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NCT ID NCT03189719
Title First-line Esophageal Carcinoma Study With Chemo vs. Chemo Plus Pembrolizumab (MK-3475-590/KEYNOTE-590)
Recruitment Completed
Gender both
Phase Phase III
Variant Requirements No
Sponsors Merck Sharp & Dohme Corp.
Indications
Therapies
Age Groups: senior | adult
Covered Countries USA | TUR | ROU | GBR | FRA | ESP | DNK | DEU | CAN | BRA | AUS | ARG

Facility Status City State Zip Country Details
Kaiser Permanente Southern California ( Site 0003) West Los Angeles California 90034 United States Details
The University of Chicago Medical Center ( Site 0001) Chicago Illinois 60637 United States Details
University of Kansas ( Site 0029) Westwood Kansas 66205 United States Details
University of Maryland Medical Center ( Site 0013) Baltimore Maryland 21201 United States Details
Dana Farber Cancer Center ( Site 0009) Boston Massachusetts 02215 United States Details
Henry Ford Cancer Center ( Site 0018) Detroit Michigan 48202 United States Details
Washington University School of Medicine ( Site 0031) Saint Louis Missouri 63110 United States Details
Roswell Park Cancer Institute ( Site 0004) Buffalo New York 14263 United States Details
Weill Cornell Medical College ( Site 0024) New York New York 10065 United States Details
University Hospitals Cleveland Medical Center ( Site 0002) Cleveland Ohio 44106 United States Details
UPMC Cancer Center/Hillman Cancer Center ( Site 0015) Pittsburgh Pennsylvania 15232 United States Details
University of Tennessee Medical Center Knoxville ( Site 0017) Knoxville Tennessee 37920 United States Details
Centro de Investigaciones Clinicas - Clinica Viedma ( Site 0603) Viedma Rio Negro R8500ACE Argentina Details
Hospital Aleman ( Site 0605) Buenos Aires C1118AAT Argentina Details
Hospital Municipal de Gastroenterologia Dr. Bonorino Udaondo ( Site 0602) Buenos Aires C1264AAA Argentina Details
Sanatorio Allende - Cordoba ( Site 0604) Cordoba X5000JHQ Argentina Details
Hospital Privado Centro Medico Cordoba ( Site 0601) Cordoba X5016KEH Argentina Details
Blacktown Hospital ( Site 2000) Blacktown New South Wales 2148 Australia Details
Liverpool Hospital. ( Site 2001) Liverpool New South Wales 2170 Australia Details
Princess Alexandra Hospital ( Site 2005) Woolloongabba Queensland 4102 Australia Details
Eastern Health ( Site 2002) Box Hill Victoria 3128 Australia Details
Peter MacCallum Cancer Centre ( Site 2003) Melbourne Victoria 3000 Australia Details
CETUS Hospital Dia Oncologia ( Site 0208) Belo Horizonte Minas Gerais 30110-022 Brazil Details
Inst de Medicina Integral Professor Fernando Figueira- IMIP ( Site 0210) Recife Pernambuco 50070-550 Brazil Details
Clinica de Hematologia e Oncologia Viver Ltda ( Site 0211) Santa Maria Rio Grande Do Sul 97015-513 Brazil Details
Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0209) Rio de Janeiro RJ 20231-050 Brazil Details
Hospital Sao Vicente de Paulo ( Site 0204) Passo Fundo RS 99010-080 Brazil Details
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 0201) Porto Alegre RS 90610-000 Brazil Details
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto. ( Site 0203) Sao Jose do Rio Preto Sao Paulo 15090-000 Brazil Details
Hospital Alemao Oswaldo Cruz ( Site 0207) Sao Paulo SP 01323-903 Brazil Details
Hospital de Clinicas de Porto Alegre ( Site 0200) Porto Alegre 90035-903 Brazil Details
Instituto do Cancer de Sao Paulo - ICESP ( Site 0206) Sao Paulo 01246-000 Brazil Details
Tom Baker Cancer Centre ( Site 0503) Calgary Alberta T2N 4N2 Canada Details
Cross Cancer Institute ( Site 0502) Edmonton Alberta T6G 1Z2 Canada Details
CancerCare Manitoba ( Site 0500) Winnipeg Manitoba R3E 0V9 Canada Details
Juravinski Cancer Center ( Site 0508) Hamilton Ontario L8V 5C2 Canada Details
The Ottawa Hospital - Cancer Care ( Site 0501) Ottawa Ontario K1H 8L6 Canada Details
Princess Margaret Cancer Centre ( Site 0505) Toronto Ontario M5G 2M9 Canada Details
CISSS de la Monteregie-Centre ( Site 0504) Greenfield Park Quebec J4V 2H1 Canada Details
Jewish General Hospital ( Site 0507) Montreal Quebec H3T 1E2 Canada Details
Hospital Regional de Concepcion Dr. Guillermo Grant Benavente ( Site 1003) Concepcion 4070038 Chile Details
Pontificia Universidad Catolica de Chile ( Site 1001) Santiago 7620002 Chile Details
Hospital Clinico Universidad de Chile ( Site 1002) Santiago 8380456 Chile Details
Clinica Alemana de Temuco ( Site 1006) Temuco 4810297 Chile Details
Anhui Provincial Hospital ( Site 0106) Hefei Anhui 230036 China Details
The First Affiliated Hospital of Anhui Medical University ( Site 0112) Hefei Anhui 230088 China Details
Peking Union Medical College Hospital ( Site 0123) Beijing Beijing 100032 China Details
The First Affiliated Hospital of Xiamen University ( Site 0119) Xiamen Fujian 361000 China Details
Guangdong General Hospital ( Site 0103) Guangzhou Guangdong 510120 China Details
The Affiliated Tumour Hospital of Harbin Medical University ( Site 0102) Harbin Heilongjiang 150081 China Details
Tongji Medical College Huazhong University of Science and Technology ( Site 0109) Wuhan Hubei 430030 China Details
Hunan Cancer Hospital ( Site 0105) Changsha Hunan 410013 China Details
PLA Cancer Centre of Nanjing Bayi Hospital ( Site 0110) Nanjing Jiangsu 210002 China Details
Zhongda Hospital Southeast University ( Site 0125) Nanjing Jiangsu 210009 China Details
Jilin Cancer Hospital ( Site 0101) Changchun Jilin 130012 China Details
The First Affiliated Hospital of Xi an Jiaotong University ( Site 0120) Xi'an Shannxi 710061 China Details
Zhejiang Cancer Hospital ( Site 0116) Hangzhou Zhejiang 310022 China Details
Beijing Cancer Hospital ( Site 0100) Beijing 100142 China Details
Fujian Provincial Cancer Hospital ( Site 0104) Fuzhou 350014 China Details
Shanghai Chest Hospital ( Site 0111) Shanghai 200030 China Details
Fudan University Shanghai Cancer Center ( Site 0108) Shanghai 200032 China Details
Renji Hospital Shanghai Jiaotong University School of Medicine ( Site 0114) Shanghai 200127 China Details
Henan Cancer Hospital ( Site 0107) Zhengzhou 450008 China Details
Rodrigo Botero SAS ( Site 2703) Medellin Antioquia 050030 Colombia Details
Oncomedica S.A. ( Site 2701) Monteria Cordoba 230018 Colombia Details
CIMCA Centro de Investigacion y Manejo del Cancer ( Site 2600) San Jose 10103 Costa Rica Details
Policlinico San Bosco ( Site 2602) San Jose 10103 Costa Rica Details
ICIMED - Instituto de Investigacion en Ciencias Medicas ( Site 2601) San Jose 10108 Costa Rica Details
Rigshospitalet ( Site 2301) Copenhagen 2100 Denmark Details
Odense Universitetshospital ( Site 2300) Odense 5000 Denmark Details
Centre Leon Berard ( Site 0307) Lyon Cedex 8 69373 France Details
CHU Brest - Institut de Cancerologie et d Hematologie ( Site 0305) Brest 29200 France Details
Centre Francois Baclesse ( Site 0310) Caen 14076 France Details
Centre Oscar Lambret ( Site 0304) Lille 59020 France Details
Institut du Cancer de Montpellier ( Site 0306) Montpellier 34298 France Details
CHU de Nantes - Hotel Dieu ( Site 0303) Nantes Cedex 1 44093 France Details
Institut Mutualiste Montsouris ( Site 0300) Paris 75014 France Details
CHU de Saint Etienne Hopital Nord ( Site 0309) Saint Etienne 42055 France Details
Staedtisches Klinikum Dresden ( Site 1507) Dresden 01067 Germany Details
Haematologisch-Onkologische Praxis Eppendorf Facharztzentrum Eppendorf - Hope ( Site 1502) Hamburg 20249 Germany Details
Universitaetsklinikum Leipzig ( Site 1501) Leipzig 04103 Germany Details
Klinikum Ludwigsburg ( Site 1509) Ludwigsburg 71640 Germany Details
Universitatsklinikum Mannheim GmbH ( Site 1504) Mannheim 68167 Germany Details
Klinik fuer Haematologie. Onkologie und Gastroenterologie ( Site 1508) Moenchengladbach 41063 Germany Details
III. Medizinische Klinik Klinikum rechts der Isar ( Site 1506) Munchen 81675 Germany Details
Centro de Investigacion Oncologica ( Site 1402) Guatemala 01010 Guatemala Details
Oncomedica ( Site 1400) Guatemala 01010 Guatemala Details
Grupo Medico Angeles ( Site 1401) Guatemala 01015 Guatemala Details
Medi-K Cayala ( Site 1404) Guatemala 01016 Guatemala Details
Centro Regional de Sub Especialidades Medicas SA ( Site 1403) Quetzaltenango 09001 Guatemala Details
Humanity Health Research Centre ( Site 1603) Hong Kong Hong Kong Details
Pamela Youde Nethersole Eastern Hospital ( Site 1601) Hong Kong Hong Kong Details
Princess Margaret Hospital. ( Site 1602) Hong Kong Hong Kong Details
Queen Mary Hospital ( Site 1600) Hong Kong Hong Kong Details
Aichi Cancer Center Hospital ( Site 0902) Nagoya Aichi 464-8681 Japan Details
National Cancer Center Hospital East ( Site 0908) Kashiwa Chiba 277-8577 Japan Details
National Hospital Organization Shikoku Cancer Center ( Site 0901) Matsuyama Ehime 791-0280 Japan Details
Hokkaido University Hospital ( Site 0916) Sapporo Hokkaido 060-8648 Japan Details
Hyogo Cancer Center ( Site 0913) Akashi Hyogo 673-8558 Japan Details
Kobe City Medical Center General Hospital ( Site 0929) Kobe Hyogo 650-0047 Japan Details
Ibaraki Prefectural Central Hospital ( Site 0918) Kasama Ibaraki 309-1793 Japan Details
University of Tsukuba Hospital ( Site 0910) Tsukuba Ibaraki 305-8576 Japan Details
Kagawa University Hospital ( Site 0915) Kita-gun Kagawa 761-0793 Japan Details
St. Marianna University School of Medicine Hospital ( Site 0903) Kawasaki Kanagawa 216-8511 Japan Details
Kanagawa Cancer Center ( Site 0921) Yokohama Kanagawa 241-8515 Japan Details
Oita University Hospital ( Site 0930) Yufu Oita 879-5593 Japan Details
Kansai Medical University Hospital ( Site 0931) Hirakata Osaka 573-1191 Japan Details
Kindai University Hospital ( Site 0917) Osakasayama Osaka 589-8511 Japan Details
Osaka University Hospital ( Site 0911) Suita Osaka 565-0871 Japan Details
Osaka Medical College Hospital ( Site 0925) Takatsuki Osaka 569-8686 Japan Details
Saitama Cancer Center ( Site 0926) Kitaadachi-gun Saitama 362-0806 Japan Details
Shizuoka Cancer Center Hospital and Research Institute ( Site 0914) Sunto-gun Shizuoka 411-8777 Japan Details
Kyorin University Hospital ( Site 0905) Mitaka Tokyo 181-8611 Japan Details
Chiba University Hospital ( Site 0909) Chiba 260-8677 Japan Details
Chiba Cancer Center ( Site 0900) Chiba 260-8717 Japan Details
National Hospital Organization Kyushu Cancer Center ( Site 0906) Fukuoka 811-1395 Japan Details
Kyushu University Hospital ( Site 0922) Fukuoka 812-8582 Japan Details
Gifu University Hospital ( Site 0920) Gifu 501-1194 Japan Details
Kumamoto University Hospital ( Site 0919) Kumamoto 860-8556 Japan Details
Niigata Cancer Center Hospital ( Site 0924) Niigata 951-8566 Japan Details
Osaka International Cancer Institute ( Site 0923) Osaka 541-8567 Japan Details
Osaka General Medical Center ( Site 0912) Osaka 558-8558 Japan Details
National Cancer Center Hospital ( Site 0907) Tokyo 104-0045 Japan Details
The Cancer Institute Hospital of JFCR ( Site 0904) Tokyo 135-8550 Japan Details
Keio University Hospital ( Site 0927) Tokyo 160-8582 Japan Details
National Cancer Center ( Site 1304) Goyang-si Gyeonggi-do 10408 Korea, Republic of Details
Chonnam National University Hwasun Hospital ( Site 1305) Hwasun Gun Jeollanam Do 58128 Korea, Republic of Details
Seoul National University Cancer Hospital ( Site 1301) Seoul 03080 Korea, Republic of Details
Severance Hospital Yonsei University Health System ( Site 1302) Seoul 03722 Korea, Republic of Details
Asan Medical Center ( Site 1303) Seoul 05505 Korea, Republic of Details
Samsung Medical Center ( Site 1300) Seoul 06351 Korea, Republic of Details
Beacon International Specialist Centre ( Site 1803) Petaling Jaya Selangor 46050 Malaysia Details
Hospital Kuala Lumpur ( Site 1805) Kuala Lumpur 50586 Malaysia Details
University Malaya Medical Centre ( Site 1802) Kuala Lumpur 59100 Malaysia Details
Instituto Regional de Enfermedades Neoplasicas del Sur IRENSUR ( Site 1702) Arequipa 04000 Peru Details
Hospital Nacional Guillermo Almenara Irigoyen ( Site 1701) Lima 15033 Peru Details
Instituto Nacional de Enfermedades Neoplasicas ( Site 1705) Lima 15038 Peru Details
S C Pelican Impex SRL ( Site 2403) Oradea Bihor 410469 Romania Details
S.C. Radiotherapy Center Cluj S.R.L ( Site 2407) Comuna Floresti Cluj 407280 Romania Details
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2404) Craiova Dolj 200347 Romania Details
S.C.Focus Lab Plus S.R.L ( Site 2401) Bucuresti Sector 2 021389 Romania Details
S C Oncocenter Oncologie Medicala S R L ( Site 2405) Timisoara Timis 300166 Romania Details
S.C.Gral Medical S.R.L ( Site 2406) Bucuresti 031422 Romania Details
Spitalul Clinic Judetean De Urgenta Constanta ( Site 2402) Constanta 900591 Romania Details
SBHCI RCOD of MHC RB ( Site 0407) Ufa Republic Of Bashkortostan 450054 Russian Federation Details
Leningrad Regional Oncology Center ( Site 0405) Saint-Petersburg Vsevolzhsk District 188663 Russian Federation Details
National Medical and Surgical Center n.a. N.I.Pirogov ( Site 0402) Moscow 105203 Russian Federation Details
N.N. Blokhin NMRCO ( Site 0401) Moscow 115478 Russian Federation Details
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 0406) Saint-Petersburg 197758 Russian Federation Details
St Petersburg City Clinical Oncology Dispensary ( Site 0409) St. Petersburg 198255 Russian Federation Details
Tomsk Scientific Research Institute of Oncology ( Site 0403) Tomsk 634028 Russian Federation Details
Cancer Care Langenhoven Drive Oncology Centre ( Site 2501) Port Elizabeth Eastern Cape 6045 South Africa Details
The Medical Oncology Centre of Rosebank ( Site 2506) Johannesburg Gauteng 2196 South Africa Details
WITS Clinical Research CMJAH Clinical Trial Site ( Site 2500) Parktown Gauteng 2193 South Africa Details
The Oncology Centre ( Site 2502) Durban Kwa-Zulu Natal 4091 South Africa Details
Cape Town Oncology Trials Pty Ltd ( Site 2508) Cape Town Western Cape 7570 South Africa Details
Outeniqua Cancercare Oncology Unit ( Site 2504) George Western Cape 6530 South Africa Details
Clinton Oncology Centre ( Site 2505) Alberton 1448 South Africa Details
Hospital Universitario Central de Asturias ( Site 0708) Oviedo Asturias 33011 Spain Details
Hosp. Gral. Universitari Germans Trias i Pujol ( Site 0701) Badalona Barcelona 08916 Spain Details
Hospital Universitari Vall d Hebron ( Site 0702) Barcelona 08035 Spain Details
Hospital Universitario Reina Sofia ( Site 0706) Cordoba 14004 Spain Details
Hospital Ramon y Cajal ( Site 0703) Madrid 28034 Spain Details
Hospital Universitario La Paz ( Site 0700) Madrid 28046 Spain Details
Complejo Hospitalario Virgen De La Victoria ( Site 0705) Malaga 29010 Spain Details
Chang Gung Med Foundation. Kaohsiung Branch ( Site 1906) Kaohsiung 833 Taiwan Details
Taipei Medical University Shuang Ho Hospital ( Site 1908) New Taipei 235 Taiwan Details
China Medical University Hospital ( Site 1904) Taichung 404 Taiwan Details
Kuang Tien General Hospital ( Site 1909) Taichung 43303 Taiwan Details
National Cheng Kung University Hospital ( Site 1905) Tainan 704 Taiwan Details
Chi Mei Medical Center Liuying ( Site 1907) Tainan 736 Taiwan Details
National Taiwan University Hospital ( Site 1900) Taipei 10002 Taiwan Details
Koo Foundation Sun Yat-Sen Cancer Center ( Site 1902) Taipei 11259 Taiwan Details
Chang Gung Medical Foundation. Linkou ( Site 1903) Taoyuan 333 Taiwan Details
Bumrungrad International Hospital ( Site 2203) Bangkok 10110 Thailand Details
Chulalongkorn Hospital ( Site 2201) Bangkok 10330 Thailand Details
Ramathibodi Hospital. ( Site 2202) Bangkok 10330 Thailand Details
Phramongkutklao Hospital ( Site 2205) Bangkok 10400 Thailand Details
Songklanagarind Hospital ( Site 2204) Songkla 90110 Thailand Details
Adana Sehir Hastanesi ( Site 0802) Adana 01370 Turkey Details
Ankara Sehir Hastanesi ( Site 0808) Ankara 06800 Turkey Details
Istanbul Medeniyet Universitesi Goztepe EAH ( Site 0807) Istanbul 34093 Turkey Details
Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 0804) Istanbul 34098 Turkey Details
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi ( Site 0801) Istanbul 34899 Turkey Details
Medical Park Izmir Hastanesi ( Site 0800) Izmir 35575 Turkey Details
Inonu Universitesi Turgut Ozal Tip Merkezi ( Site 0803) Malatya 44280 Turkey Details
Lothian University Hospitals NHS Trust ( Site 1101) Edinburgh Mid Lothian EH4 2XU United Kingdom Details
St Luke's Cancer Centre ( Site 1102) Guildford GU2 7XX United Kingdom Details
The Christie NHS Foundation Trust ( Site 1100) Manchester M20 4BX United Kingdom Details
*Shaded cells indicate that there was no data available from clinicaltrials.gov for the field