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| NCT ID | NCT02811861 |
| Title | Lenvatinib/Everolimus or Lenvatinib/Pembrolizumab Versus Sunitinib Alone as Treatment of Advanced Renal Cell Carcinoma |
| Acronym | CLEAR |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Eisai Inc. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | POL | NLD | ITA | ISR | IRL | GRC | GBR | FRA | ESP | DEU | CZE | CHE | CAN | BEL | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Stanford School of Medicine | Stanford | California | 94305-5826 | United States | Details | |
| Boca Raton Community Hospital | Boca Raton | Florida | 33486 | United States | Details | |
| Florida Cancer Specialists | Fort Myers | Florida | 33901 | United States | Details | |
| Mount Sinai Medical Center | Miami Beach | Florida | 33136 | United States | Details | |
| University of Miami | Miami | Florida | 33136 | United States | Details | |
| Florida Hospital Cancer Institute | Orlando | Florida | 32804 | United States | Details | |
| Florida Cancer Specialists ( North Region) | Saint Petersburg | Florida | 33705 | United States | Details | |
| Florida Cancer Specialists | West Palm Beach | Florida | 33401 | United States | Details | |
| Joliet Oncology - Hematology Associates | Joliet | Illinois | 60435 | United States | Details | |
| Healthcare Research Network III, LLC | Tinley Park | Illinois | 60487 | United States | Details | |
| Health Midwest Ventures Group, Inc d/b/a HCA MidAmerica Division, LLC | Overland Park | Kansas | 66209 | United States | Details | |
| Cotton-Oneil Clinical Research Center | Topeka | Kansas | 66604 | United States | Details | |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | United States | Details | |
| Associates in Oncology & Hematology, PC | Bethesda | Maryland | 20817 | United States | Details | |
| Massachusetts General Hospital- MGH | Boston | Massachusetts | 02214 | United States | Details | |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | United States | Details | |
| Karmanos Cancer Center | Detroit | Michigan | 48201 | United States | Details | |
| GU Research Network | Omaha | Nebraska | 68130 | United States | Details | |
| Nebraska Cancer Specialists | Omaha | Nebraska | 68130 | United States | Details | |
| Hackensack Medical Center | Hackensack | New Jersey | 07601 | United States | Details | |
| Montefiore Medical Center | Bronx | New York | 10461 | United States | Details | |
| Rosewell Park Cancer Institute | Buffalo | New York | 14263 | United States | Details | |
| Broome Oncology | Johnson City | New York | 13790 | United States | Details | |
| Weill Cornell Medical College New York Presbyterian Hospital | New York | New York | 10021 | United States | Details | |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | United States | Details | |
| Mission Hospital_ Cancer Care of Western North Carolina | Asheville | North Carolina | 28801 | United States | Details | |
| Oncology Hematology Care | Cincinnati | Ohio | 45242 | United States | Details | |
| Medical University of South Carolina | Charleston | South Carolina | 29412 | United States | Details | |
| SCRI - Tennessee Oncology | Nashville | Tennessee | 37203 | United States | Details | |
| Texas Oncology, P.A. | Dallas | Texas | 75231 | United States | Details | |
| Texas Oncology PA | Fort Worth | Texas | 76104 | United States | Details | |
| Texas Oncology PA - McAllen | McAllen | Texas | 78503 | United States | Details | |
| Texas Oncology PA - Paris | Paris | Texas | 75460 | United States | Details | |
| USOR Texas Oncology | The Woodlands | Texas | 77380 | United States | Details | |
| Texas Oncology PA - Tyler | Tyler | Texas | 75702 | United States | Details | |
| Box Hill Hospital | Box Hill | Victoria | 3128 | Australia | Details | |
| Austin Health | Heidelberg | Victoria | 3084 | Australia | Details | |
| Royal Hobart Hospital | Hobart | Australia | Details | |||
| Macquarie University Hospital | Macquarie park | Australia | Details | |||
| ICON Cancer Foundation | South Brisbane | Australia | Details | |||
| Sunshine Hospital | St Albans | Australia | Details | |||
| Medizinische Universitat Innsbruck | Innsbruck | Austria | Details | |||
| Krankenhaus der barmherzigen Schwestern Linz | Linz | Austria | Details | |||
| AKH - Medizinische Universität Wien | Vienna | 1090 | Austria | Details | ||
| O.L.V Ziekenhuis | Aalst | Belgium | Details | |||
| ZNA Middelheim | Antwerpen | 2260 | Belgium | Details | ||
| Imeldaziekenhuis | Bonheiden | Belgium | Details | |||
| Institut Jules Bordet | Bruxelles | 1000 | Belgium | Details | ||
| Jessa Ziekenhuis - Campus Virga Jesse | Hasselt | 3500 | Belgium | Details | ||
| Domaine Universitaire | Liege | 4000 | Belgium | Details | ||
| GZA Ziekenhuizen - Campus Sint-Augustinus | Wilrijk | 2610 | Belgium | Details | ||
| Cross Cancer Institute | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| BC Cancer Agency Vancouver Centre | Vancouver | British Columbia | V5Z 1H7 | Canada | Details | |
| St. Joseph's Healthcare Hamilton | Hamilton | Ontario | L8N 4A6 | Canada | Details | |
| London Institute of Health Sciences | London | Ontario | N6A4L6 | Canada | Details | |
| Ottawa Hospital Cancer Centre | Ottawa | Ontario | K1H 8 | Canada | Details | |
| Sunnybrook Research Institute - University of Toronto | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| Centre de santé et de services sociaux Champlain-Charles-Le Moyne | Greenfield Park | Quebec | J4V 2H1 | Canada | Details | |
| Fakultni nemocnice u sv. Anny v Brne | Brno | Czechia | Details | |||
| Masarykuv onkologicky ustav | Brno | Czechia | Details | |||
| Fakultni nemocnice Olomouc, Neurologicka klinika | Olomouc | Czechia | Details | |||
| Thomayerova nemocnice | Praha 4 | Czechia | Details | |||
| Fakultni nemocnice v Motole | Praha 5 | Czechia | Details | |||
| Nemocnice Na Bulovce | Praha 8 | Czechia | Details | |||
| ICO - Site Paul Papin | Angers | Maine Et Loire | 49055 | France | Details | |
| Centre Georges François Leclerc | Dijon cedex | 21079 | France | Details | ||
| Clinique Victor Hugo - Centre Jean Bernard | Le Mans Cedex | France | Details | |||
| Centre Leon Berard - Centre regional de lutte contre le cancer Rhone-Alpes | Lyon | France | Details | |||
| Institut Regional du Cancer de Montpellier | Montpellier | France | Details | |||
| Hopital la Petie Salpetriere | Paris | cedex 13 75651 | France | Details | ||
| Hopital Europeen Georges Pompidou | Paris | France | Details | |||
| Boulevard du Professeur Jacques Monod | Saint Herblain | 4805 | France | Details | ||
| CHU Strasbourg - Nouvel Hopital Civil | Strasbourg | France | Details | |||
| EISAI Trial site 4 | Stuttgart | Baden Wuerttemberg | 70174 | Germany | Details | |
| EISAI Trial site 1 | Tuebingen | Baden Wuerttemberg | 72076 | Germany | Details | |
| EISAI Trial site 7 | München | Bayern | 81377 | Germany | Details | |
| EISAI Trial site 6 | Frankfurt | Hessen | 60590 | Germany | Details | |
| EISAI Trial site 14 | Greifswald | Mecklenburg-Vorpommern | Germany | Details | ||
| EISAI Trial site 8 | Hannover | Niedersachsen | 30625 | Germany | Details | |
| EISAI Trial site 13 | Münster | Nordrhein Westfalen | 48149 | Germany | Details | |
| EISAI Trial site 2 | Homburg/Saar | Saarland | 66421 | Germany | Details | |
| EISAI Trial site 5 | Berlin | 12200 | Germany | Details | ||
| General Hospital of Athens "Alexandra" | Athens | 11528 | Greece | Details | ||
| University of Patras Medical School | Patras | 26504 | Greece | Details | ||
| General Hospital Papageorgiou | Thessaloníki | 56429 | Greece | Details | ||
| Interbalkan Hospital of Thessaloniki | Thessaloníki | 57001 | Greece | Details | ||
| Cork University Hospital,Wilton | Cork | Ireland | Details | |||
| Adelaide and Meath Hospital Incorp The National Children's Hospital | Dublin | Ireland | Details | |||
| Beaumont Hospital | Dublin | Ireland | Details | |||
| University Hospital Galway | Galway | Ireland | Details | |||
| Assaf Harofeh Medical Center | Be'er Ya'aqov | Israel | Details | |||
| Rambam MC | Haifa | Israel | Details | |||
| Sapir Medical Center, Meir Hospital | Kfar-Saba | Israel | Details | |||
| Rabin Medical Center-Beilinson Campus | Petah Tikva | 49100 | Israel | Details | ||
| Chaim Sheba Medical Center | Ramat-Gan | Israel | Details | |||
| Tel Aviv Sourasky Medical Center | Tel Aviv | Israel | Details | |||
| Azienda Unità Sanitaria Locale- Ravenna | Faenza | Ravenna | 48018 | Italy | Details | |
| Ospedale San Donato | Arezzo | Italy | Details | |||
| Azienda Ospedaliera Universitaria Policlinico SantOrsola Malpighi | Bologna | Italy | Details | |||
| Istituto Nazionale per la Ricerca sul Cancro di Genova | Genova | 16132 | Italy | Details | ||
| Presidio Ospedaliero Vito Fazzi | Lecce | 73100 | Italy | Details | ||
| Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori - IRST | Meldola | Italy | Details | |||
| Fondazione IRCCS Istituto Nazionale dei Tumori | Milano | 20133 | Italy | Details | ||
| A.O.U. Policlinico di Modena | Modena | 41124 | Italy | Details | ||
| Azienda Ospedaliera di Rilievo Nazionale A. Cardarelli | Napoli | 80131 | Italy | Details | ||
| Istituto Nazionale Tumori Fondazione G. Pascale | Napoli | Italy | Details | |||
| Fondazione IRCCS Policlinico San Matteo | Pavia | Italy | Details | |||
| I.R.C.S.S Fondazione Maugeri | Pavia | Italy | Details | |||
| Azienda Ospedaliera Santa Maria Degli Angeli | Pordenone | 33170 | Italy | Details | ||
| Azienda Ospedaliera San Camillo Forlanini | Roma | Italy | Details | |||
| Universita Campus Bio-Medico di Roma | Rome | Italy | Details | |||
| Facility #1 | Aichi | Japan | Details | |||
| Facility #1 | Akita | Japan | Details | |||
| Facility #1 | Aomori | Japan | Details | |||
| Facility #2 | Chiba | Japan | Details | |||
| Facility #1 | Fukuoka | Japan | Details | |||
| Facility #1 | Hiroshima | Japan | Details | |||
| Facility #1 | Hokkaido | Japan | Details | |||
| Facility #2 | Hokkaido | Japan | Details | |||
| Facility #1 | Hyogo | Japan | Details | |||
| Facility #1 | Kagawa | Japan | Details | |||
| Facility #2 | Kanagawa | Japan | Details | |||
| Facility #3 | Kanagawa | Japan | Details | |||
| Facility #1 | Nagasaki | Japan | Details | |||
| Facility #1 | Nara | Japan | Details | |||
| Facility #1 | Niigata | Japan | Details | |||
| Facility #1 | Okayama | Japan | Details | |||
| Facility #1 | Osaka | Japan | Details | |||
| Facility #2 | Osaka | Japan | Details | |||
| Facility #1 | Saitama | Japan | Details | |||
| Facility #1 | Tokushima | Japan | Details | |||
| Facility #1 | Tokyo | Japan | Details | |||
| Facility #2 | Tokyo | Japan | Details | |||
| Facility #3 | Tokyo | Japan | Details | |||
| Facility #4 | Tokyo | Japan | Details | |||
| Facility #5 | Tokyo | Japan | Details | |||
| Facility #6 | Tokyo | Japan | Details | |||
| Kyungpook National University Chilgok Hospital | Daegu | 41404 | Korea, Republic of | Details | ||
| National Cancer Center | Goyang-si | Korea, Republic of | Details | |||
| Asan Medical Center: Medical Oncology Department | Seoul | Korea, Republic of | Details | |||
| Asan Medical Center: Urology Department | Seoul | Korea, Republic of | Details | |||
| Department of Internal Medicine Division of Hematology/Oncology Cancer center 11F | Seoul | Korea, Republic of | Details | |||
| Samsung Medical Center | Seoul | Korea, Republic of | Details | |||
| Seoul National University Hospital | Seoul | Korea, Republic of | Details | |||
| Severance Hospital, Yonsei University Health System | Seoul | Korea, Republic of | Details | |||
| The Catholic University of Korea, Seoul St. Mary's Hospital | Seoul | Korea, Republic of | Details | |||
| Antoni van Leeuwenhoek | Amsterdam | 1066 CX | Netherlands | Details | ||
| VU Medisch Centrum | Amsterdam | 1081 HV | Netherlands | Details | ||
| UMC Utrecht | Utrecht | 3584 CX | Netherlands | Details | ||
| Uniwersyteckie Centrum Kliniczne | Gdansk | Poland | Details | |||
| Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie | Lublin | Poland | Details | |||
| SPWSZ w Szczecinie im. Marii Sklodowskiej-Curie | Szczecin | Poland | Details | |||
| FSBSI Russian Oncological Scientific Center n.a. N.N. Blokhin - Department of Oncology | Moscow | 115478 | Russian Federation | Details | ||
| FSBI "Moscow scientific research oncology institute n.a. P.A. Gertsen" of MoH of RF | Moscow | 125284 | Russian Federation | Details | ||
| FSBSI Russian Oncological Scientific Center n.a. N.N. Blokhin - Department of Urology | Moscow | Russian Federation | Details | |||
| FBHI Privolzhskiy District Medical Centre FMBA of Russia | Nizhniy Novgorod | Russian Federation | Details | |||
| SBHI of Novosibirsk region "Novosibirsk Regional Oncological Dispensary" | Novosibirsk | 630108 | Russian Federation | Details | ||
| FSBI "National Medical Research Radiological Center" of the MoH of the RF | Obninsk | 249036 | Russian Federation | Details | ||
| BHI of Omsk region "Clinical Oncology Dispensary" | Omsk | 644013 | Russian Federation | Details | ||
| Hospital Universitario Marques de Valdecilla | Santander | Cantabria | 39008 | Spain | Details | |
| Hospital Clinic i Provincial de Barcelona | Barcelona | 08036 | Spain | Details | ||
| ICO l'Hospitalet - Hospital Duran I Reynals | Barcelona | 08908 | Spain | Details | ||
| Hospital de la Santa Creu i Sant Pau | Barcelona | Spain | Details | |||
| Hospital Universitari Vall d'Hebron | Barcelona | Spain | Details | |||
| Hospital San Pedro de Alcantara | Caceres | 10003 | Spain | Details | ||
| Hospital Universitario Reina Sofia | Cordoba | Spain | Details | |||
| Hospital Universitario Ramon y Cajal | Madrid | 28034 | Spain | Details | ||
| Hospital General Universitario Gregorio Maranon | Madrid | Spain | Details | |||
| Hospital Universitario Clinico San Carlos | Madrid | Spain | Details | |||
| Hospital Universitario HM Madrid Sanchinarro | Madrid | Spain | Details | |||
| MD Anderson Cancer Centre | Madrid | Spain | Details | |||
| Hospital Universitario Central de Asturias | Oviedo | 33011 | Spain | Details | ||
| Hospital Universitario Virgen del Rocio | Seville | Spain | Details | |||
| Oncologia | Valencia | 46009 | Spain | Details | ||
| Inselspital - Universitaetsspital Bern | Bern | Switzerland | Details | |||
| Royal Bournemouth General Hospital | Bournemouth | United Kingdom | Details | |||
| Velindre Cancer Centre | Cardiff | United Kingdom | Details | |||
| Western General Hospital | Edinburgh | United Kingdom | Details | |||
| Beatson West Of Scotland Cancer Centre | Glasgow | G12 0YN | United Kingdom | Details | ||
| St. James's University Hospital | Leeds | LS9 7TF | United Kingdom | Details | ||
| Guy's Hospital | London | United Kingdom | Details | |||
| Royal Free Hospital | London | United Kingdom | Details | |||
| Christie Hospital NHS Foundation Trust | Manchester | M20 4BX | United Kingdom | Details |