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| NCT ID | NCT03734029 |
| Title | Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04] |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Daiichi Sankyo |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | SWE | ITA | ISR | HUN | GRC | GBR | FRA | ESP | DEU | CHE | CAN | BEL | AUT |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Aichi Cancer Center Hospital | Nagoya | Aichi-Ken | 464-8681 | Japan | Details | |
| Ajou University Hospital | Suwon | Gyeonggi-do | 16499 | Korea, Republic of | Details | |
| Akademiska Sjukhuset | Uppsala | 75185 | Sweden | Details | ||
| AKH - Medizinische Universität Wien (4305) | Vienna | 1090 | Austria | Details | ||
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | United States | Details | |
| Anhui Provincial Hospital | Hefei | Anhui | 230001 | China | Details | |
| Asan Medical Center | Seoul | 05505 | Korea, Republic of | Details | ||
| Athens Medical Center | Athens | 15125 | Greece | Details | ||
| Azienda Ospedaliera Card. G. Panico | Tricase | Lecce | 73039 | Italy | Details | |
| Azienda Ospedaliera Univ. Policlinico Gaspare Rodolico | Catania | 95125 | Italy | Details | ||
| Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi | Bologna | 40138 | Italy | Details | ||
| Azienda Ospedaliera Universitaria Policlinico Tor Vergata | Roma | 00133 | Italy | Details | ||
| Azienda Ospedaliero Universitaria Mater Domini-Campus Universitario | Catanzaro | 88100 | Italy | Details | ||
| Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili) | Brescia | 25100 | Italy | Details | ||
| Azienda Socio Sanitaria Territoriale di Monza (Presidio San Gerardo) | Monza | Milano | 20900 | Italy | Details | |
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234-2165 | United States | Details | |
| Baptist Cancer Center | Memphis | Tennessee | 38120 | United States | Details | |
| Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaza | Gyula | 5700 | Hungary | Details | ||
| Bioclinic Thessaloniki | Thessaloníki | 54622 | Greece | Details | ||
| BloomTrials Clinical Research, LLC | Dallas | Texas | 75234 | United States | Details | |
| Brig Center for Cancer Care and Survivorship | Knoxville | Tennessee | 37909 | United States | Details | |
| Cancer Care Associates Medical Group, Inc. TORI | Redondo Beach | California | 90277 | United States | Details | |
| Cancer Center of Kansas | Wichita | Kansas | 67214 | United States | Details | |
| Cancer Hospital Chinese Academy of Medical Sciences | Beijing | Beijing | 100021 | China | Details | |
| Cancer Institute Hospital of JFCR | Koto-Ku | Tokyo-To | 135-8550 | Japan | Details | |
| Cancer Treatment Centers of America | Zion | Illinois | 60099 | United States | Details | |
| Cancer Treatment Centers of America at Western Regional Medical Center | Goodyear | Arizona | 85338 | United States | Details | |
| Cancer Treatment Centers of America-Georgia | Newnan | Georgia | 30263 | United States | Details | |
| CARIO - Centre Armoricain de Radiothérapie, Imagerie médicale et Oncologie | Plérin | Cotes d'Armor | 22190 | France | Details | |
| Centre François Baclesse | Caen | Calvados | 14076 | France | Details | |
| Centre Hospitalier Emile Roux | Le Puy-en-Velay | Loiret | 43012 | France | Details | |
| Centre Hospitalier Universitaire Vaudois | Lausanne | 1011 | Switzerland | Details | ||
| Centre Hospitalier Valenciennes | Valenciennes | Nord | 59322 | France | Details | |
| Centre Hospitalier Wallonie picarde - Site IMC | Tournai | 7500 | Belgium | Details | ||
| Centro Hospitalar de Entre o Douro e Vouga, E.P.E - Hospital de São Sebastião | Santa Maria Da Feira | 4520-211 | Portugal | Details | ||
| Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria | Lisboa | 1649-035 | Portugal | Details | ||
| Centro Hospitalar de Trás-os-Montes e Alto Douro, EPE | Vila Real | 5000-508 | Portugal | Details | ||
| Centro Hospitalar do Alto do Ave, EPE | Guimarães | 4835-044 | Portugal | Details | ||
| Centro Hospitalar do Porto, E.P.E. - Hospital de Santo António | Porto | 4099-001 | Portugal | Details | ||
| Centro Hospitalar Vila Nova de Gaia/Espinho, E.P.E | Vila Nova De Gaia | 4434-502 | Portugal | Details | ||
| Chaim Sheba Medical Center | Ramat Gan | 52363 | Israel | Details | ||
| Chinese PLA General Hospital | Beijing | Beijing | 100853 | China | Details | |
| Christiana Care Health Services, Inc. | Newark | Delaware | 19713 | United States | Details | |
| CHU Brest - Hôpital Morvan | Brest Cedex | Finistere | 29609 | France | Details | |
| CHU UCL Namur | Namur | 5000 | Belgium | Details | ||
| Chungbuk National University Hospital | Cheongju-si | Chungcheongbuk-do | 361-711 | Korea, Republic of | Details | |
| Clinique Clementville | Montpellier | Herault | 34070 | France | Details | |
| Clinique Victor Hugo - Centre Jean Bernard | Le Mans Cedex 02 | Sarthe | 72015 | France | Details | |
| Cliniques Universitaires Saint-Luc | Bruxelles | 1200 | Belgium | Details | ||
| Complejo Hospitalario Universitario A Coruña | A Coruña | La Coruña | 15006 | Spain | Details | |
| CRLCC Eugene Marquis | Rennes-cedex | Ille Et Vilaine | 35042 | France | Details | |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | United States | Details | |
| Debreceni Egyetem | Debrecen | 4032 | Hungary | Details | ||
| Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet | Budapest | 1097 | Hungary | Details | ||
| Eastern Connecticut Hematology/Oncology Assoc. | Norwich | Connecticut | 06360 | United States | Details | |
| Euromedica General Clinic Thessaloniki | Thessaloníki | 54645 | Greece | Details | ||
| Florida Cancer Specialists (South Region) | Fort Myers | Florida | 33916 | United States | Details | |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Roma | 00168 | Italy | Details | ||
| FSBSI "Russian Oncological Scientific Center n.a. N.N. Blokhin" | Moscow | 115478 | Russian Federation | Details | ||
| Fudan University Shanghai Cancer Center | Shanghai | Shanghai | 20032 | China | Details | |
| Fukushima Medical University Hospital | Fukushima | Fukushima-Ken | 960-1295 | Japan | Details | |
| Fundação Champalimaud | Lisboa | 1400-038 | Portugal | Details | ||
| Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA | Fuzhou | Fujian | 350025 | China | Details | |
| General Hospital of Athens "Alexandra" | Athens | 11528 | Greece | Details | ||
| General Hospital of Ningxia Medical University | Yinchuan | Ningxia | 750004 | China | Details | |
| General Hospital Papageorgiou | Thessaloníki | 56429 | Greece | Details | ||
| General Oncology Hospital of Kifissia " Agioi Anargyroi" | Athens | 14564 | Greece | Details | ||
| Grand Hôpital de Charleroi | Loverval | 6280 | Belgium | Details | ||
| Hadassah University Hospital - Ein Kerem | Jerusalem | 9112001 | Israel | Details | ||
| Hakuaikai Sagara Hospital | Kagoshima | Kagoshima-Ken | 892-0833 | Japan | Details | |
| Harbin Medical University Cancer Hospital | Harbin | Heilongjiang | 150081 | China | Details | |
| Henry Ford Hospital | Detroit | Michigan | 48202 | United States | Details | |
| Hiroshima City Hiroshima Citizens Hospital | Hiroshima-shi | Hiroshima-Ken | 730-8518 | Japan | Details | |
| Hirslanden Medical Center | Aarau | 5000 | Switzerland | Details | ||
| Hopital Tenon | Paris | 75020 | France | Details | ||
| Hospital Clinic de Barcelona | Barcelona | 08036 | Spain | Details | ||
| Hospital Clinico Universitario Virgen de la Victoria | Málaga | 29010 | Spain | Details | ||
| Hospital de Basurto | Bilbao | Vizcaya | 48013 | Spain | Details | |
| Hospital de Braga | Braga | 4710-243 | Portugal | Details | ||
| Hospital del Mar | Barcelona | 08003 | Spain | Details | ||
| Hospital General Universitario de Valencia | Valencia | 46014 | Spain | Details | ||
| Hospital Quironsalud Barcelona | Barcelona | 08023 | Spain | Details | ||
| Hospital Ruber Internacional | Madrid | 28034 | Spain | Details | ||
| Hospital Universitari Vall d'Hebron | Barcelona | 08035 | Spain | Details | ||
| Hospital Universitario Clinico San Carlos | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario de Canarias | San Cristobal de la Laguna | Tenerife | 38320 | Spain | Details | |
| Hospital Universitario Donostia | San Sebastián | Guipuzcoa | 20014 | Spain | Details | |
| Hospital Universitario Ramon y Cajal | Madrid | 28034 | Spain | Details | ||
| Hospital Universitario Virgen del Rocio | Sevilla | 41013 | Spain | Details | ||
| Hospital Universitario Virgen Macarena | Sevilla | 41009 | Spain | Details | ||
| Hubei Cancer Hospital | Wuhan | Hubei | 430079 | China | Details | |
| Hyogo College of Medicine Hospital | Nishinomiya-shi | Hyogo-Ken | 663-8501 | Japan | Details | |
| Hôpital d'Instruction des Armees Begin* | Saint Mande | Val De Marne | 94160 | France | Details | |
| Hôpital Saint-Louis - Paris | Paris Cedex 10 | Paris | 75475 | France | Details | |
| ICO - Site Paul Papin | Angers Cedex 2 | Maine Et Loire | 49055 | France | Details | |
| ICO - Site René Gauducheau | Saint-Herblain | Loire Atlantique | 44805 | France | Details | |
| ICO l'Hospitalet - Hospital Duran i Reynals | L'Hospitalet De Llobregat | Barcelona | 08908 | Spain | Details | |
| IEO Istituto Europeo di Oncologia | Milano | 20141 | Italy | Details | ||
| Inha University Hospital | Incheon | Gyeonggi-do | 22332 | Korea, Republic of | Details | |
| Institut Bergonié | Bordeaux cedex | Gironde | 33076 | France | Details | |
| Institut Curie - site de Paris | Paris | 75005 | France | Details | ||
| Institut Gustave Roussy | Villejuif cedex | Val De Marne | 94805 | France | Details | |
| Institut Jules Bordet | Bruxelles | 1000 | Belgium | Details | ||
| Institut Paoli Calmettes | Marseille cedex 9 | Bouches-du-Rhône | 13009 | France | Details | |
| Institut Régional du Cancer de Montpellier | Montpellier | Herault | 34298 | France | Details | |
| Institut Sainte Catherine | Avignon Cedex 9 | Vaculuse | 84918 | France | Details | |
| Instituto Português de Oncologia do Porto Francisco Gentil, EPE | Porto | 4200-072 | Portugal | Details | ||
| Instituto Valenciano de Oncologia IVO | Valencia | 46009 | Spain | Details | ||
| Interbalkan Hospital of Thessaloniki | Thessaloníki | 57001 | Greece | Details | ||
| Ironwood Cancer & Research Centers - Chandler II | Chandler | Arizona | 85224 | United States | Details | |
| Istituto Clinico Humanitas | Rozzano | Milano | 20089 | Italy | Details | |
| Istituto Nazionale Tumori Fondazione G. Pascale | Napoli | 80131 | Italy | Details | ||
| Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet | Szolnok | 5004 | Hungary | Details | ||
| Jilin Cancer Hospital | Chang chun | Jilin | 130012 | China | Details | |
| Kanagawa Cancer Center | Yokohama | Kanagawa | 241-8515 | Japan | Details | |
| Kantonsspital Graubuenden | Chur | 7000 | Switzerland | Details | ||
| Kantonsspital St. Gallen | Saint Gallen | 9007 | Switzerland | Details | ||
| Kantonsspital Winterthur | Winterthur | 8401 | Switzerland | Details | ||
| Kaohsiung Medical University Chung-Ho Memorial Hospital | Kaohsiung | 807 | Taiwan | Details | ||
| Kaplan Medical Center | Rechovot | 7610001 | Israel | Details | ||
| Karolinska universitetssjukhuset - Solna | Solna | 17176 | Sweden | Details | ||
| Kepler Universitätsklinikum | Linz | 4020 | Austria | Details | ||
| Kindai University Hospital | Onohigashi | Osakasayama-shi | 589-8511 | Japan | Details | |
| Klinikum der Universitaet Muenchen - Campus Grosshardern | Munich | Bayern | 81377 | Germany | Details | |
| Klinikum Wels-Grieskirchen GmbH | Wels | 4600 | Austria | Details | ||
| Kyungpook National University Chilgok Hospital | Daegu | 41404 | Korea, Republic of | Details | ||
| Liaoning Cancer Hospital & Institute | Shenyang | Liaoning | 110042 | China | Details | |
| Linyi Cancer Hospital | Linyi | Shandong | 276001 | China | Details | |
| LKH - Universitätsklinikum der PMU Salzburg | Salzburg | 5020 | Austria | Details | ||
| Länssjukhuset Sundsvall-Härnösand | Sundsvall | 85186 | Sweden | Details | ||
| McGill University - Dept. Oncology Clinical Research Program | Montréal | Quebec | H2W 1S6 | Canada | Details | |
| MD Anderson Cancer Centre | Madrid | 28033 | Spain | Details | ||
| Medizinische Universität Innsbruck | Innsbruck | 6020 | Austria | Details | ||
| Memorial Healthcare System MRH Cancer Center | Hollywood | Florida | 33021 | United States | Details | |
| Memorial Sloan Kettering Hospital | New York | New York | 10065-6007 | United States | Details | |
| Moffitt Cancer Center -Tampa | Tampa | Florida | 33139 | United States | Details | |
| National Cancer Center | Goyang-si | Gyeonggi-do | 10408 | Korea, Republic of | Details | |
| National Cancer Center Hospital East | Kashiwa-shi | Chiba-Ken | 277-8577 | Japan | Details | |
| National Cheng Kung University Hospital | Tainan | 704 | Taiwan | Details | ||
| National Taiwan University Hospital | Taipei | 100 | Taiwan | Details | ||
| New York University Medical Center | New York | New York | 10016 | United States | Details | |
| NHO Hokkaido Cancer Center | Sapporo-shi | Hokkaido | 003-0804 | Japan | Details | |
| NHO Kyushu Cancer Center | Fukuoka-shi | Fukuoka-Ken | 811-1395 | Japan | Details | |
| NHO Osaka National Hospital | Osaka-shi | Osaka-Fu | 540-0006 | Japan | Details | |
| NHO Shikoku Cancer Center | Matsuyama-shi | Ehime-Ken | 791-0280 | Japan | Details | |
| Nottingham University Hospitals City Campus | Nottingham | Nottinghamshire | NG5 1PB | United Kingdom | Details | |
| Oregon Health & Science University | Portland | Oregon | 97239 | United States | Details | |
| Orlando Health, Inc. | Orlando | Florida | 32806 | United States | Details | |
| Orszagos Onkologiai Intezet | Budapest | 1122 | Hungary | Details | ||
| Ospedale degli Infermi | Rimini | 47923 | Italy | Details | ||
| Ospedale Sacro Cuore Don Calabria | Negrar | Verona | 37024 | Italy | Details | |
| Queen Mary University of London | London | Greater London | EC1M 6BQ | United Kingdom | Details | |
| Rabin Medical Center-Beilinson Campus | Petah tikva | 49100 | Israel | Details | ||
| Rambam Health Care Center | Haifa | 3109601 | Israel | Details | ||
| Royal Cornwall Hospital | Truro | Cornwall | TR1 3LJ | United Kingdom | Details | |
| Royal Free Hospital | London | Greater London | NW3 2QG | United Kingdom | Details | |
| Royal Surrey County Hospital | Guildford | Surrey | GU2 7XX | United Kingdom | Details | |
| Saint Barnabas Medical Center | Livingston | New Jersey | 07039 | United States | Details | |
| Saint Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | United States | Details | |
| Saitama Cancer Center | Kitaadachi-gun | Saitama-Ken | 362-0806 | Japan | Details | |
| Samsung Medical Center | Seoul | 06351 | Korea, Republic of | Details | ||
| SBIH of Moscow City "Moscow City Oncology Hospital №62" of Moscow Healthcare Departement | Moscow | 143423 | Russian Federation | Details | ||
| SBIH of Yaroslavl Region "Regional Clinical Oncological Hospital" | Yaroslavl | 150054 | Russian Federation | Details | ||
| Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do | 13620 | Korea, Republic of | Details | |
| Seoul National University Hospital | Seoul | 03080 | Korea, Republic of | Details | ||
| Severance Hospital, Yonsei University Health System | Seoul | 120-752 | Korea, Republic of | Details | ||
| Shaare Zedek Medical Center | Jerusalem | 9103102 | Israel | Details | ||
| Shanghai General Hospital | Shanghai | Shanghai | 200080 | China | Details | |
| Shizuoka Cancer Center | Sunto-gun | Shizuoka-Ken | 411-8777 | Japan | Details | |
| Showa University Hospital | Shinagawa-Ku | Tokyo-To | 142-8666 | Japan | Details | |
| Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine | Hangzhou | Zhejiang | 310016 | China | Details | |
| St Francis Hospital | Greenville | South Carolina | 29601 | United States | Details | |
| Stanford Cancer Institute | Palo Alto | California | 94305 | United States | Details | |
| Sun Yat-sen Memorial hospital, Sun Yat-sen University | Guangzhou | Guangdong | 510120 | China | Details | |
| Sylvester Comprehensive Cancer Center - Deerfield Beach | Boca Raton | Florida | 33426 | United States | Details | |
| SzSzB Megyei Korhazak es Egyetemi Oktatokorhaz | Nyiregyhaza | 4400 | Hungary | Details | ||
| Tel Aviv Sourasky Medical Center | Tel Aviv | 6423906 | Israel | Details | ||
| Tennessee Oncology - Skyline Satellite | Nashville | Tennessee | 37201 | United States | Details | |
| The Affiliated Drum Tower Hospital of Nanjing University | Nanjing | Jiangsu | 210008 | China | Details | |
| The Catholic University of Korea, Seoul St. Mary's Hospital | Seoul | 06591 | Korea, Republic of | Details | ||
| The Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | United States | Details | |
| The First Hospital of Jilin University | Chang chun | Jilin | 130000 | China | Details | |
| The Methodist Hospital Research Institute | Houston | Texas | 77030 | United States | Details | |
| Tokai University Hospital | Isehara | Kanagawa-Ken | 259-1193 | Japan | Details | |
| Tom Baker Cancer Center | Calgary | Alberta | T2N4N2 | Canada | Details | |
| Toranomon Hospital | Minato-Ku | Tokyo-To | 105-8470 | Japan | Details | |
| Toronto Sunnybrook Hospital | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| Touro Infirmary | New Orleans | Louisiana | 70115 | United States | Details | |
| UCLA School of Medicine | Los Angeles | California | 90095-1690 | United States | Details | |
| Unidade Local de Saúde de Matosinhos, EPE (Hospital Pedro Hispano) | Matosinhos | 4464-509 | Portugal | Details | ||
| Universitaetsklinikum Heidelberg | Heidelberg | Baden Wuerttemberg | 69120 | Germany | Details | |
| Universitaetsspital Basel | Basel | 4031 | Switzerland | Details | ||
| Universitaetsspital Zuerich | Zürich | 8091 | Switzerland | Details | ||
| Universitair Ziekenhuis Brussel | Bruxelles | 1090 | Belgium | Details | ||
| University College London Hospitals | London | Greater London | NW1 2PG | United Kingdom | Details | |
| University General Hospital of Heraklion | Heraklion | 71110 | Greece | Details | ||
| University General Hospital of Larissa | Larissa | 41110 | Greece | Details | ||
| University of California at San Francisco (PARENT) | San Francisco | California | 94158 | United States | Details | |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | United States | Details | |
| University of Pittsburgh Medical Center Health System | Pittsburgh | Pennsylvania | 15219 | United States | Details | |
| University of Texas M. D. Anderson Cancer Center - Investigational Cancer Therapeutics | Houston | Texas | 77030 | United States | Details | |
| UZ Leuven | Leuven | 3000 | Belgium | Details | ||
| Virginia Cancer Specialists | Fairfax | Virginia | 22031 | United States | Details | |
| Weill Cornell Medicine Breast Center | New York | New York | 10065 | United States | Details | |
| West China Hospital, Sichuan University | Chengdu | Sichuan | 610041 | China | Details | |
| Western General Hospital | Edinburgh | Lothian Region | EH4 2XU | United Kingdom | Details | |
| Zhejiang Cancer Hospital | Hangzhou | Zhejiang | 310022 | China | Details | |
| Ziv Medical Center | Safed | 13100 | Israel | Details |
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