center, Inc. | Philadelphia | Pennsylvania | 19124 | United States | Details | |
| CTCA - Midwestern Regional Medical Center | Zion | Illinois | 60099 | United States | Details | |
| CTCA - Southeastern Regional Medical Center | Newnan | Georgia | 30265 | United States | Details | |
| Dartmouth-Hitchcock - Norris C | Lebanon | New Hampshire | 03756 | United States | Details | |
| Dr. Leon Richard Oncology Centre | Moncton | New Brunswick | E1C 8X3 | Canada | Details | |
| E.O. Ospedali Galliera | Genova | 16128 | Italy | Details | ||
| East Valley Hematology And Oncology | Burbank | California | 91505 | United States | Details | |
| Fakultni nemocnice Olomouc | Olomouc | 779 00 | Czechia | Details | ||
| Fakultni nemocnice v Motole | Praha 5 | 150 06 | Czechia | Details | ||
| Florida Cancer Specialists | Fort Myers | Florida | 33916 | United States | Details | |
| Florida Cancer Specialists | New Port Richey | Florida | 34655 | United States | Details | |
| Fondazione Pascale, IRCCS Istituto Nazionale dei Tumori | Napoli | 80131 | Italy | Details | ||
| Forrest General Hospital | Hattiesburg | Mississippi | 39401 | United States | Details | |
| Fort Belvoir Community Hospital | Fort Belvoir | Virginia | 22060 | United States | Details | |
| Fundacion de Investigacion de Diego | San Juan | 927 | Puerto Rico | Details | ||
| Fundación Instituto Valenciano de Oncología | Valencia | 46009 | Spain | Details | ||
| Guthrie Medical Group, PC | Sayre | Pennsylvania | 18840 | United States | Details | |
| Guys and St Thomas Hospital | London | City Of London | SE1 9RT | United Kingdom | Details | |
| GZA Ziekenhuizen - Campus Sint-Augustinus | Wilrijk | Antwerpen | 2610 | Belgium | Details | |
| H. San Pedro de Alcántara | Cáceres | 10003 | Spain | Details | ||
| H. Santa Maria - Centro Hospitalar Lisboa Norte | Lisboa | 1649-035 | Portugal | Details | ||
| H.C.U. Valencia | Valencia | Comunidad | 46010 | Spain | Details | |
| H.U. Arnau de Vilanova | Lleida | 25198 | Spain | Details | ||
| H.U. Sant Joan de Reus | Reus | Tarragona | 43204 | Spain | Details | |
| H.U.V. del Rocío | Sevilla | Andalucía | 41013 | Spain | Details | |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | United States | Details | |
| Hadassah Medical Organisation, Hadassah Medical Center, Ein-Karem | Jerusalem | Yerushalayim | 91120 | Israel | Details | |
| Haga Ziekenhuis, loc. Leyenburg | Haag | Zuid-Holland | 2545 CH | Netherlands | Details | |
| Helsinki University Central Hospital (HUCH) - Meilahden Sair | Helsinki | Länsi-Suomen Lääni | 00029 | Finland | Details | |
| Hem-Onc Associates | Port Saint Lucie | Florida | 34952 | United States | Details | |
| Hospital de Navarra | Pamplona | Navarra | 31008 | Spain | Details | |
| Hospital del Mar | Barcelona | Catalunya | 08003 | Spain | Details | |
| Hospital Ntra. Sra. de Sonsoles | Ávila | 5004 | Spain | Details | ||
| Hospital Universitari I Politecnic La Fe | Valencia | 46026 | Spain | Details | ||
| Hospital Universitari Parc Taulí | Sabadell | Barcelona | 08208 | Spain | Details | |
| Hospital Universitario Clínico San Carlos | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario Ramón y Cajal | Madrid | 28034 | Spain | Details | ||
| Hospital Universitario Vall d'Hebron | Barcelona | 08023 | Spain | Details | ||
| Indiana University Health Goshen Center for Cancer Care | Goshen | Indiana | 46526 | United States | Details | |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | United States | Details | |
| Institut Català d'Oncologia-Hospital Germans Trias i Pujol | Badalona | Barcelona | 08916 | Spain | Details | |
| Institut Curie | Paris | Île-de-France | 75005 | France | Details | |
| Institut Curie - Hôpital René Huguenin | Saint-Cloud | Île-de-France | 92210 | France | Details | |
| Instituto Português Oncologia Francisco Gentil do Porto | Porto | 4200-072 | Portugal | Details | ||
| Irccs Irst | Meldola | Forli | 47014 | Italy | Details | |
| IRCCS Policlinico San Matteo | Pavia | 27100 | Italy | Details | ||
| IRCSS Fodazione Salvatore Maugeri | Pavia | 27100 | Italy | Details | ||
| Ironwood Cancer & Research Center | Chandler | Arizona | 85224 | United States | Details | |
| Istituto di Candiolo, IRCCS | Candiolo | Torino | 10060 | Italy | Details | |
| Istituto Europeo di Oncologia Via Ripamonti | Milano | 20141 | Italy | Details | ||
| Jessa Ziekenhuis - Campus Virga Jesse | Hasselt | Limburg | 3500 | Belgium | Details | |
| Kaiser Permanente Hawaii Moanalua Medical Center | Honolulu | Hawaii | 96819 | United States | Details | |
| Kaiser Permenente Medical Center | Vallejo | California | 94589 | United States | Details | |
| Kaplan Medical Center | Rehovot | HaMerkaz | 761001 | Israel | Details | |
| Kent Oncology Centre, Maidstone Hospital | Maidstone | Kent | ME16 9QQ | United Kingdom | Details | |
| Lakeridge Health Oshawa | Oshawa | Ontario | L1G 2B9 | Canada | Details | |
| M.D. Anderson Cancer Center Madrid | Madrid | 28033 | Spain | Details | ||
| Maastricht University Medical Centre | Maastricht | Limburg | 6229 HX | Netherlands | Details | |
| MAGODENT Sp. z o.o. | Warszawa | Mazowieckie | 04-125 | Poland | Details | |
| Marien Hospital | Witten | Nordrhein-Westfalen | 58452 | Germany | Details | |
| Marien Hospital Düsseldorf | Düsseldorf | Nordhein-Westfalen | 40479 | Germany | Details | |
| Masarykuv onkologicky ustav | Brno | Brno-město | 656 53 | Czechia | Details | |
| Mazowiecki Szpital Onkologiczny | Wieliszew | Mazowieckie | 05-135 | Poland | Details | |
| Medizinische Fakultät Carl Gustav Carus | Dresden | Sachsen | 01307 | Germany | Details | |
| Medizinische Universität Innsbruck | Innsbruck | Tirol | 6020 | Austria | Details | |
| MedStar Washington Hospital Center | Washington | District of Columbia | 20010 | United States | Details | |
| Meir Medical Center | Kfar Saba | HaMerkaz | 44281 | Israel | Details | |
| Memorial Cancer Institute at Memorial Regional Hospital | Hollywood | Florida | 33021 | United States | Details | |
| Mercy Hospital Saint Louis | Saint Louis | Missouri | 63141 | United States | Details | |
| Mercy Medical Center | Baltimore | Maryland | 21202 | United States | Details | |
| Mercy Physicians Of Oklahoma | Oklahoma City | Oklahoma | 73120 | United States | Details | |
| Monongahela Valley Hospital | Monongahela | Pennsylvania | 15063 | United States | Details | |
| Mount Sinai Comprehensive Cancer Center | Miami Beach | Florida | 33140 | United States | Details | |
| New England Cancer Specialists | Scarborough | Maine | 04074 | United States | Details | |
| New Jersey Hematology Oncology Associates | Brick | New Jersey | 08724 | United States | Details | |
| New Mexico Cancer Care Alliance (NMCCA) | Albuquerque | New Mexico | 87106 | United States | Details | |
| New York University Clinical Cancer Center | New York | New York | 10016 | United States | Details | |
| Northwest Georgia Oncology Centers, PC | Marietta | Georgia | 30060 | United States | Details | |
| Northwestern University Feinberg School of Medicine | Chicago | Illinois | 60611 | United States | Details | |
| Nuovo ospedale di Prato | Prato | 59100 | Italy | Details | ||
| Næstved Sygehus | Aarhus N | Zeeland | 4700 | Denmark | Details | |
| Orlndo Health Cancer Center | Orlando | Florida | 32806 | United States | Details | |
| Ospedale Belcolle Viterbo | Viterbo | 01100 | Italy | Details | ||
| Ospedale Umberto I, AOU Ospedali Riuniti Umberto I - GM.Lanc | Ancona | 60126 | Italy | Details | ||
| Palm Beach Cancer Center | West Palm Beach | Florida | 33401 | United States | Details | |
| Piedmont Cancer Institute, P.C. | Atlanta | Georgia | 30318 | United States | Details | |
| Pinnacle Health Cancer Institute | Harrisburg | Pennsylvania | 17109 | United States | Details | |
| PO A.Manzoni di Lecco, ASST Lecco - Oncologia Medica - Lecco | Lecco | 23900 | Italy | Details | ||
| PO di Cremona, ASST di Cremona - Patologia Mammaria e Breast Unit - Cremona | Cremona | 26100 | Italy | Details | ||
| PO Garibaldi-Nesima, ARNAS Garibaldi | Catania | Cantania | 95122 | Italy | Details | |
| Poudre Valley Health Care, Inc. | Fort Collins | Colorado | 80528 | United States | Details | |
| Praxis für Frauenheilkunde Anita | München | Bayern | 81925 | Germany | Details | |
| ProHEALTH CARE Associates, LLP | Lake Success | New York | 11042 | United States | Details | |
| PU Campus Bio-medico di Roma | Roma | 00128 | Italy | Details | ||
| Queens Hospital Center | Jamaica | New York | 11432 | United States | Details | |
| Rabin Medical Center - Beilinson Hospital | Petaẖ Tiqwa | HaMerkaz | 49100 | Israel | Details | |
| Regionshospitalet Herning (Herning Centralsygehus) | Herning | Central Jutland | 7400 | Denmark | Details | |
| Royal Preston Hospital | Fulwood | Lancashire | PR2 9HT | United Kingdom | Details | |
| Rush University Medical Center | Chicago | Illinois | 60612 | United States | Details | |
| Saint Barnabas Medical Center - The Cancer Center | Livingston | New Jersey | 07039 | United States | Details | |
| Saint Luke's Cancer Specialists | Kansas City | Missouri | 64111 | United States | Details | |
| Samsung Medical Center | Seoul | Seoul Teugbyeolsi | 06351 | Korea, Republic of | Details | |
| Seoul National University Hospital | Seoul | Seoul Teugbyeolsi | 03080 | Korea, Republic of | Details | |
| Severance Hospital, Yonsei University Health System | Seoul | Seoul Teugbyeolsi | 03722 | Korea, Republic of | Details | |
| Sharp Memorial Hospital | San Diego | California | 92123 | United States | Details | |
| SO S.Chiara, AOU Pisana | Pisa | 56126 | Italy | Details | ||
| Soroka Medical Center [Oncology] | Beersheba | HaDarom | 84802 | Israel | Details | |
| South Tees Hospitals NHS Foundation Trust | Middlesbrough | TS4 3BW | United Kingdom | Details | ||
| St. Joseph's Hospital | Lexington | Kentucky | 40504 | United States | Details | |
| Swedish Cancer Institute/ Swedish Health Services | Seattle | Washington | 98104 | United States | Details | |
| Tampere University Hospital | Tampere | Etelä-Suomen Lääni | 33521 | Finland | Details | |
| Tel Aviv Sourasky Medical Center | Tel Aviv | 64239 | Israel | Details | ||
| Tennessee Oncology, PLLC | Chattanooga | Tennessee | 37404 | United States | Details | |
| The Center for Cancer and Blood Disorders | Fort Worth | Texas | 76104 | United States | Details | |
| The Chaim Sheba Medical Center - Insititute of Oncology | Ramat Gan | HaMerkaz | 52621 | Israel | Details | |
| The Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | United States | Details | |
| Touro Infirmary Hospital | New Orleans | Louisiana | 70115 | United States | Details | |
| Tufts-NEMC Cancer Center | Boston | Massachusetts | 02111 | United States | Details | |
| UC Davis Comprehensive Cancer Center | Sacramento | California | 95817 | United States | Details | |
| UCLA Hematology Oncology Santa Monica | Los Angeles | California | 90095 | United States | Details | |
| Universitaetsklinikum Essen - Klinik fuer Frauenheilkunde | Essen | Nordrhein-Westfalen | 45122 | Germany | Details | |
| Universitaetsklinikum Tuebingen | Tuebingen | Baden-Württemberg | 72076 | Germany | Details | |
| University of California, San Francisco Helen Diller Family Comprehensive Cancer Center | San Francisco | California | 94115 | United States | Details | |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | United States | Details | |
| University of Virginia Cancer Center | Charlottesville | Virginia | 22908 | United States | Details | |
| University of Washington/ Seattle Cancer Care Alliance | Seattle | Washington | 98109 | United States | Details | |
| Universitätsklinikum Erlangen | Erlangen | Bayern | 91054 | Germany | Details | |
| Universtatsklinikum Heidelberg Nationales | Heidelberg | Germany | Details | |||
| Utah Cancer Specialists | Salt Lake City | Utah | 84106 | United States | Details | |
| UZ Antwerpen | Edegem | Antwerpen | 2650 | Belgium | Details | |
| UZ Brussel - Campus Jette | Brussels | Brussels Capital Region | 1090 | Belgium | Details | |
| Vejle Sygehus | Vejle | South Denmark | 7100 | Denmark | Details | |
| Wake Forest University Baptist Medical Center (WFUBMC) | Winston-Salem | North Carolina | 27157 | United States | Details | |
| Western Regional Medical Center, Inc. | Goodyear | Arizona | 85338 | United States | Details |
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