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| NCT ID | NCT03785964 |
| Title | Nirogacestat for Adults With Desmoid Tumor/Aggressive Fibromatosis (DT/AF) (DeFi) |
| Acronym | DeFi |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | SpringWorks Therapeutics |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | NLD | ITA | GBR | DEU | CAN | BEL |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Arkansas Children's Hospital | Little Rock | Arkansas | 72202 | United States | Details | |
| USC/Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | United States | Details | |
| Ronald Regan UCLA Medical Center | Los Angeles | California | 90095 | United States | Details | |
| Stanford Cancer Center | Palo Alto | California | 94304 | United States | Details | |
| UCSF Mission Bay | San Francisco | California | 94158 | United States | Details | |
| Sarcoma Oncology Research Center | Santa Monica | California | 90403 | United States | Details | |
| University of Colorado Hospital-Anschutz Cancer Pavilion (ACP) | Aurora | Colorado | 80045 | United States | Details | |
| Smilow Cancer Hospital at Yale-New Haven | New Haven | Connecticut | 06510 | United States | Details | |
| Washington Cancer Institute at MedStar Washington Hospital Center | Washington | District of Columbia | 20010 | United States | Details | |
| Mayo Clinic Florida | Jacksonville | Florida | 32224 | United States | Details | |
| Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | United States | Details | |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | United States | Details | |
| Johns Hopkins Hospital | Baltimore | Maryland | 21287 | United States | Details | |
| Massachusetts General Hosptial (MGH) | Boston | Massachusetts | 02114 | United States | Details | |
| Dana-Farber Cancer Institute (DFCI) | Boston | Massachusetts | 02215 | United States | Details | |
| University of Michigan | Ann Arbor | Michigan | 48109 | United States | Details | |
| Mayo Clinic Rochester | Rochester | Minnesota | 55905 | United States | Details | |
| Washington University School of Medicine | Saint Louis | Missouri | 63110 | United States | Details | |
| Northwell Health | Lake Success | New York | 11042 | United States | Details | |
| Columbia University Medical Center | New York | New York | 10032 | United States | Details | |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | United States | Details | |
| DUMC/Duke Cancer Center | Durham | North Carolina | 27710 | United States | Details | |
| Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | 45229 | United States | Details | |
| James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | United States | Details | |
| Oregon Health & Science University-Center for Health & Healing | Portland | Oregon | 97201 | United States | Details | |
| Abramson Cancer Center at Pennsylvania Hospital | Philadelphia | Pennsylvania | 19106 | United States | Details | |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | United States | Details | |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | United States | Details | |
| Henry-Joyce Cancer Clinic | Nashville | Tennessee | 37232 | United States | Details | |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | United States | Details | |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | United States | Details | |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | United States | Details | |
| University of Wisconsin Clinical Science Center | Madison | Wisconsin | 53792 | United States | Details | |
| Froedtert Hospital & the Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | United States | Details | |
| Institut Jules Bordet-Medical Oncology | Brussels | 1000 | Belgium | Details | ||
| Cliniques Universitaires Saint-Luc, Institut Roi Albert II | Brussels | 1200 | Belgium | Details | ||
| UZ Gent | Gent | 9000 | Belgium | Details | ||
| UZ Leuven | Leuven | 3000 | Belgium | Details | ||
| Princess Margaret Cancer Centre | Toronto | Ontario | M5G2M9 | Canada | Details | |
| McGill University Health Centre | Montréal | Quebec | H4A3JI | Canada | Details | |
| Helios Klinikum Berlin-Buch | Berlin | 13125 | Germany | Details | ||
| Universitaetsklinikum Hamburg-Eppendorf | Hamburg | 20246 | Germany | Details | ||
| Universitätsmedizin Mannheim | Mannheim | D-68167 | Germany | Details | ||
| IRCCS Istituto Ortopedico Rizzoli | Bologna | 40136 | Italy | Details | ||
| Istituto di Candiolo IRCCS Oncologia Medica | Candiolo | 10060 | Italy | Details | ||
| Fondazione IRCCS Instituto Nazionale dei Tumori di Milano | Milano | 20133 | Italy | Details | ||
| Policlinico Unvrsitario Campus Bio-Medico | Roma | 00128 | Italy | Details | ||
| Radboud University Medical Centre | Nijmegen | Gelderland | 6525GA | Netherlands | Details | |
| The Netherlands Cancer Institute | Amsterdam | 1066 | Netherlands | Details | ||
| Leiden University Medical Center (LUMC) | Leiden | 23333 | Netherlands | Details | ||
| Department of Oncology, University College of London Hospital | London | NW12PG | United Kingdom | Details | ||
| The Royal Marsden NHS Foundation Trust | London | SW36JJ | United Kingdom | Details |