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| NCT ID | NCT02626455 |
| Title | Study of Copanlisib in Combination With Standard Immunochemotherapy in Relapsed Indolent Non-Hodgkin's Lymphoma (iNHL) (CHRONOS-4) |
| Acronym | CHRONOS-4 |
| Recruitment | Terminated |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Bayer |
| Indications | |
| Therapies | |
| Age Groups: | adult |
| Covered Countries | USA | TUR | SVK | ROU | POL | ITA | ISR | IRL | HUN | GRC | GBR | FRA | FIN | ESP | DNK | DEU | CZE | CAN | BRA | BGR | BEL | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Ironwood Physicians P.C. DBA Ironwood Cancer & Res. Ctr. | Chandler | Arizona | 85224 | United States | Details | |
| Brian J. LeBerthon, MD | West Covina | California | 91790 | United States | Details | |
| SCL Health Research at St Joseph's Hospital Denver CO | Denver | Colorado | 80218 | United States | Details | |
| Lewis Hall Singletary Oncology Center | Thomasville | Georgia | 31792 | United States | Details | |
| Memorial Sloan Kettering Cancer Center- Bergen | New York | New York | 10021 | United States | Details | |
| Memorial Sloan-Kettering Cancer Center | New York | New York | 10065 | United States | Details | |
| New York Cancer and Blood Specialists | Port Jefferson Station | New York | 11776 | United States | Details | |
| Gabrail Cancer Center | Canton | Ohio | 44718 | United States | Details | |
| Oncology Consultants | Houston | Texas | 77024-2645 | United States | Details | |
| Texas Oncology- McAllen | McAllen | Texas | 78503 | United States | Details | |
| Calvary Mater Hospital Newcastle | Waratah | New South Wales | 2298 | Australia | Details | |
| Flinders Medical Centre | Bedford Park | South Australia | 5042 | Australia | Details | |
| Ashford Cancer Centre Research Pty Ltd | Kurralta Park | South Australia | 5037 | Australia | Details | |
| The Alfred Hospital | Melbourne | Victoria | 3004 | Australia | Details | |
| Fiona Stanley Hospital | Murdoch | Western Australia | 6961 | Australia | Details | |
| Eastern Health Integrated Renal Service | Box Hill | 3128 | Australia | Details | ||
| Institut Jules Bordet/Jules Bordet Instituut | Bruxelles | 1070 | Belgium | Details | ||
| UZ Gent | Gent | 9000 | Belgium | Details | ||
| UZ Leuven Gasthuisberg | Leuven | 3000 | Belgium | Details | ||
| CHU de Liège | Liege | 4000 | Belgium | Details | ||
| Centro Integrado de Oncologia de Curitiba | Curitiba | Parana | 80810-050 | Brazil | Details | |
| Irmandade da Santa Casa de Misericordia de Porto Alegre | Hospital Sao Francisco - Centro Medico Pesquisa Clinica Cardiologia | Porto Alegre | Rio Grande Do Sul | 90020-090 | Brazil | Details | |
| Hospital de Clinicas de Porto Alegre | Clinical Research Center - Surgery Research Center | Porto Alegre | Rio Grande Do Sul | 90035-903 | Brazil | Details | |
| Centro de Pesquisas Oncológicas | Florianópolis | Santa Catarina | 88034-000 | Brazil | Details | |
| Faculdade de Ciencias Medicas-Universidade Estadual Campinas | Campinas | Sao Paulo | 130839 970 | Brazil | Details | |
| Centro Multidisciplinar de Estudos Clínicos EPP - Ltda. | São Bernardo do Campo | Sao Paulo | 09715-090 | Brazil | Details | |
| IEP São Lucas | São Paulo | Sao Paulo | 01234-030 | Brazil | Details | |
| Instituto Nacional do Cancer Jose Alencar Gomes da Silva | Rio de Janeiro | 20231-050 | Brazil | Details | ||
| Hospital das Clínicas da Faculdade de Medicina da USP | Sao Paulo | 05403-000 | Brazil | Details | ||
| Hospital Israelita Albert Einstein | Morumbi - Clinical Research Department | Sao Paulo | 05651-901 | Brazil | Details | ||
| UMHAT Sveti Georgi | Plovdiv | 4000 | Bulgaria | Details | ||
| University Multiprofile Hosp. for Active Treat. Sveti Ivan | Sofia | 1431 | Bulgaria | Details | ||
| SHATHD Spec. Hospi. for Active Treatm. of Haematol. Dis. EAD | Sofia | 1756 | Bulgaria | Details | ||
| Multiprofile Hospital for Active Treatment Hristo Botev AD | Vratsa | 3000 | Bulgaria | Details | ||
| Hopital Maisonneuve-Rosemont | Montreal | Quebec | H1T 2M4 | Canada | Details | |
| Hopital du Sacre-Coeur de Montreal | Montreal | Quebec | QC H4J 1C5 | Canada | Details | |
| Hopital de L'Enfant Jesus | Quebec City | Quebec | G1J 1Z4 | Canada | Details | |
| Centre Universitaire de Sante de l'Estrie | Sherbrooke | Quebec | J1H 5N4 | Canada | Details | |
| Sociedad de Investigaciones Medicas Ltda | Temuco | Araucanía | 4810469 | Chile | Details | |
| Centro de Investigaciones Clínicas Vina del Mar Ltda. | Vina del Mar | Valparaíso | 2540364 | Chile | Details | |
| Instituto Nacional del Cáncer | Santiago | 838-0455 | Chile | Details | ||
| FuJian Medical University Union Hospital | Fuzhou | Fujian | 350000 | China | Details | |
| Guangdong Provincial People's Hospital | Guangzhou | Guangdong | 510000 | China | Details | |
| Sun Yat-sen University Cancer Center | Guangzhou | Guangdong | 510000 | China | Details | |
| Tumor Hospital of Hebei Province | Hebei | Hebei | 050000 | China | Details | |
| Henan Cancer Hospital | Zhengzhou | Henan | 450000 | China | Details | |
| Jiangsu Cancer Hospital | Nanjing | Jiangsu | 210000 | China | Details | |
| 1st Affiliated hospital of Soochow University | Suzhou | Jiangsu | 215000 | China | Details | |
| Jilin Cancer Hospital | Changchun | Jilin | 130000 | China | Details | |
| The Affiliated Hospital of Qingdao University | Shandong | Shandong | 266000 | China | Details | |
| West China Hospital Sichuan University | Chengdu | Sichuan | 610041 | China | Details | |
| The 1st Affiliated Hospital of Zhejiang University | Hangzhou | Zhejiang | 310000 | China | Details | |
| Zhejiang Cancer Hospital | Hangzhou | Zhejiang | 310022 | China | Details | |
| Fifth Medical Center, General Hospital of the Chinese People | Beijing | 100000 | China | Details | ||
| Beijing Friendship Hospital, Capital Medical University | Beijing | 100050 | China | Details | ||
| Fudan University Shanghai Cancer Center | Shanghai | 200000 | China | Details | ||
| Xinhua Hos Affiliated to SH Jiaotong Uni School of Medicine | Shanghai | 200092 | China | Details | ||
| Tianjin Medical University Cancer Institute & Hospital | Tianjin | 300000 | China | Details | ||
| Tianjin Union Medicine Centre (People's Hospital of Tianjin) | Tianjin | 300121 | China | Details | ||
| Fakultni Nemocnice Hradec Kralove | Hradec Kralove | 500 05 | Czechia | Details | ||
| Fakultni nemocnice Kralovske Vinohrady | Praha 10 | 10034 | Czechia | Details | ||
| Rigshospitalet - Hjertesygdomme | København Ø | 2100 | Denmark | Details | ||
| Odense Universitetshospital - Hæmatologisk afdeling | Odense C | 5000 | Denmark | Details | ||
| HUS, Meilahden sairaala | Helsinki | FIN-00260 | Finland | Details | ||
| Oulun yliopistollinen sairaala | Oulu | 90220 | Finland | Details | ||
| Tampereen yliopistollinen sairaala | Tampere | 33520 | Finland | Details | ||
| Turun yliopistollinen keskussairaala | Turku | 20520 | Finland | Details | ||
| Centre Hospitalier Universitaire - Angers | Angers | 49933 | France | Details | ||
| Centre Hospitalier de la Durance - Avignon | Avignon | 84000 | France | Details | ||
| Centre Hospitalier Intercommunal de la Côte Basque-Bayonne | Bayonne | 64100 | France | Details | ||
| Centre Hospitalier Universite de Grenoble | Grenoble | 38043 | France | Details | ||
| Clinique Victor Hugo - Le Mans | Le Mans Cedex 2 | 72015 | France | Details | ||
| Hôpital Dupuytren | Limoges Cedex | 87042 | France | Details | ||
| Hôpital Saint-Eloi | Montpellier Cedex | 34059 | France | Details | ||
| Hopital Hotel Dieu - Nantes | Nantes | 44000 | France | Details | ||
| Hôpital Saint Louis | Paris | 75010 | France | Details | ||
| Centre François Magendie - Pessac | Pessac | 33600 | France | Details | ||
| Hôpital de la Milétrie | Poitiers | 86021 | France | Details | ||
| Clinique Saint Anne | Strasbourg | 67000 | France | Details | ||
| Stauferklinikum Schwäbisch-Gmünd | Mutlangen | Baden-Württemberg | 73557 | Germany | Details | |
| Haematologie-Onkologie im Zentrum MVZ GmbH | Augsburg | Bayern | 86150 | Germany | Details | |
| Klinikum der Universität München Grosshadern | München | Bayern | 81377 | Germany | Details | |
| Medizinische Hochschule Hannover (MHH) | Hannover | Niedersachsen | 30625 | Germany | Details | |
| Universitaetsklinikum Muenster | Münster | Nordrhein-Westfalen | 48149 | Germany | Details | |
| Oncologianova GmbH | Recklinghausen | Nordrhein-Westfalen | 45659 | Germany | Details | |
| Marienhospital Herne Universitätsklinik | Herne | NRW | 44625 | Germany | Details | |
| Med. Fakultät der Martin-Luther-Universität Halle-Wittenberg | Halle | Sachsen-Anhalt | 6120 | Germany | Details | |
| EVANGELISMOS General Hospital of Athens | Athens | 106 76 | Greece | Details | ||
| General Hospital of Athens LAIKO | Athens | 11527 | Greece | Details | ||
| University General Hospital of Athens "ATTIKON" | Chaidari | 12462 | Greece | Details | ||
| Univ. General Hospital of Larissa | Larissa | 41110 | Greece | Details | ||
| University General Hospital of Patras | Patras | 26500 | Greece | Details | ||
| Prince of Wales Hospital | Hong Kong | MISSING | Hong Kong | Details | ||
| Semmelweis University | Budapest | 1083 | Hungary | Details | ||
| Orszagos Onkologiai Intezet | Budapest | 1122 | Hungary | Details | ||
| Somogy Varmegyei Kaposi Mor Oktato Korhaz | Kaposvar | 7400 | Hungary | Details | ||
| Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz | Nyiregyhaza | 4400 | Hungary | Details | ||
| Pecsi Tudomanyegyetem Klinikai Kozpont | Pecs | 7623 | Hungary | Details | ||
| Komarom-Esztergom Varmegyei Szent Borbala Korhaz | Tatabanya | 2800 | Hungary | Details | ||
| Cork University Hospital | Cork | T12DC4A | Ireland | Details | ||
| Mater Misericordiae University Hospital | Dublin | D07R2WY | Ireland | Details | ||
| Rambam Health Corporation | Haifa | 3109601 | Israel | Details | ||
| Hadassah Hebrew University Hospital Ein Kerem | Jerusalem | 9112001 | Israel | Details | ||
| Chaim Sheba Medical Center | Ramat Gan | 5262000 | Israel | Details | ||
| Shamir Medical Center (Assaf Harofeh) | Zerifin | 7030000 | Israel | Details | ||
| IRCCS Ospedale Policlinico San Martino | Genova | Liguria | 16132 | Italy | Details | |
| Humanitas Mirasole S.p.A. | Milano | Lombardia | 20089 | Italy | Details | |
| IRCCS Fondazione Policlinico San Matteo | Pavia | Lombardia | 27100 | Italy | Details | |
| A.O.U. Ospedali Riuniti "Umberto I - G.M.Lancisi - G.Salesi" | Ancona | Marche | 60126 | Italy | Details | |
| Aichi Cancer Center Hospital | Nagoya | Aichi | 464-8681 | Japan | Details | |
| Nagoya City University Hospital | Nagoya | Aichi | 467-8602 | Japan | Details | |
| JCHO Kyushu Hospital | Kitakyushu | Fukuoka | 806-8501 | Japan | Details | |
| Gunma University Hospital | Maebashi | Gunma | 371-8511 | Japan | Details | |
| Hyogo Cancer Center | Akashi | Hyogo | 673-8558 | Japan | Details | |
| Kobe University Hospital | Kobe | Hyogo | 650-0017 | Japan | Details | |
| Kanagawa Cancer Center | Yokohama | Kanagawa | 241-8515 | Japan | Details | |
| Tohoku University Hospital | Sendai | Miyagi | 980-8574 | Japan | Details | |
| Tenri Hospital | Tenri | Nara | 632-8552 | Japan | Details | |
| Kindai University Hospital | Osakasayama-shi | Osaka | 589-8511 | Japan | Details | |
| Saitama Medical University International Medical Center | Hidaka | Saitama | 350-1298 | Japan | Details | |
| National Cancer Center Hospital | Chuo-ku | Tokyo | 104-0045 | Japan | Details | |
| Aomori Prefectural Central Hospital | Aomori | 030-8553 | Japan | Details | ||
| National Hospital Organization Kyushu Cancer Center | Fukuoka | 811-1395 | Japan | Details | ||
| Hiroshima Red Cross & Atomic-bomb Survivors Hospital | Hiroshima | 730-8619 | Japan | Details | ||
| National Hospital Organization Kumamoto Medical Center | Kumamoto | 860-0008 | Japan | Details | ||
| Kumamoto University Hospital | Kumamoto | 860-8556 | Japan | Details | ||
| Osaka Red Cross Hospital | Osaka | 543-8555 | Japan | Details | ||
| Osaka Metropolitan University Hospital | Osaka | 545-8586 | Japan | Details | ||
| Yamagata University Hospital | Yamagata | 990-9585 | Japan | Details | ||
| Seoul National University Hospital | Seoul | Seoul Teugbyeolsi | 3080 | Korea, Republic of | Details | |
| Severance Hospital, Yonsei University Health System | Seoul | 03722 | Korea, Republic of | Details | ||
| Asan Medical Center | Seoul | 138-736 | Korea, Republic of | Details | ||
| Samsung Medical Center | Seoul | 6351 | Korea, Republic of | Details | ||
| Hospital General de México SS | México, D. F. | Distrito Federal | 6726 | Mexico | Details | |
| Centro de Investigación Clínica Chapultepec S.A. de C.V. | Morelia | Michoacán | 58260 | Mexico | Details | |
| Hospital Universitario "José Eleuterio González" | Monterrey | Nuevo Leon | TBC | Mexico | Details | |
| Centro Especializado en Investigación Clínica S.C. | Boca del Río | Veracruz | 94290 | Mexico | Details | |
| Centro de Atencion e Investigacion Clinica en Oncologia SCP | Merida | Yucatán | 97134 | Mexico | Details | |
| Szpital Morski im. PCK | Gdynia | 81-519 | Poland | Details | ||
| Pratia McM Kraków | Krakow | 30-727 | Poland | Details | ||
| Wojew. Szpital Specjalistyczny im. M. Kopernika | Lodz | 93-513 | Poland | Details | ||
| Centro Clinico Academico Braga | Braga, Portugal | Braga | 4710-243 | Portugal | Details | ||
| Centro Hospitalar Universitario do Porto | Porto | 4099-001 | Portugal | Details | ||
| IPO Porto | Porto | 4200-072 | Portugal | Details | ||
| Centro Hospitalar Vila Nova de Gaia e Espinho | Unit 1 - Clinical Research Center | Porto | 4434-502 | Portugal | Details | ||
| Sp. Judetean de Urgenta Dr. Constantin Opris Baia Mare | Baia Mare | 430031 | Romania | Details | ||
| Sc Onco Card Srl | Brasov | 500152 | Romania | Details | ||
| Spitalul Clinic Colentina | Bucuresti | 20125 | Romania | Details | ||
| Fundeni Clinical Institute | Bucuresti | 22328 | Romania | Details | ||
| Spitalul Clinic Coltea | Bucuresti | 30171 | Romania | Details | ||
| Spitalul Clinic Municipal Filantropia Craiova | Craiova | 200143 | Romania | Details | ||
| Institutul Regional de Oncologie Iasi | Iasi | 700483 | Romania | Details | ||
| Spitalul Clinic Judetean de Urgenta Sibiu | Sibiu | 550245 | Romania | Details | ||
| Kemerovo Regional Clinical Hospital | Kemerovo | 650066 | Russian Federation | Details | ||
| Clinical Oncological Dispensary of Omsk Region | Omsk | 644013 | Russian Federation | Details | ||
| Research Institute of Oncology | Rostov-on-Don | 344037 | Russian Federation | Details | ||
| RSRI of Hematology and Transfusiology | Saint-Petersburg | 191024 | Russian Federation | Details | ||
| Oncology Dispensary #2 | Sochi | 354057 | Russian Federation | Details | ||
| Siberian State Medical University | Tomsk | 634050 | Russian Federation | Details | ||
| Republican Clinical Oncology Dispensary | Ufa | 450054 | Russian Federation | Details | ||
| National University Hospital | Singapore | 119074 | Singapore | Details | ||
| National Cancer Center Singapore | Singapore | 168583 | Singapore | Details | ||
| Singapore General Hospital | Singapore | 169608 | Singapore | Details | ||
| Narodny onkologicky ustav | Bratislava | 833 10 | Slovakia | Details | ||
| Outeniqua Cancercare Oncology Unit | George | Eastern Cape | 6530 | South Africa | Details | |
| Cancercare Langenhoven | Port Elizabeth | Eastern Cape | 6045 | South Africa | Details | |
| Albert Alberts Stem Cell Transplant Research Centre | Pretoria | Gauteng | 44 | South Africa | Details | |
| Constantiaberg Medi Clinic | Cape Town | Western Cape | 7800 | South Africa | Details | |
| Institut Català d'Oncologia Badalona | Badalona | Barcelona | 8916 | Spain | Details | |
| Institut Català d'Oncologia Hospitalet | Hospitalet de Llobregat | Barcelona | 08907 | Spain | Details | |
| Hospital Universitario Clinica Puerta de Hierro | Majadahonda | Madrid | 28222 | Spain | Details | |
| Hospital Regional de Malaga | Oncologia | Malaga | Málaga | 29010 | Spain | Details | |
| Ciutat Sanitaria i Universitaria de la Vall d'Hebron | Barcelona | 08035 | Spain | Details | ||
| Hospital Clínico Universitario Lozano Blesa | Zaragoza | 50009 | Spain | Details | ||
| Changhua Christian Hospital | Changhua | 50006 | Taiwan | Details | ||
| Chang Gung Memorial Hospital Kaohsiung | Kaohsiung | 833 | Taiwan | Details | ||
| National Cheng Kung University Hospital | Tainan | 704 | Taiwan | Details | ||
| National Taiwan University Hospital | Taipei | 100 | Taiwan | Details | ||
| Taipei Veterans General Hospital | Taipei | 11217 | Taiwan | Details | ||
| Phramongkutklao Hospital | Bangkok | 10400 | Thailand | Details | ||
| Siriraj Hospital, Mahidol | Bangkok | 10700 | Thailand | Details | ||
| Ankara Universitesi Tip Fakultesi Hastanesi | Ankara | 6100 | Turkey | Details | ||
| Trakya Univ. Tip Fak. | Edirne | 22030 | Turkey | Details | ||
| Istanbul Universitesi Istanbul Tip Fakultesi | Istanbul | 34093 | Turkey | Details | ||
| Marmara Uni. Tip Fak. Pendik EAH Hematoloji BD | Istanbul | 34899 | Turkey | Details | ||
| Dokuz Eylul Universitesi Tip Fakultesi | Izmir | 35100 | Turkey | Details | ||
| Ege Universitesi Tip Fakultesi | Izmir | 35100 | Turkey | Details | ||
| Erciyes Universitesi Tip Fakultesi | Kayseri | 38039 | Turkey | Details | ||
| Ondokuz Mayis Uni Tip Fakultesi | Samsun | 55139 | Turkey | Details | ||
| Karadeniz Teknik Universitesi Tip Fakultesi | Trabzon | 61080 | Turkey | Details | ||
| CNE "Clinical Center of Oncology, Hematology, Transplantology and Palliative Care of the Cherkasy Regional Council" | Cherkasy | 18009 | Ukraine | Details | ||
| Municipal Non-Profit Enterprise "City Clinical Hospital ?4" of the Dnipro City Council | Dnipro | 49102 | Ukraine | Details | ||
| Clinic of National cancer institute - scientific and research department of pediatric oncology | Kyiv | 03022 | Ukraine | Details | ||
| State Institution - Institute of Blood Pathology and Transfusion Medicine NAMS of Ukraine | Lviv | 79044 | Ukraine | Details | ||
| CNE "Zaporizhzhia Regional Clinical Hospital" of Zaporizhzhia regional council | Zaporizhzhya | 69600 | Ukraine | Details | ||
| Royal Devon & Exeter Hospital | Exeter | Devon | EX2 5DW | United Kingdom | Details | |
| Northwick Park Hospital | Harrow | London | HA1 3UJ | United Kingdom | Details | |
| St George's Hospital | Kogarah | London | 2217 | United Kingdom | Details | |
| Dorset County Hospital | Dorchester | DT1 2JY | United Kingdom | Details | ||
| Royal Marsden Hospital (London) | London | SW3 6JJ | United Kingdom | Details | ||
| Singleton Hospital | Swansea | SA2 8QA | United Kingdom | Details |