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| NCT ID | NCT02576431 |
| Title | A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors (NAVIGATE) |
| Acronym | NAVIGATE |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase II |
| Variant Requirements | No |
| Sponsors | Bayer |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior | child |
| Covered Countries | USA | TUR | SWE | SVK | ITA | IRL | FRA | ESP | DNK | DEU | CZE | CAN | BRA | BEL | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Stanford Cancer Center | Palo Alto | California | 94304 | United States | Details | |
| UCLA-Santa Monica Medical Center | Santa Monica | California | 90404 | United States | Details | |
| Memorial Hospital West | Pembroke | Florida | 33028 | United States | Details | |
| The University of Chicago Medical Center (UCMC) | Chicago | Illinois | 60637 | United States | Details | |
| Massachusetts General Hospital | Boston | Massachusetts | 02114-2696 | United States | Details | |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 2215 | United States | Details | |
| Memorial Sloan-Kettering Cancer Center | New York | New York | 10065 | United States | Details | |
| University of North Carolina Hospitals | Chapel Hill | North Carolina | 27312 | United States | Details | |
| Wake Forest Baptist Health | Winston-Salem | North Carolina | 27157 | United States | Details | |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | United States | Details | |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | United States | Details | |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111-2497 | United States | Details | |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57105 | United States | Details | |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | United States | Details | |
| University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | United States | Details | |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | United States | Details | |
| University of Washington | Seattle | Washington | 98195 | United States | Details | |
| West Virginia University | Morgantown | West Virginia | 26505 | United States | Details | |
| Centro Estudios Médicos e Invest. Clínicas "Dr. N. Quirno" | Buenos Aires | Ciudad Auton. De Buenos Aires | TBC | Argentina | Details | |
| Hospital Alemán | Buenos Aires | Ciudad Auton. De Buenos Aires | TBC | Argentina | Details | |
| Fundación Cenit para la Investigación en Neurociencias | Caba | Ciudad Auton. De Buenos Aires | C1125 ABD | Argentina | Details | |
| Centro Medico Austral | TBC | Ciudad Auton. De Buenos Aires | C1019ABS | Argentina | Details | |
| Centro Médico San Roque | San Miguel de Tucumán | Tucuman | T4000HXU | Argentina | Details | |
| Macquarie University Hospital | Sydney | New South Wales | 2109 | Australia | Details | |
| Royal Darwin Hospital | Tiwi | Northern Territory | 810 | Australia | Details | |
| St John of God Healthcare | Subiaco | Western Australia | 6008 | Australia | Details | |
| Institut Jules Bordet/Jules Bordet Instituut | Bruxelles | 1070 | Belgium | Details | ||
| Hosp. Araujo Jorge da Associação de Combate ao Câncer | Goiânia | Goiás | 74605-070 | Brazil | Details | |
| Cenantron Centro Avançado de Tratamento Oncológico, Ltda. | Belo Horizonte | Minas Gerais | 30130-090 | Brazil | Details | |
| Fundacao Pio XII - Hospital de Cancer de Barretos | Barretos/SP | Sao Paulo | 14784-400 | Brazil | Details | |
| Instituto do Cancer do Estado de Sao Paulo | São Paulo | Sao Paulo | 01246-000 | Brazil | Details | |
| Real e Benemérita Associação Portuguesa de Beneficência | São Paulo | Sao Paulo | 01323-001 | Brazil | Details | |
| IBCC - Instituto Brasileiro de Controle do Cancer | São Paulo | Sao Paulo | 03102-002 | Brazil | Details | |
| Instituto Nacional do Câncer - INCA - HC II | Rio de Janeiro | 20081-250 | Brazil | Details | ||
| INCA - Hospital do Cancer III | Rio de Janeiro | 20560-120 | Brazil | Details | ||
| Oncoclínicas Rio de Janeiro S.A | Rio de Janeiro | 22250-905 | Brazil | Details | ||
| Hospital Sirio Libanes | Sao Paulo | 01409-000 | Brazil | Details | ||
| Tom Baker Cancer Centre | Calgary | Alberta | T2N 4N2 | Canada | Details | |
| Sun Yat-sen University Cancer Center | Guangzhou | Guangdong | 510000 | China | Details | |
| Sichuan University West China Hospital | Chengdu | Sichuan | MISSING | China | Details | |
| Beijing Cancer Hospital | Beijing | 100142 | China | Details | ||
| Zhongshan Hospital, Fudan University | Shanghai | 200032 | China | Details | ||
| Instituto Nacional de Cancerología INC Colombia | Bogota | Cundinamarca | 111511 | Colombia | Details | |
| Oncomédica S.A. | Montería | Córdoba | 230002 | Colombia | Details | |
| Fundación Oftalmológica de Santander Carlos Ardila Lule | Florida Blanca | Santander | 681004 | Colombia | Details | |
| Fakultní Nemocnice Olomouc | Olomouc | 77900 | Czechia | Details | ||
| Rigshospitalet - Kræftbehandling | Copenhagen OE | 2100 | Denmark | Details | ||
| Hopital Jean Minjoz | Besancon | 25030 | France | Details | ||
| Institut Bergonié - Unicancer Nouvelle Aquitaine | Bordeaux Cedex | 33076 | France | Details | ||
| Hopital Saint Antoine - Paris | Clamart | 92141 | France | Details | ||
| Centre Antoine Lacassagne | Nice Cedex 2 | 6189 | France | Details | ||
| Hôpital de la Pitié-Salpétrière | Paris | 75651 | France | Details | ||
| Hôpital de la Milétrie | Poitiers | 86021 | France | Details | ||
| Institut de Cancérologie de l'Ouest - Saint Herblain | Saint-Herblain | 44800 | France | Details | ||
| ICANS - Institut de Cancérologie de Strasbourg Europe | Strasbourg | 67033 | France | Details | ||
| Charité Comprehensive Cancer Center (CCCC) | Berlin | 12203 | Germany | Details | ||
| All India Institute of Medical Sciences | Bhubaneswar | Odisha | 751019 | India | Details | |
| Jawaharlal Institute Of Postgraduate Medical Education and R | Gorimedu | Pondicherry | 605006 | India | Details | |
| St Vincents University Hospital | Dublin 4 | TBC | Ireland | Details | ||
| A.O.R.N. San Giuseppe Moscati | Avellino | Campania | 83100 | Italy | Details | |
| A.O.U. di Bologna Policlinico S.Orsola Malpighi | Bologna | Emilia-Romagna | 40138 | Italy | Details | |
| A.S.U. Friuli Centrale - A. Regionale Coordinamento Salute | Udine | Friuli-Venezia Giulia | 33038 | Italy | Details | |
| IRCCS Istituti Fisioterapici Ospitalieri - IFO | Roma | Lazio | 144 | Italy | Details | |
| Istituto Europeo di Oncologia s.r.l | Milano | Lombardia | 20141 | Italy | Details | |
| Istituto Oncologico Veneto | Padova | Veneto | 35128 | Italy | Details | |
| Nagoya University Hospital | Nagoya | Aichi | 466-8560 | Japan | Details | |
| National Cancer Center Hospital East | Kashiwa | Chiba | 277-8577 | Japan | Details | |
| Hokkaido University Hospital | Sapporo | Hokkaido | 060-8648 | Japan | Details | |
| The Cancer Institute Hospital of JFCR | Koto-ku | Tokyo | 135-8550 | Japan | Details | |
| Seoul National University Hospital | Seoul | Seoul Teugbyeolsi | 3080 | Korea, Republic of | Details | |
| Severance Hospital, Yonsei University Health System | Seoul | 03722 | Korea, Republic of | Details | ||
| Asan Medical Center | Seoul | 138-736 | Korea, Republic of | Details | ||
| Samsung Medical Center | Seoul | 6351 | Korea, Republic of | Details | ||
| IPO Porto | Porto | 4200-072 | Portugal | Details | ||
| Arkhangelsk Clinical Oncology Dispensary | Arkhangelsk | 163045 | Russian Federation | Details | ||
| Republican Clinical Oncology Dispensary Kazan | Kazan | 420029 | Russian Federation | Details | ||
| Russian Oncological Scientific Center n.a. N.N. Blokhin RAMS | Moscow | 115478 | Russian Federation | Details | ||
| 1st Moscow State Medical University n.a. I.M.Sechenov | Moscow | 119991 | Russian Federation | Details | ||
| Clinical Diagnostical Center | Nizhny Novgorod | 603006 | Russian Federation | Details | ||
| St. Petersburg Clinical Onc. Cent. of Spec. Types of Care | St. Petersburg | 197758 | Russian Federation | Details | ||
| National Cancer Center Singapore | Singapore | 168583 | Singapore | Details | ||
| Onkologicky Ustav Svatej Alzbety, s.r.o. | Bratislava | 812 50 | Slovakia | Details | ||
| Narodny onkologicky ustav | Bratislava | 833 10 | Slovakia | Details | ||
| Institut Català d'Oncologia Hospitalet | Hospitalet de Llobregat | Barcelona | 08907 | Spain | Details | |
| Hospital del Mar | Barcelona | 08003 | Spain | Details | ||
| Ciutat Sanitaria i Universitaria de la Vall d'Hebron | Barcelona | 08035 | Spain | Details | ||
| Hospital General Universitario Gregorio Maranon | Oncologia | Madrid | 28007 | Spain | Details | ||
| Fundacion Jimenez Diaz (Clinica de la Concepcion) | Madrid | 28040 | Spain | Details | ||
| Centro Integral Oncológico Clara Campal | Madrid | 28050 | Spain | Details | ||
| Karolinska Universitetssjukhuset i Solna | Stockholm | 171 76 | Sweden | Details | ||
| Tri-Service General Hospital | Taipei City | 114 | Taiwan | Details | ||
| Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital | Ankara | 6800 | Turkey | Details | ||
| Trakya Univ. Tip Fak. | Edirne | 22030 | Turkey | Details | ||
| Istanbul Universitesi Istanbul Tip Fakultesi | Istanbul | 34093 | Turkey | Details | ||
| Istanbul Universitesi Cerrahpasa-Cerrahpasa Tip Fakultesi | Istanbul | 34098 | Turkey | Details | ||
| TC Saglik Bakanligi Goztepe ProfDr Suleyman Yalcin Sehir Has | Istanbul | 34722 | Turkey | Details | ||
| Izmir Katip Celebi Universitesi Ataturk Egitim ve Arastirma | Izmir | 35360 | Turkey | Details | ||
| Erciyes Universitesi Tip Fakultesi | Kayseri | 38039 | Turkey | Details |