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| NCT ID | NCT03820986 |
| Title | Safety and Efficacy Study of Pembrolizumab (MK-3475) Combined With Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Advance Melanoma (MK-7902-003/E7080-G000-312/LEAP-003) |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Merck Sharp & Dohme Corp. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | SWE | POL | ITA | ISR | GBR | FRA | ESP | DEU | CHE | CAN | BRA | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| The Angeles Clinic and Research Institute ( Site 0707) | Los Angeles | California | 90025 | United States | Details | |
| UCSF Helen Diller Family Comprehensive Cancer Center ( Site 0704) | San Francisco | California | 30322 | United States | Details | |
| California Pacific Medical Center Research Institute ( Site 0705) | San Francisco | California | 94115 | United States | Details | |
| John Wayne Cancer Institute ( Site 0706) | Santa Monica | California | 90404 | United States | Details | |
| University of Colorado Cancer Center ( Site 0708) | Aurora | Colorado | 80045 | United States | Details | |
| Yale Cancer Center ( Site 0709) | New Haven | Connecticut | 06510 | United States | Details | |
| Baptist MD Anderson Cancer Center ( Site 0767) | Jacksonville | Florida | 32207 | United States | Details | |
| Mid-Florida Cancer Centers ( Site 0764) | Orange City | Florida | 32763 | United States | Details | |
| AMG Oncology ( Site 0714) | Park Ridge | Illinois | 60068 | United States | Details | |
| Illinois Cancer Care, PC ( Site 0765) | Peoria | Illinois | 61615 | United States | Details | |
| Minnesota Oncology Specialist, PA ( Site 0766) | Fridley | Minnesota | 55432 | United States | Details | |
| St. Vincent Frontier Cancer Center ( Site 0724) | Billings | Montana | 59102 | United States | Details | |
| Atlantic Health System ( Site 0768) | Morristown | New Jersey | 07960 | United States | Details | |
| Valley Hospital ( Site 0749) | Paramus | New Jersey | 07652 | United States | Details | |
| University of North Carolina - Cancer Hospital ( Site 0751) | Chapel Hill | North Carolina | 27514 | United States | Details | |
| OHSU Center for Health & Healing ( Site 0731) | Portland | Oregon | 97239 | United States | Details | |
| Inova Schar Cancer Institute ( Site 0739) | Fairfax | Virginia | 22031-4867 | United States | Details | |
| Lismore Base Hospital ( Site 0453) | Lismore | Australian Capital Territory | 2480 | Australia | Details | |
| Melanoma Institute Australia ( Site 0452) | North Sydney | New South Wales | 2060 | Australia | Details | |
| Westmead Hospital ( Site 0451) | Westmead | New South Wales | 2145 | Australia | Details | |
| Princess Alexandra Hospital ( Site 0454) | Wooloongabba | Queensland | 4102 | Australia | Details | |
| Eastern Health ( Site 0457) | Box Hill | Victoria | 3128 | Australia | Details | |
| Fiona Stanley Hospital ( Site 0456) | Murdoch | Western Australia | 6150 | Australia | Details | |
| LKH Universitatsklinikum Graz ( Site 0776) | Graz | Steiermark | 8036 | Austria | Details | |
| Medizinische Universitat Wien ( Site 0778) | Wien | 1090 | Austria | Details | ||
| PERSONAL - Oncologia de Precisao e Personalizada ( Site 0399) | Belo Horizonte | Minas Gerais | 30130-090 | Brazil | Details | |
| Hospital de Caridade de Ijui ( Site 0391) | Ijui | Rio Grande Do Sul | 98700-000 | Brazil | Details | |
| Hospital Sao Vicente de Paulo ( Site 0396) | Passo Fundo | Rio Grande Do Sul | 99010-080 | Brazil | Details | |
| Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 0397) | Porto Alegre | Rio Grande Do Sul | 90610-000 | Brazil | Details | |
| Instituto Nacional de Cancer Hospital do Cancer II ( Site 0394) | Rio de Janeiro | 20220-410 | Brazil | Details | ||
| BC Cancer-Kelowna - Sindi Ahluwalia Hawkins Centre ( Site 0661) | Kelowna | British Columbia | V1Y 5L3 | Canada | Details | |
| Lions Gate Hospital ( Site 0662) | North Vancouver | British Columbia | V7L 2L7 | Canada | Details | |
| Sunnybrook Research Institute ( Site 0654) | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0652) | Montreal | Quebec | H2W 3E4 | Canada | Details | |
| McGill University Health Centre ( Site 0651) | Montreal | Quebec | H4A 3J1 | Canada | Details | |
| Centro Investigación del Cáncer James Lind ( Site 0425) | Temuco | Araucania | 4780000 | Chile | Details | |
| Fundacion Arturo Lopez Perez FALP ( Site 0421) | Santiago | Region M. De Santiago | 7500921 | Chile | Details | |
| Pontificia Universidad Catolica de Chile ( Site 0422) | Santiago | Region M. De Santiago | 8330024 | Chile | Details | |
| Sociedad Medica Aren y Bachero Limitada ( Site 0426) | Santiago | Region M. De Santiago | 8420383 | Chile | Details | |
| Oncocentro ( Site 0424) | Vina del Mar | Valparaiso | 2520598 | Chile | Details | |
| Beijing Cancer Hospital ( Site 0601) | Beijing | Beijing | 100036 | China | Details | |
| Fujian Provincial Cancer Hospital ( Site 0612) | Fuzhou | Fujian | 350014 | China | Details | |
| Sun Yat-Sen University Cancer Center ( Site 0602) | Guangzhou | Guangdong | 510000 | China | Details | |
| Henan Cancer Hospital ( Site 0610) | Zhengzhou | Henan | 450003 | China | Details | |
| Nanjing Drum Tower Hospital ( Site 0609) | Nanjing | Jiangsu | 210008 | China | Details | |
| The First Hospital Of Jilin University ( Site 0603) | Chang Chun | Jilin | 130021 | China | Details | |
| Fudan University Shanghai Cancer Center ( Site 0607) | Shanghai | Shanghai | 200032 | China | Details | |
| Tianjin Medical University Cancer Institute & Hospital ( Site 0606) | Tianjin | Tianjin | 300060 | China | Details | |
| Yunnan Cancer Hospital ( Site 0604) | Kunming | Yunnan | 430030 | China | Details | |
| Sir Run Run Shaw Hospital ( Site 0605) | Hangzhou | Zhejiang | 310018 | China | Details | |
| Zhejiang Cancer Hospital ( Site 0608) | Hangzhou | Zhejiang | 310022 | China | Details | |
| Hopital ARCHET 2 ( Site 0009) | Nice | Alpes-Maritimes | 06200 | France | Details | |
| Hopital La Timone ( Site 0002) | Marseille | Bouches-du-Rhone | 13385 | France | Details | |
| CHU Dijon Bourgogne ( Site 0010) | Dijon | Cote-d Or | 21079 | France | Details | |
| Institut Claudius Regaud IUCT Oncopole ( Site 0003) | Toulouse | Haute-Garonne | 31059 | France | Details | |
| Hopital Ambroise Pare Boulogne ( Site 0007) | Boulogne-Billancourt | Hauts-de-Seine | 92100 | France | Details | |
| CHRU Lille - Hopital Claude Huriez ( Site 0004) | Lille | Nord | 59037 | France | Details | |
| CHU de Rouen ( Site 0013) | Rouen | Seine-Maritime | 76000 | France | Details | |
| Centre Hospitalier Victor Dupouy ( Site 0012) | Argenteuil | Val-d Oise | 95100 | France | Details | |
| Institut Gustave Roussy ( Site 0001) | Villejuif | Val-de-Marne | 94805 | France | Details | |
| CHU de la Miletrie Poitiers ( Site 0011) | Poitiers | Vienne | 86021 | France | Details | |
| Klinik fur Dermatologie Allergologie und Venerologie ( Site 0035) | Hannover | Baden-Wurttemberg | 30625 | Germany | Details | |
| Universitaetsklinikum Erlangen ( Site 0044) | Erlangen | Bayern | 91054 | Germany | Details | |
| Universitaetsklinikum Wuerzburg-Department of Dermatology ( Site 0036) | Wuerzburg | Bayern | 97080 | Germany | Details | |
| Hautkrebszentrum Buxtehude ( Site 0037) | Buxtehude | Niedersachsen | 21614 | Germany | Details | |
| Universitaetsklinikum Carl Gustav Carus ( Site 0041) | Dresden | Sachsen | 01307 | Germany | Details | |
| Universitaetsklinikum Leipzig ( Site 0040) | Leipzig | Sachsen | 04103 | Germany | Details | |
| Universitaetsklinikum Schleswig-Holstein Campus Kiel ( Site 0033) | Kiel | Schleswig-Holstein | 24105 | Germany | Details | |
| SRH Wald-Klinikum Gera GmbH ( Site 0042) | Gera | Thuringen | 07548 | Germany | Details | |
| HaEmek Medical Center ( Site 0306) | Afula | 1834111 | Israel | Details | ||
| Soroka Medical Center ( Site 0303) | Beer Sheva | 8457108 | Israel | Details | ||
| Rambam Medical Center ( Site 0301) | Haifa | 3109601 | Israel | Details | ||
| Hadassah Ein Karem Hebrew University Medical Center ( Site 0305) | Jerusalem | 9112001 | Israel | Details | ||
| Rabin Medical Center ( Site 0302) | Petah Tikva | 4941492 | Israel | Details | ||
| Chaim Sheba Medical Center ( Site 0304) | Ramat Gan | 5262000 | Israel | Details | ||
| Sourasky Medical Center ( Site 0307) | Tel Aviv | 6423906 | Israel | Details | ||
| Shamir Medical Center-Assaf Harofeh ( Site 0308) | Zerifin | 70300 | Israel | Details | ||
| ASST Papa Giovanni XXIII ( Site 0062) | Bergamo | Abruzzo | 24127 | Italy | Details | |
| Azienda Ospedaliera Universitaria Senese ( Site 0065) | Siena | Toscana | 53100 | Italy | Details | |
| Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 0064) | Milano | 20133 | Italy | Details | ||
| Istituto Europeo di Oncologia ( Site 0067) | Milano | 20141 | Italy | Details | ||
| Istituto Nazionale Tumori Fondazione Pascale ( Site 0061) | Napoli | 80131 | Italy | Details | ||
| Istituto Oncologico Veneto ( Site 0063) | Padova | 35128 | Italy | Details | ||
| Kyungpook National University Chilgok Hospital ( Site 0553) | Daegu | Taegu-Kwangyokshi | 41404 | Korea, Republic of | Details | |
| Seoul National University Hospital ( Site 0554) | Seoul | 03080 | Korea, Republic of | Details | ||
| Severance Hospital Yonsei University Health System ( Site 0552) | Seoul | 03722 | Korea, Republic of | Details | ||
| Samsung Medical Center ( Site 0551) | Seoul | 06351 | Korea, Republic of | Details | ||
| Centrum Onkologii im.prof. F. Lukaszczyka w Bydgoszczy ( Site 0273) | Bydgoszcz | Kujawsko-pomorskie | 85-796 | Poland | Details | |
| Pratia MCM Krakow ( Site 0280) | Krakow | Malopolskie | 30-510 | Poland | Details | |
| Uniwersyteckie Centrum Kliniczne ( Site 0281) | Gdansk | Pomorskie | 80-214 | Poland | Details | |
| Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 0278) | Gliwice | Slaskie | 44-102 | Poland | Details | |
| Szpital Kliniczny im. Heliodora Swiecickiego Uniwers Medyczn ( Site 0272) | Poznan | Wielkopolskie | 60-780 | Poland | Details | |
| Cancer Care Langenhoven Drive Oncology Centre ( Site 0805) | Port Elizabeth | Eastern Cape | 6045 | South Africa | Details | |
| Sandton Oncology Medical Group PTY LTD ( Site 0802) | Johannesburg | Gauteng | 2196 | South Africa | Details | |
| Cape Town Oncology Trials Pty Ltd ( Site 0803) | Kraaifontein | Western Cape | 7570 | South Africa | Details | |
| Hospital Duran i Reinals ICO de Hospitalet ( Site 0187) | Hospitalet del Llobregat | Barcelona | 08908 | Spain | Details | |
| Hospital Universitario Marques de Valdecilla ( Site 0181) | Santander | Cantabria | 39008 | Spain | Details | |
| Complejo Hospitalario Universitario A Coruna. CHUAC ( Site 0182) | A Coruna | La Coruna | 15006 | Spain | Details | |
| Hospital Universitario Insular de Gran Canaria ( Site 0189) | Las Palmas de Gran Canaria | Las Palmas | 35001 | Spain | Details | |
| Hospital Clinic i Provincial Barcelona ( Site 0190) | Barcelona | 08036 | Spain | Details | ||
| Hospital General Universitario Gregorio Maranon ( Site 0191) | Madrid | 28009 | Spain | Details | ||
| Hospital Universitario Ramon y Cajal ( Site 0183) | Madrid | 28034 | Spain | Details | ||
| Hospital Universitario La Paz ( Site 0184) | Madrid | 28046 | Spain | Details | ||
| Hospital Universitario Carlos Haya ( Site 0186) | Malaga | 29010 | Spain | Details | ||
| Laenssjukhuset Ryhov ( Site 0215) | Jonkoping | Jonkopings Lan | 551 85 | Sweden | Details | |
| Centrallasarettet Vaxjo ( Site 0214) | Vaxjo | Kronobergs Lan | 351 85 | Sweden | Details | |
| Skanes Universitetssjukhus ( Site 0213) | Lund | Skane Lan | 221 85 | Sweden | Details | |
| Karolinska Universitetssjukhuset ( Site 0211) | Solna | Stockholms Lan | 171 64 | Sweden | Details | |
| Akademiska Sjukhuset ( Site 0218) | Uppsala | Uppsala Lan | 751 85 | Sweden | Details | |
| Norrlands Universitetssjukhus ( Site 0216) | Umea | Vasterbottens Lan | 901 85 | Sweden | Details | |
| Sahlgrenska Universitetssjukhuset ( Site 0212) | Goteborg | Vastra Gotalands Lan | 413 45 | Sweden | Details | |
| Universitaetsspital Basel ( Site 0094) | Basel | Basel-Stadt | 4031 | Switzerland | Details | |
| Kantonsspital Graubuenden ( Site 0091) | Chur | Grisons | 7000 | Switzerland | Details | |
| Kantonsspital Winterthur ( Site 0095) | Winterthur | Zurich | 8401 | Switzerland | Details | |
| Universitaetsspital Zuerich ( Site 0092) | Zuerich-Flughafen | Zurich | 8058 | Switzerland | Details | |
| Western General Hospital ( Site 0121) | Edinburgh | Edinburgh, City Of | EH4 2XU | United Kingdom | Details | |
| Guys and St Thomas NHS Foundation Trust ( Site 0126) | London | London, City Of | SE1 9RT | United Kingdom | Details | |
| Derriford Hospital ( Site 0129) | Plymouth | PL6 8DH | United Kingdom | Details | ||
| Singleton Hospital ( Site 0131) | Swansea | SA2 8QA | United Kingdom | Details |