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| NCT ID | NCT03755791 |
| Title | Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Subjects With Advanced HCC Who Have Not Received Previous Systemic Anticancer Therapy (COSMIC-312) |
| Acronym | COSMIC-312 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Exelixis |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | TUR | ROU | POL | NZL | NLD | ITA | ISR | IRL | HUN | GBR | FRA | ESP | DEU | CZE | CHE | CAN | BRA | BEL | AUT | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Exelixis Clinical Site #208 | Phoenix | Arizona | 85004 | United States | Details | |
| Exelixis Clinical Site #159 | Tucson | Arizona | 85719 | United States | Details | |
| Exelixis Clinical Site #44 | La Jolla | California | 92037 | United States | Details | |
| Exelixis Clinical Site #112 | Los Angeles | California | 90033 | United States | Details | |
| Exelixis Clinical Site #200 | Orange | California | 92868-3201 | United States | Details | |
| Exelixis Clinical Site #2 | Rialto | California | 92377 | United States | Details | |
| Exelixis Clinical Site #207 | San Diego | California | 92093 | United States | Details | |
| Exelixis Clinical Site #109 | San Francisco | California | 94115 | United States | Details | |
| Exelixis Clinical Site #54 | San Francisco | California | 94158 | United States | Details | |
| Exelixis Clinical Site #58 | Washington | District of Columbia | 20007 | United States | Details | |
| Exelixis Clinical Site #191 | Miami | Florida | 33125 | United States | Details | |
| Exelixis Clinical Site #4 | Atlanta | Georgia | 30318 | United States | Details | |
| Exelixis Clinical Site #195 | Chicago | Illinois | 60612 | United States | Details | |
| Exelixis Clinical Site #120 | Chicago | Illinois | 60637 | United States | Details | |
| Exelixis Clinical Site #6 | Baltimore | Maryland | 21202 | United States | Details | |
| Exelixis Clinical Site #7 | Burlington | Massachusetts | 01805 | United States | Details | |
| Exelixis Clinical Site #11 | Kansas City | Missouri | 64128 | United States | Details | |
| Exelixis Clinical Site #5 | Kansas City | Missouri | 64131 | United States | Details | |
| Exelixis Clinical Site #8 | Saint Louis | Missouri | 63110 | United States | Details | |
| Exelixis Clinical Site #1 | Las Vegas | Nevada | 89169 | United States | Details | |
| Exelixis Clinical Site #14 | New Brunswick | New Jersey | 08903 | United States | Details | |
| Exelixis Clinical Site #76 | Albuquerque | New Mexico | 87131 | United States | Details | |
| Exelixis Clinical Site #12 | Chapel Hill | North Carolina | 27599-7600 | United States | Details | |
| Exelixis Clinical Site #39 | Toledo | Ohio | 43614 | United States | Details | |
| Exelixis Clinical Site #176 | Portland | Oregon | 97213 | United States | Details | |
| Exelixis Clinical Site #88 | Philadelphia | Pennsylvania | 19107 | United States | Details | |
| Exelixis Clinical Site #144 | Charleston | South Carolina | 29425 | United States | Details | |
| Exelixis Clinical Site #199 | Dallas | Texas | 75246 | United States | Details | |
| Exelixis Clinical Site #154 | Houston | Texas | 77030 | United States | Details | |
| Exelixis Clinical Site #19 | Temple | Texas | 76508 | United States | Details | |
| Exelixis Clinical Site #13 | Seattle | Washington | 98101 | United States | Details | |
| Exelixis Clinical Site #46 | Seattle | Washington | 98109 | United States | Details | |
| Exelixis Clinical Site #3 | Spokane | Washington | 99208 | United States | Details | |
| Exelixis Clinical Site #217 | City of Buenos Aires | Buenos Aires | C1118AAT | Argentina | Details | |
| Exelixis Clinical Site #213 | City of Buenos Aires | Buenos Aires | C1199ABB | Argentina | Details | |
| Exelixis Clinical Site #216 | City of Buenos Aires | Buenos Aires | C1264AAA | Argentina | Details | |
| Exelixis Clinical Site #219 | Pilar | Buenos Aires | B1629ODT | Argentina | Details | |
| Exelixis Clinical Site #220 | Rosario | Santa Fe | 2000 | Argentina | Details | |
| Exelixis Clinical Site #201 | Rosario | Santa Fe | S2000CVB | Argentina | Details | |
| Exelixis Clinical Site #78 | Camperdown | New South Wales | 2050 | Australia | Details | |
| Exelixis Clinical Site #165 | Darlinghurst | New South Wales | 2010 | Australia | Details | |
| Exelixis Clinical Site #171 | Kingswood | New South Wales | 2747 | Australia | Details | |
| Exelixis Clinical Site #126 | Kogarah | New South Wales | 2217 | Australia | Details | |
| Exelixis Clinical Site #155 | Westmead | New South Wales | 2145 | Australia | Details | |
| Exelixis Clinical Site #142 | Greenslopes | Queensland | 4120 | Australia | Details | |
| Exelixis Clinical Site #17 | Kurralta Park | South Australia | Australia | Details | ||
| Exelixis Clinical Site #107 | Box Hill | Victoria | 3128 | Australia | Details | |
| Exelixis Clinical Site #166 | Heidelberg | Victoria | 3084 | Australia | Details | |
| Exelixis Clinical Site #72 | Parkville | Victoria | 3050 | Australia | Details | |
| Exelixis Clinical Site #190 | Nedlands | Western Australia | 6009 | Australia | Details | |
| Exelixis Clinical Site #150 | Klagenfurt | Kärnten | 9020 | Austria | Details | |
| Exelixis Clinical Site #137 | St. Pölten | Lower Austria | 3100 | Austria | Details | |
| Exelixis Clinical Site #64 | Linz | Oberosterreich | 4010 | Austria | Details | |
| Exelixis Clinical Site #198 | Graz | Steiermark | 8036 | Austria | Details | |
| Exelixis Clinical Site #174 | Wien | 1090 | Austria | Details | ||
| Exelixis Clinical Site #50 | Brussels | California | 1070 | Belgium | Details | |
| Exelixis Clinical Site #65 | Brussels | 1200 | Belgium | Details | ||
| Exelixis Clinical Site #169 | Edegem | 2650 | Belgium | Details | ||
| Exelixis Clinical Site #148 | Gent | 9000 | Belgium | Details | ||
| Exelixis Clinical Site #57 | Haine-Saint-Paul | 7100 | Belgium | Details | ||
| Exelixis Clinical Site #188 | Leuven | 3000 | Belgium | Details | ||
| Exelixis Clinical Site #102 | Liège | 4000 | Belgium | Details | ||
| Exelixis Clinical Site #184 | Salvador | BA | 40110-060 | Brazil | Details | |
| Exelixis Clinical Site #89 | Belo Horizonte | MG | 30110-022 | Brazil | Details | |
| Exelixis Clinical Site #98 | Belo Horizonte | MG | 30130-090 | Brazil | Details | |
| Exelixis Clinical Site #113 | Curitiba | PR | 81520-060 | Brazil | Details | |
| Exelixis Clinical Site #203 | Porto Alegre | RS | 90050-170 | Brazil | Details | |
| Exelixis Clinical Site #175 | Barretos | SP | 14784-400 | Brazil | Details | |
| Exelixis Clinical Site #121 | Jaú | SP | 17210-120 | Brazil | Details | |
| Exelixis Clinical Site #186 | São Paulo | SP | 01246-900 | Brazil | Details | |
| Exelixis Clinical Site #156 | São Paulo | SP | 01321-001 | Brazil | Details | |
| Exelixis Clinical Site #187 | São Paulo | SP | 01509-010 | Brazil | Details | |
| Exelixis Clinical Site #181 | São Paulo | SP | 04538-132 | Brazil | Details | |
| Exelixis Clinical Site #91 | São Paulo | 04543-000 | Brazil | Details | ||
| Exelixis Clinical Site #71 | Calgary | Alberta | T2N 4N2 | Canada | Details | |
| Exelixis Clinical Site #205 | Edmonton | Alberta | T6G 2B7 | Canada | Details | |
| Exelixis Clinical Site #34 | Winnipeg | Manitoba | R3E 0V9 | Canada | Details | |
| Exelixis Clinical Site #222 | Halifax | Nova Scotia | B3H 2Y9 | Canada | Details | |
| Exelixis Clinical Site #194 | Hamilton | Ontario | L8V 5C2 | Canada | Details | |
| Exelixis Clinical Site #212 | Ottawa | Ontario | K1H 8L6 | Canada | Details | |
| Exelixis Clinical Site #85 | Montréal | Quebec | H3T 1E2 | Canada | Details | |
| Exelixis Clinical Site #233 | Hefei | Anhui | 230036 | China | Details | |
| Exelixis Clinical Site #228 | Fuzhou | Fujian | 350014 | China | Details | |
| Exelixis Clinical Site #225 | Xiamen | Fujian | 361004 | China | Details | |
| Exelixis Clinical Site #242 | Guangzhou | Guangdong | 510280 | China | Details | |
| Exelixis Clinical Site #227 | Harbin | Heilongjiang | 150081 | China | Details | |
| Exelixis Clinical Site #230 | Zhengzhou | Henan | 450008 | China | Details | |
| Exelixis Clinical Site #231 | Changsha | Hunan | 410008 | China | Details | |
| Exelixis Clinical Site #224 | Changsha | Hunan | 410013 | China | Details | |
| Exelixis Site #241 | Changsha | Hunan | 410013 | China | Details | |
| Exelixis Clinical Site #185 | Nanjing | Jiangsu | 210002 | China | Details | |
| Exelixis Clinical Site #221 | Nanchang | Jiangxi | 330006 | China | Details | |
| Exelixis Clinical Site #238 | Nanchang | Jiangxi | 330006 | China | Details | |
| Exelixis Clinical Site #234 | Jiangyin | Jiansu | 214400 | China | Details | |
| Exelixis Clinical Site #246 | Changchun | Jilin | 130012 | China | Details | |
| Exelixis Clinical Site #229 | Changchun | Jilin | 130021 | China | Details | |
| Exelixis Clinical Site #236 | Shenyang | Liaoning | 110006 | China | Details | |
| Exelixis Clinical Site #226 | Linyi | Shandong | 276000 | China | Details | |
| Exelixis Clinical Site #235 | Chengdu | Sichuan | 610041 | China | Details | |
| Exelixis Clinical Site #218 | Hangzhou | Zhejiang | 310016 | China | Details | |
| Exelixis Clinical Site #223 | Hangzhou | Zhejiang | 310022 | China | Details | |
| Exelixis Site #239 | Beijing | 100034 | China | Details | ||
| Exelixis Clinical Site #237 | Beijing | 100050 | China | Details | ||
| Exelixis Site #240 | Shanghai | 200001 | China | Details | ||
| Exelixis Clinical Site #232 | Shanghai | 201305 | China | Details | ||
| Exelixis Clinical Site #130 | Montería | Cordoba | 230002 | Colombia | Details | |
| Exelixis Clinical Site #18 | Hradec Králové | 500 05 | Czechia | Details | ||
| Exelixis Clinical Site #37 | Olomouc | 779 00 | Czechia | Details | ||
| Exelixis Clinical Site #10 | Praha 4 | 140 59 | Czechia | Details | ||
| Exelixis Clinical Site #38 | Praha 5 | 150 06 | Czechia | Details | ||
| Exelixis Clinical Site #43 | Amiens | 80054 | France | Details | ||
| Exelixis Clinical Site #27 | Besancon | 25030 | France | Details | ||
| Exelixis Clinical Site #56 | Bondy Cedex | 93140 | France | Details | ||
| Exelixis Clinical Site #29 | Caen Cedex 09 | 14033 | France | Details | ||
| Exelixis Clinical Site #48 | Clichy | 92110 | France | Details | ||
| Exelixis Clinical Site #23 | Grenoble | 38043 | France | Details | ||
| Exelixis Clinical Site #55 | Lille Cedex | 59037 | France | Details | ||
| Exelixis Clinical Site #16 | Lyon Cedex 4 | 69317 | France | Details | ||
| Exelixis Clinical Site #31 | Montbeliard | 25250 | France | Details | ||
| Exelixis Clinical Site #49 | Montpellier | 34295 | France | Details | ||
| Exelixis Clinical Site #47 | Nantes | 44093 | France | Details | ||
| Exelixis Clinical Site #51 | Nice | 06202 | France | Details | ||
| Exelixis Clinical Site #20 | Pessac | 33604 | France | Details | ||
| Exelixis Clinical Site #32 | Vandœuvre-lès-Nancy | 54511 | France | Details | ||
| Exelixis Clinical Site #69 | Batumi | 6000 | Georgia | Details | ||
| Exelixis Clinical Site #66 | Tbilisi | 0112 | Georgia | Details | ||
| Exelixis Clinical Site #68 | Tbilisi | 0114 | Georgia | Details | ||
| Exelixis Clinical Site #67 | Tbilisi | 0144 | Georgia | Details | ||
| Exelixis Clinical Site #70 | Tbilisi | 0186 | Georgia | Details | ||
| Exelixis Clinical Site #244 | Frankfurt | Hessen | 60590 | Germany | Details | |
| Exelixis Clinical Site #210 | Kassel | Hessen | 34125 | Germany | Details | |
| Exelixis Clinical Site #214 | Berlin | 13125 | Germany | Details | ||
| Exelixis Clinical Site #215 | Hamburg | 20246 | Germany | Details | ||
| Exelixis Clinical Site #146 | Hong Kong | Hong Kong | Details | |||
| Exelixis Clinical Site #42 | Hong Kong | Hong Kong | Details | |||
| Exelixis Clinical Site #9 | Hong Kong | Hong Kong | Details | |||
| Exelixis Clinical Site #140 | Budapest | 1083 | Hungary | Details | ||
| Exelixis Clinical Site #25 | Debrecen | 4032 | Hungary | Details | ||
| Exelixis Clinical Site #26 | Szeged | 6720 | Hungary | Details | ||
| Exelixis Clinical Site #170 | Dublin | 8 | Ireland | Details | ||
| Exelixis Clinical Site #30 | Jerusalem | 9112001 | Israel | Details | ||
| Exelixis Clinical Site #33 | Petah Tikva | 4941492 | Israel | Details | ||
| Exelixis Clinical Site #40 | Ramat-Gan | 5262101 | Israel | Details | ||
| Exelixis Clinical Site #35 | Rehovot | 7661041 | Israel | Details | ||
| Exelixis Clinical Site #163 | Tricase | Lecce | 73039 | Italy | Details | |
| Exelixis Clinical Site #53 | Rozzano | Milano | 20089 | Italy | Details | |
| Exelixis Clinical Site #158 | Bologna | 40138 | Italy | Details | ||
| Exelixis Clinical Site #152 | Brescia | 25124 | Italy | Details | ||
| Exelixis Clinical Site #147 | Milan | 20122 | Italy | Details | ||
| Exelixis Clinical Site #149 | Napoli | 80131 | Italy | Details | ||
| Exelixis Clinical Site #131 | Novara | 28100 | Italy | Details | ||
| Exelixis Clinical Site #167 | Roma | 00168 | Italy | Details | ||
| Exelixis Clinical Site #177 | Torino | 10126 | Italy | Details | ||
| Exelixis Clinical Site #182 | Torino | 10128 | Italy | Details | ||
| Exelixis Clinical Site #243 | Udine | 33100 | Italy | Details | ||
| Exelixis Clinical Site #157 | Goyang-si | Gyeonggi-do | 10408 | Korea, Republic of | Details | |
| Exelixis Clinical Site #127 | Suwon | Gyeonggi-do | 16499 | Korea, Republic of | Details | |
| Exelixis Clinical Site #77 | Busan | 47392 | Korea, Republic of | Details | ||
| Exelixis Clinical Site #86 | Busan | 49201 | Korea, Republic of | Details | ||
| Exelixis Clinical Site #114 | Busan | 49241 | Korea, Republic of | Details | ||
| Exelixis Clinical Site #75 | Incheon | 22332 | Korea, Republic of | Details | ||
| Exelixis Clinical Site #104 | Seoul | 03080 | Korea, Republic of | Details | ||
| Exelixis Clinical Site #105 | Seoul | 03080 | Korea, Republic of | Details | ||
| Exelixis Clinical Site #99 | Seoul | 05505 | Korea, Republic of | Details | ||
| Exelixis Clinical Site #79 | Seoul | 06273 | Korea, Republic of | Details | ||
| Exelixis Clinical Site #93 | Seoul | 06351 | Korea, Republic of | Details | ||
| Exelixis Clinical Site #141 | Tuxtla Gutiérrez | Chiapas | 29038 | Mexico | Details | |
| Exelixis Clinical Site #135 | León | Guanajuato | 37000 | Mexico | Details | |
| Exelixis Clinical Site #132 | Monterrey | Nuevo Leon | 64000 | Mexico | Details | |
| Exelixis Clinical Site #133 | Ciudad De México | 06700 | Mexico | Details | ||
| Exelixis Clinical Site #160 | Mexico City | 06760 | Mexico | Details | ||
| Exelixis Clinical Site #134 | San Luis Potosí | 78250 | Mexico | Details | ||
| Exelixis Clinical Site #153 | Veracruz | 94300 | Mexico | Details | ||
| Exelixis Clinical Site #92 | Maastricht | Limburg | 6229 HX | Netherlands | Details | |
| Exelixis Clinical Site #52 | Amsterdam | Noord-Holland | 1105 AZ | Netherlands | Details | |
| Exelixis Clinical Site #84 | Rotterdam | Zuid-Holland | 3015 GD | Netherlands | Details | |
| Exelixis Clinical Site #36 | Utrecht | 3584 CX | Netherlands | Details | ||
| Exelixis Clinical Site #60 | Grafton | Auckland | 1023 | New Zealand | Details | |
| Exelixis Clinical Site #62 | Newton | Wellington | 6021 | New Zealand | Details | |
| Exelixis Clinical Site #118 | Cebu City | 6000 | Philippines | Details | ||
| Exelixis Clinical Site #117 | Pasig City | 1605 | Philippines | Details | ||
| Exelixis Clinical Site #136 | Quezon City | 1102 | Philippines | Details | ||
| Exelixis Clinical Site #41 | Warszawa | Mazowieckie | 02-507 | Poland | Details | |
| Exelixis Clinical Site #24 | Gdansk | Pomorskie | 80-952 | Poland | Details | |
| Exelixis Clinical Site #15 | Mysłowice | Slaskie | 41-400 | Poland | Details | |
| Exelixis Clinical Site #204 | Cluj-Napoca | Cluj | 400015 | Romania | Details | |
| Exelixis Clinical Site #211 | Cluj-Napoca | Cluj | 400015 | Romania | Details | |
| Exelixis Clinical Site #202 | Cluj-Napoca | Cluj | 400641 | Romania | Details | |
| Exelixis Clinical Site #206 | Bucuresti | 022328 | Romania | Details | ||
| Exelixis Clinical Site #209 | Iaşi | 700483 | Romania | Details | ||
| Exelixis Clinical Site #74 | Kislino | Kursk Region | 305524 | Russian Federation | Details | |
| Exelixis Clinical Site #81 | Kaluga | 248007 | Russian Federation | Details | ||
| Exelixis Clinical Site #95 | Krasnodar | 350040 | Russian Federation | Details | ||
| Exelixis Clinical Site #108 | Moscow | 115478 | Russian Federation | Details | ||
| Exelixis Clinical Site #101 | Murmansk | 183047 | Russian Federation | Details | ||
| Exelixis Clinical Site #80 | Nizhny Novgorod | 603137 | Russian Federation | Details | ||
| Exelixis Clinical Site #111 | Saint Petersburg | 197758 | Russian Federation | Details | ||
| Exelixis Clinical Site #90 | Saint-Petersburg | 197758 | Russian Federation | Details | ||
| Exelixis Clinical Site #73 | Sochi | 354057 | Russian Federation | Details | ||
| Exelixis Clinical Site #106 | Singapore | 169610 | Singapore | Details | ||
| Exelixis Clinical Site #97 | Singapore | 217562 | Singapore | Details | ||
| Exelixis Clinical Site #116 | Singapore | 308433 | Singapore | Details | ||
| Exelixis Clinical Site #28 | Santander | Cantabria | 39008 | Spain | Details | |
| Exelixis Clinical Site #21 | Majadahonda | Madrid | 28222 | Spain | Details | |
| Exelixis Clinical Site #22 | Majadahonda | Madrid | 28222 | Spain | Details | |
| Exelixis Clinical Site #59 | Pamplona | Navarra | 31008 | Spain | Details | |
| Exelixis Clinical Site #103 | Barcelona | 08908 | Spain | Details | ||
| Exelixis Clinical Site #164 | Madrid | 28007 | Spain | Details | ||
| Exelixis Clinical Site #63 | Madrid | 28046 | Spain | Details | ||
| Exelixis Clinical Site #168 | Valencia | 46009 | Spain | Details | ||
| Exelixis Clinical Site #45 | Zaragoza | 50009 | Spain | Details | ||
| Exelixis Clinical Site #115 | Basel | 4031 | Switzerland | Details | ||
| Exelixis Clinical Site #172 | Bern | 3010 | Switzerland | Details | ||
| Exelixis Clinical Site #110 | Saint Gallen | 9007 | Switzerland | Details | ||
| Exelixis Clinical Site #61 | Zurich | 8091 | Switzerland | Details | ||
| Exelixis Clinical Site #119 | Changhua | 500 | Taiwan | Details | ||
| Exelixis Clinical Site #162 | Kaohsiung | 833 | Taiwan | Details | ||
| Exelixis Clinical Site #161 | Taichung | 407 | Taiwan | Details | ||
| Exelixis Clinical Site #197 | Tainan City | 704 | Taiwan | Details | ||
| Exelixis Clinical Site #145 | Tainan | 736 | Taiwan | Details | ||
| Exelixis Clinical Site #82 | Taipei | 10002 | Taiwan | Details | ||
| Exelixis Clinical Site #128 | Taipei | 10491 | Taiwan | Details | ||
| Exelixisi Clinical Site #100 | Taipei | 11217 | Taiwan | Details | ||
| Exelixis Clinical Site #94 | Taoyuan | 333 | Taiwan | Details | ||
| Exelixis Clinical Site #96 | Pathum Wan | Bangkok | 10330 | Thailand | Details | |
| Exelixis Clinical Site #139 | Hat Yai | Songkla | 90110 | Thailand | Details | |
| Exelixis Clinical Site #143 | Chiang Mai | 50200 | Thailand | Details | ||
| Exelixis Clinical Site #183 | Khon Kaen | 40002 | Thailand | Details | ||
| Exelixis Clinical Site #189 | Istanbul | Instanbul | 34098 | Turkey | Details | |
| Exelixis Clinical Site #193 | Ankara | 06010 | Turkey | Details | ||
| Exelixis Clinical Site #178 | Ankara | 06230 | Turkey | Details | ||
| Exelixis Clinical Site #173 | Edirne | 22030 | Turkey | Details | ||
| Exelixis Clinical Site #179 | Istanbul | 34214 | Turkey | Details | ||
| Exelixis Clinical Site #180 | Malatya | 44280 | Turkey | Details | ||
| Exelixis Clinical Site #125 | Chernivtsi | 58013 | Ukraine | Details | ||
| Exelixis Clinical Site #122 | Dnipro | 49102 | Ukraine | Details | ||
| Exelixis Clinical Site #123 | Kharkiv | 61070 | Ukraine | Details | ||
| Exelixis Clinical Site #124 | Odesa | 65055 | Ukraine | Details | ||
| Exelixis Clinical Site #138 | Uzhhorod | 88000 | Ukraine | Details | ||
| Exelixis Clinical Site #83 | Bristol | England | BS2 8ED | United Kingdom | Details | |
| Exelixis Clinical Site #87 | Cambridge | England | CB2 0QQ | United Kingdom | Details | |
| Exelixis Clinical Site #151 | London | England | NW3 2QG | United Kingdom | Details | |
| Exelixis Clinical Site #129 | London | England | W12 0HS | United Kingdom | Details | |
| Exelixis Clinical Site #192 | Manchester | England | M20 4BX | United Kingdom | Details | |
| Exelixis Clinical Site #196 | Belfast | Northern Ireland | BT9 7AB | United Kingdom | Details |