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NCT ID NCT03906071
Title Phase 3 Study of Sitravatinib Plus Nivolumab vs Docetaxel in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer (SAPPHIRE)
Acronym SAPPHIRE
Recruitment Active, not recruiting
Gender both
Phase Phase III
Variant Requirements Yes
Sponsors Mirati Therapeutics Inc.
Indications
Therapies
Age Groups: adult | senior
Covered Countries USA | NLD | ITA | ISR | HUN | GBR | FRA | ESP | DEU | CHE | CAN | BEL

Facility Status City State Zip Country Details
Alabama Oncology - Grandview Birmingham Alabama 35243 United States Details
Clearview Cancer Institute - Huntsville Huntsville Alabama 35805 United States Details
Palo Verde Cancer Specialists - Glendale Glendale Arizona 85304 United States Details
The Oncology Institute of Hope & Innovation - Tucson Tucson Arizona 85745 United States Details
Yuma Regional Medical Center Yuma Arizona 85364 United States Details
NEA Baptist Fowler Family Center for Cancer Care Jonesboro Arkansas 72401 United States Details
Saint Bernards Medical Center Jonesboro Arkansas 72401 United States Details
Highlands Oncology Group - Springdale Springdale Arkansas 72762 United States Details
Comprehensive Blood and Cancer Center - Bakersfield Bakersfield California 93309 United States Details
Beverly Hills Cancer Center Beverly Hills California 90211 United States Details
California Cancer Associates for Research and Excellence (cCARE) - Fresno Cancer Center Fresno California 93720 United States Details
Providence Medical Foundation - Virginia K. Crosson Cancer Center - Fullerton Fullerton California 92835 United States Details
City of Hope - Long Beach Elm Long Beach California 90813 United States Details
Cancer and Blood Specialty Clinic Los Alamitos California 90720 United States Details
Los Angeles Hematology Oncology Medical Group Los Angeles California 90017 United States Details
University of California Los Angeles - Jonsson Comprehensive Cancer Center Los Angeles California 90095 United States Details
Hoag Memorial Hospital Presbyterian - Newport Beach Newport Beach California 92663 United States Details
The Oncology Institute of Hope & Innovation - Northridge Northridge California 91325 United States Details
Redlands Hematology Oncology - Dr. Emad Ibrahim MD Redlands California 92373 United States Details
The Oncology Institute of Hope & Innovation - Riverside Riverside California 92501 United States Details
University of California San Francisco San Francisco California 94143 United States Details
California Cancer Associates for Research and Excellence (cCare) - San Marcos San Marcos California 92069 United States Details
Torrance Memorial Physician Network - Cancer Care and Infusion Center Torrance California 90505 United States Details
Brian LeBerthon M.D. Medical Corporation West Covina California 91790 United States Details
The Oncology Institute of Hope & Innovation - Whittier Whittier California 90602 United States Details
SCL Health Cancer Centers of Colorado - Good Samaritan Medical Center Lafayette Colorado 80026 United States Details
Eastern Connecticut Hematology and Oncology Associates Norwich Connecticut 06360 United States Details
Michael and Dianne Bienes Comprehensive Cancer Center Fort Lauderdale Florida 33308 United States Details
SCRI - Florida Cancer Specialists - South Region Research Office Fort Myers Florida 33901 United States Details
Memorial Regional Hospital Hollywood Florida 33021 United States Details
Watson Clinic Cancer and Research Center Lakeland Florida 33805 United States Details
Mount Sinai Health System Miami Beach Florida 33140 United States Details
Florida Cancer Affiliates - Ocala - Main Ocala Florida 34474 United States Details
AdventHealth Medical Group Oncology and Hematology at Orlando Orlando Florida 32804 United States Details
SCRI - Florida Cancer Specialists - North Region Research Office Saint Petersburg Florida 33705 United States Details
SCRI - Florida Cancer Specialists - Panhandle Research Office Tallahassee Florida 32308 United States Details
SCRI - Florida Cancer Specialists - West Palm Beach West Palm Beach Florida 33401 United States Details
University Cancer & Blood Center (UCBC) - Athens Athens Georgia 30607 United States Details
Piedmont Cancer Institute - Fayetteville Atlanta Georgia 30318 United States Details
John B. Amos Cancer Center Research Columbus Georgia 31904 United States Details
Northwest Georgia Oncology Centers Wellstar - Marietta Marietta Georgia 30060 United States Details
Straub Medical Center Honolulu Hawaii 96813 United States Details
Beacon Cancer Care Coeur d'Alene Idaho 83814 United States Details
Swedish Covenant Hospital Chicago Illinois 60625-3645 United States Details
Evanston Hospital Evanston Illinois 60201 United States Details
USOR - Illinois Cancer Specialists - Niles Niles Illinois 60714 United States Details
Orchard Healthcare Research Skokie Illinois 60077 United States Details
Healthcare Research Network - Tinley Park Tinley Park Illinois 60487 United States Details
Fort Wayne Medical Oncology and Hematology - Fort Wayne South Office Fort Wayne Indiana 46804 United States Details
Goshen Center for Cancer Care Goshen Indiana 46526 United States Details
Franciscan Health Cancer Center Indianapolis Indianapolis Indiana 46237 United States Details
Indiana University Health - Arnett Cancer Care Lafayette Indiana 47904 United States Details
The University of Kansas Health System Westwood Medical Pavilion Westwood Kansas 66205 United States Details
Cancer Center of Kansas - Wichita - Heritage Plaza Wichita Kansas 67214 United States Details
Commonwealth Cancer Center - Frankfort Danville Kentucky 40422 United States Details
Norton Cancer Institute - Broadway Louisville Kentucky 40241 United States Details
New England Cancer Specialists - Scarborough Scarborough Maine 04074 United States Details
Maryland Oncology Hematology - Rockville Aquilino Cancer Center Rockville Maryland 20850-6535 United States Details
Barbara Ann Karmanos Cancer Institute Detroit Michigan 48201 United States Details
Henry Ford Hospital Detroit Michigan 48202 United States Details
USOR - Minnesota Oncology - Minneapolis Clinic Minneapolis Minnesota 55404 United States Details
HealthPartners Cancer Research Center - Frauenshuh Cancer Center Saint Louis Park Minnesota 55426-5000 United States Details
Jackson Oncology Associates - The Hederman Cancer Center Jackson Mississippi 39202 United States Details
Central Care Cancer Center - Bolivar Bolivar Missouri 65613 United States Details
Kansas City Care Health Center - Research Medical Campus Kansas City Missouri 64132 United States Details
Sisters of Charity of Leavenworth Health St. Marys Billings Montana 59102 United States Details
Saint Francis Cancer Treatment Center Grand Island Nebraska 68803 United States Details
Methodist Hospital - Omaha Omaha Nebraska 68114 United States Details
The Oncology Institute of Hope & Innovation - Henderson Henderson Nevada 89052 United States Details
Comprehensive Cancer Centers of Nevada - Southeast Henderson - Stephanie Henderson Nevada 89074 United States Details
Summit Medical Group - Florham Park Campus Florham Park New Jersey 07932 United States Details
Regional Cancer Care Associates - Little Silver Little Silver New Jersey 07739 United States Details
Cooperman Barnabas Medical Center Livingston New Jersey 07039 United States Details
Regional Cancer Care Associates - Sparta Sparta New Jersey 07871 United States Details
Broome Oncology - Johnson City Johnson City New York 13790 United States Details
Monter Cancer Center Lake Success New York 11042 United States Details
New York Cancer & Blood Specialists - Port Jefferson Medical Oncology Port Jefferson Station New York 11776 United States Details
Stony Brook University Cancer Center Stony Brook New York 11794 United States Details
Mercy Hematology and Oncology Associates Canton Ohio 44708 United States Details
USOR - Oncology Hematology Care - Blue Ash Cincinnati Ohio 45242 United States Details
Ohio State University Comprehensive Cancer Center (OSUCCC) - The James Cancer Hospital and Solove Research Institute Columbus Ohio 43210 United States Details
Tricounty Hematology and Oncology - Massillon Massillon Ohio 44646 United States Details
The Toledo Clinic Cancer Center Toledo Ohio 43623 United States Details
Mercy Clinic Oncology and Hematology - Coletta Oklahoma City Oklahoma 73120 United States Details
Providence Portland Medical Center Portland Oregon 97213 United States Details
Oregon Health and Science University Knight Cancer Institute Portland Oregon 97239 United States Details
USOR - Alliance Cancer Specialists - Horsham (Abington Hematology Oncology Associates) Horsham Pennsylvania 19044 United States Details
Fox Chase Cancer Center Philadelphia Pennsylvania 19111 United States Details
Baptist Clinical Research Institute Memphis Tennessee 38120 United States Details
Tennessee Oncology - Nashville - Centennial Clinic - Medical Oncology Nashville Tennessee 37203 United States Details
USOR - Texas Oncology - South Austin Austin Texas 78745 United States Details
USOR - Texas Oncology - Beaumont Mamie Mcfaddin Ward Cancer Center Beaumont Texas 77702 United States Details
USOR - Texas Oncology Dallas Fort Worth West (DFWW) - Methodist Dallas Cancer Center Dallas Texas 75203 United States Details
USOR - Texas Oncology - Dallas Fort Worth (DFW) - Presbyterian Cancer Center Dallas Dallas Texas 75231 United States Details
USOR - Texas Oncology - Dallas Fort Worth (DFW) - Baylor Charles A. Sammons Cancer Center Dallas Texas 75246 United States Details
USOR - Texas Oncology Northeast Texas - Denison Denison Texas 75020 United States Details
USOR - Texas Oncology - Denton Denton Texas 76201 United States Details
The Center for Cancer & Blood Disorders - Fort Worth Fort Worth Texas 76104 United States Details
Oncology Consultants - Texas Medical Center Houston Texas 77030 United States Details
USOR - Texas Oncology - Houston Willowbrook Houston Texas 77070 United States Details
Millennium Research and Clinical Development Houston Texas 77090 United States Details
USOR - US Oncology Investigational Products Center Irving Texas 75063 United States Details
USOR - Texas Oncology - McKinney McKinney Texas 75071 United States Details
Texas Oncology - San Antonio Medical Center San Antonio Texas 78240 United States Details
USOR - Texas Oncology - Sugar Land Sugar Land Texas 77479 United States Details
USOR - Texas Oncology Northeast Texas - Cancer and Research Institute - Tyler Tyler Texas 75702 United States Details
UVA Health - Comprehensive Cancer Center Charlottesville Virginia 22903 United States Details
Hematology Oncology Associates of Fredericksburg Fredericksburg Virginia 24408 United States Details
Virginia Cancer Institute - West End Richmond Virginia 23229 United States Details
Overlake Medical Center and Clinics Bellevue Washington 98004 United States Details
Providence Regional Cancer Partnership Everett Washington 98201 United States Details
Fred Hutchinson Cancer Center - Seattle Cancer Care Alliance (SCCA) Location Seattle Washington 98109--1023 United States Details
Cancer Care Northwest - North Spokane Spokane Washington 99218 United States Details
MultiCare Institute for Research & Innovation Tacoma Washington 98405 United States Details
Northwest Medical Specialties - Tacoma Tacoma Washington 98405 United States Details
Northwest Cancer Specialists, P.C. dba Compass Oncology - Tualatin Vancouver Washington 98684 United States Details
ThedaCare Regional Cancer Center Appleton Wisconsin 54911 United States Details
University Wisconsin Carbone Cancer Center Madison Wisconsin 53792 United States Details
Froedtert Hospital Milwaukee Wisconsin 53226 United States Details
Algemeen Ziekenhuis Klina Brasschaat 2930 Belgium Details
Grand Hopital de Charleroi - Notre Dame Charleroi 6000 Belgium Details
Universitair Ziekenhuis Antwerpen Edegem 2650 Belgium Details
Algemeen Ziekenhuis Maria Middelares Gent 9000 Belgium Details
Universitair Ziekenhuis Gent Gent 9000 Belgium Details
Algemeen Ziekenhuis Delta - Campus Rumbeke Roeselare 8800 Belgium Details
Algemeen Ziekenhuis Glorieux Ronse Ronse 9600 Belgium Details
Centre Hospitalier Universitaire Universite Catholique de Louvain - Site Godinne Yvoir B-5530 Belgium Details
Tom Baker Cancer Centre Calgary Alberta T2N 4N2 Canada Details
The Moncton Hospital Moncton New Brunswick E1C 6Z8 Canada Details
Saint John Regional Hospital Saint John New Brunswick E2L 4L2 Canada Details
Juravinski Cancer Centre Hamilton Ontario L8V 5C2 Canada Details
Princess Margaret Cancer Centre Toronto Ontario M5G 2M9 Canada Details
Windsor Regional Hospital Cancer Program Windsor Ontario N8W 2X3 Canada Details
Montreal Children'S Hospital Montreal Quebec H3A 0G4 Canada Details
Saskatoon Cancer Centre Saskatoon Saskatchewan S7N 4H4 Canada Details
Institut Universitaire de Cardiologie et de Pneumologie de Quebec Quebec G1V 4G5 Canada Details
Hopital Morvan Brest 29200 France Details
Hopital Louis Pradel Bron 69500 France Details
Centre Hospitalier Intercommunal de Creteil Creteil 94000 France Details
Centre Georges Francois Leclerc Dijon cedex 21079 France Details
Centre Hospitalier Le Mans Le Mans Cedex 9 72037 France Details
Centre Hospitalier Universitaire Limoges Limoges cedex 87042 France Details
Centre Leon Berard Lyon 69008 France Details
Institut Paoli-Calmettes Marseille 13009 France Details
Hopital Nord de Marseille Marseille 13015 France Details
Institut Regional du Cancer de Montpellier Montpellier Cedex 5 34298 France Details
Groupe Hospitalier de la Région de Mulhouse et Sud Alsace - Hôpital Emile Muller Mulhouse 68100 France Details
Hopital Bichat - Claude-Bernard Paris 75018 France Details
Hopital Charles-Nicolle Rouen cedex 76031 France Details
Centre Hospitalier Universitaire De Nantes - Hopital Nord Laennec Saint Herblain 44805 France Details
Institut de Cancerologie Strasbourg Europe Strasbourg 67200 France Details
Gustave Roussy Villejuif 94805 France Details
Zentralklinik Bad Berka Bad Berka 99437 Germany Details
Evangelische Lungenklinik Berlin Berlin 13125 Germany Details
Universitatsklinikum Bonn Bonn 53127 Germany Details
Kliniken Essen-Mitte - Evangelische Huyssens-Stiftung Essen 45136 Germany Details
Klinikum Esslingen Esslingen 73730 Germany Details
Asklepios Fachkliniken Munchen-Gauting Gauting 82131 Germany Details
LungenClinic Grosshansdorf Grohansdorf 22927 Germany Details
Krankenhaus Martha-Maria Halle-Dolau Halle 06120 Germany Details
Klinikverbund Allgau gGmbH - Klinik Immenstadt Immenstadt 87509 Germany Details
Klinikum Kassel Kassel 34125 Germany Details
Kliniken der Stadt Koln Koln 51109 Germany Details
SLK-Kliniken - Fachklinik Lowenstein Lowenstein 74245 Germany Details
Universitatsklinikum Schleswig-Holstein - Campus Lubeck Lubeck 23538 Germany Details
Universitatsmedizin der Johannes Gutenberg-Universitat Mainz Mainz 55131 Germany Details
Klinikum rechts der Isar der Technischen Universitat Munchen Munchen 81675 Germany Details
Munchen Klinik Bogenhausen Munchen 81925 Germany Details
Semmelweis Egyetem - Pulmonologiai Klinika Budapest 1083 Hungary Details
Orszagos Koranyi Pulmonologiai Intezet Budapest 1121 Hungary Details
Orszagos Onkologiai Intezet Budapest 1122 Hungary Details
Farkasgyepui Tudogyogyintezet Farkasgyepu 8582 Hungary Details
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz Gyor 9023 Hungary Details
Markusovszky Egyetemi Oktatokorhaz Szombathely Szombathely 9700 Hungary Details
Komarom-Esztergom Varmegyei Szent Borbala Korhaz Tatabanya 2800 Hungary Details
Reformatus Pulmonologiai Centrum Torokbalint 2045 Hungary Details
Emek Medical Center Afula 1834111 Israel Details
Soroka Medical Center Beer Sheva 84101 Israel Details
Shamir Medical Center (Assaf Harofeh) Beer Yaakov 7030000 Israel Details
The Edith Wolfson Medical Center Holon 5822012 Israel Details
Shaare Zedek Medical Center Jerusalem 9103102 Israel Details
The Chaim Sheba Medical Center Ramat Gan 5265601 Israel Details
Ziv Medical Center Zsfat 1311001 Israel Details
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo - Alessandria Alessandria 15121 Italy Details
Istituto Tumori Bari Giovanni Paolo II - IRCCS Bari 70124 Italy Details
Azienda Ospedaliero - Universitaria - Policlinico - Vittorio Emanuele Catania 95123 Italy Details
Ospedale di Cremona Cremona 26100 Italy Details
Ospedale Vito Fazzi Lecce Lecce 73100 Italy Details
"Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST" Meldola 47014 Italy Details
Istituto Europeo di Oncologia Milan 20141 Italy Details
Fondazione IRCCS San Gerardo dei Tintori Monza 20900 Italy Details
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale Napoli 80131 Italy Details
Azienda Ospedaliero-Universitaria di Parma Parma 43126 Italy Details
Ospedale Guglielmo da Saliceto Piacenza 29100 Italy Details
Azienda Ospedaliero-Universitaria Pisana Pisa 56126 Italy Details
Istituto Nazionale Tumori Regina Elena Roma 00144 Italy Details
Ospedale di Circolo e Fondazione Macchi Varese 21100 Italy Details
Het Nederlands Kanker Instituut Amsterdam 1066 CX Netherlands Details
Amsterdam Universitair Medische Centra (UMC) - Locatie Vrije Universiteit Medisch Centrum Amsterdam 1081 HV Netherlands Details
Amphia Ziekenhuis - Breda Molengracht Breda 4818 CK Netherlands Details
Hagaziekenhuis Van Den Haag - Leyweg Den Haag 2545 AA Netherlands Details
Albert Schweitzer Ziekenhuis - Dordwijk Dordrecht 3318 AT Netherlands Details
Martini Ziekenhuis Groningen 9728 NT Netherlands Details
Maastricht Universitair Medisch Centrum Maastricht 6229 HX Netherlands Details
Radboud University Medical Center Nijmegen 6525 GA Netherlands Details
Erasmus Medisch Centrum Rotterdam 3015 GD Netherlands Details
Franciscus Gasthuis & Vlietland - Gasthuis Rotterdam 3045 PM Netherlands Details
Jeroen Bosch Ziekenhuis - Hertogenbosch s-Hertogenbosch 5223 GZ Netherlands Details
St. Antonius Ziekenhuis - Ziekenhuis Utrecht Utrecht 3543 AZ Netherlands Details
Universitair Medisch Centrum Utrecht Utrecht 3584 CX Netherlands Details
Isala Zwolle Zwolle 8025 AB Netherlands Details
Complejo Hospitalario Universitario A Coruna A Coruna 15006 Spain Details
Institut Catala dOncologia Badalona Badalona 08916 Spain Details
Hospital del Mar - Parc de Salut Mar Barcelona 08003 Spain Details
Hospital Universitari Dexeus Barcelona 08028 Spain Details
Hospital Universitari Vall dHebron Barcelona 08035 Spain Details
Hospital Universitario de Jaen Jaen 23007 Spain Details
Complejo Hospitalario Universitario Insular Materno Infantil Las Palmas de Gran Canaria 35016 Spain Details
Hospital de Leon Leon 24008 Spain Details
Hospital Universitario Lucus Augusti Lugo 27003 Spain Details
Complejo Hospitalario Ruber Juan Bravo Madrid 28006 Spain Details
Hospital Universitario La Princesa Madrid 28006 Spain Details
Clinica Universidad de Navarra - Madrid Madrid 28027 Spain Details
Hospital Universitario Ramon y Cajal Madrid 28034 Spain Details
Hospital Clinico San Carlos Madrid 28040 Spain Details
Hospital Universitario Fundacion Jimenez Diaz Madrid 28040 Spain Details
Hospital Universitario 12 de Octubre Madrid 28041 Spain Details
Hospital Universitario La Paz Madrid 28046 Spain Details
Hospital Universitario Puerta de Hierro - Majadahonda Majadahonda 28222 Spain Details
Hospital Regional Universitario de Malaga - Hospital Civil Malaga 29009 Spain Details
Hospital Universitario Central de Asturias Oviedo 33011 Spain Details
Hospital Clinico Universitario de Santiago Santiago de Compostela 15706 Spain Details
IVO - Fundacion Instituto Valenciano de Oncologia Valencia 46009 Spain Details
Hospital Universitari i Politecnic La Fe Valencia 46026 Spain Details
Hospital Alvaro Cunqueiro - Clinico Universitario Vigo Vigo 36312 Spain Details
Inselspital Universitatsspital Bern Bern 3010 Switzerland Details
Hopitaux Universitaires de Geneve Geneve 1205 Switzerland Details
Centre Hospitalier Universitaire Vaudois Lausanne Lausanne 1011 Switzerland Details
Kantonsspital Winterthur Winterthur 8401 Switzerland Details
Velindre University NHS Trust Cardiff CF14 2TL United Kingdom Details
Royal Cornwall Hospitals NHS Trust Cornwall TR1 3LJ United Kingdom Details
University Hospitals of Leicester NHS Trust Leicester LE1 5WW United Kingdom Details
Royal Free London NHS Foundation Trust London NW3 2QG United Kingdom Details
The Royal Marsden NHS Foundation Trust London SW3 6JJ United Kingdom Details
The Christie NHS Foundation Trust Manchester M20 4BX United Kingdom Details
East and North Hertfordshire NHS Trust Middlesex HA6 2RN United Kingdom Details
*Shaded cells indicate that there was no data available from clinicaltrials.gov for the field