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| NCT ID | NCT03829319 |
| Title | Safety and Efficacy Study of Pemetrexed + Platinum Chemotherapy + Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-7902-006/E7080-G000-315/LEAP-006) |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | Merck Sharp & Dohme Corp. |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | TUR | POL | NZL | ISR | GBR | FRA | ESP | DEU | CAN | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| El Camino Hospital Cancer Center ( Site 0529) | Mountain View | California | 94040 | United States | Details | |
| Yale University ( Site 0519) | New Haven | Connecticut | 06520-8028 | United States | Details | |
| Holy Cross Hospital ( Site 0512) | Fort Lauderdale | Florida | 33308 | United States | Details | |
| Mercy Health-Paducah Medical Oncology and Hematology ( Site 0570) | Paducah | Kentucky | 42003 | United States | Details | |
| Henry Ford Health System ( Site 0563) | Detroit | Michigan | 48202 | United States | Details | |
| Saint Lukes Cancer Institute ( Site 0541) | Kansas City | Missouri | 64111 | United States | Details | |
| Broome Oncology, LLC ( Site 0562) | Johnson City | New York | 13790 | United States | Details | |
| Sanford Health Roger Maris Cancer Center ( Site 0533) | Fargo | North Dakota | 58122 | United States | Details | |
| Stephenson Cancer Center ( Site 0504) | Oklahoma City | Oklahoma | 73104 | United States | Details | |
| Good Samaritan Hospital Corvallis ( Site 0521) | Corvallis | Oregon | 97330 | United States | Details | |
| Thomas Jefferson University Hospital ( Site 0548) | Philadelphia | Pennsylvania | 19107 | United States | Details | |
| Abington Hospital - Asplundh Cancer Center ( Site 0575) | Willow Grove | Pennsylvania | 19090 | United States | Details | |
| West Cancer Center - East Campus ( Site 0544) | Germantown | Tennessee | 38138 | United States | Details | |
| Parkland Health & Hospital System ( Site 0576) | Dallas | Texas | 75235 | United States | Details | |
| UT Southwestern Medical Center ( Site 0558) | Dallas | Texas | 75390 | United States | Details | |
| Utah Cancer Specialists ( Site 0523) | Salt Lake City | Utah | 84106 | United States | Details | |
| West Virginia University ( Site 0526) | Morgantown | West Virginia | 26506 | United States | Details | |
| Centro de Oncologia e Investigacion Buenos Aires COIBA ( Site 0367) | Berazategui | Buenos Aires | B1884BBF | Argentina | Details | |
| Instituto de Investigaciones Clinicas Mar del Plata ( Site 0371) | Mar del Plata | Buenos Aires | B7600FZO | Argentina | Details | |
| CEMIC ( Site 0370) | Buenos Aires | Caba | C1431FWO | Argentina | Details | |
| Sanatorio Parque ( Site 0365) | Rosario | Santa Fe | S2000DSV | Argentina | Details | |
| Hospital Aleman ( Site 0368) | Buenos Aires | C1118AAT | Argentina | Details | ||
| Instituto Medico Especializado Alexander Fleming ( Site 0369) | Buenos Aires | C1426ANZ | Argentina | Details | ||
| CEMAIC ( Site 0374) | Cordoba | X5008HHW | Argentina | Details | ||
| CER San Juan Centro Polivalente de Asistencia e Investigacion Clinica ( Site 0372) | San Juan | J5402DIL | Argentina | Details | ||
| Blacktown Hospital Western Sydney Local Health District ( Site 0008) | Blacktown | New South Wales | 2148 | Australia | Details | |
| Port Macquarie Base Hospital ( Site 0001) | Port Macquarie | New South Wales | 2444 | Australia | Details | |
| Chris OBrien Lifehouse ( Site 0006) | Sydney | New South Wales | 2050 | Australia | Details | |
| Westmead Hospital ( Site 0009) | Sydney | New South Wales | 2145 | Australia | Details | |
| Cairns Hospital ( Site 0002) | Cairns | Queensland | 4870 | Australia | Details | |
| The Prince Charles Hospital ( Site 0010) | Chermside | Queensland | 4032 | Australia | Details | |
| Ballarat Health Services ( Site 0003) | Ballarat | Victoria | 3350 | Australia | Details | |
| Moncton Hospital - Horizon Health Network ( Site 0410) | Moncton | New Brunswick | E1C 6Z8 | Canada | Details | |
| Juravinski Cancer Centre ( Site 0407) | Hamilton | Ontario | L8V 1C3 | Canada | Details | |
| Kingston Health Sciences Centre ( Site 0414) | Kingston | Ontario | K7L 2V7 | Canada | Details | |
| Lakeridge Health ( Site 0406) | Oshawa | Ontario | L1G 2B9 | Canada | Details | |
| Sault Area Hospital ( Site 0413) | Sault Ste Marie | Ontario | P6B 0A8 | Canada | Details | |
| Hopital Cite de la Sante de Laval ( Site 0400) | Laval | Quebec | H7M 3L9 | Canada | Details | |
| CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0412) | Montreal | Quebec | H3T 1M5 | Canada | Details | |
| CIUSSS de la Mauricie et du Centre du Quebec ( Site 0408) | Trois-Rivieres | Quebec | G8Z 3R9 | Canada | Details | |
| CHU de Quebec-Universite Laval-Hotel Dieu de Quebec ( Site 0403) | Quebec | G1R 2J6 | Canada | Details | ||
| Centro de Investigacion y desarrollo Oncologico SpA - CIDO SpA ( Site 0380) | Temuco | Araucania | 4810218 | Chile | Details | |
| Clinica Universidad Catolica del Maule ( Site 0385) | Talca | Maule | 3465584 | Chile | Details | |
| OrlandiOncologia ( Site 0381) | Santiago | Region M. De Santiago | 7500713 | Chile | Details | |
| Fundacion Arturo Lopez Perez FALP ( Site 0383) | Santiago | Region M. De Santiago | 7500921 | Chile | Details | |
| Pontificia Universidad Catolica de Chile ( Site 0382) | Santiago | Region M. De Santiago | 8330032 | Chile | Details | |
| Bradford Hill Centro de Investigaciones Clinicas ( Site 0387) | Santiago | Region M. De Santiago | 8420383 | Chile | Details | |
| Oncocentro ( Site 0384) | Vina del Mar | Valparaiso | 2520598 | Chile | Details | |
| Centro Oncologico Antofagasta ( Site 0386) | Antofagasta | 1240000 | Chile | Details | ||
| Peking Union Medical College Hospital ( Site 0108) | Beijing | Beijing | 100006 | China | Details | |
| Cancer Hospital Chinese Academy of Medical Science ( Site 0117) | Beijing | Beijing | 100021 | China | Details | |
| Beijing Cancer Hospital ( Site 0120) | Beijing | Beijing | 100036 | China | Details | |
| The Second Hospital Affiliated to AMU ( Site 0119) | Chongqing | Chongqing | 400037 | China | Details | |
| First Affiliated Hospital of The Third Military Medical University ( Site 0118) | Chongqing | Chongqing | 400038 | China | Details | |
| Fujian Provincial Cancer Hospital ( Site 0102) | Fuzhou | Fujian | 350014 | China | Details | |
| Southern Medical University Nanfang Hospital ( Site 0121) | Guangzhou | Guangdong | 510515 | China | Details | |
| The Third Affiliated Hospital of Harbin Medical University ( Site 0100) | Harbin | Heilongjiang | 150081 | China | Details | |
| Henan Cancer Hospital ( Site 0112) | Zhengzhou | Henan | 450008 | China | Details | |
| Wuhan Union Hospital Cancer Center-Cancer Center ( Site 0123) | Wuhan | Hubei | 430022 | China | Details | |
| Hubei Cancer Hospital ( Site 0122) | Wuhan | Hubei | 430079 | China | Details | |
| Jilin Cancer Hospital ( Site 0115) | Changchun | Jilin | 130103 | China | Details | |
| Zhongshan Hospital Fudan University ( Site 0103) | Shanghai | Shanghai | 200032 | China | Details | |
| Shanghai Pulmonary Hospital ( Site 0101) | Shanghai | Shanghai | 200443 | China | Details | |
| Tianjin Medical University Cancer Institute & Hospital ( Site 0111) | Tian Jin | Tianjin | 300060 | China | Details | |
| Cancer Hospital Affiliated to Xinjiang Medical University ( Site 0110) | Urumuqi | Xinjiang | 830000 | China | Details | |
| The First Affiliated Hospital Zhejiang University ( Site 0109) | Hangzhou | Zhejiang | 310003 | China | Details | |
| Zhejiang Cancer Hospital ( Site 0113) | Hangzhou | Zhejiang | 310022 | China | Details | |
| The First Affiliated Hospital of Wenzhou Medical University ( Site 0124) | Wen Zhou | Zhejiang | 325000 | China | Details | |
| Centre Paul Strauss ( Site 0144) | Strasbourg | Bas-Rhin | 67065 | France | Details | |
| Hopital Nord du Marseille ( Site 0147) | Marseille | Bouches-du-Rhone | 13015 | France | Details | |
| Hopital Foch ( Site 0145) | Suresnes | Hauts-de-Seine | 92151 | France | Details | |
| Centre de Cancerologie du Grand Montpellier ( Site 0142) | Montpellier | Herault | 34070 | France | Details | |
| Hopital Laennec ( Site 0146) | Nantes cedex 1 | Loire-Atlantique | 44093 | France | Details | |
| Hopital Robert Schuman ( Site 0143) | Vantoux | Moselle | 57070 | France | Details | |
| Hopital Cardiologique Louis Pradel ( Site 0141) | Bron | Rhone-Alpes | 69500 | France | Details | |
| L'hopital Nord-Ouest - Centre Hospitalier de Villefranche sur Saone ( Site 0149) | Villefranche sur Saone | Rhone | 69655 | France | Details | |
| Hopital Cochin ( Site 0140) | Paris | 75014 | France | Details | ||
| Klinikum Esslingen GmbH ( Site 0164) | Esslingen | Baden-Wurttemberg | 73730 | Germany | Details | |
| Krankenhaus Nordwest ( Site 0169) | Frankfurt | Hessen | 60488 | Germany | Details | |
| Pius Hospital Oldenburg ( Site 0170) | Oldenburg | Niedersachsen | 26121 | Germany | Details | |
| Uniklinik RWTH Aachen ( Site 0160) | Aachen | Nordrhein-Westfalen | 52074 | Germany | Details | |
| Universitaetsklinikum des Saarlandes ( Site 0165) | Homburg | Saarland | 66421 | Germany | Details | |
| Krankenhaus Martha Maria Halle-Doelau ( Site 0166) | Halle | Sachsen-Anhalt | 06120 | Germany | Details | |
| LungenClinic Grosshansdorf GmbH ( Site 0171) | Grosshansdorf | Schleswig-Holstein | 22927 | Germany | Details | |
| Hamato-Onkologie Hamburg Prof. Laack und Partner ( Site 0161) | Hamburg | 20251 | Germany | Details | ||
| Soroka Medical Center ( Site 0222) | Beer Sheva | 8410101 | Israel | Details | ||
| Rambam Medical Center ( Site 0223) | Haifa | 3109601 | Israel | Details | ||
| Shaare Zedek Medical Center-Oncology ( Site 0229) | Jerusalem | 9013102 | Israel | Details | ||
| Meir Medical Center ( Site 0221) | Kfar Saba | 4428164 | Israel | Details | ||
| Holy Family Hospital ( Site 0228) | Nazareth | 1641101 | Israel | Details | ||
| Rabin Medical Center ( Site 0224) | Petah Tikva | 4941492 | Israel | Details | ||
| Sheba Medical Center ( Site 0220) | Ramat Gan | 5262000 | Israel | Details | ||
| Sourasky Medical Center ( Site 0225) | Tel Aviv | 6423906 | Israel | Details | ||
| Shamir Medical Center-Assaf Harofeh ( Site 0227) | Zerifin | 70300 | Israel | Details | ||
| National Hospital Organization Nagoya Medical Center ( Site 0017) | Nagoya | Aichi | 460-0001 | Japan | Details | |
| Fujita Health University Hospital ( Site 0016) | Toyoake | Aichi | 470-1192 | Japan | Details | |
| National Cancer Center Hospital East ( Site 0024) | Kashiwa | Chiba | 277-8577 | Japan | Details | |
| Kanazawa University Hospital ( Site 0018) | Kanazawa | Ishikawa | 920-8641 | Japan | Details | |
| Osaka Habikino Medical Center ( Site 0020) | Habikino | Osaka | 583-8588 | Japan | Details | |
| Kansai Medical University Hospital ( Site 0022) | Hirakata | Osaka | 573-1191 | Japan | Details | |
| Niigata Cancer Center Hospital ( Site 0019) | Niigata | 951-8566 | Japan | Details | ||
| National Cancer Center Hospital ( Site 0026) | Tokyo | 104-0045 | Japan | Details | ||
| Tokyo Metropolitan Komagome Hospital ( Site 0015) | Tokyo | 113-8677 | Japan | Details | ||
| The Cancer Institute Hospital of JFCR ( Site 0021) | Tokyo | 135-8550 | Japan | Details | ||
| Wakayama Medical University Hospital ( Site 0025) | Wakayama | 641-8510 | Japan | Details | ||
| Chungbuk National University Hospital ( Site 0062) | Cheongju si | Chungbuk | 28644 | Korea, Republic of | Details | |
| National Cancer Center ( Site 0061) | Goyang-si | Kyonggi-do | 10408 | Korea, Republic of | Details | |
| The Catholic University of Korea St. Vincent s Hospital ( Site 0064) | Gyeonggi-do | Kyonggi-do | 16247 | Korea, Republic of | Details | |
| Severance Hospital Yonsei University Health System ( Site 0063) | Seoul | 03722 | Korea, Republic of | Details | ||
| Tauranga Hospital ( Site 0004) | Tauranga | Bay Of Plenty | 3112 | New Zealand | Details | |
| Auckland City Hospital ( Site 0011) | Auckland | 1023 | New Zealand | Details | ||
| Centrum Onkologii im.prof. F. Lukaszczyka w Bydgoszczy ( Site 0601) | Bydgoszcz | Kujawsko-pomorskie | 85-796 | Poland | Details | |
| Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii ( Site 0613) | Lodz | Lodzkie | 93-513 | Poland | Details | |
| Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0603) | Warszawa | Mazowieckie | 02-781 | Poland | Details | |
| Pleszewskie Centrum Medyczne w Pleszewie Sp. z o.o. ( Site 0615) | Pleszew | Wielkopolskie | 63-300 | Poland | Details | |
| MED-POLONIA Sp. z o.o. ( Site 0609) | Poznan | Wielkopolskie | 60-693 | Poland | Details | |
| Szpital Wojewodzki im. Mikolaja Kopernika ( Site 0602) | Koszalin | Zachodniopomorskie | 75-581 | Poland | Details | |
| Leningrad Regional Oncology Center ( Site 0271) | Saint Petersburg | Leningradskaya Oblast | 197758 | Russian Federation | Details | |
| Moscow Regional Oncological Dispensary ( Site 0274) | Balashikha | Moskovskaya Oblast | 143900 | Russian Federation | Details | |
| City Clinical Hospital 1 na. NI. Pirogov ( Site 0270) | Moscow | Moskva | 119049 | Russian Federation | Details | |
| Central Clinical Hospital with outpatient Clinic ( Site 0262) | Moscow | Moskva | 121359 | Russian Federation | Details | |
| National Medical Research Radiology Centre ( Site 0260) | Moscow | Moskva | 125284 | Russian Federation | Details | |
| FSAI Treatment and Rehabilitation Centre of the MoH and SD of RF ( Site 0264) | Moscow | Moskva | 125367 | Russian Federation | Details | |
| Nizhniy Novgorod Region Oncology Dispensary ( Site 0272) | Nizhniy Novgorod | Nizhegorodskaya Oblast | 603081 | Russian Federation | Details | |
| Omsk Clinical Oncology Dispensary ( Site 0267) | Omsk | Omskaya Oblast | 644013 | Russian Federation | Details | |
| Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 0269) | Saint Petersburg | Sankt-Peterburg | 197758 | Russian Federation | Details | |
| First Pavlov State Medical University of Saint Petersburg-Department of Oncology ( Site 0273) | Saint-Petersburg | Sankt-Peterburg | 197022 | Russian Federation | Details | |
| SAHI Republican Clinical Oncological Dispensary of the MoH of RT ( Site 0261) | Kazan | Tatarstan, Respublika | 420029 | Russian Federation | Details | |
| ICO L Hospitalet ( Site 0234) | Hospitalet de Llobregat | Barcelona | 08907 | Spain | Details | |
| Complejo Hospitalario Universitario A Coruna ( Site 0239) | A Coruna | La Coruna | 15006 | Spain | Details | |
| Hospital Universitario Insular de Gran Canaria ( Site 0244) | Las Palmas de Gran Canaria | Las Palmas | 35001 | Spain | Details | |
| Hospital General Universitario de Valencia ( Site 0231) | Valencia | Valenciana, Comunitat | 46014 | Spain | Details | |
| Hospital Universitario La Fe ( Site 0233) | Valencia | Valenciana, Comunitat | 46026 | Spain | Details | |
| Hospital General Universitario de Alicante ( Site 0240) | Alicante | 03010 | Spain | Details | ||
| Hospital Santa Creu i Sant Pau ( Site 0241) | Barcelona | 08025 | Spain | Details | ||
| Hospital General Universitario Gregorio Maranon ( Site 0237) | Madrid | 28009 | Spain | Details | ||
| Hospital Clinico San Carlos ( Site 0235) | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario La Paz ( Site 0236) | Madrid | 28046 | Spain | Details | ||
| Complejo Hospitalario de Malaga ( Site 0238) | Malaga | 29010 | Spain | Details | ||
| Hospital Universitario Miguel Servet ( Site 0242) | Zaragoza | 50009 | Spain | Details | ||
| Cukurova Universitesi Tıp Fakultesi Balcalı Hastanesi ( Site 0314) | Adana | 01330 | Turkey | Details | ||
| Hacettepe Universitesi Tıp Fakultesi ( Site 0316) | Ankara | 06100 | Turkey | Details | ||
| Ankara Universitesi Tip Fakultesi. ( Site 0317) | Ankara | 06620 | Turkey | Details | ||
| Ankara Sehir Hastanesi ( Site 0323) | Ankara | 06800 | Turkey | Details | ||
| Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 0312) | Istanbul | 34098 | Turkey | Details | ||
| Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 0310) | Istanbul | 34722 | Turkey | Details | ||
| Ege Universitesi Tip Fakultesi ( Site 0313) | Izmir | 35100 | Turkey | Details | ||
| Inonu Universitesi Medical Fakultesi ( Site 0318) | Malatya | 44280 | Turkey | Details | ||
| Cambridge University Hospitals NHS Trust ( Site 0293) | Cambridge | Cambridgeshire | CB2 0QQ | United Kingdom | Details | |
| North Middlesex University Hospital NHS Trust ( Site 0291) | London | London, City Of | N18 1QX | United Kingdom | Details | |
| Guys and St Thomas NHS Foundation Trust ( Site 0280) | London | London, City Of | SE1 9RT | United Kingdom | Details | |
| St Georges University Hospitals NHS Foundation Trust. ( Site 0292) | London | London, City Of | SW17 0QT | United Kingdom | Details | |
| Aberdeen Royal Infirmary ( Site 0288) | Aberdeen | Scotland | AB25 2ZN | United Kingdom | Details | |
| Leeds Teaching Hospital NHS Trust. St. James University Hospital ( Site 0276) | Leeds | LS9 7TF | United Kingdom | Details | ||
| Leicester Royal Infirmary ( Site 0284) | Leicester | LE1 5WW | United Kingdom | Details | ||
| Christie NHS Foundation Trust ( Site 0275) | Manchester | M20 4BX | United Kingdom | Details | ||
| Nottingham City Hospital Campus ( Site 0287) | Nottingham | NG5 1PB | United Kingdom | Details | ||
| The Clatterbridge Cancer Centre NHS Foundation Trust ( Site 0286) | Wirral | CH63 4JY | United Kingdom | Details |