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| NCT ID | NCT03512197 |
| Title | A Global Study of the Efficacy and Safety of Midostaurin + Chemotherapy in Newly Diagnosed Patients With FLT3 Mutation Negative (FLT3-MN) Acute Myeloid Leukemia (AML) |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | Novartis Pharmaceuticals |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | TUR | POL | NOR | ITA | ISR | FRA | ESP | DEU | CZE | CHE | BRA | BGR | BEL | AUT | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| University of Chicago Medical Center . | Chicago | Illinois | 60637 | United States | Details | |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02115 | United States | Details | |
| Oregon Health and Science Univ | Portland | Oregon | 97239 | United States | Details | |
| Novartis Investigative Site | Caba | Buenos Aires | C1118AAT | Argentina | Details | |
| Novartis Investigative Site | Westmead | New South Wales | 2145 | Australia | Details | |
| Novartis Investigative Site | Woolloongabba | Queensland | 4102 | Australia | Details | |
| Novartis Investigative Site | Prahran | Victoria | 3181 | Australia | Details | |
| Novartis Investigative Site | Murdoch | Western Australia | 6150 | Australia | Details | |
| Novartis Investigative Site | Linz | A-4010 | Austria | Details | ||
| Novartis Investigative Site | Vienna | 1140 | Austria | Details | ||
| Novartis Investigative Site | Wien | 1090 | Austria | Details | ||
| Novartis Investigative Site | Antwerpen | 2060 | Belgium | Details | ||
| Novartis Investigative Site | Brugge | 8000 | Belgium | Details | ||
| Novartis Investigative Site | Roeselare | 8800 | Belgium | Details | ||
| Novartis Investigative Site | Porto Alegre | RS | 90035-003 | Brazil | Details | |
| Novartis Investigative Site | Sao Paulo | SP | 04014-002 | Brazil | Details | |
| Novartis Investigative Site | Sao Paulo | 01221 900 | Brazil | Details | ||
| Novartis Investigative Site | Sofia | 1756 | Bulgaria | Details | ||
| Novartis Investigative Site | Brno - Bohunice | 625 00 | Czechia | Details | ||
| Novartis Investigative Site | Plzen-Bory | 30599 | Czechia | Details | ||
| Novartis Investigative Site | Bayonne | Bayonne Cedex | 64109 | France | Details | |
| Novartis Investigative Site | Angers Cedex 1 | 49033 | France | Details | ||
| Novartis Investigative Site | Avignon | 84000 | France | Details | ||
| Novartis Investigative Site | Dijon | 21034 | France | Details | ||
| Novartis Investigative Site | Lille Cedex | 59037 | France | Details | ||
| Novartis Investigative Site | Nantes Cedex 1 | 44093 | France | Details | ||
| Novartis Investigative Site | Paris | 75012 | France | Details | ||
| Novartis Investigative Site | Pierre Benite | 69495 | France | Details | ||
| Novartis Investigative Site | Toulouse | 31059 | France | Details | ||
| Novartis Investigative Site | Regensburg | Bavaria | 93053 | Germany | Details | |
| Novartis Investigative Site | Schwerin | Brandenburg | 19049 | Germany | Details | |
| Novartis Investigative Site | Bad Saarow | 15526 | Germany | Details | ||
| Novartis Investigative Site | Berlin | 10967 | Germany | Details | ||
| Novartis Investigative Site | Berlin | 12351 | Germany | Details | ||
| Novartis Investigative Site | Berlin | 13125 | Germany | Details | ||
| Novartis Investigative Site | Berlin | 13353 | Germany | Details | ||
| Novartis Investigative Site | Bochum | 44892 | Germany | Details | ||
| Novartis Investigative Site | Bonn | 53105 | Germany | Details | ||
| Novartis Investigative Site | Braunschweig | 38114 | Germany | Details | ||
| Novartis Investigative Site | Darmstadt | 64283 | Germany | Details | ||
| Novartis Investigative Site | Duesseldorf | 40225 | Germany | Details | ||
| Novartis Investigative Site | Duisburg | 47166 | Germany | Details | ||
| Novartis Investigative Site | Eschweiler | 52249 | Germany | Details | ||
| Novartis Investigative Site | Essen Werden | 45239 | Germany | Details | ||
| Novartis Investigative Site | Flensburg | 24939 | Germany | Details | ||
| Novartis Investigative Site | Giessen | 35392 | Germany | Details | ||
| Novartis Investigative Site | Gottingen | 37075 | Germany | Details | ||
| Novartis Investigative Site | Hamburg | 20099 | Germany | Details | ||
| Novartis Investigative Site | Hamburg | 20246 | Germany | Details | ||
| Novartis Investigative Site | Hannover | 30625 | Germany | Details | ||
| Novartis Investigative Site | Homburg | 66421 | Germany | Details | ||
| Novartis Investigative Site | Karlsruhe | 76133 | Germany | Details | ||
| Novartis Investigative Site | Kiel | 24116 | Germany | Details | ||
| Novartis Investigative Site | Leipzig | 04103 | Germany | Details | ||
| Novartis Investigative Site | Luebeck | 23538 | Germany | Details | ||
| Novartis Investigative Site | Magdeburg | 39120 | Germany | Details | ||
| Novartis Investigative Site | Mainz | 55131 | Germany | Details | ||
| Novartis Investigative Site | Muenchen | 80377 | Germany | Details | ||
| Novartis Investigative Site | Osnabrueck | 49076 | Germany | Details | ||
| Novartis Investigative Site | Paderborn | 33098 | Germany | Details | ||
| Novartis Investigative Site | Rostock | 18057 | Germany | Details | ||
| Novartis Investigative Site | Siegen | 57072 | Germany | Details | ||
| Novartis Investigative Site | Stuttgart | 70176 | Germany | Details | ||
| Novartis Investigative Site | Stuttgart | 70376 | Germany | Details | ||
| Novartis Investigative Site | Ulm | 89081 | Germany | Details | ||
| Novartis Investigative Site | Wuerzburg | 97080 | Germany | Details | ||
| Novartis Investigative Site | Zwickau | 08060 | Germany | Details | ||
| Novartis Investigative Site | Haifa | 3109601 | Israel | Details | ||
| Novartis Investigative Site | Petach Tikva | 4941492 | Israel | Details | ||
| Novartis Investigative Site | Tel Aviv | 6423906 | Israel | Details | ||
| Novartis Investigative Site | Alessandria | AL | 15100 | Italy | Details | |
| Novartis Investigative Site | Ancona | AN | 60126 | Italy | Details | |
| Novartis Investigative Site | Bergamo | BG | 24127 | Italy | Details | |
| Novartis Investigative Site | Brescia | BS | 25123 | Italy | Details | |
| Novartis Investigative Site | Catania | CT | 95123 | Italy | Details | |
| Novartis Investigative Site | Milano | MI | 20162 | Italy | Details | |
| Novartis Investigative Site | Modena | MO | 41124 | Italy | Details | |
| Novartis Investigative Site | Palermo | PA | 90146 | Italy | Details | |
| Novartis Investigative Site | Piacenza | PC | 29100 | Italy | Details | |
| Novartis Investigative Site | Pescara | PE | 65124 | Italy | Details | |
| Novartis Investigative Site | Perugia | PG | 06129 | Italy | Details | |
| Novartis Investigative Site | Reggio Calabria | RC | 89124 | Italy | Details | |
| Novartis Investigative Site | Roma | RM | 00133 | Italy | Details | |
| Novartis Investigative Site | Roma | RM | 00161 | Italy | Details | |
| Novartis Investigative Site | Roma | RM | 00168 | Italy | Details | |
| Novartis Investigative Site | Taranto | TA | 74100 | Italy | Details | |
| Novartis Investigative Site | Torino | TO | 10126 | Italy | Details | |
| Novartis Investigative Site | Vicenza | VI | 36100 | Italy | Details | |
| Novartis Investigative Site | Nagoya-city | Aichi | 466-8650 | Japan | Details | |
| Novartis Investigative Site | Matsuyama-city | Ehime | 790-8524 | Japan | Details | |
| Novartis Investigative Site | Fukuoka city | Fukuoka | 812-8582 | Japan | Details | |
| Novartis Investigative Site | Fukushima city | Fukushima | 960 1295 | Japan | Details | |
| Novartis Investigative Site | Gifu shi | Gifu | 500 8513 | Japan | Details | |
| Novartis Investigative Site | Fukuyama | Hiroshima | 720-0001 | Japan | Details | |
| Novartis Investigative Site | Tsukuba city | Ibaraki | 305-8576 | Japan | Details | |
| Novartis Investigative Site | Isehara | Kanagawa | 259-1193 | Japan | Details | |
| Novartis Investigative Site | Nagasaki-city | Nagasaki | 852-8501 | Japan | Details | |
| Novartis Investigative Site | Okayama city | Okayama | 701-1192 | Japan | Details | |
| Novartis Investigative Site | Hirakata-city | Osaka | 573-1191 | Japan | Details | |
| Novartis Investigative Site | Osaka Sayama | Osaka | 589 8511 | Japan | Details | |
| Novartis Investigative Site | Hamamatsu | Shizuoka | 432-8580 | Japan | Details | |
| Novartis Investigative Site | Shimotsuke | Tochigi | 329-0498 | Japan | Details | |
| Novartis Investigative Site | Bunkyo ku | Tokyo | 113-8677 | Japan | Details | |
| Novartis Investigative Site | Bunkyo-ku | Tokyo | 113-8603 | Japan | Details | |
| Novartis Investigative Site | Aomori | 030 8553 | Japan | Details | ||
| Novartis Investigative Site | Kyoto | 606 8507 | Japan | Details | ||
| Novartis Investigative Site | Osaka | 534-0021 | Japan | Details | ||
| Novartis Investigative Site | Yamagata | 990 9585 | Japan | Details | ||
| Novartis Investigative Site | Bergen | NO-5021 | Norway | Details | ||
| Novartis Investigative Site | Oslo | 0424 | Norway | Details | ||
| Novartis Investigative Site | Gdansk | 80 952 | Poland | Details | ||
| Novartis Investigative Site | Lisboa | 1099 023 | Portugal | Details | ||
| Novartis Investigative Site | Porto | 4200-072 | Portugal | Details | ||
| Novartis Investigative Site | Cordoba | Andalucia | 14004 | Spain | Details | |
| Novartis Investigative Site | Sevilla | Andalucia | 41013 | Spain | Details | |
| Novartis Investigative Site | Salamanca | Castilla Y Leon | 37007 | Spain | Details | |
| Novartis Investigative Site | Hospitalet de LLobregat | Catalunya | 08907 | Spain | Details | |
| Novartis Investigative Site | Caceres | Extremadura | 10003 | Spain | Details | |
| Novartis Investigative Site | Barakaldo | Pais Vasco | 48903 | Spain | Details | |
| Novartis Investigative Site | Barcelona | 08041 | Spain | Details | ||
| Novartis Investigative Site | Madrid | 28034 | Spain | Details | ||
| Novartis Investigative Site | Madrid | 28041 | Spain | Details | ||
| Novartis Investigative Site | Valencia | 46026 | Spain | Details | ||
| Novartis Investigative Site | Zaragoza | 50009 | Spain | Details | ||
| Novartis Investigative Site | Bern | 3010 | Switzerland | Details | ||
| Novartis Investigative Site | Zurich | 8091 | Switzerland | Details | ||
| Novartis Investigative Site | Putzu City | Chiayi Hsien | 61363 | Taiwan | Details | |
| Novartis Investigative Site | Kuei Shan Chiang | Taoyuan Taiwan ROC | 33305 | Taiwan | Details | |
| Novartis Investigative Site | Kaohsiung City | 83301 | Taiwan | Details | ||
| Novartis Investigative Site | Taipei | 10002 | Taiwan | Details | ||
| Novartis Investigative Site | Adana | 01330 | Turkey | Details | ||
| Novartis Investigative Site | Ankara | 06100 | Turkey | Details | ||
| Novartis Investigative Site | Aydin | 09100 | Turkey | Details |