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| NCT ID | NCT02562443 |
| Title | Controlled Study of Rigosertib Versus Physician's Choice of Treatment in MDS Patients After Failure of an HMA (INSPIRE) |
| Acronym | INSPIRE |
| Recruitment | Terminated |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Onconova Therapeutics, Inc. |
| Indications | |
| Therapies | |
| Age Groups: | adult |
| Covered Countries | USA | SWE | POL | ITA | ISR | IRL | HUN | HRV | GBR | FRA | EST | ESP | DEU | CZE | CHE | CAN | BEL | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | United States | Details | |
| USC Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | United States | Details | |
| UCLA Medical Center | Los Angeles | California | 90095 | United States | Details | |
| Cancer Specialists of North Florida | Fleming Island | Florida | 32003 | United States | Details | |
| UF Health Shands Cancer Hospital | Gainesville | Florida | 32608 | United States | Details | |
| Mid Florida Hematology and Oncology Centers | Orange City | Florida | 32763 | United States | Details | |
| Advanced Research Institute, Inc | Saint Petersburg | Florida | 33710 | United States | Details | |
| Rush University Medical Center | Chicago | Illinois | 60612 | United States | Details | |
| University of Illinois Cancer Center | Chicago | Illinois | 60612 | United States | Details | |
| Loyola University Chicago at Loyola University Medical Center | Maywood | Illinois | 60153 | United States | Details | |
| Indiana University Health Hospital | Indianapolis | Indiana | 46202 | United States | Details | |
| The University of Kansas Cancer Center | Westwood | Kansas | 66205 | United States | Details | |
| Tulane Medical Center | New Orleans | Louisiana | 70112 | United States | Details | |
| University of Maryland Greenebaum Cancer Center | Baltimore | Maryland | 21201 | United States | Details | |
| Tufts Medical Center | Boston | Massachusetts | 02111 | United States | Details | |
| University of Minnesota Physicians Bone Marrow Transplant Clinic | Minneapolis | Minnesota | 55455 | United States | Details | |
| Mayo Clinic | Rochester | Minnesota | 55905 | United States | Details | |
| John Theurer Cancer Center at Hackensack University Medical Center | Hackensack | New Jersey | 07601 | United States | Details | |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | United States | Details | |
| The Valley Hospital | Ridgewood | New Jersey | 07450 | United States | Details | |
| Mount Sinai School of Medicine | New York | New York | 10029 | United States | Details | |
| Columbia University Medical Center | New York | New York | 10032 | United States | Details | |
| New York Medical College | Valhalla | New York | 10595 | United States | Details | |
| Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | United States | Details | |
| Albert Einstein Medical Center, Cancer Center | Philadelphia | Pennsylvania | 19141 | United States | Details | |
| Greenville Health System (GHS) Cancer Institute | Greenville | South Carolina | 29605 | United States | Details | |
| UT Southwestern Medical Center | Dallas | Texas | 75390-9015 | United States | Details | |
| MD Anderson Cancer Center | Houston | Texas | 77030 | United States | Details | |
| Emily Couric Clinical Cancer Center | Charlottesville | Virginia | 22903 | United States | Details | |
| Seattle Cancer Care Alliance (SCCA) | Seattle | Washington | 98109 | United States | Details | |
| University of Wisconsin Clinical Science Center | Madison | Wisconsin | 53792 | United States | Details | |
| Marshfield Clinic - Marshfield Center | Marshfield | Wisconsin | 54449 | United States | Details | |
| Icon Cancer Care Icon South Brisbane | South Brisbane | Queensland | 4101 | Australia | Details | |
| Royal Hobart Hospital | Hobart | Tasmania | 7000 | Australia | Details | |
| Monash Health, Monash Medical Centre | Melbourne | Victoria | 3168 | Australia | Details | |
| Hospital of the Elisabethinen Linz GmbH | Linz | 4020 | Austria | Details | ||
| Salzburg University Hospital | Salzburg | 5020 | Austria | Details | ||
| Hanusch Hospital | Vienna | 1140 | Austria | Details | ||
| Antwerp Hospital Network Stuivenberg | Antwerp | 2060 | Belgium | Details | ||
| University Hospital Ghent | Ghent | 9000 | Belgium | Details | ||
| University Hospital Leuven, Campus Gasthuisberg | Leuven | 3000 | Belgium | Details | ||
| CHU UCL Namur - Site Godinne | Yvoir | B-5530 | Belgium | Details | ||
| CancerCare Manitoba | Winnipeg | Manitoba | R3E 0V9 | Canada | Details | |
| Sunnybrook Research Institute | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| Princess Margaret Cancer Centre | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| Jewish General Hospital | Montreal | Quebec | H3T 1E2 | Canada | Details | |
| Klinički bolnički centar Osijek | Osijek | 31000 | Croatia | Details | ||
| Clinical Hospital Merkur | Zagreb | 10000 | Croatia | Details | ||
| Klinički bolnicki centar Sestre milosrdnice | Zagreb | 10000 | Croatia | Details | ||
| Klinički bolnički centar Zagreb | Zagreb | 10000 | Croatia | Details | ||
| University Hospital Brno | Brno | 625 00 | Czechia | Details | ||
| University Hospital Hradec Kralove | Hradec Kralove | 500 05 | Czechia | Details | ||
| University Hospital Ostrava, Department of Hematooncology | Ostrava Poruba | 708 52 | Czechia | Details | ||
| General University Hospital | Prague 2 | 128 00 | Czechia | Details | ||
| Institute of Hematology and Blood Transfusion | Prague 2 | 128 20 | Czechia | Details | ||
| North Estonia Medical Centre | Tallinn | 13419 | Estonia | Details | ||
| Tartu University Hospital | Tartu | 51014 | Estonia | Details | ||
| CHD Vendée | La Roche Sur Yon Cedex 9 | 85925 | France | Details | ||
| Hôpital Claude Huriez, CHRU Lille | Lille Cedex | 59037 | France | Details | ||
| Institut Paoli-Calmettes | Marseille | 13009 | France | Details | ||
| Hôpital l'Archet 1 | Nice Cedex 3 | 06202 | France | Details | ||
| Institut de Cancérologie du Gard | Nimes Cedex 9 | 30029 | France | Details | ||
| Hôpital Saint Louis | Paris Cedex 10 | 75475 | France | Details | ||
| Centre Hospitalier Lyon-Sud | Pierre-Bénite | 69495 | France | Details | ||
| Hôpital civil, Strasbourg | Strasbourg Cedex | 67091 | France | Details | ||
| CHRU Tours Hôspital Bretonneau | Tours | 37044 | France | Details | ||
| Universitätsklinikum Carl Gustav Carus | Dresden | 01307 | Germany | Details | ||
| Marien Hospital Düsseldorf | Düsseldorf | 40479 | Germany | Details | ||
| Universitätsklinikum Frankfurt am Main | Frankfurt | 60590 | Germany | Details | ||
| Semmelweis University Medical School | Budapest | 1083 | Hungary | Details | ||
| Somogy County Kaposi Mór Teaching Hospital | Kaposvár | 7400 | Hungary | Details | ||
| Jósa András Teaching Hospital | Nyíregyháza | 4400 | Hungary | Details | ||
| University of Pécs 1st Department of Internal Medicine | Pécs | 7624 | Hungary | Details | ||
| Hemato Oncology Clinic Pvt. Ltd | Ahmedabad | Gujarat | 380009 | India | Details | |
| St. John's Medical College Hospital | Bangalore | Karnataka | 560034 | India | Details | |
| Tata Memorial Hospital | Mumbai | Maharashtra | 400012 | India | Details | |
| Jaslok Hospital and Research Center | Mumbai | Maharashtra | 400026 | India | Details | |
| Sahyadri Clinical Research and Development Center | Pune | Maharashtra | 411004 | India | Details | |
| Christian Medical College | Vellore | Tamil Nadu | 632004 | India | Details | |
| Institute Of Hematology And Transfusion Medicine | Kolkata | West Bengal | 700073 | India | Details | |
| Cork University Hospital | Cork | Ireland | Details | |||
| Adelaide and Meath Hospital, Incorporating the National Children's Hospital | Dublin | Dublin 24 | Ireland | Details | ||
| University Hospital Waterford | Waterford | Ireland | Details | |||
| Ha'Emek Medical Center | 'Afula | 1834111 | Israel | Details | ||
| Soroka University Medical Center | Beer Sheva | 84101 | Israel | Details | ||
| Rambam Medical Center | Haifa | 31096 | Israel | Details | ||
| Hadassah Medical Center | Jerusalem | 91120 | Israel | Details | ||
| Kaplan Medical Center | Rehovot | 76100 | Israel | Details | ||
| Sourasky Medical Center | Tel Aviv | 64239 | Israel | Details | ||
| The Chaim Sheba Medical Center | Tel Hashomer | 52621 | Israel | Details | ||
| Polyclinic S. Orsola-Malpighi | Bologna | 40138 | Italy | Details | ||
| Azienda Ospedaliera Spedali Civili | Brescia | 25123 | Italy | Details | ||
| Azienda Ospedaliero Universitaria Careggi | Firenze | 50134 | Italy | Details | ||
| Azienda Ospedaliero-Universitaria Maggiore della Carità | Novara | 28100 | Italy | Details | ||
| A.O.U. Pisana, Divisione di Ematologia - University Hospital of Pisa | Pisa | 56126 | Italy | Details | ||
| Policlinico Universitario Tor Vergata | Roma | 00133 | Italy | Details | ||
| Ospedale S. Eugenio - S. Eugenio Hospital | Roma | 00144 | Italy | Details | ||
| Azienda Ospedaliera Santa Maria di Terni | Terni | 05100 | Italy | Details | ||
| Cittá della Salute e della Scienza di Torino | Torino | 10126 | Italy | Details | ||
| Kokura Memorial Hospital | Kitakyushu | Fukuoka | 802-8555 | Japan | Details | |
| Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers | Fukuyama | Hiroshima | 720-0001 | Japan | Details | |
| Sapporo Medical University Hospital | Sapporo | Hokkaido | 060-8556 | Japan | Details | |
| Kanazawa University Hospital | Kanazawa | Ishikawa | 920-8641 | Japan | Details | |
| Yokohama City University Hospital | Yokohama-shi | Kanagawa | 236-0004 | Japan | Details | |
| Shimane University Hospital | Izumo | Shimane | 693-8501 | Japan | Details | |
| Japanese Red Cross Medical Center | Shibuya | Tokyo | 150-8935 | Japan | Details | |
| Akita University Hospital | Akita | 010-8543 | Japan | Details | ||
| Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital | Bunkyo-ku | 113-8677 | Japan | Details | ||
| National Hospital Organization Kyushu Cancer Center | Fukuoka-shi | 811-1395 | Japan | Details | ||
| Kagoshima University Hospital | Kagoshima | 890-8544 | Japan | Details | ||
| Tokai Central Hospital of the Mutual Aid Association of Public School Teachers | Kakamigahara | 504-8601 | Japan | Details | ||
| Saitama Medical Center | Kawagoe | 350-8550 | Japan | Details | ||
| Kobe City Hospital Organization Kobe City Medical Center General Hospital | Kobe | 650-0047 | Japan | Details | ||
| National Hospital Organization Kumamoto Medical Center | Kumamoto | 860-008, | Japan | Details | ||
| Japanese Red Cross Kyoto Daini Hospital | Kyoto | 602-8026 | Japan | Details | ||
| Nagasaki University Hospital | Nagasaki | 852-8102 | Japan | Details | ||
| Japanese Red Cross Nagoya Daini Hospital | Nagoya-shi | 466-8650 | Japan | Details | ||
| Niigata University Medical and Dental Hospital | Niigata | 951-8510, | Japan | Details | ||
| Oita Prefectural Hospital | Oita | 870-8511 | Japan | Details | ||
| National Hospital Organization Okayama Medical Center | Okayama | 701-1192 | Japan | Details | ||
| Kindai University Hospital | Osakasayama-shi | 589-8511 | Japan | Details | ||
| Hokkaido University Hospital | Sapporo-shi | 060-8648 | Japan | Details | ||
| Tohoku University Hospital | Sendai-shi | 980-8574 | Japan | Details | ||
| NTT Medical Center Tokyo | Shinagawa-ku | 141-8625 | Japan | Details | ||
| Tokyo Medical University Hospital | Shinjuku-ku | 160-0023 | Japan | Details | ||
| Dokkyo Medical University Hospital | Tochigi | 321-0293 | Japan | Details | ||
| Tokushima University Hospital | Tokushima | 770-8503 | Japan | Details | ||
| Yamagata University Hospital | Yamagata | 990-9585 | Japan | Details | ||
| Saiseikai Yokohamashi Nanbu Hospital | Yokohama-shi | 234-8503 | Japan | Details | ||
| University of Fukui Hospital | Yoshida | 910-1193 | Japan | Details | ||
| Independent Public Healthcare Facility University Hospital in Cracow, Clinical Department of Hematology | Kraków | 31-501 | Poland | Details | ||
| Independent Public Health Care Facility of the Ministry of Internal Affairs with Warmia and Mazury Oncology Centre in Olsztyn | Olsztyn | 10-228 | Poland | Details | ||
| Ludwik Rydygier Provinicial Hospital in Suwalki, Department of Clinical Oncology and Hematology | Suwalki | 16-400 | Poland | Details | ||
| MTZ Clinical Research Sp. z o.o. | Warsaw | 02-106 | Poland | Details | ||
| Independent Public University Hospital No. 1 in Wroclaw, Department of Hematology, Blood Cancers and Bone Marrow | Wroclaw | 50-367 | Poland | Details | ||
| State Autonomous Healthcare Institution of Kemerovo region "Kemerovo Regional Clinical Hospital n.a. S.V. Belyaev", | Kemerovo | 650066 | Russian Federation | Details | ||
| State Budgetary Healthcare Institution of Moscow City | Moscow | 129301 | Russian Federation | Details | ||
| FSBI "Russian Scientific Research Hematology and Tranfusiology Institute of the Federal Biomedical Agency" | Saint Petersburg | 191024 | Russian Federation | Details | ||
| Hospital Son Llàtzer | Palma de Mallorca | Balearic Islands | 07198 | Spain | Details | |
| Hospital Duran i Reynals - Instituto Catalán de Oncología | Hospitalet de Llobregat | Barcelona | 08908 | Spain | Details | |
| Hospital Universitario Vall d'Hebron | Barcelona | 08035 | Spain | Details | ||
| Hospital Universitari Germans Trias i Pujol | Barcelona | 08916 | Spain | Details | ||
| Hospital Universitario Gregorio Marañón | Madrid | 28007 | Spain | Details | ||
| Fundación Jiménez Díaz | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario Virgen de la Victoria | Málaga | 29010 | Spain | Details | ||
| Hospital Universitario Salamanca | Salamanca | 37007 | Spain | Details | ||
| Hospital Universitari i Politècnic La Fe | Valencia | 46026 | Spain | Details | ||
| Karolinska University Hospital | Stockholm | Huddinge | 141 57 | Sweden | Details | |
| Skåne University Hospital, Department of Hematology | Lund | 222 82 | Sweden | Details | ||
| Uppsala University Hospital | Uppsala | 751 81 | Sweden | Details | ||
| Linköping University Hospital | Linköping | Östergötland | 581 85 | Sweden | Details | |
| University Hospital and University of Bern; Inselspital Bern | Bern | 3010 | Switzerland | Details | ||
| University Hospital Zurich | Zurich | 8091 | Switzerland | Details | ||
| Royal Bournemouth Hospital | Bournemouth | Dorset | BH7 7DW | United Kingdom | Details | |
| Aberdeen Royal Infirmary | Aberdeen | Scotland | AB25 2ZN | United Kingdom | Details | |
| The Royal Liverpool University Hospital | Liverpool | L7 8XP | United Kingdom | Details | ||
| St Bartholomew's Hospital, Barts Health NHS Trust | London | EC1A 7BE | United Kingdom | Details | ||
| King's College Hospital NHS Foundation Trust | London | SE5 9RS | United Kingdom | Details |