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| NCT ID | NCT03734016 |
| Title | A Study of Zanubrutinib (BGB-3111) Versus Ibrutinib in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia |
| Acronym | ALPINE |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | BeiGene |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | SWE | POL | NZL | NLD | ITA | GBR | FRA | ESP | DEU | CZE | BEL | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Carti Cancer Center | Little Rock | Arkansas | 72205 | United States | Details | |
| David Geffen School of Medicine At UCLA | Los Angeles | California | 90095 | United States | Details | |
| Rocky Mountain Cancer Centers Boulder | Boulder | Colorado | 80303 | United States | Details | |
| Scri Florida Cancer Specialists South | Fort Myers | Florida | 33901 | United States | Details | |
| Scri Florida Cancer Specialists North | Saint Petersburg | Florida | 33705 | United States | Details | |
| Augusta University | Augusta | Georgia | 30912 | United States | Details | |
| Scri Hca Midwest Health | Kansas City | Kansas | 64132 | United States | Details | |
| Norton Cancer Institute Pavilion | Louisville | Kentucky | 40207 | United States | Details | |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | United States | Details | |
| Forrest General Hospital Cancer Center | Hattiesburg | Mississippi | 39401 | United States | Details | |
| Nebraska Medical Center | Omaha | Nebraska | 68198 | United States | Details | |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89169 | United States | Details | |
| Atlantic Health System | Morristown | New Jersey | 07960 | United States | Details | |
| Morristown Medical Center | Morristown | New Jersey | 07960 | United States | Details | |
| Columbia University Medical Center | New York | New York | 10032 | United States | Details | |
| Clinical Research Alliance, Inc | Westbury | New York | 11590 | United States | Details | |
| Duke University Hospital | Durham | North Carolina | 27705 | United States | Details | |
| Oregon Health and Science University | Portland | Oregon | 97239 | United States | Details | |
| Willamette Valley Cancer Center | Springfield | Oregon | 97477 | United States | Details | |
| Scri Tennessee Oncology Chattanooga | Chattanooga | Tennessee | 37404 | United States | Details | |
| Sarah Cannon Cancer Center | Nashville | Tennessee | 37203 | United States | Details | |
| Texas Oncology Fort Worth Cancer Center | Fort Worth | Texas | 76104-2150 | United States | Details | |
| The University of Texas Md Anderson Cancer Center | Houston | Texas | 77030-4009 | United States | Details | |
| Joe Arrington Cancer Research and Treatment Center | Lubbock | Texas | 79410 | United States | Details | |
| Texas Oncology San Antonio Medical Center Usor | San Antonio | Texas | 78240 | United States | Details | |
| Texas Oncology Tyler Longview | Tyler | Texas | 75702 | United States | Details | |
| Blue Ridge Cancer Care (Oncology and Hematology Associates of Southwest Virginia) | Roanoke | Virginia | 24014 | United States | Details | |
| Va Puget Sound Health Care System | Seattle | Washington | 98108 | United States | Details | |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109 | United States | Details | |
| Medical Oncology Associates | Spokane | Washington | 99208 | United States | Details | |
| Calvary Mater Newcastle | Waratah | New South Wales | 2298 | Australia | Details | |
| Princess Alexandra Hospital | Brisbane | Queensland | 4102 | Australia | Details | |
| Icon Cancer Foundation | South Brisbane | Queensland | 4101 | Australia | Details | |
| Box Hill Hospital | Box Hill | Victoria | 3128 | Australia | Details | |
| Monash Health | Clayton | Victoria | 3168 | Australia | Details | |
| Peninsula Private Hospital | Frankston | Victoria | 3199 | Australia | Details | |
| Royal Perth Hospital | Perth | Western Australia | 6000 | Australia | Details | |
| Gasthuiszusters Antwerpen Sint Augustinus | Wilrijk | 2610 | Belgium | Details | ||
| Peking University Third Hospital | Beijing | Beijing | 100000 | China | Details | |
| Beijing Friendship Hospital, Capital Medical University | Beijing | Beijing | 100050 | China | Details | |
| Peking Union Medical College Hospital | Beijing | Beijing | 100730 | China | Details | |
| Fujian Medical University Union Hospital | Fuzhou | Fujian | 350001 | China | Details | |
| Quanzhou First Affliated Hospital of Fujian Medical University | Quanzhou | Fujian | 362000 | China | Details | |
| Guangdong Provincial Peoples Hospital | Guangzhou | Guangdong | 510080 | China | Details | |
| Nanfang Hospital of Southern Medical University | Guangzhou | Guangdong | 510515 | China | Details | |
| Henan Cancer Hospital | Zhengzhou | Henan | 450000 | China | Details | |
| Union Hospital of Tongji Medical College, Huazhong University of Science and Technology | Wuhan | Hubei | 430022 | China | Details | |
| Jiangsu Province Hospital | Nanjing | Jiangsu | 210029 | China | Details | |
| The First Hospital of Jilin University | Changchun | Jilin | 130021 | China | Details | |
| Shengjing Hospital of China Medical University | Shenyang | Liaoning | 110004 | China | Details | |
| Affiliated Zhongshan Hospital of Fudan University | Shanghai | Shanghai | 200032 | China | Details | |
| Tongji Hospital of Tongji University | Shanghai | Shanghai | 200092 | China | Details | |
| West China Hospital, Sichuan University | Chengdu | Sichuan | 610041 | China | Details | |
| Institute of Hematology and Hospital of Blood Disease | Tianjin | Tianjin | 300020 | China | Details | |
| Tianjin Medical University Cancer Institute and Hospital | Tianjin | Tianjin | 300060 | China | Details | |
| The First Affiliated Hospital, Zhejiang University School of Medicine | Hangzhou | Zhejiang | 310003 | China | Details | |
| The First Provincial Wenzhou Hospital of Zhejiang | Wenzhou | Zhejiang | 325000 | China | Details | |
| Fakultni Nemocnice Brno | Brno | 62500 | Czechia | Details | ||
| Fakultni Nemocnice Hradec Kralove | Hradec Kralove | 50005 | Czechia | Details | ||
| Fakultni Nemocnice Olomouc | Olomouc | 77900 | Czechia | Details | ||
| Fakultni Nemocnice Ostrava | Ostrava | 708 00 | Czechia | Details | ||
| Hopital Prive Sevigne | Cesson Sevigne | 35510 | France | Details | ||
| Centre Hospitalier Departemental de Vendee | La Roche sur Yon | 85925 | France | Details | ||
| Centre Hospitalier Le Mans | Le Mans | 72037 | France | Details | ||
| Chu Hopital Lyon Sud | PierreBenite | 69495 | France | Details | ||
| Centre Hospitalier Universitaire de Poitier Hopital de La Miletrie Hopital Jean Bernard | Poitiers | 86000 | France | Details | ||
| Chu Tours Hopital Bretonneau Service Pneumologie | Tours | 37000 | France | Details | ||
| Evangelisches Krankenhaus Hamm | Hamm | 59063 | Germany | Details | ||
| Uniklinik Koln (Aor) | Koln | 50937 | Germany | Details | ||
| Ospedale San Raffaele | Milano | 20132 | Italy | Details | ||
| Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda | Milano | 20162 | Italy | Details | ||
| Fondazione Policlinico Universitario Agostino Gemelli | Roma | 168 | Italy | Details | ||
| Azienda Ospedaliera Citta Della Salute E Della Scienza Di Torino | Torino | 10126 | Italy | Details | ||
| Gelre Ziekenhuizen | Apeldoorn | 7334 DZ | Netherlands | Details | ||
| Albert Schweitzer Ziekenhuis | Nijmegen | 6525 GA | Netherlands | Details | ||
| Middlemore Clinical Trials | Auckland | 2025 | New Zealand | Details | ||
| Christchurch Hospital (Canterbury Health Laboratories) | Christchurch | 8011 | New Zealand | Details | ||
| Waikato Hospital | Hamilton Waikato | 3204 | New Zealand | Details | ||
| North Shore Hospital | Takapuna | 0622 | New Zealand | Details | ||
| Tauranga Hospital | Tauranga | 3112 | New Zealand | Details | ||
| Wellington Regional Hospital (Ccdhb) | Wellington | 6021 | New Zealand | Details | ||
| Interhem Opieka Szpitalna | Bialystok | 15748 | Poland | Details | ||
| Szpital Specjalist W Brzozowie,Podkarpacki Osrodek Onkologiczny | Brzozow | 36-200 | Poland | Details | ||
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Zespol Szpitali Miejskich | Chorzow | 41-500 | Poland | Details | ||
| Uniwersyteckie Centrum Kliniczne | Gdansk | 80-952 | Poland | Details | ||
| Copernicus Podmiot Leczniczy Sp Z Oo Wojewodzkie Centrum Onkologii | Gdask | 80-219 | Poland | Details | ||
| Malopolskie Centrum Medyczne Sc | Krakow | 30-510 | Poland | Details | ||
| Wojewodzki Szpital Specjalistyczny W Legnicy | Legnica | 59-220 | Poland | Details | ||
| Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi | Lodz | 93-510 | Poland | Details | ||
| Examen Sp Z Oo | Poznan | 60-569 | Poland | Details | ||
| Hospital Universitari Germans Trias I Pujol | Badalona | 08916 | Spain | Details | ||
| Hospital de La Santa Creu I Sant Pau | Barcelona | 08025 | Spain | Details | ||
| Hospital Universitario Vall Dhebron | Barcelona | 08035 | Spain | Details | ||
| Hospital Clinic I Provincial | Barcelona | 08036 | Spain | Details | ||
| Ico Girona | Girona | 17007 | Spain | Details | ||
| Hospital Universitario Ramon Y Cajal | Madrid | 28034 | Spain | Details | ||
| Hospital Universitario La Paz | Madrid | 28046 | Spain | Details | ||
| Hospital Universitario Puerta de Hierro Majadahonda | Majadahonda | 28222 | Spain | Details | ||
| Hospital Universitario Marques de Valdecilla | Santander | 39008 | Spain | Details | ||
| Hospital Virgen de La Salud | Toledo | 45004 | Spain | Details | ||
| Skanes Universitetssjukhus I Lund | Lund | 221 85 | Sweden | Details | ||
| Karolinska Universitetssjukhuset Solna | Stockholm | 171 76 | Sweden | Details | ||
| Namik Kemal University | Tekirdag | 59100 | Turkey | Details | ||
| Nhs Grampian Ppds | Aberdeen | AB25 2ZN | United Kingdom | Details | ||
| Birmingham Heartlands Hospital | Birmingham | B9 5SS | United Kingdom | Details | ||
| The Royal Bournemouth and Christchurch Hospitals Nhs Foundation | Bournemouth | BH7 7DW | United Kingdom | Details | ||
| Kent and Canterbury Hospital | Canterbury | CT1 3NG | United Kingdom | Details | ||
| St Jamess Institute of Oncology | Leeds | LS9 7LP | United Kingdom | Details | ||
| Norfolk and Norwich University Hospitals Nhs Foundation Trust | Norwich | NR4 7UY | United Kingdom | Details | ||
| Nottingham University Hospitals Nhs Trust | Nottingham | NG51PB | United Kingdom | Details | ||
| Derriford Hospital | Plymouth | PL6 8DH | United Kingdom | Details | ||
| Southampton General Hospital | Southampton | SO16 6YD | United Kingdom | Details | ||
| Sunderland Royal Hospital | Sunderland | SR4 7TP | United Kingdom | Details |