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| NCT ID | NCT02614794 |
| Title | A Study of Tucatinib vs. Placebo in Combination With Capecitabine & Trastuzumab in Patients With Advanced HER2+ Breast Cancer (HER2CLIMB) |
| Acronym | HER2CLIMB |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase II |
| Variant Requirements | No |
| Sponsors | Seattle Genetics, Inc. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | ITA | ISR | GBR | FRA | ESP | DNK | DEU | CZE | CHE | CAN | BEL | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35249 | United States | Details | |
| University of South Alabama - Mitchell Cancer Institute | Mobile | Alabama | 36604 | United States | Details | |
| Cancer Treatment Centers of America - Phoenix | Goodyear | Arizona | 85338 | United States | Details | |
| Arizona Oncology Associates, PC - HAL | Phoenix | Arizona | 85016 | United States | Details | |
| City of Hope National Medical Center | Duarte | California | 91010-3000 | United States | Details | |
| TRIO - Central Regulatory Office | Los Angeles | California | 90095 | United States | Details | |
| UCLA Medical Center / David Geffen School of Medicine | Los Angeles | California | 90095 | United States | Details | |
| Torrance Memorial Physician Network - TRIO | Redondo Beach | California | 90277 | United States | Details | |
| University of California at San Francisco | San Francisco | California | 94134 | United States | Details | |
| Kaiser Permanente San Marcos Medical Offices | San Marcos | California | 92078 | United States | Details | |
| Central Coast Medical Oncology Corporation TRIO | Santa Maria | California | 93454 | United States | Details | |
| Kaiser Permanente Medical Center Northern California | Vallejo | California | 94589 | United States | Details | |
| University of Colorado Hospital / University of Colorado | Aurora | Colorado | 80045-0510 | United States | Details | |
| Yale Cancer Center | New Haven | Connecticut | 06520 | United States | Details | |
| Lombardi Cancer Center / Georgetown University Medical Center | Washington | District of Columbia | 20007 | United States | Details | |
| Florida Cancer Specialists - South Region | Fort Myers | Florida | 33901 | United States | Details | |
| Memorial Regional Hospital TRIO | Hollywood | Florida | 33021 | United States | Details | |
| Baptist MD Anderson Cancer Center | Jacksonville | Florida | 32207 | United States | Details | |
| Mount Sinai Medical Center / Florida | Miami Beach | Florida | 33140 | United States | Details | |
| University of Miami | Miami | Florida | 33136 | United States | Details | |
| Orlando Health, Inc. TRIO | Orlando | Florida | 32806 | United States | Details | |
| Florida Cancer Specialists - North Region | Saint Petersburg | Florida | 33705 | United States | Details | |
| H. Lee Moffitt Cancer Center and Research Institute | Tampa | Florida | 33612 | United States | Details | |
| Florida Cancer Specialists - East West Palm Beach, FL (SCRI) | West Palm Beach | Florida | 33401 | United States | Details | |
| Winship Cancer Institute / Emory University School of Medicine | Atlanta | Georgia | 30322 | United States | Details | |
| Northside Hospital | Atlanta | Georgia | 30342 | United States | Details | |
| Augusta University | Augusta | Georgia | 30912 | United States | Details | |
| Cancer Treatment Centers of America | Newnan | Georgia | 30265 | United States | Details | |
| Rush University Medical Center | Chicago | Illinois | 60612 | United States | Details | |
| University of Chicago | Chicago | Illinois | 60637-1470 | United States | Details | |
| Illinois Cancer Specialists / Advocate Lutheran General Hospital | Niles | Illinois | 60714 | United States | Details | |
| Carle Cancer Center | Urbana | Illinois | 61801 | United States | Details | |
| University of Kansas Cancer Center | Westwood | Kansas | 66205 | United States | Details | |
| University of Maryland | Baltimore | Maryland | 21201 | United States | Details | |
| Maryland Oncology Hematology, P.A. | Rockville | Maryland | 20850 | United States | Details | |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | United States | Details | |
| Henry Ford Health System | Detroit | Michigan | 48202 | United States | Details | |
| William Beaumont Hospital | Royal Oak | Michigan | 48073 | United States | Details | |
| Virginia Piper Cancer Institute | Minneapolis | Minnesota | 55407 | United States | Details | |
| Saint Luke's Cancer Institute LLC | Kansas City | Missouri | 64113 | United States | Details | |
| Nebraska Cancer Specialists | Omaha | Nebraska | 68130 | United States | Details | |
| Dartmouth-Hitchcock Medical Center/ Norris Cotton Cancer Center | Lebanon | New Hampshire | 03756 | United States | Details | |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | United States | Details | |
| Montefiore Medical Center | Bronx | New York | 10467 | United States | Details | |
| Mount Sinai Beth Israel | New York | New York | 10003 | United States | Details | |
| New York University (NYU) Cancer Institute | New York | New York | 10016 | United States | Details | |
| Stony Brook University Cancer Center | Stony Brook | New York | 11794 | United States | Details | |
| UNC Lineberger Comprehensive Cancer Center / University of North Carolina | Chapel Hill | North Carolina | 27599 | United States | Details | |
| Duke University Medical Center | Durham | North Carolina | 27710 | United States | Details | |
| Leo W. Jenkins Cancer Services / Brody School of Medicine East Carolina University | Greenville | North Carolina | 27834 | United States | Details | |
| James Cancer Hospital / Ohio State University | Columbus | Ohio | 43210 | United States | Details | |
| Providence Portland Medical Center | Portland | Oregon | 97213 | United States | Details | |
| Oregon Health and Science University | Portland | Oregon | 97239-3098 | United States | Details | |
| Northwest Cancer Specialists, P.C. | Tualatin | Oregon | 97062 | United States | Details | |
| University of Pennsylvania / Perelman Center for Advanced Medicine | Philadelphia | Pennsylvania | 19104 | United States | Details | |
| Cancer Treatment Centers of America / Eastern Regional Medical Center | Philadelphia | Pennsylvania | 19124 | United States | Details | |
| Roper St. Francis Healthcare | Charleston | South Carolina | 29414 | United States | Details | |
| Medical University of South Carolina/Hollings Cancer Center | Charleston | South Carolina | 29425 | United States | Details | |
| Wellmont Cancer Institute | Kingsport | Tennessee | 37660 | United States | Details | |
| Tennessee Oncology - Nashville | Nashville | Tennessee | 37203 | United States | Details | |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37204 | United States | Details | |
| Texas Oncology - Austin Midtown | Austin | Texas | 78705 | United States | Details | |
| Texas Oncology Methodist | Dallas | Texas | 75203 | United States | Details | |
| Texas Oncology - Denton South | Denton | Texas | 76210 | United States | Details | |
| The Center for Cancer and Blood Disorders: Fortworth | Fort Worth | Texas | 76104 | United States | Details | |
| Texas Oncology - Houston Memorial City | Houston | Texas | 77024 | United States | Details | |
| MD Anderson Cancer Center / University of Texas | Houston | Texas | 77030-4095 | United States | Details | |
| Baylor Clinic | Houston | Texas | 77030 | United States | Details | |
| Joe Arrington Cancer Research and Treatment Center | Lubbock | Texas | 79410 | United States | Details | |
| Paris Regional Medical Center / US Oncology | Paris | Texas | 75460 | United States | Details | |
| Texas Oncology - Plano East | Plano | Texas | 75075 | United States | Details | |
| Texas Oncology - San Antonio Medical Center Northeast | San Antonio | Texas | 78212 | United States | Details | |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | United States | Details | |
| US Oncology Central Regulatory | The Woodlands | Texas | 77380 | United States | Details | |
| Texas Oncology - Deke Slayton Cancer Center | Webster | Texas | 77598 | United States | Details | |
| University of Utah | Salt Lake City | Utah | 84112 | United States | Details | |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | United States | Details | |
| Shenandoah Oncology P.C. | Winchester | Virginia | 22601 | United States | Details | |
| Swedish Cancer Institute | Seattle | Washington | 98104 | United States | Details | |
| Seattle Cancer Care Alliance / University of Washington | Seattle | Washington | 98109-1023 | United States | Details | |
| Carbone Cancer Center / University of Wisconsin | Madison | Wisconsin | 53792 | United States | Details | |
| Austin Hospital | Heidelberg | 3084 | Australia | Details | ||
| Cabrini Education and Research Precinct | Malvern | 3144 | Australia | Details | ||
| Peter MacCallum Cancer Centre | Melbourne | 3000 | Australia | Details | ||
| Breast Cancer Research Centre | Nedlands | 6009 | Australia | Details | ||
| Mater Hospital | North Sydney | 2060 | Australia | Details | ||
| Icon Cancer Care South Brisbane | South Brisbane | 4101 | Australia | Details | ||
| Mater Health Services | South Brisbane | 4101 | Australia | Details | ||
| Sunshine Hospital | St Albans | 3021 | Australia | Details | ||
| Westmead Hospital | Westmead | 2145 | Australia | Details | ||
| LKH- Universitat Klinikum Graz | Graz | 8036 | Austria | Details | ||
| Medizinische Universitat Innsbruck | Innsbruck | 6020 | Austria | Details | ||
| KH d. Barmherzigen Schwestern Linz | Linz | 4010 | Austria | Details | ||
| LKH Salzburg, Universitatsklinikum der PMU | Salzburg | 5020 | Austria | Details | ||
| AZ Klina | Brasschaat | 2930 | Belgium | Details | ||
| Cliniques Universitaires Saint Luc | Brussels | 1200 | Belgium | Details | ||
| Grand Hopital de Charleroi | Charleroi | 6000 | Belgium | Details | ||
| Centre Hospitalier de l'Ardenne | Libramont | 6800 | Belgium | Details | ||
| CHU UCL Namur-Site de Saint Elisabeth | Namur | 5000 | Belgium | Details | ||
| Tom Baker Cancer Centre | Calgary | T2N 4N2 | Canada | Details | ||
| University of Alberta / Cross Cancer Institute | Edmonton | T6G 1Z2 | Canada | Details | ||
| Queen Elizabeth II Health Sciences Centre | Halifax | B3H 2Y9 | Canada | Details | ||
| Jewish General Hospital | Montreal | H3T 1E2 | Canada | Details | ||
| Hopital du Saint-Sacrement, CHU de Quebec-Universite Laval | Quebec | G1S 4L8 | Canada | Details | ||
| Allan Blair Cancer Centre | Regina | S4T7T1 | Canada | Details | ||
| Saskatoon Cancer Centre | Saskatoon | S7N 4H4 | Canada | Details | ||
| H. Bliss Murphy Cancer Centre | St John's | A1B 3V6 | Canada | Details | ||
| Sunnybrook Health Sciences Centre | Toronto | M4N 3M5 | Canada | Details | ||
| University Health Network, Princess Margaret Hospital | Toronto | M5G 2M9 | Canada | Details | ||
| British Columbia Cancer Agency - Vancouver Centre | Vancouver | V5Z 4E6 | Canada | Details | ||
| Fakultni nemocnice Hradec Kralove-oddeleni klinicke hematologie | Hradec Kralove | 500 05 | Czechia | Details | ||
| Fakultni Nemocnice Olomouc (Fnol) - Onkologicka Klinika | Olomouc | 77520 | Czechia | Details | ||
| Aalborg Universitetshospital | Aalborg | 9100 | Denmark | Details | ||
| Rigs Hospiltalet | Copenhagen | DK 2100 | Denmark | Details | ||
| Herlev Hospital | Herlev | 2730 | Denmark | Details | ||
| Odense University Hospital | Odense C | 5000 | Denmark | Details | ||
| Sygehus Lillebaelt - Vejle Sygehus | Vejle | 7100 | Denmark | Details | ||
| University Hospital of Besancon | Besancon cedex | 25030 | France | Details | ||
| Clinique Victor Hugo | Le Mans | 72000 | France | Details | ||
| Centre Leon Berard - Centre regional de lutte contre le cancer Rhone-Alpes | Lyon | 69373 | France | Details | ||
| Institut Paoli Calmettes | Marseille | 13273 | France | Details | ||
| Institute Curie - Centre de Lutte Contre Le Cancer CLCC de Paris | Paris | 75005 | France | Details | ||
| Centre Hospitalier Lyon Sud | Pierre Bénite Cedex | 69495 | France | Details | ||
| Institut Jean Godinot | REIMS Cedex | 51056 | France | Details | ||
| Centre Eugene Marquis | Rennes Cedex | 35042 | France | Details | ||
| Hopitaux Universitaires de Strasbourg | Strasbourg | 67200 | France | Details | ||
| Institut Claudius Regaud | Toulouse Cedex 9 | 31059 | France | Details | ||
| CHU Tours - Hopital Bretonneau | TOURS Cedex 09 | 37044 | France | Details | ||
| Charite Universitatsmedizin Berlin | Berlin | 10117 | Germany | Details | ||
| Kliniken Essen-Mitte - Evang. Huyssens-Stiftung | Essen | 45136 | Germany | Details | ||
| Universitaetsklinikum Hamburg-Eppendorf (UKE) - Onkologisches Zentrum - Interdisziplinaere Klinik und Poliklinik fuer Stammzelltransplantation | Hamburg | 20246 | Germany | Details | ||
| Medizinische Hochschule Hannover | Hannover | 30625 | Germany | Details | ||
| Universitatsklinikum Schleswig-Holstein | Kiel | 24105 | Germany | Details | ||
| InVO- Institut fUr Versorgungsforschung in der onkologie GbR | Koblenz | 56068 | Germany | Details | ||
| Universitatsklinikum Koln | Köln | 50937 | Germany | Details | ||
| HOPE- Onkologisches Zentrum Rotkreuzklinikum | Munchen | 80639 | Germany | Details | ||
| Sana Klinikum Offenbach GmbH | Offenbach am Main | 63069 | Germany | Details | ||
| Rambam Health Corp. | Haifa | 31096 | Israel | Details | ||
| Hadassah Medical Center | Jerusalem | 91120 | Israel | Details | ||
| Meir Medical Center | Kfar Saba | 44281 | Israel | Details | ||
| Rabin Medical Center | Petach Tikva | 49414 | Israel | Details | ||
| Kaplan Medical Center | Rehovot | 76100 | Israel | Details | ||
| Tel Aviv Sourasky Medical Center | Tel Aviv | 64239 | Israel | Details | ||
| Sheba Medical Center | Tel Hashomer | 52621 | Israel | Details | ||
| Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-Malpighi | Bologna | 40138 | Italy | Details | ||
| Ospedale di Bolzano | Bolzano | 39100 | Italy | Details | ||
| Presido Ospedaliero- Senatore Antonio Perrino | Brindisi | 72100 | Italy | Details | ||
| Ospedale Ramazzini di Carpi | Carpi | 41012 | Italy | Details | ||
| Ospedale Policlinico San Martino | Genova | 16132 | Italy | Details | ||
| Istituto Europeo di Oncologia | Milano | 20141 | Italy | Details | ||
| IRCSS Policlinico San Matteo | Pavia | 27100 | Italy | Details | ||
| Azienda Ospedaliera S. Maria di Terni | Terni | 05100 | Italy | Details | ||
| A.O.U. - Ospedali Riuniti di Ancona | Torrette | 60126 | Italy | Details | ||
| Hospital Cuf Descobertas R. Mario Botas Parque das Nacoes | Lisboa | 1998-018 | Portugal | Details | ||
| Centro Hospitalar do Porto - Hospital Santo Antonio | Porto | 4099-001 | Portugal | Details | ||
| Hospital Universitario Vall d'Hebron | Barcelona | 08035 | Spain | Details | ||
| Hospital Clinic i Provincial de Barcelona | Barcelona | 08036 | Spain | Details | ||
| Hospital San Pedro de Alcantara | Caceres | 10002 | Spain | Details | ||
| Complejo Asistencial Universitario de Leon | Leon | 24008 | Spain | Details | ||
| Hospital General Universitario Gregorio Marañon | Madrid | 28007 | Spain | Details | ||
| Hospital Universitario 12 de Octubre | Madrid | 28041 | Spain | Details | ||
| Hospital Son Espases | Palma de Mallorca | 07010 | Spain | Details | ||
| Hospital Clinico Univ De Santiago De Compostela | Santiago de Compostela | 15706 | Spain | Details | ||
| Hospital Arnau De Vilanova | Valencia | 46015 | Spain | Details | ||
| Hospital Clinico Universitario Lozano Blesa de Zaragoza | Zaragoza | 50009 | Spain | Details | ||
| Institute of Oncology of Southern Switzerland | Bellinzona | 6500 | Switzerland | Details | ||
| Colchester Hospital University NHS Foundation Trust | Colchester | C04 5JL | United Kingdom | Details | ||
| The Royal Marsden Hospital | London | SW3 6JJ | United Kingdom | Details | ||
| Sarah Cannon Research Institute UK | London | W1G 6AD | United Kingdom | Details | ||
| The Christie NHS Foundation Trust | Manchester | M20 4BX | United Kingdom | Details | ||
| Mount Vernon Hospital, UK | Northwood | HA6 2RN | United Kingdom | Details | ||
| Nottingham University Hospitals NHS Trust | Nottingham | NG5 1PD | United Kingdom | Details | ||
| Peterborough City Hospital | Peterborough | PE3 9GZ | United Kingdom | Details | ||
| Weston Park Hospital- UK | Sheffield | S10 2SJ | United Kingdom | Details | ||
| The Royal Marsden Hospital (Surrey) | Sutton | SM2 5PT | United Kingdom | Details | ||
| Royal Cornwall Hospitals NHS Trust | Truro | TR1 3LQ | United Kingdom | Details |