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| NCT ID | NCT03322540 |
| Title | Pembrolizumab Plus Epacadostat vs Pembrolizumab Plus Placebo in Metastatic Non-Small Cell Lung Cancer (KEYNOTE-654-05/ECHO-305-05) |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase II |
| Variant Requirements | Yes |
| Sponsors | Incyte Corporation |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | POL | ITA | ISR | IRL | GBR | EST | ESP | DNK | CHE | CAN | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Pacific Cancer Medical Center, Inc. | Anaheim | California | 92801 | United States | Details | |
| Innovative Clinical Research Institute | Whittier | California | 90603 | United States | Details | |
| Florida Cancer Specialists (South Region) | Fort Myers | Florida | 33916 | United States | Details | |
| Florida Cancer Specialists (North Region) | Saint Petersburg | Florida | 33705 | United States | Details | |
| Southeastern Regional Medical Center, Inc. | Newnan | Georgia | 30265 | United States | Details | |
| Anne Arundel Health System Research Institute | Annapolis | Maryland | 21401 | United States | Details | |
| Weinberg Cancer Institute at Franklin Square | Baltimore | Maryland | 21237 | United States | Details | |
| Maryland Oncology Hematology, P.A. | Rockville | Maryland | 20850 | United States | Details | |
| UMass Memorial Medical Center | Worcester | Massachusetts | 01655 | United States | Details | |
| Minnesota Oncology Hematology, PA | Coon Rapids | Minnesota | 55433 | United States | Details | |
| Nebraska Cancer Specialists | Omaha | Nebraska | 68130 | United States | Details | |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15224 | United States | Details | |
| Tennessee Oncology, PLLC/The Sarah Cannon Research Institute | Chattanooga | Tennessee | 37404 | United States | Details | |
| Tennessee Oncology, PLLC/The Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | United States | Details | |
| Texas Oncology-South Austin | Austin | Texas | 78745 | United States | Details | |
| Austin Health-Austin Hospital | Heidelberg | Victoria | 3084 | Australia | Details | |
| St John of God Murdoch Medical Clinic | Murdoch | Western Australia | 6150 | Australia | Details | |
| Cross Cancer Institute | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| Moncton Hospital - Horizon Health Network | Moncton | New Brunswick | E1C 6Z8 | Canada | Details | |
| William Osler Health System | Brampton | Ontario | L6R 3J7 | Canada | Details | |
| Cancer Centre of Southeastern Ontario at Kingston General Hospital | Kingston | Ontario | K7L 2V7 | Canada | Details | |
| Sault Area Hospital | Sault Ste Marie | Ontario | P6B 0A8 | Canada | Details | |
| Rigshospitalet | Copenhagen | 2100 | Denmark | Details | ||
| Regionshospitalet Herning | Herning | 7400 | Denmark | Details | ||
| Odense Universitetshospital | Odense | 5000 | Denmark | Details | ||
| SA Tartu Ulikooli Kliinikum | Tartu | 51014 | Estonia | Details | ||
| Galway University Hospital | Galway | Connacht | H91 YR71 | Ireland | Details | |
| St Vincents University Hospital | Dublin | Dublin 4 | Ireland | Details | ||
| Soroka Medical Center | Beer Sheva | 8457108 | Israel | Details | ||
| Rambam Medical Center | Haifa | 31096 | Israel | Details | ||
| Meir Medical Center | Kfar Saba | 4428164 | Israel | Details | ||
| Rabin Medical Center | Petah Tikva | 4941492 | Israel | Details | ||
| Chaim Sheba Medical Center | Ramat Gan | 52621 | Israel | Details | ||
| IRCCS A.O.U. San Martino - IST | Genova | 16132 | Italy | Details | ||
| Policlinico Universitario Agostino Gemelli | Roma | 00168 | Italy | Details | ||
| National Hospital Organization Nagoya Medical Center | Nagoya | Aichi | 460-0001 | Japan | Details | |
| National Hospital Organization Shikoku Cancer Center | Matsuyama | Ehime | 791-0280 | Japan | Details | |
| Kurume University Hospital | Kurume | Fukuoka | 830-0011 | Japan | Details | |
| Kanazawa University Hospital | Kanazawa | Ishikawa | 920-8641 | Japan | Details | |
| Kanagawa Cancer Center | Yokohama | Kanagawa | 241-8515 | Japan | Details | |
| Sendai Kousei Hospital | Sendai | Miyagi | 980-0873 | Japan | Details | |
| Kansai Medical University Hospital | Hirakata | Osaka | 573-1191 | Japan | Details | |
| Kindai University Hospital | Osakasayama | Osaka | 589-8511 | Japan | Details | |
| Shizuoka Cancer Center | Nagaizumi-chō | Shizuoka Prefecture | 411-8777 | Japan | Details | |
| National Hospital Organization Kyushu Cancer Center | Fukuoka | 811-1395 | Japan | Details | ||
| Kyushu University Hospital | Fukuoka | 812-8582 | Japan | Details | ||
| Niigata Cancer Center Hospital | Niigata | 951-8566 | Japan | Details | ||
| Okayama University Hospital | Okayama | 700-8558 | Japan | Details | ||
| National Cancer Center Hospital | Tokyo | 104-0045 | Japan | Details | ||
| Nippon Medical School Hospital | Tokyo | 113-8603 | Japan | Details | ||
| The Cancer Institute Hospital of JFCR | Tokyo | 135-8550 | Japan | Details | ||
| Wakayama Medical University Hospital | Wakayama | 641-8509 | Japan | Details | ||
| Chungbuk National University Hospital | Cheongju si | Chungcheongbuk Do | 28644 | Korea, Republic of | Details | |
| Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do | 13620 | Korea, Republic of | Details | |
| Gacheon University Gil Medical Center | Incheon | 21565 | Korea, Republic of | Details | ||
| Hospital Tengku Ampuan Afzan | Kuantan | Pahang | 25100 | Malaysia | Details | |
| Institut Kanser Negara - National Cancer Institute | Putrajaya | Wilayah Persekutuan | 62250 | Malaysia | Details | |
| University Malaya Medical Centre | Kuala Lumpur | 59100 | Malaysia | Details | ||
| Pantai Hospital Kuala Lumpur | Kuala Lumpur | Malaysia | Details | |||
| Sarawak General Hospital | Kuching | Malaysia | Details | |||
| Swietokrzyskie Centrum Onkologii SPZOZ | Kielce | Swietokrzyskie | 25-734 | Poland | Details | |
| Centrum Onkologii im. Prof. Franciszka Lukaszczyka | Bydgoszcz | 85-796 | Poland | Details | ||
| Centrum Onkologii. Instytut im. Marii Sklodowskiej-Curie | Gliwice | 44-101 | Poland | Details | ||
| Swietokrzyskie Centrum Onkologii SPZOZ | Kielce | 25-734 | Poland | Details | ||
| Przychodnia Lekarska Komed | Konin | 62-500 | Poland | Details | ||
| Samodzielny Publiczny Zespol Gruzlicy i Chorob Pluc | Olsztyn | 10-357 | Poland | Details | ||
| Wojewodzki Szpital im. Zofii z Zamoyskich Tarnowskiej w Tarnobrzegu | Tarnobrzeg | 39-400 | Poland | Details | ||
| Centrum Onkologii-Instytut im. Marii Sklodowskiej-Curie | Warszawa | 02-781 | Poland | Details | ||
| Belgorod Regional Oncology Dispensary | Belgorod | 308010 | Russian Federation | Details | ||
| Central Clinical Hospital with polyclinic | Moscow | 121359 | Russian Federation | Details | ||
| Moscow Research Oncology Institute named after P.A. Hertsen | Moscow | 125284 | Russian Federation | Details | ||
| SBHI Leningrad Regional Clinical Hospital | Saint Petersburg | 194291 | Russian Federation | Details | ||
| SBHI Samara Regional Clinical Oncology Dispensary | Samara | 443031 | Russian Federation | Details | ||
| Republican Clinical Oncology Dispensary of Republic of Bashkortostan | Ufa | 450054 | Russian Federation | Details | ||
| Hospital Alvaro Cunqueiro | Vigo | Pontevedra | 36312 | Spain | Details | |
| Hospital General de Alicante | Alicante | 03010 | Spain | Details | ||
| Hospital del Mar | Barcelona | 8003 | Spain | Details | ||
| Hospital Clinico San Carlos | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario 12 de Octubre | Madrid | 28041 | Spain | Details | ||
| Hospital Universitario Virgen Macarena | Sevilla | 41009 | Spain | Details | ||
| Hospital Clinico de Valencia | Valencia | 46010 | Spain | Details | ||
| Oncological Institute of Southern Switzerland | Bellinzona | 6500 | Switzerland | Details | ||
| Inselspital Universitatsspital Bern | Bern | 3010 | Switzerland | Details | ||
| Hopitaux Universitaires de Geneve HUG. | Geneva | 1211 | Switzerland | Details | ||
| Kantonsspital Winterthur | Winterthur | 8401 | Switzerland | Details | ||
| Universitaetsspital Zuerich | Zuerich | 8091 | Switzerland | Details | ||
| Basken Uni. Adana Dr.Turgut Noyan Uygulama ve Arastirma Merkezi | Adana | 01120 | Turkey | Details | ||
| Ankara University Medical Faculty | Ankara | 06100 | Turkey | Details | ||
| Akdeniz Universitesi Tip Fakultesi | Antalya | 07059 | Turkey | Details | ||
| Erciyes Universitesi Tip Fakultesi | Kayseri | 38039 | Turkey | Details | ||
| Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi | Konya | 42080 | Turkey | Details | ||
| MI Kryviy Rih Center of Dnipropetrovsk Regional Council | Kryvyi Rih | Dnipropetrovsk Region | 50048 | Ukraine | Details | |
| Dnipropetrovsk City Multidiscipline Clinical Hosp.4 of DRC | Dnipropetrovsk | 49102 | Ukraine | Details | ||
| Grigoriev Institute for medical Radiology NAMS of Ukraine | Kharkiv | 61024 | Ukraine | Details | ||
| PP PPC Acinus Medical and Diagnostic Centre | Kirovohrad | 25001 | Ukraine | Details | ||
| Kyiv City Clinical Oncological Center | Kyiv | 03115 | Ukraine | Details | ||
| Dobryi Prognoz | Kyiv | 03126 | Ukraine | Details | ||
| Volyn Regional Oncological Dispensary | Lutsk | 43018 | Ukraine | Details | ||
| MI Odessa Regional Oncological Centre | Odesa | 65055 | Ukraine | Details | ||
| Zaporizhzhya Regional Clinical Oncology Center | Zaporizhzhya | 69040 | Ukraine | Details | ||
| Leeds Teaching Hospital NHS Trust. St. James University Hospital | Leeds | LS9 7TF | United Kingdom | Details |