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| NCT ID | NCT03713593 |
| Title | Safety and Efficacy of Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) Versus Lenvatinib as First-line Therapy in Participants With Advanced Hepatocellular Carcinoma (MK-7902-002/E7080-G000-311/LEAP-002) |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Merck Sharp & Dohme Corp. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | POL | NZL | ITA | IRL | GBR | FRA | ESP | DEU | CAN | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| The University of Arizona Cancer Center - North Campus ( Site 0621) | Tucson | Arizona | 85721 | United States | Details | |
| City of Hope Comprehensive Cancer Center ( Site 0587) | Duarte | California | 91010 | United States | Details | |
| Scripps Health ( Site 0644) | La Jolla | California | 92037 | United States | Details | |
| Pacific Hematology Oncology Associates ( Site 0588) | San Francisco | California | 94115 | United States | Details | |
| UCLA ( Site 0589) | Santa Monica | California | 90404 | United States | Details | |
| Georgetown University ( Site 0594) | Washington | District of Columbia | 20007 | United States | Details | |
| University of Miami, Sylvester Comprehensive Cancer Center ( Site 0596) | Miami | Florida | 33136 | United States | Details | |
| Advent Health ( Site 0595) | Orlando | Florida | 32804 | United States | Details | |
| Tampa General Medical Group ( Site 0629) | Tampa | Florida | 33606 | United States | Details | |
| Emory University Winship Cancer Institute ( Site 0639) | Atlanta | Georgia | 30322 | United States | Details | |
| University of Kansas Cancer Center ( Site 0600) | Westwood | Kansas | 66205 | United States | Details | |
| Massachusetts General Hospital ( Site 0603) | Boston | Massachusetts | 02114 | United States | Details | |
| Beth Israel Deaconess Medical Center ( Site 0716) | Boston | Massachusetts | 02215 | United States | Details | |
| Icahn School of Medicine at Mount Sinai ( Site 0611) | New York | New York | 10029 | United States | Details | |
| University of Rochester ( Site 0613) | Rochester | New York | 14642 | United States | Details | |
| Stony Brook University Medical Center - Cancer Center ( Site 0612) | Stony Brook | New York | 11794 | United States | Details | |
| University of Oklahoma Health Science Center ( Site 0625) | Oklahoma City | Oklahoma | 73104 | United States | Details | |
| Oregon Health & Science University ( Site 0645) | Portland | Oregon | 97239 | United States | Details | |
| Eastern Regional Medical Center, Inc. ( Site 0626) | Philadelphia | Pennsylvania | 19124 | United States | Details | |
| Central Texas Veterans Healthcare System ( Site 0617) | Temple | Texas | 76504 | United States | Details | |
| Cancer Care Northwest ( Site 0636) | Spokane | Washington | 99218 | United States | Details | |
| Royal Prince Alfred Hospital ( Site 0001) | Camperdown | New South Wales | 2050 | Australia | Details | |
| Princess Alexandra Hospital ( Site 0007) | Wooloongabba | Queensland | 4102 | Australia | Details | |
| Monash Health-Monash Medical Centre ( Site 0004) | Clayton | Victoria | 3168 | Australia | Details | |
| St Vincents Hospital Melbourne ( Site 0003) | Fitzroy | Victoria | 3065 | Australia | Details | |
| Liverpool Hospital. ( Site 0002) | Liverpool | 2170 | Australia | Details | ||
| BC Cancer-Vancouver Center ( Site 0056) | Vancouver | British Columbia | V5Z 4E6 | Canada | Details | |
| London Health Sciences Centre ( Site 0053) | London | Ontario | N6A 5A5 | Canada | Details | |
| Sunnybrook Research Institute ( Site 0055) | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| Princess Margaret Cancer Centre ( Site 0050) | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| McGill University Health Centre ( Site 0052) | Montreal | Quebec | H4A 3J1 | Canada | Details | |
| Clinica Universidad Catolica del Maule ( Site 0065) | Talca | Region Del Maule | 3465584 | Chile | Details | |
| Fundacion Arturo Lopez Perez ( Site 0064) | Santiago | Region Metropolitana De Santiago | 7500921 | Chile | Details | |
| Pontificia Universidad Catolica de Chile ( Site 0070) | Santiago | Region Metropolitana De Santiago | 8330024 | Chile | Details | |
| Instituto Clinico Oncologico del Sur ( Site 0067) | Temuco | 4810469 | Chile | Details | ||
| First Affiliated Hospital of Anhui Medical University ( Site 0095) | Hefei | Anhui | 230088 | China | Details | |
| Cancer Hospital Chinese Academy of Medical Sciences ( Site 0100) | Beijing | Beijing | 100021 | China | Details | |
| Beijing Cancer Hospital ( Site 0088) | Beijing | Beijing | 100142 | China | Details | |
| 900 Hospital of the Joint ( Site 0091) | Fuzhou | Fujian | 350025 | China | Details | |
| Guangdong General Hospital ( Site 0092) | Guangzhou | Guangdong | 510080 | China | Details | |
| Southern Medical University Nanfang Hospital ( Site 0102) | Guangzhou | Guangdong | 510515 | China | Details | |
| Harbin Medical University Cancer Hospital ( Site 0089) | Harbin | Heilongjiang | 610000 | China | Details | |
| Wuhan Union hospital Cancer Center ( Site 0105) | Wuhan | Hubei | 430022 | China | Details | |
| Hunan Cancer Hospital ( Site 0094) | Changsha | Hunan | 410006 | China | Details | |
| The Third Xiangya Hospital of Central South University ( Site 0093) | Changsha | Hunan | 410013 | China | Details | |
| The 81st Hospital of PLA ( Site 0085) | Nanjing | Jiangsu | 210031 | China | Details | |
| Fudan University Shanghai Cancer Center ( Site 0086) | Shanghai | Shanghai | 200032 | China | Details | |
| The First Affiliated Hospital of Xi an Jiaotong University ( Site 0090) | XI An | Shanxi | 710061 | China | Details | |
| West China Hospital of Sichuan University ( Site 0087) | Chengdu | Sichuan | 610000 | China | Details | |
| Affiliated Tumor Hospital of Xinjiang Medical University ( Site 0109) | Urumqi | Xinjiang | 830001 | China | Details | |
| The First Affiliated Hospital of Zhejiang University ( Site 0097) | Hangzhou | Zhejiang | 310003 | China | Details | |
| Sir Run Run Shaw Hospital ( Site 0110) | Hangzhou | Zhejiang | 310016 | China | Details | |
| Zhejiang Cancer Hospital ( Site 0101) | Hangzhou | Zhejiang | 310022 | China | Details | |
| Zhongshan Hospital Fudan University ( Site 0096) | Shanghai | 200032 | China | Details | ||
| Fundacion Centro de Investigacion Clinica CIC ( Site 0141) | Medellin | Antioquia | 050021 | Colombia | Details | |
| Hospital Pablo Tobon Uribe ( Site 0144) | Medellin | Antioquia | 050034 | Colombia | Details | |
| Hospital General de Medellin Luz Castro de Gutierrez ( Site 0137) | Medellin | Antioquia | 500515 | Colombia | Details | |
| Biomelab S A S ( Site 0145) | Barranquilla | Atlantico | 080002 | Colombia | Details | |
| Administradora Country SA - Clinica del Country ( Site 0146) | Bogota | Distrito Capital De Bogota | 110221 | Colombia | Details | |
| Instituto Nacional de Cancerologia E.S.E ( Site 0142) | Bogota | Distrito Capital De Bogota | 111511 | Colombia | Details | |
| Fundacion Valle del Lili ( Site 0140) | Cali | Valle Del Cauca | 760032 | Colombia | Details | |
| Centro Medico Imbanaco de Cali S.A ( Site 0139) | Cali | Valle Del Cauca | 760042 | Colombia | Details | |
| Institut Sainte Catherine ( Site 0167) | Avignon | 84918 | France | Details | ||
| Hopital Beaujon ( Site 0160) | Clichy | 92110 | France | Details | ||
| CHU Henri Mondor ( Site 0162) | Creteil | 94000 | France | Details | ||
| CHRU de Lille - Hopital Claude Huriez ( Site 0159) | Lille | 59037 | France | Details | ||
| Hopital de la Croix Rousse ( Site 0157) | Lyon | 69004 | France | Details | ||
| Hopital Saint Joseph ( Site 0166) | Marseille | 13285 | France | Details | ||
| Centre Hospitalier Regional du Orleans ( Site 0169) | Orleans | 45100 | France | Details | ||
| Centre Eugene Marquis ( Site 0158) | Rennes | 35042 | France | Details | ||
| CHU de Nancy Hopital Brabois Adultes ( Site 0164) | Vandoeuvre les Nancy | 54500 | France | Details | ||
| Klinikum der Universitaet Aachen - RWTH ( Site 0185) | Aachen | 52074 | Germany | Details | ||
| Universitaetsklinikum Carl Gustav Carus der TU Dresden ( Site 0178) | Dresden | 01307 | Germany | Details | ||
| Universitaetsklinikum Essen ( Site 0188) | Essen | 45147 | Germany | Details | ||
| Universitaetsklinikum Frankfurt ( Site 0180) | Frankfurt am Main | 60596 | Germany | Details | ||
| Universitaetsklinikum Hamburg-Eppendorf ( Site 0184) | Hamburg | 20246 | Germany | Details | ||
| Universitaetsklinik Koeln ( Site 0189) | Koeln | 50937 | Germany | Details | ||
| Universitaetsklinikum Leipzig ( Site 0187) | Leipzig | 04103 | Germany | Details | ||
| Otto-Von-Guericke-Universitaet Magdeburg ( Site 0182) | Magdeburg | 39120 | Germany | Details | ||
| Universitaetsklinikum Tuebingen ( Site 0179) | Tuebingen | 72076 | Germany | Details | ||
| Universitaetsklinikum Wuerzburg ( Site 0186) | Wuerzburg | 97080 | Germany | Details | ||
| St Vincents University Hospital ( Site 0242) | Dublin | D04 T6F4 | Ireland | Details | ||
| Mater Misericordiae University Hospital ( Site 0241) | Dublin | D07 R2WY | Ireland | Details | ||
| Ospedale Sacro Cuore - Don Calabria ( Site 0289) | Negrar | VR | 37024 | Italy | Details | |
| Centro di Riferimento Oncologico de Aviano Istituto Nazionale Tumori ( Site 0292) | Aviano | 33081 | Italy | Details | ||
| Policlinico S. Orsola-Malpighi ( Site 0286) | Bologna | 40138 | Italy | Details | ||
| Istituto Oncologico Veneto ( Site 0287) | Padova | 35128 | Italy | Details | ||
| Az Osp Univ Policlin Paolo Giaccone ( Site 0284) | Palermo | 90127 | Italy | Details | ||
| Fondazione Salvatore Maugeri IRCCS. ( Site 0290) | Pavia | 27100 | Italy | Details | ||
| Azienda Ospedaliero-Univers. Pisana Ospedale S. Chiara ( Site 0291) | Pisa | 56126 | Italy | Details | ||
| Policlinico Universitario Campus Biomedico ( Site 0288) | Roma | 00128 | Italy | Details | ||
| Aichi Cancer Center Hospital ( Site 0316) | Nagoya | Aichi | 464-8681 | Japan | Details | |
| National Cancer Center Hospital East ( Site 0306) | Kashiwa | Chiba | 277-8577 | Japan | Details | |
| Kurume University Hospital ( Site 0322) | Kurume | Fukuoka | 830-0011 | Japan | Details | |
| Hokkaido P.W.F.A.C Sapporo-Kosei General Hospital ( Site 0304) | Sapporo | Hokkaido | 060-0033 | Japan | Details | |
| Kanazawa University Hospital ( Site 0315) | Kanazawa | Ishikawa | 920-8641 | Japan | Details | |
| Kagawa University Hospital ( Site 0324) | Kita-gun | Kagawa | 761-0793 | Japan | Details | |
| Kagawa Prefectural Central Hospital ( Site 0325) | Takamatsu | Kagawa | 760-8557 | Japan | Details | |
| Toranomon Hospital Kajigaya ( Site 0312) | Kawasaki | Kanagawa | 213-8587 | Japan | Details | |
| Yokohama City University Medical Center ( Site 0313) | Yokohama | Kanagawa | 232-0024 | Japan | Details | |
| Kanagawa Cancer Center ( Site 0314) | Yokohama | Kanagawa | 241-8515 | Japan | Details | |
| Kindai University Hospital ( Site 0319) | Osakasayama | Osaka | 589-8511 | Japan | Details | |
| Kyorin University Hospital ( Site 0309) | Mitaka | Tokyo | 181-8611 | Japan | Details | |
| Musashino Red Cross Hospital ( Site 0310) | Musashino | Tokyo | 180-8610 | Japan | Details | |
| Chiba University Hospital ( Site 0305) | Chiba | 260-8677 | Japan | Details | ||
| National Hospital Organization Kyushu Medical Center ( Site 0321) | Fukuoka | 810-8563 | Japan | Details | ||
| Hiroshima University Hospital ( Site 0320) | Hiroshima | 734-8551 | Japan | Details | ||
| Osaka Red Cross Hospital ( Site 0317) | Osaka | 543-8555 | Japan | Details | ||
| Saga-Ken Medical Centre Koseikan ( Site 0323) | Saga | 840-8571 | Japan | Details | ||
| National Cancer Center Hospital ( Site 0307) | Tokyo | 104-0045 | Japan | Details | ||
| Toranomon Hospital ( Site 0311) | Tokyo | 105-8470 | Japan | Details | ||
| The University of Tokyo Hospital ( Site 0308) | Tokyo | 113-8655 | Japan | Details | ||
| Wakayama Medical University Hospital ( Site 0318) | Wakayama | 641-8510 | Japan | Details | ||
| Seoul National University Bundang Hospital ( Site 0464) | Seongnam-si | Kyonggi-do | 13620 | Korea, Republic of | Details | |
| Seoul National University Hospital ( Site 0462) | Seoul | Seoul-teukbyeolsi [Seoul] | 03080 | Korea, Republic of | Details | |
| Yonsei University Severance Hospital ( Site 0463) | Seoul | Seoul-teukbyeolsi [Seoul] | 03722 | Korea, Republic of | Details | |
| Asan Medical Center ( Site 0460) | Seoul | Seoul-teukbyeolsi [Seoul] | 05505 | Korea, Republic of | Details | |
| Samsung Medical Center ( Site 0461) | Seoul | 06351 | Korea, Republic of | Details | ||
| Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran ( Site 0363) | Ciudad de Mexico | Cdmx | 14080 | Mexico | Details | |
| Hospital Civil de Guadalajara Fray Antonio Alcalde ( Site 0365) | Guadalajara | Jalisco | 44280 | Mexico | Details | |
| Centro de Investigacion Medica Aguascalientes ( Site 0355) | Aguascalientes | 20116 | Mexico | Details | ||
| Medical Care and Research S.A. de C.V. ( Site 0359) | Merida | 97070 | Mexico | Details | ||
| CRYPTEX Investigacion Clinica S.A. de C.V. ( Site 0362) | Mexico City | 06100 | Mexico | Details | ||
| Oaxaca Site Management Organization S.C. ( Site 0366) | Oaxaca | 68000 | Mexico | Details | ||
| Unidad Medica Oncologica ( Site 0369) | Puebla | 72530 | Mexico | Details | ||
| Auckland City Hospital ( Site 0376) | Auckland | 1023 | New Zealand | Details | ||
| Christchurch Hospital ( Site 0377) | Christchurch | 8011 | New Zealand | Details | ||
| Wojewodzki Szpital Specjalistyczny nr 4 w Bytomiu ( Site 0419) | Bytom | Slaskie | 41-902 | Poland | Details | |
| Szpital Wojewodzki w Koszalinie im. Mikolaja Kopernika ( Site 0421) | Koszalin | Zachodniopomorskie | 75-581 | Poland | Details | |
| ID Clinic ( Site 0431) | Myslowice | 41-400 | Poland | Details | ||
| Ars Medical Sp. z o.o. ( Site 0433) | Pila | 64-920 | Poland | Details | ||
| MTZ Clinical Research Sp. z o. o. ( Site 0427) | Warsaw | 02-106 | Poland | Details | ||
| Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0418) | Warszawa | 02-034 | Poland | Details | ||
| N.N. Blokhin NMRCO ( Site 0439) | Moscow | Moskva | 115478 | Russian Federation | Details | |
| First Moscow State Medical University n.a. I.M.Sechenov ( Site 0453) | Moscow | Moskva | 119881 | Russian Federation | Details | |
| Railway Hospital of OJSC ( Site 0447) | Saint Petersburg | Sankt-Peterburg | 195271 | Russian Federation | Details | |
| City Clinical Oncology Center ( Site 0446) | Saint Petersburg | Sankt-Peterburg | 198255 | Russian Federation | Details | |
| Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 0450) | Krasnoyarsk | 660133 | Russian Federation | Details | ||
| Pyatigorsk Oncology Dispensary ( Site 0441) | Pyatigorsk | 357502 | Russian Federation | Details | ||
| Hospital Universitari Vall d Hebron ( Site 0508) | Barcelona | Barcelona [Barcelona] | 08035 | Spain | Details | |
| Hospital Universitario Puerta de Hierro ( Site 0513) | Majadahonda | Madrid | 28222 | Spain | Details | |
| Hospital General Universitario Gregorio Maranon ( Site 0504) | Madrid | 28007 | Spain | Details | ||
| Hospital Universitario Ramon y Cajal ( Site 0514) | Madrid | 28034 | Spain | Details | ||
| Hospital Universitario La Paz ( Site 0510) | Madrid | 28046 | Spain | Details | ||
| Complejo Hospitalario Universitario de Santiago ( Site 0506) | Santiago de Compostela | 15706 | Spain | Details | ||
| Hospital Universitario Virgen del Rocio ( Site 0509) | Sevilla | 41013 | Spain | Details | ||
| Hospital Universitario y Politecnico La Fe de Valencia ( Site 0505) | Valencia | 46026 | Spain | Details | ||
| Kaohsiung Medical University Chung-Ho Memorial Hospital ( Site 0529) | Kaoshiung | 807 | Taiwan | Details | ||
| China Medical University Hospital ( Site 0527) | Taichung | 404 | Taiwan | Details | ||
| Taichung Veterans General Hospital ( Site 0526) | Taichung | 407 | Taiwan | Details | ||
| National Cheng Kung University Hospital ( Site 0528) | Tainan | 70457 | Taiwan | Details | ||
| National Taiwan University Hospital ( Site 0523) | Taipei | 100 | Taiwan | Details | ||
| Taipei Veterans General Hospital ( Site 0524) | Taipei | 112 | Taiwan | Details | ||
| Chang Gung Medical Foundation. Linkou ( Site 0525) | Taoyuan | 333 | Taiwan | Details | ||
| Siriraj Hospital. Mahidol Univerisity ( Site 0213) | Bangkok Noi | Bangkok | 10700 | Thailand | Details | |
| Songklanagarind Hospital ( Site 0214) | HatYai | Songkhla | 90110 | Thailand | Details | |
| Chiang Mai University Maharaj Nakorn Chiang Mai Hospital ( Site 0211) | Chiang Mai | 50200 | Thailand | Details | ||
| Adana Sehir Hastanesi ( Site 0549) | Adana | 01250 | Turkey | Details | ||
| Hacettepe Uni. Tip Fakultesi ( Site 0553) | Ankara | 06100 | Turkey | Details | ||
| Abdurrahman Yurtaslan Onkoloji Hastanesi ( Site 0551) | Ankara | 06200 | Turkey | Details | ||
| Akdeniz Universitesi Tip Fakultesi ( Site 0548) | Antalya | 07070 | Turkey | Details | ||
| Trakya Universitesi Tip Fakultesi ( Site 0544) | Edirne | 22030 | Turkey | Details | ||
| Erzurum Ataturk University Faculty of Medicine ( Site 0546) | Erzurum | 25240 | Turkey | Details | ||
| Bezmi Alem Universitesi Tıp Fakultesi ( Site 0547) | İstanbul | 34093 | Turkey | Details | ||
| Necmettin Erbakan Universitesi Meram Tip Fakultesi ( Site 0550) | Konya | 42080 | Turkey | Details | ||
| Inonu Universitesi Medical Fakultesi ( Site 0545) | Malatya | 44280 | Turkey | Details | ||
| Royal Free London NHS Foundation Trust ( Site 0567) | London | London, City Of | NW3 2QG | United Kingdom | Details | |
| Kings College Hospital NHS Foundation Trust ( Site 0565) | London | London, City Of | SE5 9RS | United Kingdom | Details | |
| The Clatterbridge Cancer Centre NHS Foundation Trust ( Site 0573) | Birkenhead | CH63 4JY | United Kingdom | Details | ||
| The Beatson West of Scotland Cancer Centre ( Site 0566) | Glasgow | G12 0YN | United Kingdom | Details | ||
| The Christie NHS Foundation Trust ( Site 0575) | Manchester | M20 4BX | United Kingdom | Details | ||
| Nottingham University Hospitals NHS Trust ( Site 0569) | Nottingham | NG5 1PB | United Kingdom | Details |