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| NCT ID | NCT03143153 |
| Title | A Study to Evaluate Efficacy in Subjects With Esophageal Cancer Treated With Nivolumab and Ipilimumab or Nivolumab Combined With Fluorouracil Plus Cisplatin Versus Fluorouracil Plus Cisplatin (CheckMate 648) |
| Acronym | CheckMate 648 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Bristol-Myers Squibb |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | TUR | ROU | POL | ITA | GBR | FRA | ESP | DNK | CZE | CAN | BRA | AUT | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Southern Cancer Center, Inc. | Mobile | Alabama | 36608 | United States | Details | |
| Arizona Cancer Center | Tucson | Arizona | 85724 | United States | Details | |
| Usc/Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | United States | Details | |
| Rocky Mountain Cancer Centers | Denver | Colorado | 80218 | United States | Details | |
| University Of Miami Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | United States | Details | |
| Miami Cancer Institute at Baptist Health, Inc. | Miami | Florida | 33176 | United States | Details | |
| Moffitt Cancer Center | Tampa | Florida | 33612 | United States | Details | |
| Winship Cancer Institute | Atlanta | Georgia | 30322 | United States | Details | |
| Northwest Georgia Oncology Center, P.C. | Marietta | Georgia | 30060 | United States | Details | |
| Hackensack Meridian Jersey Shore University Medical Center | Neptune | New Jersey | 07753 | United States | Details | |
| Oncology Associates Of Oregon, Pc | Eugene | Oregon | 97401 | United States | Details | |
| Northwest Cancer Specialists, P.C. | Portland | Oregon | 97227 | United States | Details | |
| Baylor Charles A. Sammons Cancer Center | Dallas | Texas | 75246 | United States | Details | |
| Local Institution - 0028 | Houston | Texas | 77030 | United States | Details | |
| Oncology & Hematology Associates Of Southwest Virginia, Inc. | Roanoke | Virginia | 24014 | United States | Details | |
| Local Institution - 0203 | Morgantown | West Virginia | 26506-9162 | United States | Details | |
| Local Institution - 0050 | Capital Federal | Buenos Aires | 1264 | Argentina | Details | |
| Local Institution - 0086 | Rosario | Santa FE | 2000 | Argentina | Details | |
| Local Institution - 0048 | Buenos Aires | 1417 | Argentina | Details | ||
| Local Institution - 0087 | La Rioja | 5300 | Argentina | Details | ||
| Local Institution - 0232 | Tamworth | New South Wales | 2340 | Australia | Details | |
| Local Institution - 0011 | Douglas | Queensland | 4814 | Australia | Details | |
| Local Institution - 0010 | Murdoch | Western Australia | 6150 | Australia | Details | |
| Local Institution - 0241 | Salzburg | 5020 | Austria | Details | ||
| Local Institution - 0017 | Salvador | Bahia | 41950-640 | Brazil | Details | |
| Local Institution - 0227 | Ipatinga | Minas Gerais | 35160-158 | Brazil | Details | |
| Local Institution - 0021 | Ijui | RIO Grande DO SUL | 98700-000 | Brazil | Details | |
| Local Institution - 0016 | Porto Alegre | RIO Grande DO SUL | 90610-000 | Brazil | Details | |
| Local Institution - 0019 | Barretos | Sao Paulo | 14780-070 | Brazil | Details | |
| Local Institution - 0226 | Jau | Sao Paulo | 17210-080 | Brazil | Details | |
| Local Institution - 0018 | São José do Rio Preto | São Paulo | 15090000 | Brazil | Details | |
| Local Institution - 0228 | Rio de Janeiro | 22793-080 | Brazil | Details | ||
| Local Institution - 0020 | Sao Paulo | 01246-000 | Brazil | Details | ||
| Local Institution - 0095 | Moncton | New Brunswick | E1C 6Z8 | Canada | Details | |
| Local Institution - 0082 | Montreal | Quebec | H3T 1E2 | Canada | Details | |
| Local Institution - 0222 | Montreal | Quebec | H4A 3J1 | Canada | Details | |
| Local Institution - 0037 | Trois-Rivieres | Quebec | G8Z 3R9 | Canada | Details | |
| Local Institution - 0053 | Santiago | Metropolitana | 8320000 | Chile | Details | |
| Local Institution - 0214 | Santiago | Metropolitana | Chile | Details | ||
| Local Institution - 0207 | Hefei | Anhui | 230022 | China | Details | |
| Local Institution - 0197 | Hefei | Anhui | 230061 | China | Details | |
| Local Institution - 0182 | Beijing | Beijing | 100032 | China | Details | |
| Local Institution - 0179 | Beijing | Beijing | 100071 | China | Details | |
| Local Institution - 0216 | Beijing | Beijing | 100853 | China | Details | |
| Local Institution - 0217 | Fuzhou | Fujian | 350014 | China | Details | |
| Local Institution - 0219 | Fuzhou | Fujian | 350025 | China | Details | |
| Local Institution - 0199 | Shantou | Guangdong | 515041 | China | Details | |
| Local Institution - 0185 | Harbin | Heilongjiang | 155040 | China | Details | |
| Local Institution - 0193 | Zhengzhou | Henan | 0 | China | Details | |
| Local Institution - 0195 | Zhengzhou | Henan | 450008 | China | Details | |
| Local Institution - 0194 | Zhengzhou | Henan | 450052 | China | Details | |
| Local Institution - 0249 | Changsha | Hunan | 410000 | China | Details | |
| Local Institution - 0212 | Changsha | Hunan | 410008 | China | Details | |
| Local Institution - 0201 | Nanjing | Jiangsu | 210000 | China | Details | |
| Local Institution - 0180 | Changchun | Jilin | 130021 | China | Details | |
| Local Institution - 0183 | Xi'an | Shan3xi | 710038 | China | Details | |
| Local Institution - 0215 | Shanghai | Shanghai | 200030 | China | Details | |
| Local Institution - 0200 | Shanghai | Shanghai | 200032 | China | Details | |
| Local Institution - 0184 | Hangzhou | Zhejiang | 310003 | China | Details | |
| Local Institution - 0247 | Linhai | Zhejiang | 317000 | China | Details | |
| Local Institution - 0220 | Shenyang | 110042 | China | Details | ||
| Local Institution - 0248 | Xi'An | 0 | China | Details | ||
| Local Institution - 0059 | Bogota | 0 | Colombia | Details | ||
| Local Institution - 0058 | Medellin | 050034 | Colombia | Details | ||
| Local Institution - 0224 | Monteria | 230001 | Colombia | Details | ||
| Local Institution - 0094 | Pereira | 660004 | Colombia | Details | ||
| Local Institution - 0083 | Brno | 625 00 | Czechia | Details | ||
| Local Institution - 0008 | Brno | 656 53 | Czechia | Details | ||
| Local Institution - 0006 | Novy Jicin | 741 01 | Czechia | Details | ||
| Local Institution - 0099 | Odense | 5000 | Denmark | Details | ||
| Local Institution - 0116 | Lille | Nord | 59000 | France | Details | |
| Local Institution - 0114 | Caen | 14076 | France | Details | ||
| Local Institution - 0112 | Montpellier | 34090 | France | Details | ||
| Local Institution - 0113 | Rennes Cedex | 35042 | France | Details | ||
| Local Institution - 0242 | Toulouse | 31059 | France | Details | ||
| Local Institution - 0115 | Villejuif | 94800 | France | Details | ||
| Local Institution - 0035 | Hong Kong | 0 | Hong Kong | Details | ||
| Local Institution - 0070 | Kowloon | Hong Kong | Details | |||
| Local Institution - 0085 | Bergamo | 24127 | Italy | Details | ||
| Local Institution - 0039 | Milano | 20133 | Italy | Details | ||
| Local Institution - 0084 | Padova | Padova | Italy | Details | ||
| Local Institution - 0240 | Pisa | 56126 | Italy | Details | ||
| Local Institution - 0152 | Akita-shi | Akita | 010-8543 | Japan | Details | |
| Local Institution - 0104 | Hirosaki-shi | Aomori | 0368563 | Japan | Details | |
| Local Institution - 0173 | Kashiwa-shi | Chiba | 2778577 | Japan | Details | |
| Local Institution - 0169 | Matsuyama-shi | Ehime | 7900024 | Japan | Details | |
| Local Institution - 0119 | Matsuyama-shi | Ehime | 7910280 | Japan | Details | |
| Local Institution - 0174 | Fukuoka-shi | Fukuoka | 8111395 | Japan | Details | |
| Local Institution - 0142 | Fukuoka-shi | Fukuoka | 8128582 | Japan | Details | |
| Local Institution - 0103 | Fukushima-shi | Fukushima | 9601295 | Japan | Details | |
| Local Institution - 0154 | Gifu City | Gifu | 5011194 | Japan | Details | |
| Local Institution - 0176 | Ota | Gunma | 3738550 | Japan | Details | |
| Local Institution - 0100 | Hiroshima-Shi | Hiroshima | 7348551 | Japan | Details | |
| Local Institution - 0111 | Sapporo-shi | Hokkaido | 060-8648 | Japan | Details | |
| Local Institution - 0170 | Akashi-shi | Hyogo | 6738558 | Japan | Details | |
| Local Institution - 0118 | Kobe-shi | Hyogo | 6500047 | Japan | Details | |
| Local Institution - 0172 | Kobe | Hyogo | 6500017 | Japan | Details | |
| Local Institution - 0171 | Kanazawa | Ishikawa | 920-8530 | Japan | Details | |
| Local Institution - 0229 | Kagoshima-shi | Kagoshima | 8908520 | Japan | Details | |
| Local Institution - 0127 | Isehara | Kanagawa | 259-1193 | Japan | Details | |
| Local Institution - 0109 | Kawasaki-shi | Kanagawa | 216-8511 | Japan | Details | |
| Local Institution - 0105 | Sagamihara-shi | Kanagawa | 2520375 | Japan | Details | |
| Local Institution - 0147 | Yokohama-shi | Kanagawa | 2360004 | Japan | Details | |
| Local Institution - 0117 | Yokohama-shi | Kanagawa | 2418515 | Japan | Details | |
| Local Institution - 0141 | Kumamoto-shi | Kumamoto | 8608556 | Japan | Details | |
| Local Institution - 0120 | Kamigyo-ku | Kyoto | 602-8566 | Japan | Details | |
| Local Institution - 0144 | Sendai | Miyagi | 9808575 | Japan | Details | |
| Local Institution - 0146 | Niigata-shi | Niigata | 9518566 | Japan | Details | |
| Local Institution - 0135 | Kurashiki-shi | Okayama | 7010192 | Japan | Details | |
| Local Institution - 0137 | Okayama-shi | Okayama | 7008558 | Japan | Details | |
| Local Institution - 0221 | Hirakata | Osaka | 573-1191 | Japan | Details | |
| Local Institution - 0138 | Osaka-shi | Osaka | 5418567 | Japan | Details | |
| Local Institution - 0098 | Osakasayama | Osaka | 589-8511 | Japan | Details | |
| Local Institution - 0107 | Suita | Osaka | 5650871 | Japan | Details | |
| Local Institution - 0139 | Takatsuki City | Osaka | 5698686 | Japan | Details | |
| Local Institution - 0230 | Hidaka-shi | Saitama | 3501298 | Japan | Details | |
| Local Institution - 0175 | Kitaadachi-gun | Saitama | 3620806 | Japan | Details | |
| Local Institution - 0143 | Sunto-gun | Shizuoka | 411-8777 | Japan | Details | |
| Local Institution - 0148 | Shimotsuga-gun | Tochigi | 321-0293 | Japan | Details | |
| Local Institution - 0106 | Bunkyo-ku | Tokyo | 113-8159 | Japan | Details | |
| Local Institution - 0110 | Bunkyo-ku | Tokyo | 1138677 | Japan | Details | |
| Local Institution - 0128 | Chuo-ku | Tokyo | 104-8560 | Japan | Details | |
| Local Institution - 0136 | Chuo-ku | Tokyo | 1040045 | Japan | Details | |
| Local Institution - 0126 | Koto-ku | Tokyo | 1358550 | Japan | Details | |
| Local Institution - 0156 | Minato-ku | Tokyo | 1058470 | Japan | Details | |
| Local Institution - 0245 | Ota-ku | Tokyo | 1438541 | Japan | Details | |
| Local Institution - 0140 | Shinagawa-ku | Tokyo | 1428666 | Japan | Details | |
| Local Institution - 0196 | Shinjuku-Ku | Tokyo | 1608582 | Japan | Details | |
| Local Institution - 0155 | Shinjuku-ku | Tokyo | 1628666 | Japan | Details | |
| Local Institution - 0231 | Toyama-shi | Toyama | 9300194 | Japan | Details | |
| Local Institution - 0178 | Wakayama-shi | Wakayama | 641-8510 | Japan | Details | |
| Local Institution - 0238 | Ube-shi | Yamaguchi | 7558505 | Japan | Details | |
| Local Institution - 0101 | Chiba | 260-8717 | Japan | Details | ||
| Local Institution - 0153 | Chiba | 2608670 | Japan | Details | ||
| Local Institution - 0145 | Kyoto | 606-8507 | Japan | Details | ||
| Local Institution - 0108 | Shizuoka | 4208527 | Japan | Details | ||
| Local Institution - 0129 | Seongnam-si | Kyǒnggi-do | 13620 | Korea, Republic of | Details | |
| Local Institution - 0165 | Seoul | Seoul-teukbyeolsi [Seoul] | 02841 | Korea, Republic of | Details | |
| Local Institution - 0166 | Busan | 49241 | Korea, Republic of | Details | ||
| Local Institution - 0150 | Daegu | 41404 | Korea, Republic of | Details | ||
| Local Institution - 0149 | Daejeon | 35015 | Korea, Republic of | Details | ||
| Local Institution - 0236 | Jeonju-si | 54907 | Korea, Republic of | Details | ||
| Local Institution - 0235 | Seoul | 01812 | Korea, Republic of | Details | ||
| Local Institution - 0130 | Seoul | 05505 | Korea, Republic of | Details | ||
| Local Institution - 0177 | Seoul | 06351 | Korea, Republic of | Details | ||
| Local Institution - 0168 | Seoul | 06591 | Korea, Republic of | Details | ||
| Local Institution - 0151 | Seoul | 07345 | Korea, Republic of | Details | ||
| Local Institution - 0131 | Seoul | 08308 | Korea, Republic of | Details | ||
| Local Institution - 0123 | Seoul | 120-752 | Korea, Republic of | Details | ||
| Local Institution - 0157 | Ulsan | 44033 | Korea, Republic of | Details | ||
| Local Institution - 0090 | Tuxtla Gutierrez | Chiapas | 29038 | Mexico | Details | |
| Local Institution - 0102 | Mexico | Distrito Federal | 14000 | Mexico | Details | |
| Local Institution - 0071 | Merida | Yucatan | 97138 | Mexico | Details | |
| Local Institution - 0234 | San Luis Potosi | 78200 | Mexico | Details | ||
| Local Institution - 0092 | Callao | 02 | Peru | Details | ||
| Local Institution - 0060 | Lima | 34 | Peru | Details | ||
| Local Institution - 0093 | Lima | Lima 11 | Peru | Details | ||
| Local Institution - 0024 | Lublin | 20-081 | Poland | Details | ||
| Local Institution - 0022 | Warszawa | 02-781 | Poland | Details | ||
| Local Institution - 0243 | Porto | 4200-072 | Portugal | Details | ||
| Local Institution - 0081 | Bucuresti | 021389 | Romania | Details | ||
| Local Institution - 0079 | Cluj-Napoca | 400015 | Romania | Details | ||
| Local Institution - 0076 | Craiova | 200347 | Romania | Details | ||
| Local Institution - 0080 | Suceava | 720237 | Romania | Details | ||
| Local Institution - 0089 | Moscow | 121309 | Russian Federation | Details | ||
| Local Institution - 0088 | St Petersburg | 198255 | Russian Federation | Details | ||
| Local Institution - 0033 | Singapore | Central Singapore | 168583 | Singapore | Details | |
| Local Institution - 0034 | Singapore | 119228 | Singapore | Details | ||
| Local Institution - 0063 | Barcelona | 08035 | Spain | Details | ||
| Local Institution - 0062 | Madrid | 28050 | Spain | Details | ||
| Local Institution - 0161 | Tainan | TNN | 704 | Taiwan | Details | |
| Local Institution - 0158 | Changhua | 50006 | Taiwan | Details | ||
| Local Institution - 0163 | Kaohsiung County | 0 | Taiwan | Details | ||
| Local Institution - 0167 | Kaohsiung | 807 | Taiwan | Details | ||
| Local Institution - 0133 | Kaohsiung | 833 | Taiwan | Details | ||
| Local Institution - 0164 | Keelung | 204 | Taiwan | Details | ||
| Local Institution - 0132 | Taichung | 40447 | Taiwan | Details | ||
| Local Institution - 0160 | Tainan | 71004 | Taiwan | Details | ||
| Local Institution - 0124 | Taipei | 100 | Taiwan | Details | ||
| Local Institution - 0162 | Taipei | 10449 | Taiwan | Details | ||
| Local Institution - 0134 | Taipei | 11217 | Taiwan | Details | ||
| Local Institution - 0159 | Taoyuan | 333 | Taiwan | Details | ||
| Local Institution - 0096 | Ankara | 06100 | Turkey | Details | ||
| Local Institution - 0125 | Diyarbakır | 21280 | Turkey | Details | ||
| Local Institution - 0122 | Edrine | 22010 | Turkey | Details | ||
| Local Institution - 0069 | London | Greater London | NW1 2PG | United Kingdom | Details | |
| Local Institution - 0066 | London | Greater London | SW3 6JJ | United Kingdom | Details | |
| Local Institution - 0031 | Manchester | Greater Manchester | M20 4BX | United Kingdom | Details | |
| Local Institution - 0237 | London | EC1A 7BE | United Kingdom | Details | ||
| Local Institution - 0029 | Surrey | SM2 5PT | United Kingdom | Details |