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| NCT ID | NCT03580655 |
| Title | (PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase II |
| Variant Requirements | No |
| Sponsors | Blueprint Medicines Corporation |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | POL | NOR | NLD | ITA | GBR | FRA | ESP | DNK | DEU | CAN | AUT |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Stanford Cancer Institute | Stanford | California | 94305 | United States | Details | |
| Rush University Medical Center | Chicago | Illinois | 60612 | United States | Details | |
| The University of Kansas Cancer Center | Westwood | Kansas | 66205 | United States | Details | |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | United States | Details | |
| University of Michigan | Ann Arbor | Michigan | 48109 | United States | Details | |
| Washington University School of Medicine | Saint Louis | Missouri | 63110 | United States | Details | |
| Roswell Park Comprehensive Cancer Center | Buffalo | New York | 14263 | United States | Details | |
| Herbert Irving Comprehensive Cancer Center | New York | New York | 10032 | United States | Details | |
| University of Pennsylvania, Abramson Cancer Center | Philadelphia | Pennsylvania | 19104 | United States | Details | |
| University of Texas, MD Anderson Cancer Center | Houston | Texas | 77030 | United States | Details | |
| Mays Cancer Center | San Antonio | Texas | 78229 | United States | Details | |
| Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | United States | Details | |
| Medizinische Universität Wien, Universitätsklinik für Innere Medizin I, Klinische Abteilung für Hämatologie und Hämostaseologie | Vienna | 1090 | Austria | Details | ||
| St. Michael's Hospital | Toronto | Ontario | M5B 1W8 | Canada | Details | |
| Odense University Hospital, Department of Haematology | Odense | DK-5000 | Denmark | Details | ||
| Hôpital Necker-Enfants Malades | Paris | 75015 | France | Details | ||
| CHU Toulouse - Hôpital Larrey | Toulouse | 31059 | France | Details | ||
| Uniklinik RWTH Aachen, Klinik für Hämatologie, Onkologie, Hämostaseologie und Stammzelltranslplantation | Aachen | 52074 | Germany | Details | ||
| Universitätsklinikum Hamburg-Eppendorf, Zentrum für Onkologie | Hamburg | 20246 | Germany | Details | ||
| Universitätsklinikum Leipzig, Medizinische Klinik und Poliklinik I - Hämatologie und Zelltherapie, lnternistische Onkologie, Hämostaseologie | Leipzig | 04103 | Germany | Details | ||
| Universitätsmedizin Mannheim III. Medizinische Klinik | Mannheim | 68167 | Germany | Details | ||
| Klinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar der TU München | Munich | 81675 | Germany | Details | ||
| Azienda Ospedaliero-Universitaria Careggi, CRIMM - Centro di Ricerca ed Innovazione per le Malattie Mieloproliferative | Florence | 50134 | Italy | Details | ||
| A.O. OO.RR. S.Giovanni di Dio e Ruggi d'Aragona, University of Salerno | Salerno | 84131 | Italy | Details | ||
| Centro Ricerche Cliniche di Verona - Azienda Ospedaliera Universitaria Integrata di Verona | Verona | 37134 | Italy | Details | ||
| University Medical Center Groningen (UMCG) | Groningen | 9713 GZ | Netherlands | Details | ||
| Oslo University Hospital-Rikshospitalet, Hematology | Oslo | 0372 | Norway | Details | ||
| Uniwersyteckie Centrum Kliniczne, Klinika Hematologii i Transplantologii | Gdańsk | 80-214 | Poland | Details | ||
| Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu, Klinice Hematologii, Nowotworów Krwi i Transplantacji Szpiku | Wrocław | 50-367 | Poland | Details | ||
| lnstituto de Estudios de Mastocitosis de Castilla la Mancha, Hospital Virgen del Valle - Complejo Hospitalario de Toledo | Toledo | 45071 | Spain | Details | ||
| Beatson West of Scotland Cancer Centre - NHS Greater Glasgow and Clyde | Glasgow | G12 0YN | United Kingdom | Details | ||
| Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital | London | SE1 9RT | United Kingdom | Details |