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| NCT ID | NCT03767244 |
| Title | A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy |
| Acronym | PROTEUS |
| Recruitment | Active, not recruiting |
| Gender | male |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Janssen Research & Development, LLC |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | POL | NLD | ITA | ISR | GBR | FRA | ESP | DEU | CZE | CAN | BRA | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | United States | Details | |
| University of Southern California | Los Angeles | California | 90033 | United States | Details | |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | United States | Details | |
| University of California Los Angeles | Los Angeles | California | 90095 | United States | Details | |
| University of California Irvine Medical Center Chao Family Comprehensive Cancer Center | Orange | California | 92868 | United States | Details | |
| UC Davis Medical Center | Sacramento | California | 95817 | United States | Details | |
| AdventHealth Medical Group Urology of Denver | Denver | Colorado | 80210 | United States | Details | |
| Colorado Clinical Research | Lakewood | Colorado | 80228 | United States | Details | |
| Stamford Hospital | Stamford | Connecticut | 06904 | United States | Details | |
| Urology Specialists LLC | Hialeah | Florida | 33002 | United States | Details | |
| Mayo Clinic - Division Of Hematology/oncology | Jacksonville | Florida | 32224 | United States | Details | |
| Miami Cancer Institute at Baptist Health / Baptist Health Medical Group | Miami | Florida | 33176 | United States | Details | |
| Florida Hospital | Orlando | Florida | 32804 | United States | Details | |
| Emory University - Winship Cancer Institute | Atlanta | Georgia | 30322-1013 | United States | Details | |
| University of Chicago | Chicago | Illinois | 60637 | United States | Details | |
| Ochsner LSU Health Shreveport - Regional Urology | Shreveport | Louisiana | 71106 | United States | Details | |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02115 | United States | Details | |
| Beth Isreal Deaconess Medical Center | Boston | Massachusetts | 02215 | United States | Details | |
| Michigan Institute of Urology, PC | Troy | Michigan | 48084 | United States | Details | |
| Saint Louis University | Saint Louis | Missouri | 63110 | United States | Details | |
| Urology Cancer Center, PC | Omaha | Nebraska | 68130 | United States | Details | |
| Albany Medical College | Albany | New York | 12208 | United States | Details | |
| Great Lakes Physician PC d/b/a Western New York Urology Associates | Cheektowaga | New York | 14225 | United States | Details | |
| Memorial Sloan-Kettering Cancer Center | New York | New York | 10065 | United States | Details | |
| Weill Cornell Medical College | New York | New York | 10065 | United States | Details | |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | United States | Details | |
| University of North Carolina | Chapel Hill | North Carolina | 27599 | United States | Details | |
| Duke University School of Medicine | Durham | North Carolina | 27705 | United States | Details | |
| Medication Management LLC | Greensboro | North Carolina | 27403 | United States | Details | |
| Carolina Urology Partners, PLLC | Huntersville | North Carolina | 28078 | United States | Details | |
| Cleveland VA Medical Center | Cleveland | Ohio | 44106 | United States | Details | |
| Oklahoma City VAMC | Oklahoma City | Oklahoma | 73104 | United States | Details | |
| MidLantic Urology | Bala-Cynwyd | Pennsylvania | 19004 | United States | Details | |
| Omega Medical Research | Warwick | Rhode Island | 02886 | United States | Details | |
| Medical University of South Carolina | Charleston | South Carolina | 29403 | United States | Details | |
| Ralph H. Johnson Veterans Affairs Medical Center | Charleston | South Carolina | 29425 | United States | Details | |
| Greenville Health | Greenville | South Carolina | 29605 | United States | Details | |
| Carolina Urologic Research Center | Myrtle Beach | South Carolina | 29572 | United States | Details | |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | United States | Details | |
| VA North Texas Health Care System | Dallas | Texas | 75216 | United States | Details | |
| MD Anderson Cancer Center | Houston | Texas | 77030 | United States | Details | |
| Virginia Urology | Richmond | Virginia | 23235 | United States | Details | |
| Urology of Virginia, PLCC | Virginia Beach | Virginia | 23462 | United States | Details | |
| CAMC Memorial Hospital, Charleston Area Medical Center Physicians | Charleston | West Virginia | 25304 | United States | Details | |
| Hospital Aleman | Caba | 1118 | Argentina | Details | ||
| Hospital Italiano de Buenos Aires | Ciudad Autonoma de | C1199ABB | Argentina | Details | ||
| Cemaic Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica | Cordoba | 5000 | Argentina | Details | ||
| Centro Urologico Profesor Bengio | Cordoba | X5000KPH | Argentina | Details | ||
| Uroclinica | Mendoza | 5500 | Argentina | Details | ||
| Clinica Mayo de UMCB | San Miguel de Tucuman | 4000 | Argentina | Details | ||
| Epworth Eastern Hospital | Box Hill | 3128q | Australia | Details | ||
| St Vincent s Hospital Sydney | Darlinghurst | 2010 | Australia | Details | ||
| Austin Health | Heidelberg | 3084 | Australia | Details | ||
| Australian Urology Associates Pty Ltd | Malvern | 3144 | Australia | Details | ||
| Royal Melbourne Hospital | Parkville | 3052 | Australia | Details | ||
| Northern Cancer Institute | St Leonards | 2065 | Australia | Details | ||
| Australian Clinical Trials - SAN Clinic | Wahroonga | 2076 | Australia | Details | ||
| Westmead Hospital | Westmead | 2145 | Australia | Details | ||
| Princess Alexandra Hospital | Woolloongabba | 4102 | Australia | Details | ||
| Associacao de Combate ao Cancer em Goias - Hospital de Cancer Araujo Jorge | Goiania | 74605-070 | Brazil | Details | ||
| Oncosite - Centro de Pesquisa Clínica em Oncologia Ltda | Ijui | 98700-000 | Brazil | Details | ||
| Liga Norte Riograndense Contra O Cancer | Natal | 59075-740 | Brazil | Details | ||
| Irmandade Santa Casa de Misericordia de Porto Alegre | Porto Alegre | 90020-090 | Brazil | Details | ||
| Universidade do Estado do Rio de Janeiro - UERJ | Rio de Janeiro | 20551-030 | Brazil | Details | ||
| Associacao Umane | Sao Paulo | 01232-910 | Brazil | Details | ||
| Fundacao Faculdade de Medicina - Instituto do Cancer do Estado de Sao Paulo | Sao Paulo | 01246 000 | Brazil | Details | ||
| Instituto Do Cancer Brasil | Tres Lagoas | 79601-001 | Brazil | Details | ||
| Prostate Cancer Centre | Calgary | Alberta | T2V 1P9 | Canada | Details | |
| Vancouver Prostate Centre, Gordon and Leslie Diamond Health Care Centre | Vancouver | British Columbia | V5Z 1M9 | Canada | Details | |
| Nova Scotia Health Authority | Halifax | Nova Scotia | B3H 2Y9 | Canada | Details | |
| London Health Sciences Center | London | Ontario | N6A 5W9 | Canada | Details | |
| Sunnybrook Health Sciences Center | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| University Health Network UHN Princess Margaret Cancer Centre | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| CHUM - Centre hospitalier universitaire de Montreal | Montreal | Quebec | H2X 0A9 | Canada | Details | |
| CHU de Quebec Universite Laval Hopital de l Enfant Jesus | Quebec | G1R 2J6 | Canada | Details | ||
| Fakultni nemocnice Hradec Kralove | Hradec Králove | 500 05 | Czechia | Details | ||
| Krajská nemocnice Liberec | Liberec | 460 63 | Czechia | Details | ||
| Uromedical Center s.r.o. | Olomouc | 77200 | Czechia | Details | ||
| Fakultni nemocnice Plzen, Urologicka klinika | Plzen | 305 99 | Czechia | Details | ||
| Thomayerova nemocnice | Praha 4 | 140 59 | Czechia | Details | ||
| Vseobecna fakultni nemocnice v Praze | Praha | 120 00 | Czechia | Details | ||
| CHU d'Angers | Angers | 49933 | France | Details | ||
| CHRU Besancon Hopital Jean Minjoz | Besançon Cedex | 25030 | France | Details | ||
| Hopital Pellegrin CHU Bordeaux | Bordeaux N/a | 33076 | France | Details | ||
| APHP - Hopital Henri Mondor | Créteil | 94010 | France | Details | ||
| Hopital Edouard Herriot - CHU Lyon | Lyon cedex 03 | 69437 | France | Details | ||
| CHU de Nantes hotel Dieu | Nantes | 44000 | France | Details | ||
| Institut Mutualiste Montsouris | Paris | 75014 | France | Details | ||
| Clinique de la Croix du Sud | Quint-Fonsegrives | 31130 | France | Details | ||
| Chu Rennes Hopital Pontchaillou | Rennes Cedex | 35033 | France | Details | ||
| CHU de Toulouse - Hôpital Rangueil | Toulouse Cedex 9 | 31059 | France | Details | ||
| CHRU Tours Hopital Bretonneau | Tours | 37000 | France | Details | ||
| Universitaetsklinikum der RWTH Aachen | Aachen | 52074 | Germany | Details | ||
| Städtisches Klinikum Braunschweig gGmbH - Standort Salzdahlumer | Braunschweig | 38126 | Germany | Details | ||
| Universitatsklinikum Essen | Essen | 45147 | Germany | Details | ||
| Universitatsklinikum Frankfurt | Frankfurt am Main | 60590 | Germany | Details | ||
| Prostata zentrum Nordwest | Gronau | 48599 | Germany | Details | ||
| Martini-Klinik am Universitätsklinikum Hamburg-Eppendorf Urologie | Hamburg | 20246 | Germany | Details | ||
| Universitätsklinikum des Saarlandes | Homburg/Saar | 66421 | Germany | Details | ||
| Universitaetsklinikum Koelnt | Koeln | 50937 | Germany | Details | ||
| Universitatsklinikum Schleswig Holstein Campus Lubeck | Lubeck | 23538 | Germany | Details | ||
| Praxis Dr. med. Ralf Eckert | Lutherstadt Eisleben | 06295 | Germany | Details | ||
| Klinikum St. Elisabeth Straubing GmbH | Straubing | 94315 | Germany | Details | ||
| Kliniken Nordoberpfalz, Klinik für Urologie | Weiden/Opf | 92637 | Germany | Details | ||
| Praxisgemeinschaft f. Onkologie u. Urologie - Germany | Wilhelmshaven | 26389 | Germany | Details | ||
| Asaf Harofe Medical Center | Beer Yaakov | 60930 | Israel | Details | ||
| Rambam Health Care Campus | Haifa | 31096 | Israel | Details | ||
| Tel Aviv University Sackler School of Medicine - Meir Medical Center (MMC) | Kfar Saba | 4428164 | Israel | Details | ||
| Rabin Medical Center | Petach Tikva | 49100 | Israel | Details | ||
| The Chaim Sheba Medical Center | Ramat Gan | 52621 | Israel | Details | ||
| Tel Aviv Sourasky Medical Center | Tel Aviv | 64239 | Israel | Details | ||
| Policlinico Abano Terme | Abano Terme | 35031 | Italy | Details | ||
| Generale Regionale F. Miulli | Acquaviva delle Fonti | 70021 | Italy | Details | ||
| Ospedale di Bassano del Grappa | Bassano del Grappa | 36061 | Italy | Details | ||
| ASST Spedali Civili Brescia | Brescia | 25123 | Italy | Details | ||
| ASL2 Lanciano - Vasto - Chieti - Ospedale 'SS Annunziata' di Chieti | Chieti | 66100 | Italy | Details | ||
| Azienda Ospedaliero Universitaria Careggi | Firenze | 50134 | Italy | Details | ||
| San Raffaele Turro - Istituto di Ricovero e Cura a Carattere Scientifico | MIlano | 20127 | Italy | Details | ||
| Ospedale San Raffaele | Milano | 20132 | Italy | Details | ||
| Istituto Europeo di Oncologia | Milano | 20141 | Italy | Details | ||
| Clinica di Urologia Policlinico di Modena - Universita di Modena e reggio Emilia | Modena | 41100 | Italy | Details | ||
| Università del Piemonte Orientale - Ospedale Maggiore della Carità di Novara | Novara | 28100 | Italy | Details | ||
| Universita degli Studi di Torino - Azienda Ospedaliero-Universitaria San Luigi Gonzaga | Orbassano | 10043 | Italy | Details | ||
| Universita Campus Bio-Medico di Roma | Roma | 00128 | Italy | Details | ||
| Istituto Nazionale Tumori Regina Elena | Roma | 00144 | Italy | Details | ||
| Azienda Ospedaliera Sant Andrea | Roma | 00189 | Italy | Details | ||
| Ospedale Molinette, AO Città della Salute e della Scienza di | Torino | 10126 | Italy | Details | ||
| UOC di Urologia AOU Integrata di Verona - Polo Chirurgico Confortini - Ospedale Borgo Trento | Verona | 37126 | Italy | Details | ||
| Akita University Hospital | Akita | 010-8543 | Japan | Details | ||
| Chiba University Hospital | Chiba | 260 8677 | Japan | Details | ||
| Chiba Cancer Center | Chuo-ku, Chiba-City, | 260-8717 | Japan | Details | ||
| Hakodate Goryoukaku Hospital | Hakodate | 040-8611 | Japan | Details | ||
| Hirosaki University Hospital | Hirosaki | 036-8203 | Japan | Details | ||
| Kanazawa University Hospital | Kanazawa | 920 8641 | Japan | Details | ||
| Kobe City Medical Center General Hospital | Kobe | 650-0047 | Japan | Details | ||
| Dokkyo Medical University Saitama Medical Center | Koshigaya | 343-8555 | Japan | Details | ||
| Kurume University Hospital | Kurume | 830-0011 | Japan | Details | ||
| Kyoto University Hospital | Kyoto | 606-8507 | Japan | Details | ||
| Aso Co.,Ltd Iizuka Hospital | Matsuyama | 791-0280 | Japan | Details | ||
| Kitasato University Hospital | Minami-Ku, Sagamihara-Shi | 252-0375 | Japan | Details | ||
| University of Miyazaki Hospital | Miyazaki | 889-1692 | Japan | Details | ||
| Nagano Municipal Hospital | Nagano | 381-8551 | Japan | Details | ||
| Osaka International Cancer Institute | Osaka City | 541 8567 | Japan | Details | ||
| Kindai University Hospital | Osaka Sayama shi | 589 8511 | Japan | Details | ||
| Toho University Sakura Medical Center | Sakura | 285-8741 | Japan | Details | ||
| Hokkaido University Hospital | Sapporo-shi | 060-8648 | Japan | Details | ||
| Iwate Medical University Hospital | Shiwa-gun | 028-3695 | Japan | Details | ||
| Juntendo University Hospital | Tokyo | 113-8421 | Japan | Details | ||
| Nippon Medical School Hospital | Tokyo | 113-8603 | Japan | Details | ||
| Yamaguchi University Hospital | Ube | 755-8505 | Japan | Details | ||
| Yokohama City University Medical Center | Yokohama | 232 0024 | Japan | Details | ||
| Chonnam National University Hospital | Gwangju | 61469 | Korea, Republic of | Details | ||
| Seoul National University Bundang Hospital | Gyeonggi-do | 13605 | Korea, Republic of | Details | ||
| Severance Hospital Yonsei University Health System | Seoul | 03722 | Korea, Republic of | Details | ||
| Asan Medical Center | Seoul | 05505 | Korea, Republic of | Details | ||
| The Catholic University of Korea Seoul St Marys Hospital | Seoul | 06591 | Korea, Republic of | Details | ||
| Antoni van Leeuwenhoek | Amsterdam | 1066 CX | Netherlands | Details | ||
| Catharinaziekenhuis | Eindhoven | 5623 EJ | Netherlands | Details | ||
| St. Antonius Ziekenhuis (St. Antonius Hospital) | Nieuwegein | 3430EM | Netherlands | Details | ||
| Canisius-Wilhelmina Ziekenhuis | Nijmegen | 6524 KD | Netherlands | Details | ||
| Samodzielny Publiczny Wielospecjalistyczny Zakład Opieki Zdrowotnej MSWiA w Bydgoszczy | Bydgoszcz | 85-015 | Poland | Details | ||
| Szpital Uniwersytecki NR 1 IM. Dr. Antoniego Jurasza | Bydgoszcz | 85-094 | Poland | Details | ||
| Szpital Wojewodzki im Mikolaja Kopernika w Koszalinie | Koszalin | 75-581 | Poland | Details | ||
| Pratia MCM Krakow | Krakow | 30 727 | Poland | Details | ||
| City Clinic Sp. z o.o. | Warszawa | 02-473 | Poland | Details | ||
| Dolnoslaskie Centrum Onkologii, Oddzial Chirurgii Onkologicznej II - Urologia | Wrocław | 53-413 | Poland | Details | ||
| Altai Regional Oncology Dispensary | Barnaul | 656049 | Russian Federation | Details | ||
| Chelyabinsk Regional Clinical Center Of Oncology And Nuclear Medicine | Chelyabinsk | 454087 | Russian Federation | Details | ||
| Moscow City Clinical Hospital # 62 | Moscow | 125130 | Russian Federation | Details | ||
| Hertzen Oncology Research Institute | Moscow | 125284 | Russian Federation | Details | ||
| Clinical Oncology Dispensary | Omsk | 644013 | Russian Federation | Details | ||
| Medical-sanitary unit 'Neftyanik' | Tyumen | 625000 | Russian Federation | Details | ||
| Vologda Regional Oncological Dispensary | Vologda | 160012 | Russian Federation | Details | ||
| Hosp Univ A Coruna | A Coruna | 15006 | Spain | Details | ||
| Hosp Univ Vall D Hebron | Barcelona | 8035 | Spain | Details | ||
| Hosp. Puerta Del Mar | Cadiz | 11009 | Spain | Details | ||
| Hosp. Gral. Univ. de Castellon | Castellón | 12004 | Spain | Details | ||
| Hosp. de Jerez de La Frontera | Jerez de la Frontera | 11407 | Spain | Details | ||
| Hosp. Univ. Ramon Y Cajal | Madrid | 28034 | Spain | Details | ||
| Hosp. Univ. 12 de Octubre | Madrid | 28041 | Spain | Details | ||
| Hosp. Univ. La Paz | Madrid | 28046 | Spain | Details | ||
| Fund. Hosp. de Manacor | Manacor | 07500 | Spain | Details | ||
| Hosp Virgen de La Victoria | Málaga | 29010 | Spain | Details | ||
| Hosp. Univ. Marques de Valdecilla | Santander | 39008 | Spain | Details | ||
| Hosp. Virgen Del Rocio | Sevilla | 41013 | Spain | Details | ||
| Inst. Valenciano de Oncologia | Valencia | 46009 | Spain | Details | ||
| Hosp. Clinico Univ. de Valencia | Valencia | 46010 | Spain | Details | ||
| Kaohsiung Medical University Chung Ho Memorial Hospital | Kaohsiung | 807 | Taiwan | Details | ||
| China Medical University Hospital | Taichung | 40447 | Taiwan | Details | ||
| Taichung Veterans General Hospital | Taichung | 40705 | Taiwan | Details | ||
| Tungs' Taichung MetroHarbor Hospital | Taichung | 435 | Taiwan | Details | ||
| Chi Mei Medical Center Yong Kang | Tainan | 710 | Taiwan | Details | ||
| National Taiwan University Hospital. | Taipei | 10002 | Taiwan | Details | ||
| Southmead Hospital | Bristol | BS10 5NB | United Kingdom | Details | ||
| University Hospital of Wales | Cardiff | CF14 4XW | United Kingdom | Details | ||
| Ninewells Hospital | Dundee | DD2 1UB | United Kingdom | Details | ||
| The Royal Marsden NHS Trust | London | SW3 6JJ | United Kingdom | Details | ||
| University College London | London | WC1E 6BT | United Kingdom | Details | ||
| Lancashire Teaching Hospitals NHS Foundation Trust Royal Preston Hospital | Preston | PR2 9HT | United Kingdom | Details | ||
| Royal Marsden Hospital | Sutton | SM2 5PT | United Kingdom | Details | ||
| MidYorkshire NHS Trust | Wakefield | WF1 4DG | United Kingdom | Details | ||
| New Cross Hospital | Wolverhampton | WV10 0QP | United Kingdom | Details |