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NCT ID NCT03515837
Title Study of Pemetrexed + Platinum Chemotherapy With or Without Pembrolizumab (MK-3475) in Adults With Tyrosine Kinase Inhibitor- (TKI)-Resistant Epidermal Growth Factor Receptor- (EGFR)-Mutated Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-789/KEYNOTE-789)
Recruitment Completed
Gender both
Phase Phase III
Variant Requirements No
Sponsors Merck Sharp & Dohme Corp.
Indications
Therapies
Age Groups: adult | senior
Covered Countries USA | SWE | ITA | ISR | GBR | FRA | ESP | DEU | CAN | BRA | AUS

Facility Status City State Zip Country Details
Cedars-Sinai Medical Center ( Site 0070) Los Angeles California 90048 United States Details
Pacific Cancer Care ( Site 0058) Monterey California 93940 United States Details
UC Irvine Medical Center/Chao Family Comprehensive Cancer Center ( Site 0092) Orange California 92868 United States Details
St. Joseph Heritage Healthcare ( Site 0003) Santa Rosa California 95403 United States Details
North Shore University Health System ( Site 0030) Evanston Illinois 60201 United States Details
Siouxland Regioinal Cancer Center dba June E. Nylen Cancer Center ( Site 0065) Sioux City Iowa 51101 United States Details
Southdale Cancer Care, University of Minnesota Medical Center- Edina ( Site 0048) Edina Minnesota 55435 United States Details
Saint Lukes Hospital of Kansas City ( Site 0060) Kansas City Missouri 64111 United States Details
New York Oncology Hematology P.C ( Site 8000) Albany New York 12208 United States Details
Monter Cancer Center ( Site 0054) Lake Success New York 11042 United States Details
Memorial Sloan Kettering Cancer Center-Rockerfeller Patient Pavilion ( Site 0049) New York New York 10022 United States Details
White Plains Hospital Center for Cancer Care ( Site 0014) White Plains New York 10601 United States Details
Providence Portland Medical Center ( Site 0097) Portland Oregon 97213 United States Details
Kaiser Permanente Northwest ( Site 0037) Portland Oregon 97227 United States Details
Parkland Health & Hospital System ( Site 2102) Dallas Texas 75235 United States Details
University of Texas Southwestern Medical Center at Dallas ( Site 0035) Dallas Texas 75390 United States Details
Utah Cancer Specialists ( Site 0001) Salt Lake City Utah 84106 United States Details
Emily Couric Clinical Cancer Center ( Site 0020) Charlottesville Virginia 22903 United States Details
Froedtert Hospital & the Medical College of Wisconsin ( Site 0041) Milwaukee Wisconsin 53226 United States Details
Chris OBrien Lifehouse ( Site 0200) Camperdown New South Wales 2050 Australia Details
Westmead Hospital ( Site 0201) Westmead New South Wales 2145 Australia Details
Eastern Health ( Site 0202) Box Hill Victoria 3128 Australia Details
Austin Health ( Site 0203) Heidelberg Victoria 3084 Australia Details
Liga Norte Riograndense Contra o Cancer ( Site 1909) Natal Rio Grande Do Norte 59075-740 Brazil Details
Hospital de Caridade de Ijui ( Site 1907) Ijui Rio Grande Do Sul 98700-000 Brazil Details
Hospital Bruno Born ( Site 1913) Lajeado Rio Grande Do Sul 95900-010 Brazil Details
Hospital de Clinicas de Porto Alegre ( Site 1905) Porto Alegre Rio Grande Do Sul 90035-903 Brazil Details
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 1904) Porto Alegre Rio Grande Do Sul 90610-000 Brazil Details
Fundacao Pio XII - Hospital de Cancer de Barretos ( Site 1911) Barretos Sao Paulo 14784-400 Brazil Details
Hosp. Clinicas da Fac. de Medicina de Ribeirao Preto - USP ( Site 1912) Ribeirao Preto Sao Paulo 14048-900 Brazil Details
Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 1903) Sao Paulo 01246-000 Brazil Details
William Osler Health System ( Site 0100) Brampton Ontario L6R 3J7 Canada Details
Sunnybrook Health Sciences, Odette Cancer Centre ( Site 0102) Toronto Ontario M4N 3M5 Canada Details
Princess Margaret Cancer Centre ( Site 0104) Toronto Ontario M5G 2M9 Canada Details
Jewish General Hospital ( Site 0105) Montreal Quebec H3T 1E2 Canada Details
The First Affiliated Hospital of Anhui Medical University ( Site 0721) Hefei Anhui 230088 China Details
Cancer Hospital Chinese Academy of Medical Sciences ( Site 0717) Beijing Beijing 100021 China Details
Peking Union Medical College Hospital ( Site 0703) Beijing Beijing 100032 China Details
Beijing Cancer Hospital ( Site 0718) Beijing Beijing 100036 China Details
Southwest Hospital, The Third Military Medical University ( Site 0725) Chongqing Chongqing 400038 China Details
Fujian Cancer Hospital ( Site 0723) Fuzhou Fujian 350014 China Details
The Affiliated Tumour Hospital of Harbin Medical University ( Site 0706) Harbin Heilongjiang 150081 China Details
Henan Cancer Hospital ( Site 0711) Zhengzhou Henan 450008 China Details
Xiangya Hospital of Central South University ( Site 0710) Changsha Hunan 410008 China Details
Hunan Cancer Hospital ( Site 0722) Changsha Hunan 410013 China Details
Jiangsu Cancer Hospital ( Site 0719) Nanjing Jiangsu 210000 China Details
The First Hospital of Jilin University ( Site 0702) Chang chun Jilin 130021 China Details
Jilin Cancer Hospital ( Site 0705) Changchun Jilin 130103 China Details
Shanghai Chest Hospital ( Site 0700) Shanghai Shanghai 200030 China Details
Zhongshan Hospital Fudan University ( Site 0712) Shanghai Shanghai 200433 China Details
Tangdu Hospital ( Site 0708) XI An Shanxi 710038 China Details
The First Affiliated Hospital of Xi an Jiaotong University ( Site 0709) XI An Shanxi 710061 China Details
Affiliated Tumor Hospital of Xinjiang Medical University ( Site 0701) Urumqi Xinjiang 830000 China Details
The First Affiliated Hospital.Zhejiang University ( Site 0713) Hangzhou Zhejiang 310003 China Details
Sir Run Run Shaw Hospital School of Medicine, Zhejiang University ( Site 0715) Hangzhou Zhejiang 310016 China Details
Zhejiang Cancer Hospital ( Site 0716) Hangzhou Zhejiang 310022 China Details
Centre Leon Berard ( Site 0801) Lyon Auvergne 69008 France Details
CHU Caen Service de Pneumologie ( Site 0804) Caen Calvados 14033 France Details
Centre Georges Francois Leclerc ( Site 0809) Dijon Cote-d'Or 21000 France Details
Hopital Jean Minjoz Besancon ( Site 0805) Besancon Doubs 25030 France Details
Hopital Prive d'Antony ( Site 0811) Antony Hauts-de-Seine 92160 France Details
C.H.U. de Tours - Hopital Bretonneau ( Site 0806) Tours Indre-et-Loire 37044 France Details
Centre D Oncologie de Gentilly ( Site 0810) Nancy Meurthe-et-Moselle 54100 France Details
Clinique Victor Hugo ( Site 0802) Le Mans Sarthe 72000 France Details
CHU Poitiers ( Site 0803) Poitiers Vienne 86021 France Details
Robert Bosch Krankenhaus Klinik Schillerhoehe ( Site 0904) Gerlingen Baden-Wurttemberg 70839 Germany Details
Universitaetsklinikum Mannheim ( Site 0911) Mannheim Baden-Wurttemberg 68167 Germany Details
Klinikum Wuerzburg Mitte gGmbH ( Site 0901) Wuerzburg Bayern 97074 Germany Details
Pius Hospital Oldenburg ( Site 0905) Oldenburg Niedersachsen 26121 Germany Details
Florence Nightingale Krankenhaus ( Site 0912) Duesseldorf Nordrhein-Westfalen 40489 Germany Details
Kliniken Essen-Mitte ( Site 0900) Essen Nordrhein-Westfalen 45136 Germany Details
Universitaetsklinikum Muenster ( Site 0906) Muenster Nordrhein-Westfalen 48149 Germany Details
Medizinische Fakultaet Carl Gustav Carus der TU Dresden ( Site 0907) Dresden Sachsen 01307 Germany Details
Asklepios Klinikum Hamburg ( Site 0908) Hamburg 21075 Germany Details
Hong Kong Integrated Oncology Centre ( Site 0304) Hong Kong Hong Kong Details
Queen Mary Hospital ( Site 0301) Hong Kong Hong Kong Details
Queen Mary Hospital ( Site 0303) Hong Kong Hong Kong Details
Hong Kong United Oncology Centre ( Site 0306) Kowloon Hong Kong Details
Tuen Mun Hospital ( Site 0305) Tuen Mun Hong Kong Details
Barzilai Medical Center ( Site 1706) Ashkelon HaDarom 7830604 Israel Details
Soroka Medical Center ( Site 1702) Beer-Sheva HaDarom 8457108 Israel Details
Meir Medical Center ( Site 1701) Kfar-Saba HaMerkaz 4428164 Israel Details
Rabin Medical Center ( Site 1704) Petah Tikva HaMerkaz 4941492 Israel Details
Ha Emek Medical Center ( Site 1707) Afula HaTsafon 1834111 Israel Details
Rambam Medical Center ( Site 1703) Haifa Heifa 3109601 Israel Details
Chaim Sheba Medical Center. ( Site 1700) Ramat Gan Tell Abib 5265601 Israel Details
Sourasky Medical Center ( Site 1705) Tel Aviv Tell Abib 6423906 Israel Details
Istituto Europeo di Oncologia ( Site 1303) Milano Lombardia 20141 Italy Details
Ospedale San Vincenzo di Taormina ( Site 1302) Taormina Messina 98039 Italy Details
AOU San Luigi Gonzaga di Orbassano ( Site 1300) Orbassano Torino 10043 Italy Details
IRCCS Giovanni Paolo II. Ospedale Oncologico ( Site 1305) Bari 70124 Italy Details
Azienda Ospedaliero Universitaria Careggi ( Site 1301) Firenze 50134 Italy Details
Azienda Ospedaliera dei Colli V. Monaldi ( Site 1306) Napoli 80131 Italy Details
Universita Campus Bio-Medico di Roma ( Site 1304) Roma 00128 Italy Details
National Hospital Organization Nagoya Medical Center ( Site 0608) Nagoya Aichi 460-0001 Japan Details
Aichi Cancer Center Hospital ( Site 0612) Nagoya Aichi 464-8681 Japan Details
Fujita Health University Hospital ( Site 0619) Toyoake Aichi 470-1192 Japan Details
National Cancer Center Hospital East ( Site 0601) Kashiwa Chiba 277-8577 Japan Details
National Hospital Organization Shikoku Cancer Center ( Site 0616) Matsuyama Ehime 791-0280 Japan Details
Hyogo Cancer Center ( Site 0604) Akashi Hyogo 673-8558 Japan Details
Kanazawa University Hospital ( Site 0617) Kanazawa Ishikawa 920-8641 Japan Details
Kanagawa Cancer Center ( Site 0609) Yokohama Kanagawa 241-8515 Japan Details
Kansai Medical University Hospital ( Site 0606) Hirakata Osaka 573-1191 Japan Details
Shizuoka Cancer Center Hospital and Research Institute ( Site 0602) Sunto-gun Shizuoka 411-8777 Japan Details
National Hospital Organization Kyushu Medical Center ( Site 0621) Fukuoka 810-8563 Japan Details
Kyushu University Hospital ( Site 0605) Fukuoka 812-8582 Japan Details
Niigata Cancer Center Hospital ( Site 0610) Niigata 951-8566 Japan Details
Okayama University Hospital ( Site 0614) Okayama 700-8558 Japan Details
Osaka International Cancer Institute ( Site 0611) Osaka 541-8567 Japan Details
National Cancer Center Hospital ( Site 0603) Tokyo 104-0045 Japan Details
Toranomon Hospital ( Site 0615) Tokyo 105-8470 Japan Details
Tokyo Metropolitan Komagome Hospital ( Site 0618) Tokyo 113-8677 Japan Details
Wakayama Medical University Hospital ( Site 0613) Wakayama 641-8510 Japan Details
Chungbuk National University Hospital ( Site 0404) Cheongju si Chungcheongbuk-do [Chungbuk] 28644 Korea, Republic of Details
Gachon University Gil Medical Center ( Site 0408) Incheon Incheon-gwangyeoksi [Incheon] 21565 Korea, Republic of Details
National Cancer Center ( Site 0400) Gyeonggi-do Kyonggi-do 10408 Korea, Republic of Details
Seoul National University Bundang Hospital ( Site 0405) Seongnam-si Kyonggi-do 13620 Korea, Republic of Details
Seoul National University Hospital ( Site 0402) Seoul Seoul-teukbyeolsi [Seoul] 03080 Korea, Republic of Details
Asan Medical Center ( Site 0407) Seoul Seoul-teukbyeolsi [Seoul] 05505 Korea, Republic of Details
Samsung Medical Center ( Site 0403) Seoul Seoul-teukbyeolsi [Seoul] 06351 Korea, Republic of Details
The Catholic University of Korea. Seoul St. Mary s Hospital ( Site 0406) Seoul Seoul-teukbyeolsi [Seoul] 06591 Korea, Republic of Details
Ulsan University Hospital ( Site 0401) Ulsan Ulsan-Kwangyokshi 44033 Korea, Republic of Details
Instituto Jaliscience de Cancerologia ( Site 2000) Guadalajara Jalisco 44280 Mexico Details
Medica Sur S.A.B de C.V. ( Site 2003) Mexico City 14050 Mexico Details
Oaxaca Site Management Organization SC ( Site 2001) Oaxaca 68000 Mexico Details
Instituto Nacional de Cancerologia. ( Site 2007) Tlalpan 14080 Mexico Details
Hospitalo Univ. Germans Trias i Pujol ( Site 1100) Badalona Barcelona [Barcelona] 08916 Spain Details
Hospital de la Santa Creu i Sant Pau ( Site 1102) Barcelona Barcelona [Barcelona] 08025 Spain Details
Hospital Universitari Vall d Hebron ( Site 1106) Barcelona Barcelona [Barcelona] 08035 Spain Details
Hospital Ramon y Cajal ( Site 1101) Madrid 28034 Spain Details
Hospital Universitario 12 de Octubre ( Site 1103) Madrid 28041 Spain Details
Complejo Hospitalario Carlos Haya de Malaga ( Site 1107) Malaga 29010 Spain Details
Hospital Universitario Virgen Macarena ( Site 1104) Sevilla 41009 Spain Details
Linkopings Universitetssjukhus ( Site 1504) Linkoping Ostergotlands Lan [se-05] 581 85 Sweden Details
Skanes Universitetssjukhus Lund ( Site 1503) Lund Skane Lan [se-12] 221 85 Sweden Details
Karolinska Universitetssjukhuset Solna ( Site 1500) Solna Stockholms Lan [se-01] 171 64 Sweden Details
Sahlgrenska Universitetssjukhuset ( Site 1502) Goteborg Vastra Gotalands Lan [se-14] 413 45 Sweden Details
Taipei Tzu Chi Hospital ( Site 0512) New Taipei City New Taipei 231 Taiwan Details
Changhua Christian Hospital ( Site 0509) Changhua 50006 Taiwan Details
National Taiwan University Hospital Hsin-Chu Branch ( Site 0511) Hsinchu 300 Taiwan Details
Hualien Tzu Chi Medical Center-Hospital ( Site 0510) Hualien 970 Taiwan Details
Kaohsiung Chang Gung Memorial Hospital ( Site 0507) Kaohsiung 833 Taiwan Details
Taipei Medical University Shuang Ho Hospital ( Site 0508) New Taipei 235 Taiwan Details
China Medical University Hospital ( Site 0505) Taichung 40447 Taiwan Details
Taichung Veterans General Hospital ( Site 0504) Taichung 40705 Taiwan Details
National Cheng Kung University Hospital ( Site 0506) Tainan 704 Taiwan Details
National Taiwan University Hospital ( Site 0500) Taipei 100 Taiwan Details
Mackay Memorial Hospital ( Site 0503) Taipei 104 Taiwan Details
Taipei Veterans General Hospital ( Site 0501) Taipei 11217 Taiwan Details
Chang Gung Medical Foundation. Linkou ( Site 0502) Taoyuan 333 Taiwan Details
Sussex University Hospitals ( Site 1003) Brighton Brighton And Hove BN2 5BE United Kingdom Details
Western General Hospital ( Site 1009) Edinburgh Edinburgh, City Of EH4 2XU United Kingdom Details
Leicester Royal Infirmary ( Site 1000) Leicester Leicestershire LE1 5WW United Kingdom Details
University College London Hospitals NHS Foundation Trust ( Site 1006) London London, City Of NW1 2PG United Kingdom Details
Chelsea & Westminster Hospital ( Site 1001) London London, City Of SW10 9NH United Kingdom Details
Birmingham Heartlands Hospital ( Site 1002) Birmingham B9 5SS United Kingdom Details
St James s University Hospital ( Site 1008) Leeds LS9 7TF United Kingdom Details
Barking Havering and Redbridge University Hospitals NHS Trust Queen s Hospital ( Site 1004) Romford RM7 0AG United Kingdom Details
*Shaded cells indicate that there was no data available from clinicaltrials.gov for the field