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| NCT ID | NCT03829332 |
| Title | Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) in Adults With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Treatment-naïve Nonsmall Cell Lung Cancer (NSCLC) (MK-7902-007/E7080-G000-314/LEAP-007) |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Merck Sharp & Dohme Corp. |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | TUR | POL | ITA | ISR | HUN | FRA | EST | CAN | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Alaska Clinical Research Center ( Site 0511) | Anchorage | Alaska | 99503 | United States | Details | |
| Ironwood Cancer & Research Centers ( Site 0541) | Chandler | Arizona | 85224 | United States | Details | |
| CBCC Global Research, Inc. ( Site 0532) | Bakersfield | California | 93309 | United States | Details | |
| Scripps Cancer Center ( Site 0521) | La Jolla | California | 92037 | United States | Details | |
| Florida Hospital ( Site 0526) | Orlando | Florida | 32803 | United States | Details | |
| Northwest Georgia Oncology Centers PC ( Site 0518) | Marietta | Georgia | 30060 | United States | Details | |
| Illinois Cancer Care, PC ( Site 0557) | Peoria | Illinois | 61615 | United States | Details | |
| Parkview Cancer Center ( Site 0542) | Fort Wayne | Indiana | 46845 | United States | Details | |
| University of Kentucky School of Medicine & Hospitals ( Site 0517) | Lexington | Kentucky | 40536 | United States | Details | |
| Anne Arundel Medical Center Oncology and Hematology ( Site 0514) | Annapolis | Maryland | 21401 | United States | Details | |
| Munson Medical Center ( Site 0512) | Traverse City | Michigan | 49684 | United States | Details | |
| Park Nicollet Frauenshuh Cancer Center ( Site 0554) | Saint Louis Park | Minnesota | 55426 | United States | Details | |
| University of Missouri Health Care ( Site 0555) | Columbia | Missouri | 65212 | United States | Details | |
| Billings Clinic Cancer Center ( Site 0508) | Billings | Montana | 59101 | United States | Details | |
| Cone Health Cancer Center at Alamance Regional ( Site 0527) | Greensboro | North Carolina | 27403 | United States | Details | |
| Genesis Cancer Care Center ( Site 0559) | Zanesville | Ohio | 43701 | United States | Details | |
| Oregon Health Sciences University ( Site 0544) | Portland | Oregon | 97239 | United States | Details | |
| Central Texas Veterans Healthcare System ( Site 0533) | Temple | Texas | 76504 | United States | Details | |
| Orange Health Services ( Site 0002) | Orange | New South Wales | 2800 | Australia | Details | |
| Wollongong Private Hospital ( Site 0005) | Wollongong | New South Wales | 2500 | Australia | Details | |
| The Prince Charles Hospital ( Site 0011) | Chermside | Queensland | 4032 | Australia | Details | |
| Ballarat Oncology and Haematology Services ( Site 0008) | Wendouree | Victoria | 3355 | Australia | Details | |
| St John of God Murdoch Medical Clinic ( Site 0001) | Perth | Western Australia | 6150 | Australia | Details | |
| Cross Cancer Institute ( Site 0400) | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| Lions Gate Hospital ( Site 0407) | North Vancouver | British Columbia | V7L 2L7 | Canada | Details | |
| William Osler Health System (Brampton Civic Hospital) ( Site 0402) | Brampton | Ontario | L6R 3J7 | Canada | Details | |
| Windsor Regional Cancer Program ( Site 0404) | Windsor | Ontario | N8W 2X3 | Canada | Details | |
| McGill University Health Centre ( Site 0418) | Montreal | Quebec | H4A 3J1 | Canada | Details | |
| Beijing Chest Hospital Capital Medical University ( Site 0111) | Beijing | Anhui | 101149 | China | Details | |
| Anhui Provincial Hospital ( Site 0108) | Hefei | Anhui | 230001 | China | Details | |
| The First Affiliated Hospital of Anhui Medical University ( Site 0113) | Hefei | Anhui | 230088 | China | Details | |
| Peking Union Medical College Hospital ( Site 0105) | Beijing | Beijing | 100006 | China | Details | |
| Beijing Cancer Hospital ( Site 0102) | Beijing | Beijing | 100036 | China | Details | |
| Xiangya Hospital of Central South University ( Site 0115) | Changsha | Hunan | 410008 | China | Details | |
| Hunan Cancer Hospital ( Site 0104) | Changsha | Hunan | 410013 | China | Details | |
| Jiangsu Cancer Hospital ( Site 0101) | Nanjing | Jiangsu | 210009 | China | Details | |
| The First Hospital of Jilin University ( Site 0110) | Chang chun | Jilin | 130021 | China | Details | |
| Zhongshan Hospital Fudan University ( Site 0100) | Shanghai | Shanghai | 200433 | China | Details | |
| Shanghai Chest Hospital ( Site 0112) | Shanghai | Shanghai | 230000 | China | Details | |
| 1st Affil Hosp of Med College of Xi'an Jiaotong University ( Site 0103) | XiAn | Shanxi | 710061 | China | Details | |
| West China Hospital of Sichuan University ( Site 0117) | Chengdu | Sichuan | 510115 | China | Details | |
| The First Affiliated Hospital Zhejiang University ( Site 0106) | Hangzhou | Zhejiang | 310003 | China | Details | |
| Hangzhou First People's Hospital ( Site 0109) | Hangzhou | Zhejiang | 310006 | China | Details | |
| 2nd Affil Hosp of Zhejiang University College of Medicine ( Site 0114) | Hangzhou | Zhejiang | 310009 | China | Details | |
| Zhejiang Cancer Hospital ( Site 0116) | Hangzhou | Zhejiang | 310022 | China | Details | |
| Hospital General de Medellin Luz Castro de Gutierrez ( Site 0368) | Medellin | Antioquia | 050015 | Colombia | Details | |
| Fundacion Centro de Investigacion Clinica CIC ( Site 0366) | Medellin | Antioquia | 050021 | Colombia | Details | |
| Biomelab S A S ( Site 0365) | Barranquilla | Atlantico | 080002 | Colombia | Details | |
| Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 0374) | Valledupar | Cesar | 200001 | Colombia | Details | |
| Oncomedica S.A. ( Site 0372) | Monteria | Cordoba | 230002 | Colombia | Details | |
| Centro Medico Imbanaco de Cali S.A ( Site 0369) | Cali | Valle Del Cauca | 760023 | Colombia | Details | |
| AS Ida-Tallinna Keskhaigla ( Site 0161) | Tallinn | Harjumaa | 11312 | Estonia | Details | |
| SA Pohja-Eesti Regionaalhaigla ( Site 0162) | Tallin | Harjumaa | 13419 | Estonia | Details | |
| SA Tartu Ulikooli Kliinikum ( Site 0160) | Tartu | Tartumaa | 50406 | Estonia | Details | |
| CHU Jean Minjoz ( Site 0167) | Besancon | Doubs | 25000 | France | Details | |
| Institut Curie - Centre Rene Huguenin ( Site 0181) | Saint-Cloud | Hauts-de-Seine | 92210 | France | Details | |
| ICM Val D Auerelle ( Site 0177) | Montpellier | Herault | 34090 | France | Details | |
| CHU de Grenoble - Hopital Michallon ( Site 0169) | La Tronche | Isere | 38700 | France | Details | |
| Institut de Cancerologie de l Ouest Centre Rene Gauducheau ( Site 0185) | Saint Herblain | Loire-Atlantique | 44805 | France | Details | |
| Centre Hospitalier de la Cote Basque ( Site 0173) | Bayonne | Pyrenees-Atlantiques | 64109 | France | Details | |
| CHU de Rouen ( Site 0174) | Rouen | Seine-Maritime | 76000 | France | Details | |
| CHU Amiens Sud ( Site 0182) | Amiens | Somme | 80054 | France | Details | |
| Centre hospitalier Toulon Sainte-Musse ( Site 0172) | Toulon | Var | 83056 | France | Details | |
| Institut Curie ( Site 0166) | Paris | 75248 | France | Details | ||
| Bekes Megyei Kozponti Korhaz - Pandy Kalman Tagkorhaza ( Site 0207) | Gyula | Bekes | 5700 | Hungary | Details | |
| Borsod-Abauj-Zemplen Megyei Kozponti Korhaz es Egyetemi Oktatokorhaz ( Site 0202) | Miskolc | Borsod-Abauj-Zemplen | 3529 | Hungary | Details | |
| CRU Hungary KFT ( Site 0209) | Miskolc | Borsod-Abauj-Zemplen | 3529 | Hungary | Details | |
| Petz Aladar Megyei Oktato Korhaz ( Site 0213) | Gyor | Gyor-Moson-Sopron | 9024 | Hungary | Details | |
| Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 0203) | Szolnok | Jasz-Nagykun-Szolnok | 5000 | Hungary | Details | |
| Tudogyogyintezet Torokbalint ( Site 0205) | Torokbalint | Pest | 2045 | Hungary | Details | |
| Semmelweis Egyetem ( Site 0210) | Budapest | 1083 | Hungary | Details | ||
| Somogy Megyei Kaposi Mor Oktato Korhaz ( Site 0217) | Kaposvar | 7400 | Hungary | Details | ||
| Bnei Zion Medical Center ( Site 0227) | Haifa | Heifa | 3339419 | Israel | Details | |
| Sheba Medical Center ( Site 0220) | Ramat Gan | Tel Aviv | 5266202 | Israel | Details | |
| Soroka Medical Center ( Site 0222) | Beer Sheva | 8457108 | Israel | Details | ||
| Rambam Medical Center ( Site 0223) | Haifa | 3109601 | Israel | Details | ||
| Meir Medical Center ( Site 0221) | Kfar-Saba | 4428132 | Israel | Details | ||
| Rabin Medical Center ( Site 0224) | Petah Tikva | 4941492 | Israel | Details | ||
| Sourasky Medical Center ( Site 0225) | Tel Aviv | 6423906 | Israel | Details | ||
| Barzilai Medical Center ( Site 0226) | Ashkelon | Ḥeifā | 7830604 | Israel | Details | |
| Azienda Ospedaliera S. Giovanni Addolorata-Oncologia Medica ( Site 0233) | Roma | Lazio | 00185 | Italy | Details | |
| Presidio Ospedaliero San Vincenzo ( Site 0231) | Taormina | Messina | 98039 | Italy | Details | |
| Centro di Riferimento Oncologico CRO ( Site 0235) | Aviano | Pordenone | 33081 | Italy | Details | |
| Azienda Ospedaliera San Giuseppe Moscati ( Site 0234) | Avellino | 83100 | Italy | Details | ||
| Universita Magna Grecia ( Site 0230) | Catanzaro | 88100 | Italy | Details | ||
| A.O. Universitaria Careggi ( Site 0236) | Firenze | 50134 | Italy | Details | ||
| Ospedale Santa Maria delle Croci ( Site 0232) | Ravenna | 48121 | Italy | Details | ||
| Policlinico Gemelli di Roma ( Site 0237) | Roma | 00168 | Italy | Details | ||
| Aichi Cancer Center Hospital ( Site 0018) | Nagoya | Aichi | 464-8681 | Japan | Details | |
| Kurume University Hospital ( Site 0025) | Kurume | Fukuoka | 830-0011 | Japan | Details | |
| Hyogo Cancer Center ( Site 0021) | Akashi | Hyogo | 673-8558 | Japan | Details | |
| Kanagawa Cardiovascular and Respiratory Center ( Site 0026) | Yokohama | Kanagawa | 236-0051 | Japan | Details | |
| Kanagawa Cancer Center ( Site 0023) | Yokohama | Kanagawa | 241-8515 | Japan | Details | |
| Miyagi Cancer Center ( Site 0028) | Natori | Miyagi | 981-1293 | Japan | Details | |
| Sendai Kousei Hospital ( Site 0022) | Sendai | Miyagi | 980-0873 | Japan | Details | |
| Kindai University Hospital ( Site 0017) | Osakasayama | Osaka | 589-8511 | Japan | Details | |
| National Hospital Organization Kinki-chuo Chest Medical Center ( Site 0027) | Sakai | Osaka | 591-8555 | Japan | Details | |
| National Hospital Organization Kyushu Medical Center ( Site 0015) | Fukuoka | 810-8563 | Japan | Details | ||
| Kyushu University Hospital ( Site 0030) | Fukuoka | 812-8582 | Japan | Details | ||
| Okayama University Hospital ( Site 0020) | Okayama | 700-8558 | Japan | Details | ||
| Osaka International Cancer Institute ( Site 0019) | Osaka | 541-8567 | Japan | Details | ||
| Toranomon Hospital ( Site 0016) | Tokyo | 105-8470 | Japan | Details | ||
| Juntendo University Hospital ( Site 0029) | Tokyo | 113-8431 | Japan | Details | ||
| Nippon Medical School Hospital ( Site 0024) | Tokyo | 113-8603 | Japan | Details | ||
| Chungbuk National University Hospital ( Site 0079) | Cheongju si | Chungbuk | 28644 | Korea, Republic of | Details | |
| Seoul National University Bundang Hospital ( Site 0075) | Seongnam-si | Kyonggi-do | 13620 | Korea, Republic of | Details | |
| Ulsan University Hospital ( Site 0077) | Ulsan | Ulsan-Kwangyokshi | 44033 | Korea, Republic of | Details | |
| Asan Medical Center ( Site 0076) | Seoul | 05505 | Korea, Republic of | Details | ||
| SMG-SNU Boramae Medical Center ( Site 0078) | Seoul | 07061 | Korea, Republic of | Details | ||
| Hospital Tengku Ampuan Afzan ( Site 0062) | Kuantan | Pahang | 25100 | Malaysia | Details | |
| Hospital Pulau Pinang. ( Site 0065) | Georgetown | Pulau Pinang | 10990 | Malaysia | Details | |
| Sarawak General Hospital ( Site 0064) | Kuching | Sarawak | 93586 | Malaysia | Details | |
| Beacon Hospital Sdn Bhd ( Site 0067) | Petaling Jaya | Selangor | 46050 | Malaysia | Details | |
| Institut Kanser Negara - National Cancer Institute ( Site 0063) | Putrajaya | Wilayah Persekutuan Putrajaya | 62250 | Malaysia | Details | |
| University Malaya Medical Centre ( Site 0061) | Kuala Lumpur | 59100 | Malaysia | Details | ||
| Gleneagles Penang ( Site 0066) | Pulau Pinang | 10050 | Malaysia | Details | ||
| Medica Sur S.A.B de C.V. ( Site 0384) | Mexico City | Distrito Federal | 14050 | Mexico | Details | |
| Consultorios de Medicina Especializada del Sector Privado ( Site 0388) | Guadalajara | Jalisco | 44680 | Mexico | Details | |
| Centro de Estudios de Investigacion Metabolicos y Cardiovasculares ( Site 0381) | Madero | Tamaulipas | 89440 | Mexico | Details | |
| Instituto Nacional de Cancerologia. ( Site 0382) | Mexico City | 14080 | Mexico | Details | ||
| Oaxaca Site Management Organization SC ( Site 0389) | Oaxaca | 68000 | Mexico | Details | ||
| SPZOZ USK nr 1 im. Norberta Barlickiego UM w Lodzi ( Site 0256) | Lodz | Lodzkie | 99-153 | Poland | Details | |
| Szpital Uniwersytecki im. Karola Marcinkowskiego ( Site 0247) | Zielona Gora | Lubuskie | 65-046 | Poland | Details | |
| Krakowski Szpital Specjalistyczny im Jana Pawla II ( Site 0253) | Krakow | Malopolskie | 31-202 | Poland | Details | |
| Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie ( Site 0243) | Krakow | Malopolskie | 31-826 | Poland | Details | |
| Centrum Medyczne Pratia Ostroleka ( Site 0242) | Ostroleka | Mazowieckie | 07-410 | Poland | Details | |
| Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0252) | Warszawa | Mazowieckie | 02-781 | Poland | Details | |
| Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 0250) | Przemysl | Podkarpackie | 37-700 | Poland | Details | |
| Ars Medical Sp. z o.o. ( Site 0254) | Pila | Wielkopolskie | 64-920 | Poland | Details | |
| Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 0262) | Ufa | Baskortostan, Respublika | 450054 | Russian Federation | Details | |
| Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 0266) | Krasnoyarsk | Krasnoyarskiy Kray | 660133 | Russian Federation | Details | |
| SBHI Samara Regional Clinical Oncology Dispensary ( Site 0265) | Samara | Samarskaya Oblast | 443031 | Russian Federation | Details | |
| SBHI Leningrad Regional Clinical Hospital ( Site 0263) | Saint Petersburg | Sankt-Peterburg | 194291 | Russian Federation | Details | |
| Railway Hospital of OJSC ( Site 0268) | Saint Petersburg | Sankt-Peterburg | 195271 | Russian Federation | Details | |
| City Clinical Oncology Center ( Site 0260) | Saint Petersburg | Sankt-Peterburg | 198255 | Russian Federation | Details | |
| Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 0269) | Kazan | Tatarstan, Respublika | 420029 | Russian Federation | Details | |
| National Taiwan University Hospital Hsin-Chu Branch ( Site 0087) | Hsinchu | 300 | Taiwan | Details | ||
| Taipei Medical University Shuang Ho Hospital ( Site 0090) | New Taipei | 235 | Taiwan | Details | ||
| National Cheng Kung University Hospital ( Site 0086) | Tainan | 70457 | Taiwan | Details | ||
| National Taiwan University Hospital ( Site 0088) | Taipei | 10002 | Taiwan | Details | ||
| Koo Foundation Sun Yat-Sen Cancer Center ( Site 0091) | Taipei | 112 | Taiwan | Details | ||
| Taipei Veterans General Hospital ( Site 0089) | Taipei | 112 | Taiwan | Details | ||
| Necmettin Erbakan Universitesi Meram Tip Fakultesi ( Site 0321) | Konya | Adana | 42080 | Turkey | Details | |
| Gulhane Egitim ve Arastirma Hastanesi ( Site 0316) | Ankara | 06010 | Turkey | Details | ||
| Abdurrahman Yurtaslan Onkoloji Hastanesi ( Site 0318) | Ankara | 06200 | Turkey | Details | ||
| Baskent Universitesi Ankara Hastanesi ( Site 0319) | Ankara | 06490 | Turkey | Details | ||
| Antalya Memorial Hospital Department of Medical Oncology ( Site 0324) | Antalya | 07020 | Turkey | Details | ||
| Akdeniz Universitesi Tip Fakultesi ( Site 0322) | Antalya | 07070 | Turkey | Details | ||
| Dokuz Eylul Universitesi Arastirma Uygulama Hastanesi ( Site 0314) | Izmir | 35340 | Turkey | Details | ||
| Sakarya Universitesi Egitim ve Arastirma Hastanesi ( Site 0323) | Sakarya | 54290 | Turkey | Details | ||
| Samsun Medical Park Hastanesi ( Site 0320) | Samsun | 55200 | Turkey | Details | ||
| Cherkasy Regional Hospital ( Site 0336) | Cherkasy | Cherkaska Oblast | 18009 | Ukraine | Details | |
| City Clinical Hosp.4 of DCC ( Site 0338) | Dnipro | Dnipropetrovska Oblast | 49102 | Ukraine | Details | |
| MI Precarpathian Clinical Oncology Center ( Site 0346) | Ivano-Frankivsk | Ivano-Frankivska Oblast | 76018 | Ukraine | Details | |
| Regional Centre of Oncology-Thoracic organs ( Site 0337) | Kharkiv | Kharkivska Oblast | 61070 | Ukraine | Details | |
| Ukranian Center of TomoTherapy ( Site 0344) | Kropyvnytskiy | Kirovohradska Oblast | 25011 | Ukraine | Details | |
| Medical Center Verum ( Site 0334) | Kyiv | Kyivska Oblast | 03039 | Ukraine | Details | |
| Kyiv City Clinical Oncology Centre ( Site 0339) | Kyiv | Kyivska Oblast | 03115 | Ukraine | Details | |
| Medical and Diagnostic Centre LLC Dobryi Prognoz ( Site 0331) | Kyiv | Kyivska Oblast | 03126 | Ukraine | Details | |
| Lviv State Oncology Regional Treatment and Diagnostic Center ( Site 0341) | Lviv | Lvivska Oblast | 79031 | Ukraine | Details | |
| MI Odessa Regional Oncological Centre ( Site 0333) | Odesa | Odeska Oblast | 65055 | Ukraine | Details | |
| Podillya Regional Center of Oncology ( Site 0343) | Vinnytsia | Vinnytska Oblast | 21029 | Ukraine | Details |