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| NCT ID | NCT03274492 |
| Title | A Study Comparing the Efficacy and Safety of Polatuzumab Vedotin With Rituximab-Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Diffuse Large B-Cell Lymphoma (POLARIX) |
| Acronym | POLARIX |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | Hoffmann-La Roche |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | POL | NZL | ITA | GBR | FRA | ESP | DEU | CZE | CHE | CAN | BRA | BEL | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Aichi Cancer Center | Aichi | 464-8681 | Japan | Details | ||
| Ankara University Faculty of Medicine Cebeci Hospital | Ankara | 06700 | Turkey | Details | ||
| Asan Medical Center | Seoul | 05505 | Korea, Republic of | Details | ||
| Ashford Cancer Center Research | Kurralta Park | South Australia | 5037 | Australia | Details | |
| Auckland City Hospital, Cancer and Blood Research | Auckland | 1023 | New Zealand | Details | ||
| AUSL di Reggio Emilia, IRCCS, P.O. Arcispedale Santa Maria Nuova | Reggio Emilia | Emilia-Romagna | Italy | Details | ||
| Austin Hospital | Heidelberg | Victoria | 3084 | Australia | Details | |
| Azienda Ospedaliera Papa Giovanni XXIII | Bergamo | Abruzzo | 24060 | Italy | Details | |
| Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino | Torino | Piemonte | 00126 | Italy | Details | |
| Azienda Ospedaliero Universitaria Maggiore della Carita di Novara | Novara | Piemonte | 28100 | Italy | Details | |
| Barts Health NHS Trust | London | EC1A 7BE | United Kingdom | Details | ||
| BC Cancer ? Vancouver | Vancouver | British Columbia | V5Z 4E6 | Canada | Details | |
| Beijing Cancer Hospital | Beijing | 100142 | China | Details | ||
| Calvary Mater Newcastle | Waratah | New South Wales | 2298 | Australia | Details | |
| Cambridge University Hospitals NHS Foundation Trust - Addenbrookes Hospital | Cambridge | CB2 0QQ | United Kingdom | Details | ||
| CancerCare Manitoba (CCMB) | Winnipeg | Manitoba | MB R3E 0V9 | Canada | Details | |
| Canterbury Health Laboratories | Christchurch | 8140 | New Zealand | Details | ||
| Centre Antoine Lacassagne | Nice | 06189 | France | Details | ||
| Centre Henri Becquerel | Rouen | 76038 | France | Details | ||
| Centre Hospitalier de La Cote Basque | Bayonne | 64109 | France | Details | ||
| Centre Hospitalier de Quimper Cornouaille (CHIC) | Quimper Cedex | 29107 | France | Details | ||
| Centre Hospitalier de Saint Brieuc - Hôpital Yves Le Foll | St Brieuc | 22027 | France | Details | ||
| Centre Leon Berard | Lyon | 69008 | France | Details | ||
| Centro de Hematologia e Hemoterapia - HEMOCENTRO UNICAMP | Campinas | São Paulo | 13083-878 | Brazil | Details | |
| CH Bretagne Atlantique | Vannes Cedex | 56017 | France | Details | ||
| CH Jolimont - Lobbes (Jolimont) | Haine-Saint-Paul | 7100 | Belgium | Details | ||
| CH Metropole de Savoie | CHAMBERY Cedex | 73011 | France | Details | ||
| CHD Vendée | La Roche Sur Yon | 85025 | France | Details | ||
| Chi-Mei Hospital, Liouying | Tainan | 736 | Taiwan | Details | ||
| Chiba Cancer Center | Chiba | 260-8717 | Japan | Details | ||
| Chiba University Hospital | Chuo-ku | 260-8670 | Japan | Details | ||
| China Medical University Hospital | Taichung | 40447 | Taiwan | Details | ||
| Chru de Strasbourg | Strasbourg | 67091 | France | Details | ||
| CHU Amiens - Hopital Sud | Amiens | 80054 | France | Details | ||
| CHU Angers | Angers | 49933 | France | Details | ||
| CHU Bretonneau | Tours | 37044 | France | Details | ||
| CHU de Brabois | Vandoeuvre Les Nancy | 54511 | France | Details | ||
| CHU de Dijon - Hopital le Bocage | Dijon | 21000 | France | Details | ||
| CHU de Nantes - Hotel Dieu | Nantes | 44093 | France | Details | ||
| CHU de Nîmes - Hôpital Carémeau | Nimes | 30029 | France | Details | ||
| CHU de Poitiers | Poitiers | 86021 | France | Details | ||
| CHU de Quebec-Universite Laval | Quebec | G1J 1Z4 | Canada | Details | ||
| CHU Lyon Sud - Service Hématologie | Pierre Benite | 69310 | France | Details | ||
| CHU Montpellier - Saint ELOI | Montpellier | 34295 | France | Details | ||
| CHU UCL Mont-Godinne | Mont-godinne | 5530 | Belgium | Details | ||
| City of Hope | Duarte | California | 91010 | United States | Details | |
| CIUSSS de l Est de l Ile de Montreal - Hopital Maisonneuve Rosemont | Montreal | Quebec | H1T 2M4 | Canada | Details | |
| Clinique Victor Hugo - Centre Jean Bernard | Le Mans Cedex 02 | 72015 | France | Details | ||
| Communal Institution 'Cherkassy Regional Oncology Dispensary' of the Cherkassy Regional Council | Cherkassy | Chernihiv Governorate | Ukraine | Details | ||
| Complejo Hospitalario de Navarra | Pamplona | Navarra | 31008 | Spain | Details | |
| Concord Repatriation General Hospital | Concord | New South Wales | 2139 | Australia | Details | |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02115 | United States | Details | |
| Dokuz Eylul Universitesi Tip Fakultesi | Lzmir | 35340 | Turkey | Details | ||
| East Kent Hospitals University NHS Foundation Trust | Canterbury | CT1 3NG | United Kingdom | Details | ||
| Ege Üniversitesi Tip Fakültesi | Lzmir | 35100 | Turkey | Details | ||
| Emory University | Atlanta | Georgia | 30322 | United States | Details | |
| Fakultni Nemocnice Hradec Kralove (FNHK) | Hradec Kralove | 500 05 | Czechia | Details | ||
| Fakultni Nemocnice Kralovske Vinohrady (FNKV) | Prague | 100 34 | Czechia | Details | ||
| Fakultni nemocnice Olomouc | Olomouc | 775 20 | Czechia | Details | ||
| Fakultni nemocnice Ostrava | Ostrava - Poruba | 708 52 | Czechia | Details | ||
| Feofaniya Center of Haematology and Chemotherapy of Haemoblastosis | Kyiv | Volhynian Governorate | 03143 | Ukraine | Details | |
| Florida Cancer Specialists | West Palm Beach | Florida | 33401 | United States | Details | |
| Florida Cancer Specialists & Research Institute | Saint Petersburg | Florida | 33705 | United States | Details | |
| Florida Cancer Specialists - Fort Myers (New Hampshire Ct) | Fort Myers | Florida | 33901-8101 | United States | Details | |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | United States | Details | |
| Fudan University Shanghai Cancer Center | Shanghai | 200032 | China | Details | ||
| Fujian Provincial Cancer Hospital | Fuzhou City | 350014 | China | Details | ||
| Fundación Jimenez Díaz | Madrid | 28040 | Spain | Details | ||
| Georgetown University Medical Center | Washington | District of Columbia | 20007 | United States | Details | |
| Gh Necker Enfants Malades | Paris | 75743 | France | Details | ||
| Greco-Hainesworth Centers for Research | Chattanooga | Tennessee | 37403 | United States | Details | |
| Henan Cancer Hospital | Zhengzhou | 450008 | China | Details | ||
| Hiroshima University Hospital | Hiroshima | 734-8551 | Japan | Details | ||
| Hokkaido University Hospital | Hokkaido | 060-8648 | Japan | Details | ||
| Hopital Claude Huriez | Lille | 59037 | France | Details | ||
| Hopital Haut-Leveque - Centre Francois Magendie | Pessac | 33604 | France | Details | ||
| Hopital Henri Mondor | Creteil | 94010 | France | Details | ||
| Hopital Jean Minjoz | Besancon | 25030 | France | Details | ||
| Hopital Pontchaillou | Rennes | 35033 | France | Details | ||
| Hopital Saint Jean | Perpignan | 66046 | France | Details | ||
| Hopital Uni Ire Dupuytren | Limoges | 87042 | France | Details | ||
| Hospital Clinic Barcelona | Barcelona | 08036 | Spain | Details | ||
| Hospital das Clinicas - FMUSP | Sao Paulo | São Paulo | 05403-000 | Brazil | Details | |
| Hospital das Clinicas - UFRGS | Porto Alegre | Rio Grande Do Sul | Brazil | Details | ||
| Hospital de la Santa Creu i Sant Pau | Barcelona | 08041 | Spain | Details | ||
| Hospital Erasto Gaertner | Curitiba | Paraná | 81520-060 | Brazil | Details | |
| Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | United States | Details | |
| Hospital Quiron Madrid | Madrid | 28233 | Spain | Details | ||
| Hospital San Pedro de Alcantara | Caceres | 10003 | Spain | Details | ||
| Hospital Universitari Dr. Josep Trueta | Girona | 17007 | Spain | Details | ||
| Hospital Universitari Vall d'Hebron | Barcelona | 08035 | Spain | Details | ||
| Hospital Universitario La Paz | Madrid | 280146 | Spain | Details | ||
| Hospital Universitario Virgen de la Victoria | Malaga | 29010 | Spain | Details | ||
| Hospital Universitario Virgen del Rocio | Sevilla | 41013 | Spain | Details | ||
| Hôpital Albert Michallon | La Tronche | 38700 | France | Details | ||
| Hôpital Saint Vincent de Paul | Lille | 59000 | France | Details | ||
| Hôpital Saint-Louis | Paris | 75475 | France | Details | ||
| Illinois Cancer Specialists | Arlington Heights | Illinois | 60005 | United States | Details | |
| Institut Bergonie | Bordeaux | 33076 | France | Details | ||
| Institut Catala d Oncologia Hospitalet | Barcelona | 08908 | Spain | Details | ||
| Institut d'Hématologie de Basse Normandie | Caen | 14000 | France | Details | ||
| Institut Gustave Roussy | Villejuif | 94805 | France | Details | ||
| Institut Universitaire du Cancer - Oncopole Toulouse (IUCT-O) | Toulouse | 31059 | France | Details | ||
| Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences | Tianjin City | 300020 | China | Details | ||
| InVO - Institut für Versorgungsforschung in der Onkologie GbR | Koblenz | 56068 | Germany | Details | ||
| IRCCS AOU San Martino - IST | Genova | Liguria | 16132 | Italy | Details | |
| Istituto Nazionale dei Tumori | Monza | Lombardia | 20052 | Italy | Details | |
| Jiangsu Cancer Hospital | Nanjing | 210009 | China | Details | ||
| Jichi Medical University Hospital | Tochigi | 329-0498 | Japan | Details | ||
| Johns Hopkins University | Baltimore | Maryland | 21287 | United States | Details | |
| Kaohsiung Medical University Hospital, Cancer Center | Kaohsiung | 807 | Taiwan | Details | ||
| Karmanos Cancer Center | Detroit | Michigan | 48201 | United States | Details | |
| Khmelnytskyi Regional Hospital | Khmelnytskyi | Kharkiv Governorate | 29000 | Ukraine | Details | |
| Kindai University Hospital | Osaka | 589-8511 | Japan | Details | ||
| Kobe City Medical Center General Hospital | Hyogo | 650-0047 | Japan | Details | ||
| Kumamoto University Hospital | Kumamoto | 860-8556 | Japan | Details | ||
| Kyushu University Hospital | Fukuoka | 812-8582 | Japan | Details | ||
| L'Union Mutualiste de la Gestion des Eaux Claires - Institut Daniel Hollard | Grenoble | 38000 | France | Details | ||
| Leningrad Regional Clinical Hospital | St Petersburg | Sankt Petersburg | 194291 | Russian Federation | Details | |
| Levine Cancer Institute - Clincal Trials Administration | Charlotte | North Carolina | 28204 | United States | Details | |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States | Details | |
| Medical University of South Carolina Hospital | Charleston | South Carolina | 29425 | United States | Details | |
| Medizinische Universität Wien | Wien | 1090 | Austria | Details | ||
| Memorial Sloan Kettering Bergen | Montvale | New Jersey | 07645 | United States | Details | |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | United States | Details | |
| Memorial Sloan Kettering Cancer Center - Commack | Commack | New York | 11725 | United States | Details | |
| Memorial Sloan Kettering Cancer Center at Westchester | Harrison | New York | 10604 | United States | Details | |
| MNE Lviv Territorial Medical Association Clinical Hospital for Palliative Care | Lviv | Chernihiv Governorate | 79007 | Ukraine | Details | |
| Monash Medical Centre | Clayton | Victoria | 3168 | Australia | Details | |
| National Cancer Center | Gyeonggi-do | 410-769 | Korea, Republic of | Details | ||
| National Cancer Center Hospital | Tokyo | 104-0045 | Japan | Details | ||
| National Cancer Center Hospital East | Chiba | 277-8577 | Japan | Details | ||
| National Hospital Organization Kyushu Cancer Center | Fukuoka | 811-1395 | Japan | Details | ||
| National Taiwan University Hospital | Taipei | 10002 | Taiwan | Details | ||
| New York University Cancer Cen | New York | New York | 10016 | United States | Details | |
| Northwest Cancer Specialists - Portland (SW Barnes Rd) | Portland | Oregon | 97225 | United States | Details | |
| Nottingham City Hospital | Nottingham | NG5 1PB | United Kingdom | Details | ||
| Ochsner Medical Center | New Orleans | Louisiana | 70121 | United States | Details | |
| Ohio State University | Columbus | Ohio | 43210 | United States | Details | |
| Oncology Associates of Oregon, P.C | Eugene | Oregon | 97401 | United States | Details | |
| Oncology Associates of Southwest Virginia, Inc. | Blacksburg | Virginia | 24060 | United States | Details | |
| Oncology/Hematology Care Clinical Trials LLC | Cincinnati | Ohio | 45236 | United States | Details | |
| Oregon HSU | Portland | Oregon | 97239 | United States | Details | |
| Osaka Metropolitan University Hospital | Osaka | 545-8586 | Japan | Details | ||
| Oxford University Hospitals NHS Foundation Trust | Oxford | OX3 7LE | United Kingdom | Details | ||
| Paracelsus Medizinischen Privatuniversitaet-Salzburger Landeskliniken (SALK) | Salzburg | 5020 | Austria | Details | ||
| PRATIA MCM Kraków | Kraków | 30-727 | Poland | Details | ||
| Prince of Wales Hospital | Randwick | New South Wales | 2031 | Australia | Details | |
| Princess Alexandra Hospital Woolloongabba | Woolloongabba | Queensland | 4102 | Australia | Details | |
| Prisma Health ? Upstate | Greenville | South Carolina | 29615 | United States | Details | |
| Pusan National University Hospital | Busan | 49241 | Korea, Republic of | Details | ||
| Pusan National University Yangsan Hospital | Yangsan | Korea, Republic of | Details | |||
| Pôle de Cancérologie ? CHU de Saint?Etienne' | St Priest en Jarez | 42270 | France | Details | ||
| Rocky Mountain Cancer Centers, LLP | Aurora | Colorado | 80012 | United States | Details | |
| Ronald Reagan UCLA Medical Center | Los Angeles | California | 90095 | United States | Details | |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | United States | Details | |
| Ruijin Hospital, Shanghai Jiaotong University School of Medicine | Shanghai City | 200025 | China | Details | ||
| Samodzielny Publiczny Zak?ad Opieki Zdrowotnej Zespó? Szpitali Miejskich w Chorzowie | Chorzów | 41-500 | Poland | Details | ||
| Samsung Medical Center | Seoul | 06351 | Korea, Republic of | Details | ||
| Seattle Cancer Care Alliance | Seattle | Washington | 98101 | United States | Details | |
| Seoul National University Hospital | Seoul | 03080 | Korea, Republic of | Details | ||
| Severance Hospital | Seoul | 03722 | Korea, Republic of | Details | ||
| Shanghai East Hospital, Tongji University | Shanghai City | 200032 | China | Details | ||
| Southern Cancer Center | Daphne | Alabama | 36526 | United States | Details | |
| SPZOZ Ministerstwa Spraw Wewn?trznych i Administracji w Poznaniu | Pozna? | 60-631 | Poland | Details | ||
| St George Hospital | Kigarah | New South Wales | 2217 | Australia | Details | |
| Städtisches Klinikum Dessau | Dessau-Roßlau | 06847 | Germany | Details | ||
| Sun Yet-sen University Cancer Center | Guangzhou | 510060 | China | Details | ||
| Sunnybrook Health Sciences Centre | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| Taipei Veterans General Hospital | Taipei | 11211 | Taiwan | Details | ||
| Tennessee Oncology - Nashville | Nashville | Tennessee | 37203 | United States | Details | |
| Texas Oncology San Antonio Medical Center | San Antonio | Texas | 78229 | United States | Details | |
| Texas Oncology-Austin Midtown | Austin | Texas | 78705 | United States | Details | |
| Texas Oncology-Tyler | Tyler | Texas | 75702 | United States | Details | |
| The Cancer Institute Hospital of JFCR | Tokyo | 135-8550 | Japan | Details | ||
| The Christie NHS Foundation Trust | Manchester | M20 4BX | United Kingdom | Details | ||
| The First Affiliated Hospital of College of Medicine, Zhejiang University | Hangzhou | 310003 | China | Details | ||
| The First Hospital of Jilin University | Changchun City | 130021 | China | Details | ||
| The Newcastle upon Tyne Hospitals NHS Foundation Trust. Freeman Hospital | Newcastle upon Tyne | NE7 7DN | United Kingdom | Details | ||
| The Ottawa Hospital | Ottawa | Ontario | K1H 8L6 | Canada | Details | |
| The University of Adelaide - The Queen Elizabeth Hospital (TQEH) | Woodville South | South Australia | 5011 | Australia | Details | |
| The University of Osaka Hospital | Osaka | 565-0871 | Japan | Details | ||
| Tianjin Medical University Cancer Institute & Hospital | Tianjing | 300060 | China | Details | ||
| Tohoku University Hospital | Miyagi | 980-8574 | Japan | Details | ||
| Tokai University Hospital | Isehara-shi | 259-1193 | Japan | Details | ||
| Union Hospital Tongji Medical College Huazhong University of Science and Technology | Wuhan City | 430022 | China | Details | ||
| Universita degli Studi Di Brescia - Azienda Ospedaliera Spedali Civili di Brescia | Brescia | Abruzzo | Italy | Details | ||
| Universita degli Studi di Roma ''La Sapienza" - Clinica Ematologica | Rome | Abruzzo | Italy | Details | ||
| Universitaetsklinikum Halle (Saale) | Halle | 06120 | Germany | Details | ||
| Universitaetsklinikum Heidelberg | Heidelberg | 69120 | Germany | Details | ||
| Universitatsklinikum Munster | Münster | 48149 | Germany | Details | ||
| University Hospital Kyoto Prefectural University of Medicine | Kyoto | 602-8566 | Japan | Details | ||
| University Hospitals Case Medical Center | Cleveland | Ohio | 44106 | United States | Details | |
| University Hospitals of Leicester NHS Trust - Leicester Royal Infirmary | Leicester | LE1 5WW | United Kingdom | Details | ||
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | United States | Details | |
| University of Alberta Hospital | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| University of Louisville Hospital | Louisville | Kentucky | 40202 | United States | Details | |
| University of Maryland | Baltimore | Maryland | 21201 | United States | Details | |
| University of Michigan Health System | Ann Arbor | Michigan | 48109 | United States | Details | |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27514 | United States | Details | |
| University of Pittsburgh Medical Center Cancer Center | Pittsburgh | Pennsylvania | 15232 | United States | Details | |
| University of Rochester Medical Center | Rochester | New York | 14642 | United States | Details | |
| University of Utah | Salt Lake City | Utah | 84112 | United States | Details | |
| Universitätsklinikum Essen | Essen | 45147 | Germany | Details | ||
| Universitätsspital Basel Gynäkologie - Onkologie | Basel | 4031 | Switzerland | Details | ||
| Univerzita Karlova v Praze 1. Lekarska Fakulta | Prague | 128 08 | Czechia | Details | ||
| UZ Gent | Gent | 9000 | Belgium | Details | ||
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | United States | Details | |
| Vivantes Klinikum Am Urban | Berlin | 10967 | Germany | Details | ||
| Waikato Hospital | Hamilton | 3240 | New Zealand | Details | ||
| Washington University | Saint Louis | Missouri | 63110 | United States | Details | |
| West Virginia Uni Med. Center - Robert Byrd Health Science | Morgantown | West Virginia | 26506 | United States | Details | |
| Westmead Hospital | Westmead | New South Wales | 2145 | Australia | Details | |
| Wiener Gesundheitsverbund ? Klinik Ottakring | Wien | 1160 | Austria | Details | ||
| Wojewódzki Szpital Specjalistyczny im. M. Kopernika | ?ód? | 93-510 | Poland | Details | ||
| Wojskowy Instytut Medyczny - Panstwowy Instytut Badawczy | Warszawa | 04-141 | Poland | Details |
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