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| NCT ID | NCT03173248 |
| Title | Study of AG-120 (Ivosidenib) vs. Placebo in Combination With Azacitidine in Participants With Previously Untreated Acute Myeloid Leukemia With an IDH1 Mutation (AGILE) |
| Acronym | AGILE |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | Institut de Recherches Internationales Servier |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | POL | NLD | ITA | ISR | GBR | FRA | ESP | DEU | CZE | CAN | BRA | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Norton Cancer Institute - Suburban | Louisville | Kentucky | 40207 | United States | Details | |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States | Details | |
| Royal Prince Alfred Hospital | Camperdown | New South Wales | 2050 | Australia | Details | |
| Royal Adelaide Hospital | Adelaide | South Australia | 5000 | Australia | Details | |
| Flinders Medical Centre | Bedford park | South Australia | 5042 | Australia | Details | |
| Salzburger Landeskliniken | Salzburg | 5020 | Austria | Details | ||
| Krankenhaus Hietzing mit Neurologischem Zentrum Rosenhugel | Wien | 1130 | Austria | Details | ||
| Unicamp Universidade Estadual de Campinas | Campinas | Sao Paulo | 13083-878 | Brazil | Details | |
| Hospital Amaral Carvalho | Jau | Sao Paulo | 17210-120 | Brazil | Details | |
| Instituto Nacional de Cancer | Rio De Janeiro | 20230-130 | Brazil | Details | ||
| Hospital Sirio Libanes | Sao Paulo | 01308-050 | Brazil | Details | ||
| Hospital Sao Jose | Sao Paulo | 01321-001 | Brazil | Details | ||
| Hospital Santa Marcelina | Sao Paulo | 08270-070 | Brazil | Details | ||
| Cancer Care Manitoba | Winnipeg | Manitoba | R3E 0V9 | Canada | Details | |
| University Health Network | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| Henan Cancer Hospital | Zhengzhou | Henan | 450008 | China | Details | |
| West China Hospital Sichuan University | Chengdu | Sichuan | 610041 | China | Details | |
| Peking Union Medical College Hospital | Beijing | China | Details | |||
| Guangdong Provincial People's Hospital | Guangzhou | 510080 | China | Details | ||
| The First Affiliated Hospital, College of Medicine, Zhejiang University | Hangzhou | 310003 | China | Details | ||
| Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences | Tianjin | 300020 | China | Details | ||
| Fakultni nemocnice Ostrava | Ostrava | Czechia | Details | |||
| Hopital Haut Leveque | Pessac | Gironde | 33604 | France | Details | |
| Hopital Bretonneau | Tours | Indre-et-Loire | 37044 | France | Details | |
| Hotel Dieu - Nantes | Nantes | Loire-Atlantique | 44093 | France | Details | |
| Centre Hospitalier Lyon Sud | Pierre-benite | Rhone | 69495 | France | Details | |
| Centre Hospitalier Le Mans | Le Mans | Sarthe | 72037 | France | Details | |
| CHRU de Brest - Hopital Morvan | Brest | 29609 | France | Details | ||
| Institut dHematologie de Basse Normandie | Caen | 14000 | France | Details | ||
| CHU de Grenoble | Grenoble | 38043 | France | Details | ||
| Centre Hospitalier de Versailles CHV Hopital Andre Mignot | Le Chesnay | 78 157 | France | Details | ||
| Groupe Hospitalier Necker Enfants Malades | Paris | 75015 | France | Details | ||
| CHRU de Poitiers La Miletrie | Poitiers | 86021 | France | Details | ||
| Hopital de Hautepierre | Strasbourg | 67200 | France | Details | ||
| EDOG - Institut Claudius Regaud - PPDS | Toulouse | 31059 | France | Details | ||
| Institut Gustave Roussy | Villejuif | 94805 | France | Details | ||
| Universitatsklinikum Essen | Essen | Nordrhein-Westfalen | 45122 | Germany | Details | |
| Klinikum Chemnitz gGmbH | Chemnitz | Sachsen | 09113 | Germany | Details | |
| Charite - Universitatsmedizin Berlin | Berlin | 13353 | Germany | Details | ||
| Medizinische Hochschule Hannover | Hannover | 30625 | Germany | Details | ||
| Universitatsklinikum Leipzig | Leipzig | 04103 | Germany | Details | ||
| LMU Klinikum der Universitat Munchen | Munchen | 81377 | Germany | Details | ||
| Universitatsklinikum Ulm | Ulm | 89081 | Germany | Details | ||
| Rabin Medical Center - PPDS | Petah Tikva | 49100 | Israel | Details | ||
| Kaplan Medical Center | Rehovot | 7610000 | Israel | Details | ||
| Shamir Medical Center Assaf Harofeh | Tzrifin | 70300 | Israel | Details | ||
| ASST dei Sette Laghi - Ospedale Di Circolo E Fondazione Macchi | Varese | Lombardia | 21100 | Italy | Details | |
| Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori IRST - PPDS | Meldola | 47014 | Italy | Details | ||
| Ospedale San Raffaele S.r.l. - PPDS | Milano | 20132 | Italy | Details | ||
| ASST Grande Ospedale Metropolitano Niguarda - Presidio Ospedaliero Ospedale Niguarda Ca' Granda | Milano | 20162 | Italy | Details | ||
| Fondazione IRCCS Policlinico San Matteo di Pavia | Pavia | 27100 | Italy | Details | ||
| Ospedale Infermi di Rimini | Rimini | 47900 | Italy | Details | ||
| Azienda Ospedaliera Citta della Salute e della Scienza di Torino | Torino | 10126 | Italy | Details | ||
| Matsuyama Red Cross Hospital | Matsuyama | Ehime | 790-8524 | Japan | Details | |
| University of Fukui Hospital | Fukui | 910-1193 | Japan | Details | ||
| Japanese Red Cross Society Himeji Hospital | Himeji | 670-8540 | Japan | Details | ||
| Kobe City Medical Center General Hospital | Kobe | Japan | Details | |||
| National Cancer Center | Goyang-si | Gyeonggido | 10408 | Korea, Republic of | Details | |
| Ajou University Hospital | Suwon-si | Gyeonggido | 16499 | Korea, Republic of | Details | |
| Pusan National University Hospital | Busan | 602-739 | Korea, Republic of | Details | ||
| Severance Hospital Yonsei University Health System | Seoul | 03722 | Korea, Republic of | Details | ||
| Seoul National University Hospital | Seoul | 110-744 | Korea, Republic of | Details | ||
| SINACOR | Culiacan | 80230 | Mexico | Details | ||
| Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | Mexico | 14000 | Mexico | Details | ||
| VU Medisch Centrum | Amsterdam | Noord-Holland | 1081 HV | Netherlands | Details | |
| Universitair Medisch Centrum Groningen | Nijmegen | 6525 GA | Netherlands | Details | ||
| Uniwersytecki Szpital Kliniczny im. Jana Mikulicza Radeckiego we Wroclawiu | Wroclaw | Dolnoslaskie | 50-367 | Poland | Details | |
| Instytut Hematologii i Transfuzjologii | Warszawa | Mazowieckie | 02-776 | Poland | Details | |
| Uniwersyteckie Centrum Kliniczne | Gdansk | 80-214 | Poland | Details | ||
| Kaluga Regional Clinical Hospital | Kaluga | 248007 | Russian Federation | Details | ||
| City Clinical Hospital # 40 | Moscow | 129301 | Russian Federation | Details | ||
| CHUS H. Clinico U. de Santiago | Santiago de Compostela | A Coruna | 15706 | Spain | Details | |
| Hospital Universitario Son Espases | Palma de Mallorca | Baleares | 07010 | Spain | Details | |
| Hospital Universitario Germans Trias i Pujol | Badalona | Barcelona | 08916 | Spain | Details | |
| Hospital Universitario de Gran Canaria Doctor Negrin | Las Palmas de Gran Canaria | Las Palmas | 35010 | Spain | Details | |
| Hospital Universitario Vall d'Hebron - PPDS | Barcelona | 08035 | Spain | Details | ||
| Hospital Clinic de Barcelona | Barcelona | 08036 | Spain | Details | ||
| Hospital General Universitario Gregorio Maranon | Madrid | 28007 | Spain | Details | ||
| Hospital Universitario Ramon y Cajal | Madrid | 28034 | Spain | Details | ||
| Hospital Universitario Fundacion Jimenez Diaz | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario 12 de Octubre | Madrid | 28041 | Spain | Details | ||
| Hospital Universitario Virgen del Rocio - PPDS | Sevilla | 41013 | Spain | Details | ||
| Hospital Universitari i Politecnic La Fe de Valencia | Valencia | 46026 | Spain | Details | ||
| Hospital Clinico Universitario Lozano Blesa | Zaragoza | 50009 | Spain | Details | ||
| Changhua Christian Medical Foundation Changhua Christian Hospital | Changhua City | 500 | Taiwan | Details | ||
| Kaohsiung Medical University Hospital | Kaohsiung | 807 | Taiwan | Details | ||
| China Medical University Hospital | Taichung City | 40447 | Taiwan | Details | ||
| Chi Mei Medical Center, Liouying | Tainan City | 736 | Taiwan | Details | ||
| National Taiwan University Hospital | Taipei | Taiwan | Details | |||
| Birmingham Heartlands Hospital | Birmingham | West Midlands | B9 5SS | United Kingdom | Details |