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| NCT ID | NCT03600883 |
| Title | A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of Sotorasib (AMG 510) in Subjects With Solid Tumors With a Specific KRAS Mutation (CodeBreaK 100) |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase Ib/II |
| Variant Requirements | No |
| Sponsors | Amgen |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | ROU | HUN | GRC | FRA | ESP | DEU | CHE | CAN | BRA | BEL | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| City of Hope National Medical Center | Duarte | California | 91010 | United States | Details | |
| University of California Los Angeles | Los Angeles | California | 90095 | United States | Details | |
| University of California at SF | San Francisco | California | 94115 | United States | Details | |
| Sarcoma Oncology Research Center LLC | Santa Monica | California | 90403 | United States | Details | |
| Rocky Mountain Cancer Centers | Denver | Colorado | 80218 | United States | Details | |
| Sarah Cannon Research Institute at HealthONE | Denver | Colorado | 80218 | United States | Details | |
| Smilow Cancer Hospital at Yale New Haven | New Haven | Connecticut | 06510 | United States | Details | |
| Medical Oncology Hematology Consultants Helen F Graham Cancer Center | Newark | Delaware | 19713 | United States | Details | |
| University of Florida Health | Gainesville | Florida | 32610 | United States | Details | |
| AdventHealth Orlando Infusion Center | Orlando | Florida | 32804 | United States | Details | |
| Moffitt Cancer Center | Tampa | Florida | 33612 | United States | Details | |
| Winship Cancer Institute | Atlanta | Georgia | 30322 | United States | Details | |
| Indiana University | Indianapolis | Indiana | 46202 | United States | Details | |
| American Oncology Partners of Maryland, PA | Bethesda | Maryland | 20817 | United States | Details | |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States | Details | |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | United States | Details | |
| University of Michigan | Ann Arbor | Michigan | 48109 | United States | Details | |
| Henry Ford Health System | Detroit | Michigan | 48202 | United States | Details | |
| Washington University | Saint Louis | Missouri | 63110-1093 | United States | Details | |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | United States | Details | |
| Laura and Isaac Perlmutter Cancer Center at New York University Langone | New York | New York | 10016 | United States | Details | |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | United States | Details | |
| Duke University Medical Center, Morris Cancer Clinic | Durham | North Carolina | 27710 | United States | Details | |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | United States | Details | |
| Cleveland Clinic | Cleveland | Ohio | 44195 | United States | Details | |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | United States | Details | |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | United States | Details | |
| University of Pittsburgh Medical Center Cancer Pavillion | Pittsburgh | Pennsylvania | 15232 | United States | Details | |
| Gibbs Cancer Center and Research Institute - Spartanburg | Spartanburg | South Carolina | 29303 | United States | Details | |
| Vanderbilt University Ingram Cancer Center | Nashville | Tennessee | 37232 | United States | Details | |
| Texas Oncology - Austin Central | Austin | Texas | 78731 | United States | Details | |
| Texas Oncology - Baylor | Dallas | Texas | 75246 | United States | Details | |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | United States | Details | |
| University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | United States | Details | |
| Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | United States | Details | |
| US Oncology Research Investigational Products Center | Fairfax | Virginia | 22031 | United States | Details | |
| Virginia Cancer Specialists PC | Fairfax | Virginia | 22031 | United States | Details | |
| Blue Ridge Cancer Care | Salem | Virginia | 24153 | United States | Details | |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | United States | Details | |
| Scientia Clinical Research Ltd | Randwick | New South Wales | 2031 | Australia | Details | |
| Princess Alexandra Hospital | Woolloongabba | Queensland | 4102 | Australia | Details | |
| The Queen Elizabeth Hospital | Woodville South | South Australia | 5011 | Australia | Details | |
| Peter MacCallum Cancer Centre | Parkville | Victoria | 3050 | Australia | Details | |
| Medizinische Universitaet Graz | Graz | 8036 | Austria | Details | ||
| Medizinische Universitaet Innsbruck | Innsbruck | 6020 | Austria | Details | ||
| Universitaetsklinikum Krems | Krems | 3500 | Austria | Details | ||
| Universitaetsklinikum Allgemeines Krankenhaus Wien | Wien | 1090 | Austria | Details | ||
| Krankenhaus Nord - Klinik Floridsdorf | Wien | 1210 | Austria | Details | ||
| Institut Jules Bordet | Brussels | B-1070 | Belgium | Details | ||
| Grand Hopital de Charleroi | Charleroi | 6000 | Belgium | Details | ||
| Universitair Ziekenhuis Antwerpen | Edegem | 2650 | Belgium | Details | ||
| Ziekenhuis Oost-Limburg | Genk | 3600 | Belgium | Details | ||
| Universitair Ziekenhuis Gent | Gent | 9000 | Belgium | Details | ||
| Jessa Ziekenhuis - Campus Virga Jesse | Hasselt | 3500 | Belgium | Details | ||
| Universitair Ziekenhuis Leuven - Campus Gasthuisberg | Leuven | 3000 | Belgium | Details | ||
| Centre Hospitalier Universitaire de Liege | Liege | 4000 | Belgium | Details | ||
| AZ Delta Campus Rumbeke | Roeselare | 8800 | Belgium | Details | ||
| Irmandade da Santa Casa de Misericordia de Porto Alegre, Nucleo de Novos Tratamentos em Cancer | Porto Alegre | Rio Grande Do Sul | 90050-170 | Brazil | Details | |
| Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul | Porto Alegre | Rio Grande Do Sul | 90610-000 | Brazil | Details | |
| Sociedade Beneficente de Senhoras Hospital Sirio Libanes | Sao Paulo | São Paulo | 01308-050 | Brazil | Details | |
| Oncologia Rede D´Or | Sao Paulo | São Paulo | 04501-000 | Brazil | Details | |
| Hospital de Base de Sao Jose do Rio Preto | São José do Rio Preto | São Paulo | 15090-000 | Brazil | Details | |
| Instituto Coi | Rio de Janeiro | 20231-050 | Brazil | Details | ||
| Tom Baker Cancer Centre | Calgary | Alberta | T2N 4N2 | Canada | Details | |
| Cross Cancer Institute | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| London Regional Cancer Program, London Health Sciences Centre | London | Ontario | N6A 5W9 | Canada | Details | |
| The Ottawa Hospital Cancer Centre | Ottawa | Ontario | K1H 8L6 | Canada | Details | |
| Princess Margaret Cancer Centre | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| McGill University Health Centre Glen Site | Montreal | Quebec | H4A 3J1 | Canada | Details | |
| Institut Bergonie | Bordeaux | 33076 | France | Details | ||
| Centre Hospitalier Intercommunal de Créteil | Créteil | 94010 | France | Details | ||
| Hopital de la Timone | Marseille cedex 5 | 13385 | France | Details | ||
| Institut Curie | Paris | 75005 | France | Details | ||
| Institut Claudius Regaud | Toulouse cedex 9 | 31059 | France | Details | ||
| Gustave Roussy | Villejuif | 94805 | France | Details | ||
| Universitätsklinikum Essen | Essen | 45147 | Germany | Details | ||
| Universitatsklinikum Koln | Köln | 50937 | Germany | Details | ||
| Klinikum der Universität München Campus Grosshadern | München | 81377 | Germany | Details | ||
| Henry Dunant Hospital Center | Athens | 11526 | Greece | Details | ||
| Metropolitan Hospital | Athens | 18547 | Greece | Details | ||
| University Hospital of Heraklion | Heraklion - Crete | 71500 | Greece | Details | ||
| Theagenion Cancer Hospital | Thessaloniki | 54007 | Greece | Details | ||
| Agios Loukas Clinic | Thessaloniki | 55236 | Greece | Details | ||
| Semmelweis Egyetem | Budapest | 1083 | Hungary | Details | ||
| Orszagos Koranyi Pulmonologiai Intezet | Budapest | 1121 | Hungary | Details | ||
| Somogy Megyei Kaposi Mor Oktato Korhaz | Kaposvar | 7400 | Hungary | Details | ||
| Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz | Szekesfehervar | 8000 | Hungary | Details | ||
| Szent Borbala Korhaz | Tatabanya | 2800 | Hungary | Details | ||
| Tudogyogyintezet Torokbalint | Torokbalint | 2045 | Hungary | Details | ||
| Aichi Cancer Center | Nagoya-shi | Aichi | 464-8681 | Japan | Details | |
| National Cancer Center Hospital East | Kashiwa-shi | Chiba | 277-8577 | Japan | Details | |
| National Hospital Organization Shikoku Cancer Center | Matsuyama-shi | Ehime | 791-0280 | Japan | Details | |
| National Hospital Organization Kyushu Cancer Center | Fukuoka-shi | Fukuoka | 811-1395 | Japan | Details | |
| National Hospital Organization Hokkaido Cancer Center | Sapporo-shi | Hokkaido | 003-0804 | Japan | Details | |
| St Marianna University Hospital | Kawasaki-shi | Kanagawa | 216-8511 | Japan | Details | |
| Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center | Yokohama-shi | Kanagawa | 241-8515 | Japan | Details | |
| Sendai Kousei Hospital | Sendai-shi | Miyagi | 980-0873 | Japan | Details | |
| Niigata Cancer Center Hospital | Niigata-shi | Niigata | 951-8566 | Japan | Details | |
| Okayama University Hospital | Okayama-shi | Okayama | 700-8558 | Japan | Details | |
| Kansai Medical University Hospital | Hirakata-shi | Osaka | 573-1191 | Japan | Details | |
| Osaka International Cancer Institute | Osaka-shi | Osaka | 541-8567 | Japan | Details | |
| Shizuoka Cancer Center | Sunto-gun | Shizuoka | 411-8777 | Japan | Details | |
| The Cancer Institute Hospital of Japanese Foundation for Cancer Research | Koto-ku | Tokyo | 135-8550 | Japan | Details | |
| Wakayama Medical University Hospital | Wakayama-shi | Wakayama | 641-8510 | Japan | Details | |
| National Cancer Center | Goyang-si Gyeonggi-do | 10408 | Korea, Republic of | Details | ||
| Seoul National University Bundang Hospital | Seongnam-si, Gyeonggi-do | 13620 | Korea, Republic of | Details | ||
| Seoul National University Hospital | Seoul | 03080 | Korea, Republic of | Details | ||
| Severance Hospital Yonsei University Health System | Seoul | 03722 | Korea, Republic of | Details | ||
| Asan Medical Center | Seoul | 05505 | Korea, Republic of | Details | ||
| Samsung Medical Center | Seoul | 06351 | Korea, Republic of | Details | ||
| The Catholic University of Korea Seoul St Marys Hospital | Seoul | 06591 | Korea, Republic of | Details | ||
| Fundacao Champalimaud | Lisboa | 1400-038 | Portugal | Details | ||
| Centro Hospitalar Universitario de Lisboa Norte EPE - Hospital Pulido Valente | Lisboa | 1769-001 | Portugal | Details | ||
| Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano | Matosinhos | 4464-513 | Portugal | Details | ||
| Centro Hospitalar Universitario do Porto EPE - Hospital de Santo Antonio | Porto | 4099-001 | Portugal | Details | ||
| Hospital Cuf porto | Porto | 4100-180 | Portugal | Details | ||
| Institutul Oncologic, Prof Dr Alexandru Trestioreanu | Bucuresti | 022328 | Romania | Details | ||
| Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca | Cluj Napoca | 400015 | Romania | Details | ||
| SC Medisprof SRL | Cluj Napoca | 400641 | Romania | Details | ||
| Centrul de Radioterapie Amethyst Cluj | Cluj Napoca | 407280 | Romania | Details | ||
| Centrul de Oncologie Sf Nectarie SRL | Craiova | 200347 | Romania | Details | ||
| Institutul Regional de Oncologie Iasi | Iasi | 700483 | Romania | Details | ||
| Spitalul Municipal Ploiesti | Ploiesti | 100337 | Romania | Details | ||
| SC Oncomed SRL | Timisoara | 300239 | Romania | Details | ||
| Hospital Universitari Germans Trias i Pujol | Badalona | Cataluña | 08916 | Spain | Details | |
| Hospital General Universitario de Valencia | Valencia | Comunidad Valenciana | 46014 | Spain | Details | |
| Hospital General Universitario Gregorio Marañon | Madrid | 28009 | Spain | Details | ||
| Clinica Universidad de Navarra | Madrid | 28027 | Spain | Details | ||
| Fundacion Jimenez Diaz | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario Madrid Sanchinarro | Madrid | 28050 | Spain | Details | ||
| Universitaetsspital Basel | Basel | 4031 | Switzerland | Details | ||
| Hopitaux Universitaires de Geneve | Geneve | 1211 | Switzerland | Details | ||
| Universitaetsspital Zuerich | Zurich | 8091 | Switzerland | Details |