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| NCT ID | NCT03302234 |
| Title | Study of Pembrolizumab Given With Ipilimumab or Placebo in Participants With Untreated Metastatic Non-small Cell Lung Cancer (MK-3475-598/KEYNOTE-598) |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | Merck Sharp & Dohme Corp. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | POL | LVA | ITA | IRL | HUN | GBR | FRA | ESP | DEU | CAN | BRA | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Mayo Clinic Cancer Center ( Site 0007) | Phoenix | Arizona | 85054 | United States | Details | |
| Disney Family Cancer Center ( Site 0035) | Burbank | California | 91505 | United States | Details | |
| Pacific Cancer Care ( Site 0001) | Monterey | California | 93940 | United States | Details | |
| John Wayne Cancer Institute ( Site 0021) | Santa Monica | California | 90404 | United States | Details | |
| Florida Hospital Cancer Institute ( Site 0009) | Orlando | Florida | 32804 | United States | Details | |
| Mercy Health-Paducah Medical Oncology and Hematology ( Site 0018) | Paducah | Kentucky | 42003 | United States | Details | |
| New England Cancer Specialists ( Site 0019) | Scarborough | Maine | 04074 | United States | Details | |
| Boston Medical Center ( Site 0025) | Boston | Massachusetts | 02118 | United States | Details | |
| Lahey Hospital & Medical Center ( Site 0020) | Burlington | Massachusetts | 01805 | United States | Details | |
| Holy Name Medical Center ( Site 0022) | Teaneck | New Jersey | 07666 | United States | Details | |
| Icahn School of Medicine at Mount Sinai ( Site 0034) | New York | New York | 10029 | United States | Details | |
| The Ohio State University Wexner Medical Center ( Site 0016) | Columbus | Ohio | 43210 | United States | Details | |
| Mid Ohio Oncology/Hematology Inc. ( Site 0003) | Columbus | Ohio | 43219 | United States | Details | |
| Providence Cancer Institute, Franz Clinic - Eastside ( Site 0031) | Portland | Oregon | 97213 | United States | Details | |
| Greenville Health System ( Site 8010) | Greenville | South Carolina | 29615 | United States | Details | |
| University of Tennessee Erlanger Oncology & Hematology ( Site 0026) | Chattanooga | Tennessee | 37403 | United States | Details | |
| Tennessee Cancer Specialists ( Site 0017) | Knoxville | Tennessee | 37909 | United States | Details | |
| Texas Oncology-Arlington South ( Site 8006) | Arlington | Texas | 76014 | United States | Details | |
| Texas Oncology-Methodist Dallas Cancer Center ( Site 8000) | Dallas | Texas | 75203 | United States | Details | |
| Texas Oncology-Flower Mound ( Site 8007) | Flower Mound | Texas | 75028 | United States | Details | |
| Texas Oncology-Longview Cancer Center ( Site 8009) | Longview | Texas | 75601 | United States | Details | |
| Northwest Cancer Specialists, P.C. ( Site 8001) | Vancouver | Washington | 98684 | United States | Details | |
| Virginia Mason Memorial- North Star Lodge Cancer Center ( Site 0033) | Yakima | Washington | 98902 | United States | Details | |
| University of Wisconsin Carbone Cancer Center ( Site 0004) | Madison | Wisconsin | 53792 | United States | Details | |
| Medical College of Wisconsin Clinical Cancer Center ( Site 0027) | Milwaukee | Wisconsin | 53226 | United States | Details | |
| Centro de Investigaciones Clinicas - Clinica Viedma ( Site 0202) | Viedma | Rio Negro | R8500ACE | Argentina | Details | |
| Sanatorio Parque ( Site 0201) | Rosario | Santa Fe | S2000DSV | Argentina | Details | |
| Hospital Aleman ( Site 0208) | Buenos Aires | C1118AAT | Argentina | Details | ||
| Hospital Privado Centro Medico Cordoba ( Site 0206) | Cordoba | X5016KEH | Argentina | Details | ||
| Centro Oncologico Riojano Integral ( Site 0203) | La Rioja | F5300COE | Argentina | Details | ||
| Sanatorio Britanico ( Site 0205) | Rosario | S2000CVB | Argentina | Details | ||
| Instituto de Oncologia de Rosario ( Site 0200) | Rosario | S2000KZE | Argentina | Details | ||
| Centro Medico San Roque ( Site 0207) | Tucuman | T4000IAK | Argentina | Details | ||
| Mater Cancer Care Centre ( Site 2102) | South Brisbane | Queensland | 4101 | Australia | Details | |
| Fiona Stanley Hospital ( Site 2105) | Perth | Western Australia | 6150 | Australia | Details | |
| Chris OBrien Lifehouse ( Site 2100) | Camperdown | 2050 | Australia | Details | ||
| The Townsville Hospital ( Site 2103) | Douglas | 4814 | Australia | Details | ||
| St Vincents Hospital Melbourne ( Site 2101) | Fitzroy | 3065 | Australia | Details | ||
| Inst de Medicina Integral Professor Fernando Figueira- IMIP ( Site 0302) | Recife | Pernambuco | 50070-550 | Brazil | Details | |
| Clinica de Hematologia e Oncologia Viver Ltda ( Site 0305) | Santa Maria | Rio Grande Do Sul | 97015-513 | Brazil | Details | |
| Hospital Nossa Senhora da Conceicao ( Site 0306) | Porto Alegre | RS | 91350-200 | Brazil | Details | |
| Instituto do Cancer de Sao Paulo - ICESP ( Site 0300) | Sao Paulo | SP | 01246-000 | Brazil | Details | |
| Hospital Alemao Oswaldo Cruz ( Site 0311) | Sao Paulo | SP | 01323-020 | Brazil | Details | |
| Escola Paulista de Medicina - UNIFESP ( Site 0304) | Sao Paulo | SP | 04024-002 | Brazil | Details | |
| Fundacao Pio XII - Hospital de Cancer de Barretos ( Site 0312) | Barretos | 14784-400 | Brazil | Details | ||
| CEPON Centro de Pesquisa Oncológicas ( Site 0307) | Florianopolis | 88034-000 | Brazil | Details | ||
| Hospital do Servidor Publico do Estado ( Site 0308) | Sao Paulo | 04039-004 | Brazil | Details | ||
| Tom Baker Cancer Centre ( Site 0119) | Calgary | Alberta | T2N 4N2 | Canada | Details | |
| CancerCare Manitoba ( Site 0106) | Winnipeg | Manitoba | R3E 0V9 | Canada | Details | |
| CIUSSS du Saguenay-Lac-St-Jean ( Site 0115) | Chicoutimi | Quebec | G7H 5H6 | Canada | Details | |
| CISSS de la Monteregie-Centre ( Site 0100) | Greenfield Park | Quebec | J4V 2H1 | Canada | Details | |
| CISSS-CA Hotel-Dieu de Levis ( Site 0108) | Levis | Quebec | G6V 3Z1 | Canada | Details | |
| CIUSSS Ouest de l'Ile - St-Mary's Hospital ( Site 0107) | Montreal | Quebec | H3T 1M5 | Canada | Details | |
| St-Jerome Medical Research Inc ( Site 0113) | St-Jerome | Quebec | J7Z 5T3 | Canada | Details | |
| Clinica Universidad Catolica del Maule ( Site 0413) | Talca | El Maule | 3465584 | Chile | Details | |
| Soc. Prosalud Montes y Orlandi Ltda (Orlandi Oncologia) ( Site 0401) | Santiago | 7500006 | Chile | Details | ||
| Pontificia Universidad Catolica de Chile ( Site 0404) | Santiago | 8330032 | Chile | Details | ||
| Instituto Nacional del Cancer ( Site 0406) | Santiago | 8380455 | Chile | Details | ||
| Hospital Clinico Vina del Mar ( Site 0400) | Vina del Mar | 2520000 | Chile | Details | ||
| Hospital Pablo Tobon Uribe ( Site 0505) | Medellin | Antioquia | 050034 | Colombia | Details | |
| Centro de Investigacion Clinica del Country ( Site 0500) | Bogota | 110221 | Colombia | Details | ||
| Clinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 0506) | Bogota | 110311 | Colombia | Details | ||
| Oncomedica S.A. ( Site 0502) | Monteria | 230002 | Colombia | Details | ||
| Instituto Cancerologico de Narino Ltda ( Site 0504) | Pasto | 520001 | Colombia | Details | ||
| Hopital Nord du Marseille ( Site 0808) | Marseille | Cedex 20 | 13015 | France | Details | |
| Institut Bergonie ( Site 0803) | Bordeaux | 33076 | France | Details | ||
| CHU de Brest. Hopital Morvan ( Site 0800) | Brest | 29200 | France | Details | ||
| Centre Hopitalier Intercommunal Creteil ( Site 0802) | Creteil | 94010 | France | Details | ||
| Centre Hospitalier Le Mans ( Site 0804) | Le Mans | 72037 | France | Details | ||
| C.H.R.U de Lille - Hopital Calmette ( Site 0805) | Lille | 59037 | France | Details | ||
| Hopital Tenon ( Site 0810) | Paris | 75020 | France | Details | ||
| Nouvel Hopital Civil ( Site 0809) | Strasbourg | 67091 | France | Details | ||
| CHU de Toulouse - Hopital Larrey ( Site 0801) | Toulouse | 31059 | France | Details | ||
| Evangelische Lungenklinik Berlin ( Site 0903) | Berlin | 13125 | Germany | Details | ||
| Vivantes Klinikum Spandau ( Site 0910) | Berlin | 13585 | Germany | Details | ||
| HELIOS Klinikum Emil von Behring ( Site 0905) | Berlin | 14165 | Germany | Details | ||
| SRH Waldklinikum Gera GmbH ( Site 0907) | Gera | 07548 | Germany | Details | ||
| LungenClinic Grosshansdorf GmbH ( Site 0908) | Grosshansdorf | 22927 | Germany | Details | ||
| Universitaetsklinikum Heidelberg ( Site 0900) | Heidelberg | 69126 | Germany | Details | ||
| Universitaetsklinikum Leipzig ( Site 0919) | Leipzig | 04103 | Germany | Details | ||
| Universitaetsklinikum Schleswig Holstein. ( Site 0918) | Luebeck | 23538 | Germany | Details | ||
| Orszagos Koranyi TBC es Pulmonologiai Intezet ( Site 1502) | Budapest | 1121 | Hungary | Details | ||
| Orszagos Koranyi TBC es Pulmonologiai Intezet ( Site 1506) | Budapest | 1122 | Hungary | Details | ||
| Orszagos Onkologiai Intezet ( Site 1509) | Budapest | 1122 | Hungary | Details | ||
| Debreceni Egyetem Klinikai Kozpont ( Site 1511) | Debrecen | 4032 | Hungary | Details | ||
| Veszprem Megyei Tudogyogyintezet ( Site 1503) | Farkasgyepu | 8582 | Hungary | Details | ||
| Petz Aladar Megyei Oktato Korhaz ( Site 1505) | Gyor | 9024 | Hungary | Details | ||
| Bekes Megyei Pandy Kalman Korhaz. ( Site 1507) | Gyula | 5700 | Hungary | Details | ||
| Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz ( Site 1504) | Szekesfehervar | 8000 | Hungary | Details | ||
| Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 1501) | Szolnok | 5000 | Hungary | Details | ||
| Beaumont Hospital ( Site 1312) | Dublin | D09 V2N0 | Ireland | Details | ||
| St James Hospital ( Site 1401) | Dublin | Dublin 8 | Ireland | Details | ||
| University Hospital Limerick ( Site 1403) | Limerick | V94 F858 | Ireland | Details | ||
| IRCCS Casa Sollievo della Sofferenza ( Site 1009) | San Giovanni Rotondo (FG) | Foggia | 71013 | Italy | Details | |
| Humanitas Research Hospital ( Site 1004) | Rozzano | Milano | 20089 | Italy | Details | |
| Ospedale Mater Salutis ( Site 1005) | Legnago | Verona | 37045 | Italy | Details | |
| ASST Spedali Civili ( Site 1001) | Brescia | 25123 | Italy | Details | ||
| Istituto Europeo di Oncologia ( Site 1007) | Milano | 20141 | Italy | Details | ||
| Ospedale San Gerardo ASST Monza ( Site 1002) | Monza | 20900 | Italy | Details | ||
| AORN dei Colli Plesso Monaldi ( Site 1003) | Napoli | 80131 | Italy | Details | ||
| Ospedale Santa Maria della Misericordia ( Site 1008) | Perugia | 06132 | Italy | Details | ||
| Seoul National University Hospital ( Site 2303) | Seoul | 03080 | Korea, Republic of | Details | ||
| Severance Hospital Yonsei University Health System ( Site 2300) | Seoul | 03722 | Korea, Republic of | Details | ||
| Asan Medical Center ( Site 2302) | Seoul | 05505 | Korea, Republic of | Details | ||
| Samsung Medical Center ( Site 2301) | Seoul | 06351 | Korea, Republic of | Details | ||
| Pauls Stradins Clinical University Hospital ( Site 1100) | Riga | 1002 | Latvia | Details | ||
| Riga East Clinical University Hospital ( Site 1111) | Riga | 1079 | Latvia | Details | ||
| Hospital Civil de Guadalajara Fray Antonio Alcalde ( Site 0603) | Guadalajara | Jalisco | 44200 | Mexico | Details | |
| Avix Investigacion Clinica S.C. ( Site 0600) | Monterrey | N.l. | 64710 | Mexico | Details | |
| Medical Care and Research S.A. de C.V. ( Site 0602) | Merida | Yucatan | 97070 | Mexico | Details | |
| Grupo Medico Camino SC ( Site 0607) | Ciudad de Mexico | 03310 | Mexico | Details | ||
| Medica Sur S.A.B de C.V. ( Site 0608) | Mexico City | 14050 | Mexico | Details | ||
| Oncologica de Puebla SA de CV ( Site 0606) | Puebla | 72530 | Mexico | Details | ||
| Hospital Nacional Guillermo Almenara Irigoyen ( Site 0705) | La Victoria | Lima | 15033 | Peru | Details | |
| Centro Especializado de Enfermedades Neoplasicas SRL-CEEN SRL ( Site 0710) | Arequipa | 04000 | Peru | Details | ||
| Instituto Regional de Enfermedades Neoplasicas del Sur IRENSUR ( Site 0704) | Arequipa | 04000 | Peru | Details | ||
| Clinica Internacional Sede San Borja ( Site 0701) | Lima | 15036 | Peru | Details | ||
| Hospital Nacional Cayetano Heredia ( Site 0706) | Lima | 15102 | Peru | Details | ||
| Clinica Peruano Americana S.A. ( Site 0703) | Trujillo | 13007 | Peru | Details | ||
| Dolnoslaskie Centrum Onkologii. ( Site 1616) | Wroclaw | Dolnoslaskie | 53-413 | Poland | Details | |
| Szpital Wojewodzki w Koszalinie im. Mikolaja Kopernika ( Site 1614) | Koszalin | Zachodniopomorskie | 75-581 | Poland | Details | |
| Powiatowe Centrum Zdrowia w Brzezinach ( Site 1615) | Brzeziny | 95-060 | Poland | Details | ||
| Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 1609) | Bydgoszcz | 85-796 | Poland | Details | ||
| Przychodnia Lekarska Komed ( Site 1602) | Konin | 62-500 | Poland | Details | ||
| Samodzielny Publiczny Zespol Gruzlicy i Chorob Pluc ( Site 1607) | Olsztyn | 10-357 | Poland | Details | ||
| MED-POLONIA Sp. z o.o. ( Site 1605) | Poznan | 60-693 | Poland | Details | ||
| Centrum Onkologii-Instytut im. Marii Skłodowskiej-Curie ( Site 1600) | Warszawa | 02-781 | Poland | Details | ||
| Universitas Annex National Hospital ( Site 1800) | Bloemfontein | Free State | 9301 | South Africa | Details | |
| Clinton Onclogy Clinic ( Site 1804) | Alberton | Gauteng | 1448 | South Africa | Details | |
| Wilgers Oncology Centre ( Site 1808) | Pretoria | Gauteng | 0081 | South Africa | Details | |
| Vincent Pallotti Hospital ( Site 1811) | Cape Town | 7405 | South Africa | Details | ||
| University of Stellenbosch and Tygerberg Hospital ( Site 1810) | Cape Town | 8000 | South Africa | Details | ||
| Dr G.A. Landers Specialist Oncologist ( Site 1803) | Durban | 4001 | South Africa | Details | ||
| Charlotte Maxeke Johannesburg Academic Hospital ( Site 1806) | Johannesburg | 2193 | South Africa | Details | ||
| Sandton Oncology Medical Group PTY LTD ( Site 1807) | Johannesburg | 2196 | South Africa | Details | ||
| GVI Oncology Clinical Research Centre ( Site 1802) | Kraaifontein | 7570 | South Africa | Details | ||
| Hospital Germans Trias i Pujol ( Site 1207) | Badalona | Barcelona | 08916 | Spain | Details | |
| Hospital Duran i Reynals ( Site 1201) | Hospitalet de Llobregat | Barcelona | 08908 | Spain | Details | |
| Hospital San Pedro de Alcantara ( Site 1208) | Caceres | Extremadura | 10003 | Spain | Details | |
| Hospital Universitario Insular de Gran Canaria ( Site 1203) | Las Palmas de Gran Canaria | Gran Canaria | 35001 | Spain | Details | |
| Hospital Universitari Vall d Hebron ( Site 1211) | Barcelona | 08035 | Spain | Details | ||
| Hospital Fundacion Jimenez Diaz - Clin. Concepcion ( Site 1209) | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario Virgen del Rocio ( Site 1200) | Sevilla | 41013 | Spain | Details | ||
| Changhua Christian Hospital ( Site 2406) | Changhua | 50006 | Taiwan | Details | ||
| Chang Gung Medical Foundation - Kaohsiung ( Site 2404) | Kaohsiung | 833 | Taiwan | Details | ||
| China Medical University Hospital ( Site 2403) | Taichung | 404 | Taiwan | Details | ||
| National Cheng Kung University Hospital ( Site 2401) | Tainan | 70457 | Taiwan | Details | ||
| National Taiwan University Hospital ( Site 2400) | Taipei | 10048 | Taiwan | Details | ||
| Mackay Memorial Hospital ( Site 2405) | Taipei | 104 | Taiwan | Details | ||
| Chang Gung Memorial Hospital - Linkou Branch ( Site 2402) | Taoyuan | 33305 | Taiwan | Details | ||
| Ramathibodi Hospital. ( Site 2563) | Ratchthevee | Bangkok | 10400 | Thailand | Details | |
| Bangkok Hospital Chiangmai ( Site 2560) | Mueang | Chiang Mai | 50000 | Thailand | Details | |
| Chulalongkorn Hospital ( Site 2561) | Bangkok | 10330 | Thailand | Details | ||
| Pramongkutklao Hospital ( Site 2564) | Bangkok | 10400 | Thailand | Details | ||
| Siriraj Hospital ( Site 2562) | Bangkok | 10700 | Thailand | Details | ||
| Khon Kaen University ( Site 2565) | Khon Kaen | 40002 | Thailand | Details | ||
| Acibadem Adana Hastanesi ( Site 1904) | Adana | 01130 | Turkey | Details | ||
| Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 1908) | Ankara | 06100 | Turkey | Details | ||
| Uludag Universitesi Tip Fakultesi ( Site 1914) | Bursa | 16059 | Turkey | Details | ||
| Ankara Sehir Hastanesi ( Site 1903) | Cankaya - Ankara | 06490 | Turkey | Details | ||
| Trakya Uni. Tip Fakultesi ( Site 1911) | Edirne | 22030 | Turkey | Details | ||
| Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 1906) | Istanbul | 34098 | Turkey | Details | ||
| Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi ( Site 1912) | Istanbul | 34899 | Turkey | Details | ||
| Ege Universitesi Tip Fakultesi Hastanesi ( Site 1901) | Izmir | 35100 | Turkey | Details | ||
| Medical Park Izmir Hospital ( Site 1900) | Izmir | 35575 | Turkey | Details | ||
| Kocaeli Universitesi Tip Fakultesi ( Site 1909) | Kocaeli | 41380 | Turkey | Details | ||
| Inonu Universitesi Tip Fakultesi ( Site 1907) | Malatya | 44280 | Turkey | Details | ||
| Karadeniz Teknik Universitesi ( Site 1910) | Trabzon | 61080 | Turkey | Details | ||
| MI Kryviy Rih Center of Dnipropetrovsk Regional Council ( Site 2005) | Kryviy Rih | Dnipropetrovsk Region | 50048 | Ukraine | Details | |
| Cherkasy Regional Hospital ( Site 2020) | Cherkasy | 18009 | Ukraine | Details | ||
| Regional Clinical Onco Dispensary_ State Medical University ( Site 2012) | Chernivtsy | 58013 | Ukraine | Details | ||
| Dnipropetrovsk City Multidiscipline Clinical Hosp.4 of DRC ( Site 2000) | Dnipropetrovsk | 49102 | Ukraine | Details | ||
| MI Prykarpatskyi Clinical Oncology Centrum ( Site 2009) | Ivano-Frankivsk | 76018 | Ukraine | Details | ||
| PP PPC Acinus Medical and Diagnostic Centre ( Site 2002) | Kropyvnytskyi | 25006 | Ukraine | Details | ||
| National Cancer Institute of the MoH of Ukraine ( Site 2015) | Kyiv | 03002 | Ukraine | Details | ||
| Kyiv City Clinical Oncological Center ( Site 2014) | Kyiv | 03115 | Ukraine | Details | ||
| Lviv State Oncology Regional Treatment and Diagnostic Center ( Site 2003) | Lviv | 79031 | Ukraine | Details | ||
| MI Odessa Regional Oncological Centre ( Site 2004) | Odesa | 65055 | Ukraine | Details | ||
| Royal Cornwall Hospital ( Site 1325) | Truro | Cornwall | TR1 3LJ | United Kingdom | Details | |
| The Royal Marsden NHS Foundation Trust. ( Site 1326) | Sutton | Surrey | SM2 5PT | United Kingdom | Details | |
| Belfast City Hospital ( Site 1302) | Belfast | BT9 7AB | United Kingdom | Details | ||
| Royal Free NHS Foundation Trust ( Site 1324) | London | NW3 2QG | United Kingdom | Details | ||
| St. Georges University Hospital NHS Foundation Trust ( Site 1321) | London | SW17 0QT | United Kingdom | Details | ||
| The Royal Marsden NHS Foundation Trust.. ( Site 1327) | London | SW3 6JJ | United Kingdom | Details | ||
| The Christie NHS Foundation Trust ( Site 1301) | Manchester | M20 4BX | United Kingdom | Details | ||
| Mount Vernon Cancer Centre ( Site 1307) | Northwood | HA6 2RN | United Kingdom | Details | ||
| Royal Wolverhampton Hospitals NHS Trust ( Site 1323) | Wolverhampton | WV10 0QP | United Kingdom | Details |