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| NCT ID | NCT03056755 |
| Title | Study Assessing the Efficacy and Safety of Alpelisib Plus Fulvestrant or Letrozole, Based on Prior Endocrine Therapy, in Patients With PIK3CA Mutant, HR+, HER2- Advanced Breast Cancer Who Have Progressed on or After Prior Treatments (BYLieve) |
| Acronym | BYLieve |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase II |
| Variant Requirements | Yes |
| Sponsors | Novartis Pharmaceuticals |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | NLD | ITA | ISR | GBR | FRA | ESP | DNK | DEU | CAN | BEL | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | United States | Details | |
| Mayo Clinic Arizona | Phoenix | Arizona | 85054 | United States | Details | |
| Kaiser Permanente Medical Group | Anaheim | California | 92807 | United States | Details | |
| Beverly Hills Cancer Center | Beverly Hills | California | 90211 | United States | Details | |
| University of Calif Irvine Med Cntr | Irvine | California | 92660 | United States | Details | |
| Kaiser Permanent Southern Californi | San Diego | California | 92120 | United States | Details | |
| UCSF | San Francisco | California | 94115 | United States | Details | |
| Yale University Yale Cancer Center | New Haven | Connecticut | 06511 | United States | Details | |
| Advent Health Cancer Institute | Orlando | Florida | 32804 | United States | Details | |
| University of Kansas Cancer Center | Kansas City | Kansas | 66205 | United States | Details | |
| University of Louisville James Graham Brown Cancer Center | Louisville | Kentucky | 40202 | United States | Details | |
| Mercy Medical Center | Baltimore | Maryland | 21202 | United States | Details | |
| Greater Baltimore Med Center Cancer Center | Baltimore | Maryland | 21204 | United States | Details | |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States | Details | |
| Lahey Clinic | Burlington | Massachusetts | 01805 | United States | Details | |
| Josephine Ford Cancer Center | Detroit | Michigan | 48202 | United States | Details | |
| St Vincent Frontier Cancer Center | Billings | Montana | 59102 | United States | Details | |
| New Mexico Cancer Care Alliance | Albuquerque | New Mexico | 87106 | United States | Details | |
| Memorial Sloane Ketterin Cancer Ctr | New York | New York | 10065 | United States | Details | |
| Uni Hosp of Cleveland Cancer Center | Cleveland | Ohio | 44106 | United States | Details | |
| Texas Oncology | Dallas | Texas | 75246 | United States | Details | |
| Cancer Care Centers of South Texas HOAST | San Antonio | Texas | 78229 | United States | Details | |
| UT Health San Antonio | San Antonio | Texas | 78229 | United States | Details | |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | United States | Details | |
| Northwest Medical Specialists | Tacoma | Washington | 98405 | United States | Details | |
| Novartis Investigative Site | Caba | Buenos Aires | C1118AAT | Argentina | Details | |
| Novartis Investigative Site | Caba | Buenos Aires | C1125ABD | Argentina | Details | |
| Novartis Investigative Site | Caba | Buenos Aires | C1426ANZ | Argentina | Details | |
| Novartis Investigative Site | Rosario | Santa Fe | S2000DSV | Argentina | Details | |
| Novartis Investigative Site | Rosario | Sante Fe | S200KZE | Argentina | Details | |
| Novartis Investigative Site | La Rioja | 5300 | Argentina | Details | ||
| Novartis Investigative Site | Leuven | 3000 | Belgium | Details | ||
| Novartis Investigative Site | Liege | 4000 | Belgium | Details | ||
| Novartis Investigative Site | Vancouver | British Columbia | V5Z 4E6 | Canada | Details | |
| Novartis Investigative Site | Halifax | Nova Scotia | B3H 2Y9 | Canada | Details | |
| Novartis Investigative Site | Kitchener | Ontario | N2G 1G3 | Canada | Details | |
| Novartis Investigative Site | Toronto | Ontario | M5B 1N9 | Canada | Details | |
| Novartis Investigative Site | Temuco | Araucania | 4810469 | Chile | Details | |
| Novartis Investigative Site | Santiago | 7500921 | Chile | Details | ||
| Novartis Investigative Site | Santiago | 8420383 | Chile | Details | ||
| Novartis Investigative Site | Odense C | DK 5000 | Denmark | Details | ||
| Novartis Investigative Site | Vejle | 7100 | Denmark | Details | ||
| Novartis Investigative Site | Nice | Alpes Maritimes | 06189 | France | Details | |
| Novartis Investigative Site | Saint-Cloud | Hauts De Seine | 92210 | France | Details | |
| Novartis Investigative Site | Bordeaux | 33076 | France | Details | ||
| Novartis Investigative Site | Caen | 14021 | France | Details | ||
| Novartis Investigative Site | Lille Cedex | 59020 | France | Details | ||
| Novartis Investigative Site | Lyon | 69373 | France | Details | ||
| Novartis Investigative Site | Montpellier | 34298 | France | Details | ||
| Novartis Investigative Site | Saint Herblain | 44805 | France | Details | ||
| Novartis Investigative Site | Strasbourg | 67000 | France | Details | ||
| Novartis Investigative Site | Toulouse | 31059 | France | Details | ||
| Novartis Investigative Site | Augsburg | 86150 | Germany | Details | ||
| Novartis Investigative Site | Berlin | 14169 | Germany | Details | ||
| Novartis Investigative Site | Dresden | 01307 | Germany | Details | ||
| Novartis Investigative Site | Erlangen | 91054 | Germany | Details | ||
| Novartis Investigative Site | Essen | 45136 | Germany | Details | ||
| Novartis Investigative Site | Heidelberg | 69120 | Germany | Details | ||
| Novartis Investigative Site | Ulm | 89081 | Germany | Details | ||
| Novartis Investigative Site | Delhi | 110 085 | India | Details | ||
| Novartis Investigative Site | Petach Tikva | 4941492 | Israel | Details | ||
| Novartis Investigative Site | Ramat Gan | 52621 | Israel | Details | ||
| Novartis Investigative Site | Rehovot | 7610001 | Israel | Details | ||
| Novartis Investigative Site | Tel Aviv | 6423906 | Israel | Details | ||
| Novartis Investigative Site | Ancona | AN | 60126 | Italy | Details | |
| Novartis Investigative Site | Bergamo | BG | 24127 | Italy | Details | |
| Novartis Investigative Site | Bologna | BO | 40138 | Italy | Details | |
| Novartis Investigative Site | Genova | GE | 16132 | Italy | Details | |
| Novartis Investigative Site | Milano | MI | 20133 | Italy | Details | |
| Novartis Investigative Site | Milano | MI | 20141 | Italy | Details | |
| Novartis Investigative Site | Roma | RM | 00168 | Italy | Details | |
| Novartis Investigative Site | Napoli | 80131 | Italy | Details | ||
| Novartis Investigative Site | Osaka-city | Osaka | 540-0006 | Japan | Details | |
| Novartis Investigative Site | Seoul | 03080 | Korea, Republic of | Details | ||
| Novartis Investigative Site | Seoul | 06351 | Korea, Republic of | Details | ||
| Novartis Investigative Site | Jalisco | 45640 | Mexico | Details | ||
| Novartis Investigative Site | Maastricht | 6229 HX | Netherlands | Details | ||
| Novartis Investigative Site | Singapore | 168583 | Singapore | Details | ||
| Novartis Investigative Site | Singapore | 217562 | Singapore | Details | ||
| Novartis Investigative Site | Sevilla | Andalucia | 41013 | Spain | Details | |
| Novartis Investigative Site | Salamanca | Castilla Y Leon | 37007 | Spain | Details | |
| Novartis Investigative Site | Barcelona | Catalunya | 08035 | Spain | Details | |
| Novartis Investigative Site | Barcelona | Catalunya | 08036 | Spain | Details | |
| Novartis Investigative Site | Hospitalet de LLobregat | Catalunya | 08907 | Spain | Details | |
| Novartis Investigative Site | Castellon | Comunidad Valenciana | 12002 | Spain | Details | |
| Novartis Investigative Site | Madrid | 28041 | Spain | Details | ||
| Novartis Investigative Site | Tainan | 70403 | Taiwan | Details | ||
| Novartis Investigative Site | Taipei | 10002 | Taiwan | Details | ||
| Novartis Investigative Site | Taipei | 103616 | Taiwan | Details | ||
| Novartis Investigative Site | Edinburgh | Scotland | EH4 2XU | United Kingdom | Details | |
| Novartis Investigative Site | Sutton | Surrey | SM2 5PT | United Kingdom | Details | |
| Novartis Investigative Site | Leicester | LE1 5WW | United Kingdom | Details | ||
| Novartis Investigative Site | London | SW3 6JJ | United Kingdom | Details | ||
| Novartis Investigative Site | Nottingham | NG5 1PB | United Kingdom | Details |