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| NCT ID | NCT03189719 |
| Title | First-line Esophageal Carcinoma Study With Chemo vs. Chemo Plus Pembrolizumab (MK-3475-590/KEYNOTE-590) |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Merck Sharp & Dohme Corp. |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | TUR | ROU | GBR | FRA | ESP | DNK | DEU | CAN | BRA | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Adana Sehir Hastanesi ( Site 0802) | Adana | 01370 | Turkey | Details | ||
| Aichi Cancer Center Hospital ( Site 0902) | Nagoya | Aichi | 464-8681 | Japan | Details | |
| Anhui Provincial Hospital ( Site 0106) | Hefei | Anhui | 230036 | China | Details | |
| Ankara Sehir Hastanesi ( Site 0808) | Ankara | 06800 | Turkey | Details | ||
| Asan Medical Center ( Site 1303) | Seoul | 05505 | Korea, Republic of | Details | ||
| Beacon International Specialist Centre ( Site 1803) | Petaling Jaya | Selangor | 46050 | Malaysia | Details | |
| Beijing Cancer Hospital ( Site 0100) | Beijing | 100142 | China | Details | ||
| Blacktown Hospital ( Site 2000) | Blacktown | New South Wales | 2148 | Australia | Details | |
| Bumrungrad International Hospital ( Site 2203) | Bangkok | 10110 | Thailand | Details | ||
| Cancer Care Langenhoven Drive Oncology Centre ( Site 2501) | Port Elizabeth | Eastern Cape | 6045 | South Africa | Details | |
| CancerCare Manitoba ( Site 0500) | Winnipeg | Manitoba | R3E 0V9 | Canada | Details | |
| Cape Town Oncology Trials Pty Ltd ( Site 2508) | Cape Town | Western Cape | 7570 | South Africa | Details | |
| Centre Francois Baclesse ( Site 0310) | Caen | 14076 | France | Details | ||
| Centre Leon Berard ( Site 0307) | Lyon | Cedex 8 | 69373 | France | Details | |
| Centre Oscar Lambret ( Site 0304) | Lille | 59020 | France | Details | ||
| Centro de Investigacion Oncologica ( Site 1402) | Guatemala | 01010 | Guatemala | Details | ||
| Centro de Investigaciones Clinicas - Clinica Viedma ( Site 0603) | Viedma | Rio Negro | R8500ACE | Argentina | Details | |
| Centro Regional de Sub Especialidades Medicas SA ( Site 1403) | Quetzaltenango | 09001 | Guatemala | Details | ||
| CETUS Hospital Dia Oncologia ( Site 0208) | Belo Horizonte | Minas Gerais | 30110-022 | Brazil | Details | |
| Chang Gung Med Foundation. Kaohsiung Branch ( Site 1906) | Kaohsiung | 833 | Taiwan | Details | ||
| Chang Gung Medical Foundation. Linkou ( Site 1903) | Taoyuan | 333 | Taiwan | Details | ||
| Chi Mei Medical Center Liuying ( Site 1907) | Tainan | 736 | Taiwan | Details | ||
| Chiba Cancer Center ( Site 0900) | Chiba | 260-8717 | Japan | Details | ||
| Chiba University Hospital ( Site 0909) | Chiba | 260-8677 | Japan | Details | ||
| China Medical University Hospital ( Site 1904) | Taichung | 404 | Taiwan | Details | ||
| Chonnam National University Hwasun Hospital ( Site 1305) | Hwasun Gun | Jeollanam Do | 58128 | Korea, Republic of | Details | |
| CHU Brest - Institut de Cancerologie et d Hematologie ( Site 0305) | Brest | 29200 | France | Details | ||
| CHU de Nantes - Hotel Dieu ( Site 0303) | Nantes Cedex 1 | 44093 | France | Details | ||
| CHU de Saint Etienne Hopital Nord ( Site 0309) | Saint Etienne | 42055 | France | Details | ||
| Chulalongkorn Hospital ( Site 2201) | Bangkok | 10330 | Thailand | Details | ||
| CIMCA Centro de Investigacion y Manejo del Cancer ( Site 2600) | San Jose | 10103 | Costa Rica | Details | ||
| CISSS de la Monteregie-Centre ( Site 0504) | Greenfield Park | Quebec | J4V 2H1 | Canada | Details | |
| Clinica Alemana de Temuco ( Site 1006) | Temuco | 4810297 | Chile | Details | ||
| Clinica de Hematologia e Oncologia Viver Ltda ( Site 0211) | Santa Maria | Rio Grande Do Sul | 97015-513 | Brazil | Details | |
| Clinton Oncology Centre ( Site 2505) | Alberton | 1448 | South Africa | Details | ||
| Complejo Hospitalario Virgen De La Victoria ( Site 0705) | Malaga | 29010 | Spain | Details | ||
| Cross Cancer Institute ( Site 0502) | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| Dana Farber Cancer Center ( Site 0009) | Boston | Massachusetts | 02215 | United States | Details | |
| Eastern Health ( Site 2002) | Box Hill | Victoria | 3128 | Australia | Details | |
| Fudan University Shanghai Cancer Center ( Site 0108) | Shanghai | 200032 | China | Details | ||
| Fujian Provincial Cancer Hospital ( Site 0104) | Fuzhou | 350014 | China | Details | ||
| Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto. ( Site 0203) | Sao Jose do Rio Preto | Sao Paulo | 15090-000 | Brazil | Details | |
| Gifu University Hospital ( Site 0920) | Gifu | 501-1194 | Japan | Details | ||
| Grupo Medico Angeles ( Site 1401) | Guatemala | 01015 | Guatemala | Details | ||
| Guangdong General Hospital ( Site 0103) | Guangzhou | Guangdong | 510120 | China | Details | |
| Haematologisch-Onkologische Praxis Eppendorf Facharztzentrum Eppendorf - Hope ( Site 1502) | Hamburg | 20249 | Germany | Details | ||
| Henan Cancer Hospital ( Site 0107) | Zhengzhou | 450008 | China | Details | ||
| Henry Ford Cancer Center ( Site 0018) | Detroit | Michigan | 48202 | United States | Details | |
| Hokkaido University Hospital ( Site 0916) | Sapporo | Hokkaido | 060-8648 | Japan | Details | |
| Hosp. Gral. Universitari Germans Trias i Pujol ( Site 0701) | Badalona | Barcelona | 08916 | Spain | Details | |
| Hospital Aleman ( Site 0605) | Buenos Aires | C1118AAT | Argentina | Details | ||
| Hospital Alemao Oswaldo Cruz ( Site 0207) | Sao Paulo | SP | 01323-903 | Brazil | Details | |
| Hospital Clinico Universidad de Chile ( Site 1002) | Santiago | 8380456 | Chile | Details | ||
| Hospital de Clinicas de Porto Alegre ( Site 0200) | Porto Alegre | 90035-903 | Brazil | Details | ||
| Hospital Kuala Lumpur ( Site 1805) | Kuala Lumpur | 50586 | Malaysia | Details | ||
| Hospital Municipal de Gastroenterologia Dr. Bonorino Udaondo ( Site 0602) | Buenos Aires | C1264AAA | Argentina | Details | ||
| Hospital Nacional Guillermo Almenara Irigoyen ( Site 1701) | Lima | 15033 | Peru | Details | ||
| Hospital Privado Centro Medico Cordoba ( Site 0601) | Cordoba | X5016KEH | Argentina | Details | ||
| Hospital Ramon y Cajal ( Site 0703) | Madrid | 28034 | Spain | Details | ||
| Hospital Regional de Concepcion Dr. Guillermo Grant Benavente ( Site 1003) | Concepcion | 4070038 | Chile | Details | ||
| Hospital Sao Vicente de Paulo ( Site 0204) | Passo Fundo | RS | 99010-080 | Brazil | Details | |
| Hospital Universitari Vall d Hebron ( Site 0702) | Barcelona | 08035 | Spain | Details | ||
| Hospital Universitario Central de Asturias ( Site 0708) | Oviedo | Asturias | 33011 | Spain | Details | |
| Hospital Universitario La Paz ( Site 0700) | Madrid | 28046 | Spain | Details | ||
| Hospital Universitario Reina Sofia ( Site 0706) | Cordoba | 14004 | Spain | Details | ||
| Humanity Health Research Centre ( Site 1603) | Hong Kong | Hong Kong | Details | |||
| Hunan Cancer Hospital ( Site 0105) | Changsha | Hunan | 410013 | China | Details | |
| Hyogo Cancer Center ( Site 0913) | Akashi | Hyogo | 673-8558 | Japan | Details | |
| Ibaraki Prefectural Central Hospital ( Site 0918) | Kasama | Ibaraki | 309-1793 | Japan | Details | |
| ICIMED - Instituto de Investigacion en Ciencias Medicas ( Site 2601) | San Jose | 10108 | Costa Rica | Details | ||
| III. Medizinische Klinik Klinikum rechts der Isar ( Site 1506) | Munchen | 81675 | Germany | Details | ||
| Inonu Universitesi Turgut Ozal Tip Merkezi ( Site 0803) | Malatya | 44280 | Turkey | Details | ||
| Inst de Medicina Integral Professor Fernando Figueira- IMIP ( Site 0210) | Recife | Pernambuco | 50070-550 | Brazil | Details | |
| Institut du Cancer de Montpellier ( Site 0306) | Montpellier | 34298 | France | Details | ||
| Institut Mutualiste Montsouris ( Site 0300) | Paris | 75014 | France | Details | ||
| Instituto do Cancer de Sao Paulo - ICESP ( Site 0206) | Sao Paulo | 01246-000 | Brazil | Details | ||
| Instituto Nacional de Enfermedades Neoplasicas ( Site 1705) | Lima | 15038 | Peru | Details | ||
| Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0209) | Rio de Janeiro | RJ | 20231-050 | Brazil | Details | |
| Instituto Regional de Enfermedades Neoplasicas del Sur IRENSUR ( Site 1702) | Arequipa | 04000 | Peru | Details | ||
| Istanbul Medeniyet Universitesi Goztepe EAH ( Site 0807) | Istanbul | 34093 | Turkey | Details | ||
| Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 0804) | Istanbul | 34098 | Turkey | Details | ||
| Jewish General Hospital ( Site 0507) | Montreal | Quebec | H3T 1E2 | Canada | Details | |
| Jilin Cancer Hospital ( Site 0101) | Changchun | Jilin | 130012 | China | Details | |
| Juravinski Cancer Center ( Site 0508) | Hamilton | Ontario | L8V 5C2 | Canada | Details | |
| Kagawa University Hospital ( Site 0915) | Kita-gun | Kagawa | 761-0793 | Japan | Details | |
| Kaiser Permanente Southern California ( Site 0003) | West Los Angeles | California | 90034 | United States | Details | |
| Kanagawa Cancer Center ( Site 0921) | Yokohama | Kanagawa | 241-8515 | Japan | Details | |
| Kansai Medical University Hospital ( Site 0931) | Hirakata | Osaka | 573-1191 | Japan | Details | |
| Keio University Hospital ( Site 0927) | Tokyo | 160-8582 | Japan | Details | ||
| Kindai University Hospital ( Site 0917) | Osakasayama | Osaka | 589-8511 | Japan | Details | |
| Klinik fuer Haematologie. Onkologie und Gastroenterologie ( Site 1508) | Moenchengladbach | 41063 | Germany | Details | ||
| Klinikum Ludwigsburg ( Site 1509) | Ludwigsburg | 71640 | Germany | Details | ||
| Kobe City Medical Center General Hospital ( Site 0929) | Kobe | Hyogo | 650-0047 | Japan | Details | |
| Koo Foundation Sun Yat-Sen Cancer Center ( Site 1902) | Taipei | 11259 | Taiwan | Details | ||
| Kuang Tien General Hospital ( Site 1909) | Taichung | 43303 | Taiwan | Details | ||
| Kumamoto University Hospital ( Site 0919) | Kumamoto | 860-8556 | Japan | Details | ||
| Kyorin University Hospital ( Site 0905) | Mitaka | Tokyo | 181-8611 | Japan | Details | |
| Kyushu University Hospital ( Site 0922) | Fukuoka | 812-8582 | Japan | Details | ||
| Leningrad Regional Oncology Center ( Site 0405) | Saint-Petersburg | Vsevolzhsk District | 188663 | Russian Federation | Details | |
| Liverpool Hospital. ( Site 2001) | Liverpool | New South Wales | 2170 | Australia | Details | |
| Lothian University Hospitals NHS Trust ( Site 1101) | Edinburgh | Mid Lothian | EH4 2XU | United Kingdom | Details | |
| Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi ( Site 0801) | Istanbul | 34899 | Turkey | Details | ||
| Medi-K Cayala ( Site 1404) | Guatemala | 01016 | Guatemala | Details | ||
| Medical Park Izmir Hastanesi ( Site 0800) | Izmir | 35575 | Turkey | Details | ||
| N.N. Blokhin NMRCO ( Site 0401) | Moscow | 115478 | Russian Federation | Details | ||
| National Cancer Center ( Site 1304) | Goyang-si | Gyeonggi-do | 10408 | Korea, Republic of | Details | |
| National Cancer Center Hospital ( Site 0907) | Tokyo | 104-0045 | Japan | Details | ||
| National Cancer Center Hospital East ( Site 0908) | Kashiwa | Chiba | 277-8577 | Japan | Details | |
| National Cheng Kung University Hospital ( Site 1905) | Tainan | 704 | Taiwan | Details | ||
| National Hospital Organization Kyushu Cancer Center ( Site 0906) | Fukuoka | 811-1395 | Japan | Details | ||
| National Hospital Organization Shikoku Cancer Center ( Site 0901) | Matsuyama | Ehime | 791-0280 | Japan | Details | |
| National Medical and Surgical Center n.a. N.I.Pirogov ( Site 0402) | Moscow | 105203 | Russian Federation | Details | ||
| National Taiwan University Hospital ( Site 1900) | Taipei | 10002 | Taiwan | Details | ||
| Niigata Cancer Center Hospital ( Site 0924) | Niigata | 951-8566 | Japan | Details | ||
| Odense Universitetshospital ( Site 2300) | Odense | 5000 | Denmark | Details | ||
| Oita University Hospital ( Site 0930) | Yufu | Oita | 879-5593 | Japan | Details | |
| Oncomedica ( Site 1400) | Guatemala | 01010 | Guatemala | Details | ||
| Oncomedica S.A. ( Site 2701) | Monteria | Cordoba | 230018 | Colombia | Details | |
| Osaka General Medical Center ( Site 0912) | Osaka | 558-8558 | Japan | Details | ||
| Osaka International Cancer Institute ( Site 0923) | Osaka | 541-8567 | Japan | Details | ||
| Osaka Medical College Hospital ( Site 0925) | Takatsuki | Osaka | 569-8686 | Japan | Details | |
| Osaka University Hospital ( Site 0911) | Suita | Osaka | 565-0871 | Japan | Details | |
| Outeniqua Cancercare Oncology Unit ( Site 2504) | George | Western Cape | 6530 | South Africa | Details | |
| Pamela Youde Nethersole Eastern Hospital ( Site 1601) | Hong Kong | Hong Kong | Details | |||
| Peking Union Medical College Hospital ( Site 0123) | Beijing | Beijing | 100032 | China | Details | |
| Peter MacCallum Cancer Centre ( Site 2003) | Melbourne | Victoria | 3000 | Australia | Details | |
| Phramongkutklao Hospital ( Site 2205) | Bangkok | 10400 | Thailand | Details | ||
| PLA Cancer Centre of Nanjing Bayi Hospital ( Site 0110) | Nanjing | Jiangsu | 210002 | China | Details | |
| Policlinico San Bosco ( Site 2602) | San Jose | 10103 | Costa Rica | Details | ||
| Pontificia Universidad Catolica de Chile ( Site 1001) | Santiago | 7620002 | Chile | Details | ||
| Princess Alexandra Hospital ( Site 2005) | Woolloongabba | Queensland | 4102 | Australia | Details | |
| Princess Margaret Cancer Centre ( Site 0505) | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| Princess Margaret Hospital. ( Site 1602) | Hong Kong | Hong Kong | Details | |||
| Queen Mary Hospital ( Site 1600) | Hong Kong | Hong Kong | Details | |||
| Ramathibodi Hospital. ( Site 2202) | Bangkok | 10330 | Thailand | Details | ||
| Renji Hospital Shanghai Jiaotong University School of Medicine ( Site 0114) | Shanghai | 200127 | China | Details | ||
| Rigshospitalet ( Site 2301) | Copenhagen | 2100 | Denmark | Details | ||
| Rodrigo Botero SAS ( Site 2703) | Medellin | Antioquia | 050030 | Colombia | Details | |
| Roswell Park Cancer Institute ( Site 0004) | Buffalo | New York | 14263 | United States | Details | |
| S C Oncocenter Oncologie Medicala S R L ( Site 2405) | Timisoara | Timis | 300166 | Romania | Details | |
| S C Pelican Impex SRL ( Site 2403) | Oradea | Bihor | 410469 | Romania | Details | |
| S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2404) | Craiova | Dolj | 200347 | Romania | Details | |
| S.C. Radiotherapy Center Cluj S.R.L ( Site 2407) | Comuna Floresti | Cluj | 407280 | Romania | Details | |
| S.C.Focus Lab Plus S.R.L ( Site 2401) | Bucuresti | Sector 2 | 021389 | Romania | Details | |
| S.C.Gral Medical S.R.L ( Site 2406) | Bucuresti | 031422 | Romania | Details | ||
| Saitama Cancer Center ( Site 0926) | Kitaadachi-gun | Saitama | 362-0806 | Japan | Details | |
| Samsung Medical Center ( Site 1300) | Seoul | 06351 | Korea, Republic of | Details | ||
| Sanatorio Allende - Cordoba ( Site 0604) | Cordoba | X5000JHQ | Argentina | Details | ||
| SBHCI RCOD of MHC RB ( Site 0407) | Ufa | Republic Of Bashkortostan | 450054 | Russian Federation | Details | |
| Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 0406) | Saint-Petersburg | 197758 | Russian Federation | Details | ||
| Seoul National University Cancer Hospital ( Site 1301) | Seoul | 03080 | Korea, Republic of | Details | ||
| Severance Hospital Yonsei University Health System ( Site 1302) | Seoul | 03722 | Korea, Republic of | Details | ||
| Shanghai Chest Hospital ( Site 0111) | Shanghai | 200030 | China | Details | ||
| Shizuoka Cancer Center Hospital and Research Institute ( Site 0914) | Sunto-gun | Shizuoka | 411-8777 | Japan | Details | |
| Songklanagarind Hospital ( Site 2204) | Songkla | 90110 | Thailand | Details | ||
| Spitalul Clinic Judetean De Urgenta Constanta ( Site 2402) | Constanta | 900591 | Romania | Details | ||
| St Luke's Cancer Centre ( Site 1102) | Guildford | GU2 7XX | United Kingdom | Details | ||
| St Petersburg City Clinical Oncology Dispensary ( Site 0409) | St. Petersburg | 198255 | Russian Federation | Details | ||
| St. Marianna University School of Medicine Hospital ( Site 0903) | Kawasaki | Kanagawa | 216-8511 | Japan | Details | |
| Staedtisches Klinikum Dresden ( Site 1507) | Dresden | 01067 | Germany | Details | ||
| Taipei Medical University Shuang Ho Hospital ( Site 1908) | New Taipei | 235 | Taiwan | Details | ||
| The Affiliated Tumour Hospital of Harbin Medical University ( Site 0102) | Harbin | Heilongjiang | 150081 | China | Details | |
| The Cancer Institute Hospital of JFCR ( Site 0904) | Tokyo | 135-8550 | Japan | Details | ||
| The Christie NHS Foundation Trust ( Site 1100) | Manchester | M20 4BX | United Kingdom | Details | ||
| The First Affiliated Hospital of Anhui Medical University ( Site 0112) | Hefei | Anhui | 230088 | China | Details | |
| The First Affiliated Hospital of Xi an Jiaotong University ( Site 0120) | Xi'an | Shannxi | 710061 | China | Details | |
| The First Affiliated Hospital of Xiamen University ( Site 0119) | Xiamen | Fujian | 361000 | China | Details | |
| The Medical Oncology Centre of Rosebank ( Site 2506) | Johannesburg | Gauteng | 2196 | South Africa | Details | |
| The Oncology Centre ( Site 2502) | Durban | Kwa-Zulu Natal | 4091 | South Africa | Details | |
| The Ottawa Hospital - Cancer Care ( Site 0501) | Ottawa | Ontario | K1H 8L6 | Canada | Details | |
| The University of Chicago Medical Center ( Site 0001) | Chicago | Illinois | 60637 | United States | Details | |
| Tom Baker Cancer Centre ( Site 0503) | Calgary | Alberta | T2N 4N2 | Canada | Details | |
| Tomsk Scientific Research Institute of Oncology ( Site 0403) | Tomsk | 634028 | Russian Federation | Details | ||
| Tongji Medical College Huazhong University of Science and Technology ( Site 0109) | Wuhan | Hubei | 430030 | China | Details | |
| Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 0201) | Porto Alegre | RS | 90610-000 | Brazil | Details | |
| Universitaetsklinikum Leipzig ( Site 1501) | Leipzig | 04103 | Germany | Details | ||
| Universitatsklinikum Mannheim GmbH ( Site 1504) | Mannheim | 68167 | Germany | Details | ||
| University Hospitals Cleveland Medical Center ( Site 0002) | Cleveland | Ohio | 44106 | United States | Details | |
| University Malaya Medical Centre ( Site 1802) | Kuala Lumpur | 59100 | Malaysia | Details | ||
| University of Kansas ( Site 0029) | Westwood | Kansas | 66205 | United States | Details | |
| University of Maryland Medical Center ( Site 0013) | Baltimore | Maryland | 21201 | United States | Details | |
| University of Tennessee Medical Center Knoxville ( Site 0017) | Knoxville | Tennessee | 37920 | United States | Details | |
| University of Tsukuba Hospital ( Site 0910) | Tsukuba | Ibaraki | 305-8576 | Japan | Details | |
| UPMC Cancer Center/Hillman Cancer Center ( Site 0015) | Pittsburgh | Pennsylvania | 15232 | United States | Details | |
| Washington University School of Medicine ( Site 0031) | Saint Louis | Missouri | 63110 | United States | Details | |
| Weill Cornell Medical College ( Site 0024) | New York | New York | 10065 | United States | Details | |
| WITS Clinical Research CMJAH Clinical Trial Site ( Site 2500) | Parktown | Gauteng | 2193 | South Africa | Details | |
| Zhejiang Cancer Hospital ( Site 0116) | Hangzhou | Zhejiang | 310022 | China | Details | |
| Zhongda Hospital Southeast University ( Site 0125) | Nanjing | Jiangsu | 210009 | China | Details |
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