Starting April 21, you’ll be asked to log in or sign up for a free account after viewing 10 content pages each month.
Don’t worry—creating an account is quick and easy, and it comes with added benefits! Once logged in, you’ll not only continue accessing the content you already enjoy, but you’ll also unlock exclusive features like interactive donut plots for variant protein effects and variant impacts across the gene.
Stay tuned for these updates, and thank you for being part of our community!
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| NCT ID | NCT03143153 |
| Title | A Study to Evaluate Efficacy in Subjects With Esophageal Cancer Treated With Nivolumab and Ipilimumab or Nivolumab Combined With Fluorouracil Plus Cisplatin Versus Fluorouracil Plus Cisplatin (CheckMate 648) |
| Acronym | CheckMate 648 |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Bristol-Myers Squibb |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | TUR | ROU | POL | ITA | GBR | FRA | ESP | DNK | CZE | CAN | BRA | AUT | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Local Institution - 0191 | Mobile | Alabama | 36608 | United States | Details | |
| Arizona Cancer Center | Tucson | Arizona | 85724 | United States | Details | |
| Usc/Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | United States | Details | |
| Local Institution - 0188 | Denver | Colorado | 80218 | United States | Details | |
| University Of Miami Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | United States | Details | |
| Local Institution - 0186 | Miami | Florida | 33176 | United States | Details | |
| Local Institution - 0225 | Tampa | Florida | 33612 | United States | Details | |
| Local Institution - 0074 | Atlanta | Georgia | 30322 | United States | Details | |
| Local Institution - 0032 | Marietta | Georgia | 30060 | United States | Details | |
| Hackensack Meridian Jersey Shore University Medical Center | Neptune | New Jersey | 07753 | United States | Details | |
| Oncology Associates Of Oregon, Pc | Eugene | Oregon | 97401 | United States | Details | |
| Northwest Cancer Specialists, P.C. | Portland | Oregon | 97227 | United States | Details | |
| Local Institution - 0210 | Dallas | Texas | 75246 | United States | Details | |
| Local Institution - 0028 | Houston | Texas | 77030 | United States | Details | |
| Local Institution - 0190 | Roanoke | Virginia | 24014 | United States | Details | |
| Local Institution - 0203 | Morgantown | West Virginia | 26506-9162 | United States | Details | |
| Local Institution - 0050 | Capital Federal | Buenos Aires | 1264 | Argentina | Details | |
| Local Institution - 0086 | Rosario | Santa FE | 2000 | Argentina | Details | |
| Local Institution - 0048 | Buenos Aires | 1417 | Argentina | Details | ||
| Local Institution - 0087 | La Rioja | 5300 | Argentina | Details | ||
| Local Institution - 0232 | Tamworth | New South Wales | 2340 | Australia | Details | |
| Local Institution - 0011 | Douglas | Queensland | 4814 | Australia | Details | |
| Local Institution - 0010 | Murdoch | Western Australia | 6150 | Australia | Details | |
| Local Institution - 0241 | Salzburg | 5020 | Austria | Details | ||
| Local Institution - 0017 | Salvador | Bahia | 41950-640 | Brazil | Details | |
| Local Institution - 0227 | Ipatinga | Minas Gerais | 35160-158 | Brazil | Details | |
| Local Institution - 0021 | Ijui | RIO Grande DO SUL | 98700-000 | Brazil | Details | |
| Local Institution - 0016 | Porto Alegre | RIO Grande DO SUL | 90610-000 | Brazil | Details | |
| Local Institution - 0019 | Barretos | Sao Paulo | 14780-070 | Brazil | Details | |
| Local Institution - 0226 | Jau | Sao Paulo | 17210-080 | Brazil | Details | |
| Local Institution - 0018 | São José do Rio Preto | São Paulo | 15090000 | Brazil | Details | |
| Local Institution - 0228 | Rio de Janeiro | 22793-080 | Brazil | Details | ||
| Local Institution - 0020 | Sao Paulo | 01246-000 | Brazil | Details | ||
| Local Institution - 0095 | Moncton | New Brunswick | E1C 6Z8 | Canada | Details | |
| Local Institution - 0082 | Montreal | Quebec | H3T 1E2 | Canada | Details | |
| Local Institution - 0222 | Montreal | Quebec | H4A 3J1 | Canada | Details | |
| Local Institution - 0037 | Trois-Rivieres | Quebec | G8Z 3R9 | Canada | Details | |
| Local Institution - 0053 | Santiago | Metropolitana | 8320000 | Chile | Details | |
| Local Institution - 0214 | Santiago | Metropolitana | Chile | Details | ||
| Local Institution - 0207 | Hefei | Anhui | 230022 | China | Details | |
| Local Institution - 0197 | Hefei | Anhui | 230061 | China | Details | |
| Local Institution - 0182 | Beijing | Beijing | 100032 | China | Details | |
| Local Institution - 0179 | Beijing | Beijing | 100071 | China | Details | |
| Local Institution - 0216 | Beijing | Beijing | 100853 | China | Details | |
| Local Institution - 0217 | Fuzhou | Fujian | 350014 | China | Details | |
| Local Institution - 0219 | Fuzhou | Fujian | 350025 | China | Details | |
| Local Institution - 0199 | Shantou | Guangdong | 515041 | China | Details | |
| Local Institution - 0185 | Harbin | Heilongjiang | 155040 | China | Details | |
| Local Institution - 0193 | Zhengzhou | Henan | 0 | China | Details | |
| Local Institution - 0195 | Zhengzhou | Henan | 450008 | China | Details | |
| Local Institution - 0194 | Zhengzhou | Henan | 450052 | China | Details | |
| Local Institution - 0249 | Changsha | Hunan | 410000 | China | Details | |
| Local Institution - 0212 | Changsha | Hunan | 410008 | China | Details | |
| Local Institution - 0201 | Nanjing | Jiangsu | 210000 | China | Details | |
| Local Institution - 0180 | Changchun | Jilin | 130021 | China | Details | |
| Local Institution - 0183 | Xi'an | Shan3xi | 710038 | China | Details | |
| Local Institution - 0215 | Shanghai | Shanghai | 200030 | China | Details | |
| Local Institution - 0200 | Shanghai | Shanghai | 200032 | China | Details | |
| Local Institution - 0184 | Hangzhou | Zhejiang | 310003 | China | Details | |
| Local Institution - 0247 | Linhai | Zhejiang | 317000 | China | Details | |
| Local Institution - 0220 | Shenyang | 110042 | China | Details | ||
| Local Institution - 0248 | Xi'An | 0 | China | Details | ||
| Local Institution - 0059 | Bogota | 0 | Colombia | Details | ||
| Local Institution - 0058 | Medellin | 050034 | Colombia | Details | ||
| Local Institution - 0224 | Monteria | 230001 | Colombia | Details | ||
| Local Institution - 0094 | Pereira | 660004 | Colombia | Details | ||
| Local Institution - 0083 | Brno | 625 00 | Czechia | Details | ||
| Local Institution - 0008 | Brno | 656 53 | Czechia | Details | ||
| Local Institution - 0006 | Novy Jicin | 741 01 | Czechia | Details | ||
| Local Institution - 0099 | Odense | 5000 | Denmark | Details | ||
| Local Institution - 0116 | Lille | Nord | 59000 | France | Details | |
| Local Institution - 0114 | Caen | 14076 | France | Details | ||
| Local Institution - 0112 | Montpellier | 34090 | France | Details | ||
| Local Institution - 0113 | Rennes Cedex | 35042 | France | Details | ||
| Local Institution - 0242 | Toulouse | 31059 | France | Details | ||
| Local Institution - 0115 | Villejuif | 94800 | France | Details | ||
| Local Institution - 0035 | Hong Kong | 0 | Hong Kong | Details | ||
| Local Institution - 0070 | Kowloon | Hong Kong | Details | |||
| Local Institution - 0085 | Bergamo | 24127 | Italy | Details | ||
| Local Institution - 0039 | Milano | 20133 | Italy | Details | ||
| Local Institution - 0084 | Padova | Padova | Italy | Details | ||
| Local Institution - 0240 | Pisa | 56126 | Italy | Details | ||
| Local Institution - 0152 | Akita-shi | Akita | 010-8543 | Japan | Details | |
| Local Institution - 0104 | Hirosaki-shi | Aomori | 0368563 | Japan | Details | |
| Local Institution - 0173 | Kashiwa-shi | Chiba | 2778577 | Japan | Details | |
| Local Institution - 0169 | Matsuyama-shi | Ehime | 7900024 | Japan | Details | |
| Local Institution - 0119 | Matsuyama-shi | Ehime | 7910280 | Japan | Details | |
| Local Institution - 0174 | Fukuoka-shi | Fukuoka | 8111395 | Japan | Details | |
| Local Institution - 0142 | Fukuoka-shi | Fukuoka | 8128582 | Japan | Details | |
| Local Institution - 0103 | Fukushima-shi | Fukushima | 9601295 | Japan | Details | |
| Local Institution - 0154 | Gifu City | Gifu | 5011194 | Japan | Details | |
| Local Institution - 0176 | Ota | Gunma | 3738550 | Japan | Details | |
| Local Institution - 0100 | Hiroshima-Shi | Hiroshima | 7348551 | Japan | Details | |
| Local Institution - 0111 | Sapporo-shi | Hokkaido | 060-8648 | Japan | Details | |
| Local Institution - 0170 | Akashi-shi | Hyogo | 6738558 | Japan | Details | |
| Local Institution - 0118 | Kobe-shi | Hyogo | 6500047 | Japan | Details | |
| Local Institution - 0172 | Kobe | Hyogo | 6500017 | Japan | Details | |
| Local Institution - 0171 | Kanazawa | Ishikawa | 920-8530 | Japan | Details | |
| Local Institution - 0229 | Kagoshima-shi | Kagoshima | 8908520 | Japan | Details | |
| Local Institution - 0127 | Isehara | Kanagawa | 259-1193 | Japan | Details | |
| Local Institution - 0109 | Kawasaki-shi | Kanagawa | 216-8511 | Japan | Details | |
| Local Institution - 0105 | Sagamihara-shi | Kanagawa | 2520375 | Japan | Details | |
| Local Institution - 0147 | Yokohama-shi | Kanagawa | 2360004 | Japan | Details | |
| Local Institution - 0117 | Yokohama-shi | Kanagawa | 2418515 | Japan | Details | |
| Local Institution - 0141 | Kumamoto-shi | Kumamoto | 8608556 | Japan | Details | |
| Local Institution - 0120 | Kamigyo-ku | Kyoto | 602-8566 | Japan | Details | |
| Local Institution - 0144 | Sendai | Miyagi | 9808575 | Japan | Details | |
| Local Institution - 0146 | Niigata-shi | Niigata | 9518566 | Japan | Details | |
| Local Institution - 0135 | Kurashiki-shi | Okayama | 7010192 | Japan | Details | |
| Local Institution - 0137 | Okayama-shi | Okayama | 7008558 | Japan | Details | |
| Local Institution - 0221 | Hirakata | Osaka | 573-1191 | Japan | Details | |
| Local Institution - 0138 | Osaka-shi | Osaka | 5418567 | Japan | Details | |
| Local Institution - 0098 | Osakasayama | Osaka | 589-8511 | Japan | Details | |
| Local Institution - 0107 | Suita | Osaka | 5650871 | Japan | Details | |
| Local Institution - 0139 | Takatsuki City | Osaka | 569-8686 | Japan | Details | |
| Local Institution - 0230 | Hidaka-shi | Saitama | 3501298 | Japan | Details | |
| Local Institution - 0175 | Kitaadachi-gun | Saitama | 3620806 | Japan | Details | |
| Local Institution - 0143 | Sunto-gun | Shizuoka | 411-8777 | Japan | Details | |
| Local Institution - 0148 | Shimotsuga-gun | Tochigi | 321-0293 | Japan | Details | |
| Local Institution - 0106 | Bunkyo-ku | Tokyo | 1138519 | Japan | Details | |
| Local Institution - 0110 | Bunkyo-ku | Tokyo | 1138677 | Japan | Details | |
| Local Institution - 0136 | Chuo-ku | Tokyo | 1040045 | Japan | Details | |
| Local Institution - 0128 | Chuo-ku | Tokyo | 1048560 | Japan | Details | |
| Local Institution - 0126 | Koto-ku | Tokyo | 1358550 | Japan | Details | |
| Local Institution - 0156 | Minato-ku | Tokyo | 1058470 | Japan | Details | |
| Local Institution - 0245 | Ota-ku | Tokyo | 1438541 | Japan | Details | |
| Local Institution - 0140 | Shinagawa-ku | Tokyo | 142-8666 | Japan | Details | |
| Local Institution - 0196 | Shinjuku-Ku | Tokyo | 1608582 | Japan | Details | |
| Local Institution - 0155 | Shinjuku-ku | Tokyo | 1628666 | Japan | Details | |
| Local Institution - 0231 | Toyama-shi | Toyama | 9300194 | Japan | Details | |
| Local Institution - 0178 | Wakayama-shi | Wakayama | 641-8510 | Japan | Details | |
| Local Institution - 0238 | Ube-shi | Yamaguchi | 7558505 | Japan | Details | |
| Local Institution - 0101 | Chiba | 260-8717 | Japan | Details | ||
| Local Institution - 0153 | Chiba | 2608670 | Japan | Details | ||
| Local Institution - 0145 | Kyoto | 606-8507 | Japan | Details | ||
| Local Institution - 0108 | Shizuoka | 4208527 | Japan | Details | ||
| Local Institution - 0129 | Seongnam-si | Kyǒnggi-do | 13620 | Korea, Republic of | Details | |
| Local Institution - 0165 | Seoul | Seoul-teukbyeolsi [Seoul] | 02841 | Korea, Republic of | Details | |
| Local Institution - 0166 | Busan | 49241 | Korea, Republic of | Details | ||
| Local Institution - 0150 | Daegu | 41404 | Korea, Republic of | Details | ||
| Local Institution - 0149 | Daejeon | 35015 | Korea, Republic of | Details | ||
| Local Institution - 0236 | Jeonju-si | 54907 | Korea, Republic of | Details | ||
| Local Institution - 0235 | Seoul | 01812 | Korea, Republic of | Details | ||
| Local Institution - 0130 | Seoul | 05505 | Korea, Republic of | Details | ||
| Local Institution - 0177 | Seoul | 06351 | Korea, Republic of | Details | ||
| Local Institution - 0168 | Seoul | 06591 | Korea, Republic of | Details | ||
| Local Institution - 0151 | Seoul | 07345 | Korea, Republic of | Details | ||
| Local Institution - 0131 | Seoul | 08308 | Korea, Republic of | Details | ||
| Local Institution - 0123 | Seoul | 120-752 | Korea, Republic of | Details | ||
| Local Institution - 0157 | Ulsan | 44033 | Korea, Republic of | Details | ||
| Local Institution - 0090 | Tuxtla Gutierrez | Chiapas | 29038 | Mexico | Details | |
| Local Institution - 0102 | Mexico | Distrito Federal | 14000 | Mexico | Details | |
| Local Institution - 0071 | Merida | Yucatan | 97138 | Mexico | Details | |
| Local Institution - 0234 | San Luis Potosi | 78200 | Mexico | Details | ||
| Local Institution - 0092 | Callao | 02 | Peru | Details | ||
| Local Institution - 0060 | Lima | 34 | Peru | Details | ||
| Local Institution - 0093 | Lima | Lima 11 | Peru | Details | ||
| Local Institution - 0024 | Lublin | 20-081 | Poland | Details | ||
| Local Institution - 0022 | Warszawa | 02-781 | Poland | Details | ||
| Local Institution - 0243 | Porto | 4200-072 | Portugal | Details | ||
| Local Institution - 0081 | Bucuresti | 021389 | Romania | Details | ||
| Local Institution - 0079 | Cluj-Napoca | 400015 | Romania | Details | ||
| Local Institution - 0076 | Craiova | 200347 | Romania | Details | ||
| Local Institution - 0080 | Suceava | 720237 | Romania | Details | ||
| Local Institution - 0089 | Moscow | 121309 | Russian Federation | Details | ||
| Local Institution - 0088 | St Petersburg | 198255 | Russian Federation | Details | ||
| Local Institution - 0033 | Singapore | Central Singapore | 168583 | Singapore | Details | |
| Local Institution - 0034 | Singapore | 119228 | Singapore | Details | ||
| Local Institution - 0063 | Barcelona | 08035 | Spain | Details | ||
| Local Institution - 0062 | Madrid | 28050 | Spain | Details | ||
| Local Institution - 0158 | Changhua County | Changhua | 50006 | Taiwan | Details | |
| Local Institution - 0161 | Tainan | TNN | 704 | Taiwan | Details | |
| Local Institution - 0163 | Kaohsiung County | 0 | Taiwan | Details | ||
| Local Institution - 0167 | Kaohsiung | 807 | Taiwan | Details | ||
| Local Institution - 0133 | Kaohsiung | 833 | Taiwan | Details | ||
| Local Institution - 0164 | Keelung | 204 | Taiwan | Details | ||
| Local Institution - 0132 | Taichung | 40447 | Taiwan | Details | ||
| Local Institution - 0160 | Tainan | 71004 | Taiwan | Details | ||
| Local Institution - 0124 | Taipei | 100 | Taiwan | Details | ||
| Local Institution - 0162 | Taipei | 10449 | Taiwan | Details | ||
| Local Institution - 0134 | Taipei | 11217 | Taiwan | Details | ||
| Local Institution - 0159 | Taoyuan | 333 | Taiwan | Details | ||
| Local Institution - 0096 | Ankara | 06100 | Turkey | Details | ||
| Local Institution - 0125 | Diyarbakır | 21280 | Turkey | Details | ||
| Local Institution - 0122 | Edrine | 22010 | Turkey | Details | ||
| Local Institution - 0069 | London | Greater London | NW1 2PG | United Kingdom | Details | |
| Local Institution - 0066 | London | Greater London | SW3 6JJ | United Kingdom | Details | |
| Local Institution - 0031 | Manchester | Greater Manchester | M20 4BX | United Kingdom | Details | |
| Local Institution - 0237 | London | EC1A 7BE | United Kingdom | Details | ||
| Local Institution - 0029 | Surrey | SM2 5PT | United Kingdom | Details |