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| NCT ID | NCT03551626 |
| Title | Study of Dabrafenib+Trametinib in the Adjuvant Treatment of Stage III BRAF V600+ Melanoma After Complete Resection to Evaluate the Impact on Pyrexia Related Outcomes (COMBI-APlus) |
| Acronym | COMBI-APlus |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | Novartis Pharmaceuticals |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | TUR | SWE | SVN | SVK | POL | NOR | LVA | LTU | ITA | ISR | HUN | GRC | GBR | FRA | FIN | CZE | CAN | BRA | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Novartis Investigative Site | Rosario | Sante Fe | S200KZE | Argentina | Details | |
| Novartis Investigative Site | Buenos Aires | C1125ABE | Argentina | Details | ||
| Novartis Investigative Site | Cordoba | X5004BAL | Argentina | Details | ||
| Novartis Investigative Site | Woolloongabba | Queensland | 4102 | Australia | Details | |
| Novartis Investigative Site | Cairns | QLD 4870 | Australia | Details | ||
| Novartis Investigative Site | Rio de Janeiro | RJ | 20220410 | Brazil | Details | |
| Novartis Investigative Site | Porto Alegre | RS | 90035-003 | Brazil | Details | |
| Novartis Investigative Site | Sao Paulo | SP | 01246 000 | Brazil | Details | |
| Novartis Investigative Site | Calgary | Alberta | T2N 4N2 | Canada | Details | |
| Novartis Investigative Site | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| Novartis Investigative Site | Hamilton | Ontario | L8V 5C2 | Canada | Details | |
| Novartis Investigative Site | London | Ontario | N6A 4L6 | Canada | Details | |
| Novartis Investigative Site | Ottawa | Ontario | K1H 8L6 | Canada | Details | |
| Novartis Investigative Site | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| Novartis Investigative Site | Toronto | Ontario | M5G 1Z6 | Canada | Details | |
| Novartis Investigative Site | Montreal | Quebec | H3T 1E2 | Canada | Details | |
| Novartis Investigative Site | Quebec | G1R 2J6 | Canada | Details | ||
| Novartis Investigative Site | Brno | Czech Republic | 656 53 | Czechia | Details | |
| Novartis Investigative Site | Prague 8 | Czech Republic | 180 00 | Czechia | Details | |
| Novartis Investigative Site | Zlin | Czech Republic | 762 75 | Czechia | Details | |
| Novartis Investigative Site | Hradec Kralove | CZE | 500 05 | Czechia | Details | |
| Novartis Investigative Site | Ostrava | Poruba | 708 52 | Czechia | Details | |
| Novartis Investigative Site | Prague | Prague 1 | 11000 | Czechia | Details | |
| Novartis Investigative Site | Olomouc | 779 00 | Czechia | Details | ||
| Novartis Investigative Site | Praha | 12808 | Czechia | Details | ||
| Novartis Investigative Site | Helsinki | 9 | Finland | Details | ||
| Novartis Investigative Site | Tampere | FIN-33521 | Finland | Details | ||
| Novartis Investigative Site | Turku | 20520 | Finland | Details | ||
| Novartis Investigative Site | Pierre Benite | Cedex 02 | 69495 | France | Details | |
| Novartis Investigative Site | Limoges | Haute Vienne | 87000 | France | Details | |
| Novartis Investigative Site | Rennes Cedex | Ille Et Vilaine | 35062 | France | Details | |
| Novartis Investigative Site | Besancon Cedex | 25030 | France | Details | ||
| Novartis Investigative Site | Bobigny Cedex | 93009 | France | Details | ||
| Novartis Investigative Site | Bordeaux Cedex | 33075 | France | Details | ||
| Novartis Investigative Site | Boulogne Billancourt | 92104 | France | Details | ||
| Novartis Investigative Site | Clermont Ferrand | 63003 | France | Details | ||
| Novartis Investigative Site | Dijon | 21034 | France | Details | ||
| Novartis Investigative Site | Grenoble Cedex 9 | 38043 | France | Details | ||
| Novartis Investigative Site | Lille Cedex | 59037 | France | Details | ||
| Novartis Investigative Site | Lorient | 56322 | France | Details | ||
| Novartis Investigative Site | Marseille Cedex 05 | 13885 | France | Details | ||
| Novartis Investigative Site | Montpellier | 34295 | France | Details | ||
| Novartis Investigative Site | Nice | 06202 | France | Details | ||
| Novartis Investigative Site | Paris 10 | 75475 | France | Details | ||
| Novartis Investigative Site | Poitiers | 86021 | France | Details | ||
| Novartis Investigative Site | Reims | 51092 | France | Details | ||
| Novartis Investigative Site | Toulouse | 31059 | France | Details | ||
| Novartis Investigative Site | Villejuif | 94800 | France | Details | ||
| Novartis Investigative Site | Athens | 115 27 | Greece | Details | ||
| Novartis Investigative Site | Athens | 18547 | Greece | Details | ||
| Novartis Investigative Site | Athens | GR 115 22 | Greece | Details | ||
| Novartis Investigative Site | Thessaloniki | 54622 | Greece | Details | ||
| Novartis Investigative Site | Budapest | H 1122 | Hungary | Details | ||
| Novartis Investigative Site | Pecs | 7623 | Hungary | Details | ||
| Novartis Investigative Site | Szeged | H 6725 | Hungary | Details | ||
| Novartis Investigative Site | Jerusalem | 9112001 | Israel | Details | ||
| Novartis Investigative Site | Ramat Gan | 52621 | Israel | Details | ||
| Novartis Investigative Site | Bergamo | BG | 24127 | Italy | Details | |
| Novartis Investigative Site | Meldola | FC | 47014 | Italy | Details | |
| Novartis Investigative Site | Antella - Bagno A Ripoli | FI | 50011 | Italy | Details | |
| Novartis Investigative Site | Genova | GE | 16132 | Italy | Details | |
| Novartis Investigative Site | Milano | MI | 20133 | Italy | Details | |
| Novartis Investigative Site | Milano | MI | 20141 | Italy | Details | |
| Novartis Investigative Site | Modena | MO | 41124 | Italy | Details | |
| Novartis Investigative Site | Palermo | PA | 90127 | Italy | Details | |
| Novartis Investigative Site | Padova | PD | 35100 | Italy | Details | |
| Novartis Investigative Site | Roma | RM | 00128 | Italy | Details | |
| Novartis Investigative Site | Roma | RM | 00167 | Italy | Details | |
| Novartis Investigative Site | Torino | TO | 10126 | Italy | Details | |
| Novartis Investigative Site | Udine | UD | 33100 | Italy | Details | |
| Novartis Investigative Site | Napoli | 80131 | Italy | Details | ||
| Novartis Investigative Site | Sapporo | Hokkaido | 060-8543 | Japan | Details | |
| Novartis Investigative Site | Chuo ku | Tokyo | 104 0045 | Japan | Details | |
| Novartis Investigative Site | Riga | LV 1079 | Latvia | Details | ||
| Novartis Investigative Site | Vilnius | LT-08660 | Lithuania | Details | ||
| Novartis Investigative Site | Alesund | NO-6026 | Norway | Details | ||
| Novartis Investigative Site | Oslo | 0379 | Norway | Details | ||
| Novartis Investigative Site | Gdansk | 80 952 | Poland | Details | ||
| Novartis Investigative Site | Warszawa | 02 781 | Poland | Details | ||
| Novartis Investigative Site | Wroclaw | 53 413 | Poland | Details | ||
| Novartis Investigative Site | Porto | 4200-072 | Portugal | Details | ||
| Novartis Investigative Site | Moscow Region Istra Village | 143423 | Russian Federation | Details | ||
| Novartis Investigative Site | Moscow | 115478 | Russian Federation | Details | ||
| Novartis Investigative Site | Omsk | 644013 | Russian Federation | Details | ||
| Novartis Investigative Site | St Petersburg | 197758 | Russian Federation | Details | ||
| Novartis Investigative Site | Bratislava | 812 50 | Slovakia | Details | ||
| Novartis Investigative Site | Kosice | 04191 | Slovakia | Details | ||
| Novartis Investigative Site | Ljubljana | 1000 | Slovenia | Details | ||
| Novartis Investigative Site | Goteborg | SE-413 45 | Sweden | Details | ||
| Novartis Investigative Site | Orebro | 701 85 | Sweden | Details | ||
| Novartis Investigative Site | Stockholm | SE 171 76 | Sweden | Details | ||
| Novartis Investigative Site | Umea | SE 901 85 | Sweden | Details | ||
| Novartis Investigative Site | Izmir | 35040 | Turkey | Details | ||
| Novartis Investigative Site | Bristol | Avon | BS2 8ED | United Kingdom | Details | |
| Novartis Investigative Site | Northwood | Middlesex | HA6 2RN | United Kingdom | Details | |
| Novartis Investigative Site | Sheffield | South Yorkshire | S10 2JF | United Kingdom | Details | |
| Novartis Investigative Site | Cambridge | CB2 2QQ | United Kingdom | Details | ||
| Novartis Investigative Site | Leeds | LS9 7TF | United Kingdom | Details | ||
| Novartis Investigative Site | Manchester | M20 4BX | United Kingdom | Details | ||
| Novartis Investigative Site | Southampton | SO16 6YD | United Kingdom | Details |