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| NCT ID | NCT02908672 |
| Title | A Study of Atezolizumab Plus Cobimetinib and Vemurafenib Versus Placebo Plus Cobimetinib and Vemurafenib in Previously Untreated BRAFv600 Mutation-Positive Patients With Metastatic or Unresectable Locally Advanced Melanoma |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | Hoffmann-La Roche |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | POL | NZL | NLD | ITA | ISR | HUN | GRC | GBR | FRA | ESP | DEU | CAN | BRA | BEL | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294-3300 | United States | Details | |
| Arizona Oncology Associates, PC - HAL | Tempe | Arizona | 85284 | United States | Details | |
| Highlands Oncology Group | Springdale | Arkansas | 72762 | United States | Details | |
| UC Irvine Medical Center | Orange | California | 92868 | United States | Details | |
| Mount Sinai Medical Center | Miami Beach | Florida | 33140 | United States | Details | |
| UF Health Cancer Center at Orlando Health | Orlando | Florida | 32824 | United States | Details | |
| Oncology Specialists, S.C. | Park Ridge | Illinois | 60068 | United States | Details | |
| St. Luke's University Health network | Bethlehem | Pennsylvania | 18015 | United States | Details | |
| Princess Alexandra Hospital | Woolloongabba | Queensland | 4102 | Australia | Details | |
| Royal Adelaide Hospital | Adelaide | South Australia | 5000 | Australia | Details | |
| Peter Maccallum Cancer Centre | Melbourne | Victoria | 3000 | Australia | Details | |
| Fiona Stanley Hospital | Murdoch | Western Australia | 6150 | Australia | Details | |
| Medical University of Graz, Department of Dermatology | Graz | 8030 | Austria | Details | ||
| LKH Innsbruck; Universitätsklinik für Dermatologie | Innsbruck | 6020 | Austria | Details | ||
| Medizinische Universität Wien; Univ.Klinik für Dermatologie | Wien | 1090 | Austria | Details | ||
| Cliniques Universitaires St-Luc | Bruxelles | 1200 | Belgium | Details | ||
| UZ Leuven Gasthuisberg | Leuven | 3000 | Belgium | Details | ||
| CHU Sart-Tilman | Liège | 4000 | Belgium | Details | ||
| Sint Augustinus Wilrijk | Wilrijk | 2610 | Belgium | Details | ||
| Clinicas Oncologicas Integradas - COI | Rio De Janeiro | RJ | 22290-160 | Brazil | Details | |
| Hospital das Clinicas - UFRGS | Porto Alegre | RS | 90035-903 | Brazil | Details | |
| Centro de Pesquisa e Ensino em Oncologia de Santa Catarina - CEPEN | Florianopolis | SC | 88020-210 | Brazil | Details | |
| Instituto do Cancer do Estado de Sao Paulo - ICESP | Sao Paulo | SP | 01246-000 | Brazil | Details | |
| Beneficencia Portuguesa de Sao Paulo | São Paulo | SP | 01321-00 | Brazil | Details | |
| Tom Baker Cancer Centre-Calgary | Calgary | Alberta | T2N 4N2 | Canada | Details | |
| Juravinski Cancer Clinic; Department of Oncology | Hamilton | Ontario | L8V 5C2 | Canada | Details | |
| LHSC - Victoria Hospital; London Regional Cancer Program | London | Ontario | N6A 4L6 | Canada | Details | |
| Lakeridge Health Oshawa; Oncology | Oshawa | Ontario | L1G 2B9 | Canada | Details | |
| The Ottawa Hospital Cancer Centre; Oncology | Ottawa | Ontario | K1H 8L6 | Canada | Details | |
| Princess Margaret Hospital | Toronto | Ontario | M4X 1K9 | Canada | Details | |
| CHU de Quebec - Hopital de l'Enfant-Jesus; Unite de Recherche en Hematologie et Oncologie | Quebec | G1J 1Z4 | Canada | Details | ||
| Groupe Hospitalier Saint André - Hôpital Saint André | Bordeaux | 33075 | France | Details | ||
| Hopital du Bocage; Dermatologie | Dijon | 21079 | France | Details | ||
| Centre Hospitalier Universitaire de Grenoble - Albert Michallon | La Tronche | 38700 | France | Details | ||
| Hopital Claude Huriez - CHU Lille | Lille | 59037 | France | Details | ||
| Hopital Saint Eloi; CHU de Montpellier; Svc de Dermatologie | Montpellier | 34295 | France | Details | ||
| CHU de Nantes; Cancéro-dermatologie | Nantes | 44093 | France | Details | ||
| Hopital Robert Debre; DERMATOLOGIE | Reims | 51092 | France | Details | ||
| Centre Eugene Marquis; Service d'oncologie | Rennes | 35042 | France | Details | ||
| CHU de Rouen - Hôpital Charles Nicolle | Rouen | 76031 | France | Details | ||
| Institut Gustave Roussy; Dermatologie | Villejuif | 94805 | France | Details | ||
| Charite - Universitätsmedizin Berlin | Berlin | 12203 | Germany | Details | ||
| Elbekliniken Buxtehude; Klinik für Dermatologie | Buxtehude | 21614 | Germany | Details | ||
| HELIOS Klinikum Erfurt; Klinik für Dermatologie & Allergologie | Erfurt | 99089 | Germany | Details | ||
| Universitätsklinikum Erlangen; Hautklinik | Erlangen | 91054 | Germany | Details | ||
| Universitatsklinikum Essen; Klinik für Dermatologie | Essen | 45147 | Germany | Details | ||
| Universitätsmedizin Göttingen; Klinik für Gastroenterologie, gastrointestinale | Göttingen | 37075 | Germany | Details | ||
| Medizinische Hochschule Hannover; Klinik für Dermatologie, Allergologie und Venerologie | Hannover | 30625 | Germany | Details | ||
| Universitatsklinik Heidelberg; Universitätshautklinik und Nationales Centrum für Tumorerkrankungen | Heidelberg | 69120 | Germany | Details | ||
| UKSH Kiel; Klinik für Dermatologie, Venerologie und Allergologie | Kiel | 24105 | Germany | Details | ||
| Klinikum d.Universität zu Köln Klinik u.Poliklinik f.Dermatologie | Köln | 50937 | Germany | Details | ||
| Universitätsklinikum Leipzig; Klinik für Dermatologie, Venerologie und Allergologie | Leipzig | 04103 | Germany | Details | ||
| UKSH Universitatsklinikum Schleswig-Holstein; Studienzentrum Dermatologie 10d | Lübeck | 23538 | Germany | Details | ||
| Universitatsklinikum Mainz; Klinik und Poliklinik fur Dermatologie | Mainz | 55131 | Germany | Details | ||
| Klinikum der Ludwigs-Maximilians-Universität München; Dermatologie | München | 80337 | Germany | Details | ||
| Fachklinik Hornheide; Dermatologie | Münster | 48157 | Germany | Details | ||
| Harzklinikum Dorothea Christiane Erxleben GmbH, Standort Quedlinburg; Hautkrebszentrum Harz | Quedlinburg | 06484 | Germany | Details | ||
| Universitätsklinikum Regensburg; Klinik und Poliklinik für Dermatologie | Regensburg | 93053 | Germany | Details | ||
| Zentrum für Dermatoonkologie, Universitäts-Hautklinik Tübingen | Tübingen | 72076 | Germany | Details | ||
| Universitätsklinikum Würzburg; Med. Klinik 1, Pneumologie | Würzburg | 97080 | Germany | Details | ||
| Laiko General Hospital Athen | Athens | 115 27 | Greece | Details | ||
| Metropolitan Hospital; Dept. of Oncology | Pireaus | 185 47 | Greece | Details | ||
| Orszagos Onkologiai Intezet; Borgyogyaszati Osztaly | Budapest | 1122 | Hungary | Details | ||
| University of Szeged Szent-Györgyi Albert Clinical Center; Department of Dermatology and Allergology | Szeged | 6720 | Hungary | Details | ||
| Rambam Health Care Campus; Oncology | Haifa | 3109601 | Israel | Details | ||
| Sharett Institute - Hadassah Hebrew University Medical Center | Jerusalem | 9112001 | Israel | Details | ||
| Rabin MC; Davidof Center - Oncology Institute | Petach Tikva | 4941492 | Israel | Details | ||
| Ella Institute - Sheba Medical Center | Ramat-Gan | 5265601 | Israel | Details | ||
| IRCCS Istituto Nazionale Tumori Fondazione Pascale; Oncologia Medica B | Napoli | Campania | 80131 | Italy | Details | |
| IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica | Meldola | Emilia-Romagna | 47014 | Italy | Details | |
| A.O. Universitaria S. Maria Della Misericordia Di Udine; Oncologia | Udine | Friuli-Venezia Giulia | 33100 | Italy | Details | |
| IFO - Istituto Regina Elena; Oncologia Medica | Roma | Lazio | 00144 | Italy | Details | |
| IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST); Oncologia Medica A | Genova | Liguria | 16132 | Italy | Details | |
| Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 2 | Milano | Lombardia | 20133 | Italy | Details | |
| Irccs Istituto Europeo Di Oncologia (IEO); Oncologia Medica | Milano | Lombardia | 20141 | Italy | Details | |
| Fondazione Del Piemonte Per L'oncologia Ircc Di Candiolo; Dipartimento Oncologico | Candiolo | Piemonte | 10060 | Italy | Details | |
| Istituto Tumori ?Giovanni Paolo II?, Oncologia | Bari | Puglia | 70124 | Italy | Details | |
| A.O.U. Senese Policlinico Santa Maria Alle Scotte | Siena | Toscana | 53100 | Italy | Details | |
| Seoul National University Hospital | Seoul | 03080 | Korea, Republic of | Details | ||
| Severance Hospital, Yonsei University Health System | Seoul | 03722 | Korea, Republic of | Details | ||
| Asan Medical Center | Seoul | 05505 | Korea, Republic of | Details | ||
| Samsung Medical Center | Seoul | 06351 | Korea, Republic of | Details | ||
| Erasmus Mc - Daniel Den Hoed Kliniek; Interne Oncologie | Rotterdam | 3015AA | Netherlands | Details | ||
| Auckland city hospital; Auckland Regional Cancer Centre and Blood Service | Auckland | 1023 | New Zealand | Details | ||
| Wellington Hospital; Wellington Blood and Cancer Centre | Newtown | 6021 | New Zealand | Details | ||
| Mid Central DHB | Palmerston North | 4442 | New Zealand | Details | ||
| Tauranga Hospital, Clinical Trials Unit; BOP Clinical School | Tauranga | 3112 | New Zealand | Details | ||
| Uniwersyteckie Centrum Kliniczne; Klinika Onkologii i Radioterapii | Gdansk | 80-214 | Poland | Details | ||
| Narodowy Inst.Onkol.im.Sk?odowskiej-Curie Pa?stw.Inst.Badawczy Kraków; Klinika Onkologii Klinicznej | Kraków | 31-115 | Poland | Details | ||
| COZL Oddzial Onkologii Klinicznej z pododdzialem Chemioterapii Dziennej | Lublin | 20-090 | Poland | Details | ||
| Uniwersytecki Szpital Kliniczny w Poznaniu | Pozna? | 60-780 | Poland | Details | ||
| Narodowy Instytut Onkologii im. Marii Sk?odowskiej-Curie - Pa?stwowy Instytut Badawczy | Warszawa | 02-781 | Poland | Details | ||
| Dolno?l?skie Centrum Onkologii, Pulmonologii i Hematologii | Wroc?aw | 53-413 | Poland | Details | ||
| IPO de Lisboa; Servico de Oncologia Medica | Lisboa | 1099-023 | Portugal | Details | ||
| IPO do Porto; Servico de Oncologia Medica | Porto | 4200-072 | Portugal | Details | ||
| Moscow City Oncology Hospital #62 | Moscovskaya Oblast | Moskovskaja Oblast | 143423 | Russian Federation | Details | |
| FSBSI "Russian Oncological Scientific Center n.a. N.N. Blokhin" | Moscow | Moskovskaja Oblast | 115478 | Russian Federation | Details | |
| FBI "Scientific Research Institute of Oncology n. a. N. N. Petrov" | Saint-Petersburg | Sankt Petersburg | Russian Federation | Details | ||
| St. Petersburg Oncology Hospital | Sankt-peterburg | Sankt Petersburg | 198255 | Russian Federation | Details | |
| Clinica Universitaria de Navarra; Servicio de Oncologia | Pamplona | Navarra | 31008 | Spain | Details | |
| Hospital Universitari Vall d'Hebron; Oncology | Barcelona | 08035 | Spain | Details | ||
| Hospital Clínic i Provincial; Servicio de Oncología | Barcelona | 08036 | Spain | Details | ||
| Hospital Ramon y Cajal; Servicio de Oncologia | Madrid | 28034 | Spain | Details | ||
| Hospital Universitario La Paz; Servicio de Oncologia | Madrid | 28046 | Spain | Details | ||
| Hospital Universitario Virgen de la Macarena; | Sevilla | 41071 | Spain | Details | ||
| Fundacion Instituto Valenciano de Oncologia (IVO) | Valencia | 46009 | Spain | Details | ||
| Hospital General Universitario de Valencia; Servicio de oncologia | Valencia | 46014 | Spain | Details | ||
| Hospital Universitario Miguel Servet; Servicio Oncologia | Zaragoza | 50009 | Spain | Details | ||
| Bristol Haematology and Oncology centre | Bristol | BS2 8ED | United Kingdom | Details | ||
| Beatson West of Scotland Cancer Centre | Glasgow | G12 0YN | United Kingdom | Details | ||
| Ipswich Hospital; Oncology Pharmacy | Ipswich | IP4 5PD | United Kingdom | Details | ||
| St James Uni Hospital; Icrf Cancer Medicine Research Unit | Leeds | LS9 7TF | United Kingdom | Details | ||
| Guys and St Thomas NHS Foundation Trust, Guys Hospital | London | SE1 9RT | United Kingdom | Details | ||
| Freeman Hospital; Northern Centre For Cancer Care | New Castle Upon Tyne | NE7 7DN | United Kingdom | Details | ||
| Singleton Hospital; Pharmacy Department | Swansea | SA2 8QA | United Kingdom | Details | ||
| Royal Cornwall Hospital | Truro | TR1 3LQ | United Kingdom | Details |