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| NCT ID | NCT03906071 |
| Title | Phase 3 Study of Sitravatinib Plus Nivolumab vs Docetaxel in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer (SAPPHIRE) |
| Acronym | SAPPHIRE |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | Mirati Therapeutics Inc. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | NLD | ITA | ISR | HUN | GBR | FRA | ESP | DEU | CHE | CAN | BEL |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201 | United States | Details | |
| Cancer and Blood Specialty Clinic | Los Alamitos | California | 90720 | United States | Details | |
| Central Care Cancer Center - Bolivar | Bolivar | Missouri | 65613 | United States | Details | |
| Centre Hospitalier Universitaire Universite Catholique de Louvain - Site Godinne | Yvoir | B-5530 | Belgium | Details | ||
| Centre Hospitalier Universitaire Vaudois Lausanne | Lausanne | 1011 | Switzerland | Details | ||
| Clearview Cancer Institute - Huntsville | Huntsville | Alabama | 35805 | United States | Details | |
| Commonwealth Cancer Center - Frankfort | Danville | Kentucky | 40422 | United States | Details | |
| Comprehensive Blood and Cancer Center - Bakersfield | Bakersfield | California | 93309 | United States | Details | |
| Cooperman Barnabas Medical Center | Livingston | New Jersey | 07039 | United States | Details | |
| Eastern Connecticut Hematology and Oncology Associates | Norwich | Connecticut | 06360 | United States | Details | |
| Fort Wayne Medical Oncology and Hematology - Fort Wayne South Office | Fort Wayne | Indiana | 46804 | United States | Details | |
| Franciscan Health Cancer Center Indianapolis | Indianapolis | Indiana | 46237 | United States | Details | |
| Froedtert Hospital | Milwaukee | Wisconsin | 53226 | United States | Details | |
| Healthcare Research Network - Tinley Park | Tinley Park | Illinois | 60487 | United States | Details | |
| Hematology Oncology Associates of Fredericksburg | Fredericksburg | Virginia | 24408 | United States | Details | |
| Henry Ford Hospital | Detroit | Michigan | 48202 | United States | Details | |
| Highlands Oncology Group - Springdale | Springdale | Arkansas | 72762 | United States | Details | |
| Hopitaux Universitaires de Geneve | Geneve | 1205 | Switzerland | Details | ||
| Hospital Universitario La Paz | Madrid | 28046 | Spain | Details | ||
| Hospital Universitario La Princesa | Madrid | 28006 | Spain | Details | ||
| Inselspital Universitatsspital Bern | Bern | 3010 | Switzerland | Details | ||
| IVO - Fundacion Instituto Valenciano de Oncologia | Valencia | 46009 | Spain | Details | ||
| Jackson Oncology Associates - The Hederman Cancer Center | Jackson | Mississippi | 39202 | United States | Details | |
| John B. Amos Cancer Center Research | Columbus | Georgia | 31904 | United States | Details | |
| Kansas City Care Health Center - Research Medical Campus | Kansas City | Missouri | 64132 | United States | Details | |
| Kantonsspital Winterthur | Winterthur | 8401 | Switzerland | Details | ||
| Local Institution - 005-072 | Newport Beach | California | 92663 | United States | Details | |
| Local Institution - 005-073 | Portland | Oregon | 97239 | United States | Details | |
| Local Institution - 005-075 | Beaumont | Texas | 77702 | United States | Details | |
| Local Institution - 005-076 | Houston | Texas | 77070 | United States | Details | |
| Local Institution - 005-079 | Ocala | Florida | 34474 | United States | Details | |
| Local Institution - 005-081 | Tacoma | Washington | 98405 | United States | Details | |
| Local Institution - 005-082 | Everett | Washington | 98201 | United States | Details | |
| Local Institution - 005-088 | Oklahoma City | Oklahoma | 73120 | United States | Details | |
| Local Institution - 005-090 | West Covina | California | 91790 | United States | Details | |
| Local Institution - 005-096 | Long Beach | California | 90813 | United States | Details | |
| Local Institution - 005-097 | Lafayette | Colorado | 80026 | United States | Details | |
| Local Institution - 005-098 | Wichita | Kansas | 67214 | United States | Details | |
| Local Institution - 005-103 | Toledo | Ohio | 43623 | United States | Details | |
| Local Institution - 005-104 | Orlando | Florida | 32804 | United States | Details | |
| Local Institution - 005-105 | Whittier | California | 90602 | United States | Details | |
| Local Institution - 005-107 | Stony Brook | New York | 11794 | United States | Details | |
| Local Institution - 005-109 | Northridge | California | 91325 | United States | Details | |
| Local Institution - 005-110 | Evanston | Illinois | 60201 | United States | Details | |
| Local Institution - 005-111 | Seattle | Washington | 98109--1023 | United States | Details | |
| Local Institution - 005-112 | Riverside | California | 92501 | United States | Details | |
| Local Institution - 005-116 | Madison | Wisconsin | 53792 | United States | Details | |
| Local Institution - 005-118 | Beverly Hills | California | 90211 | United States | Details | |
| Local Institution - 005-119 | Marietta | Georgia | 30060 | United States | Details | |
| Local Institution - 005-120 | Fort Myers | Florida | 33901 | United States | Details | |
| Local Institution - 005-120E | Naples | Florida | 34102 | United States | Details | |
| Local Institution - 005-122 | Goshen | Indiana | 46526 | United States | Details | |
| Local Institution - 005-123 | Johnson City | New York | 13790 | United States | Details | |
| Local Institution - 005-124 | Denton | Texas | 76201 | United States | Details | |
| Local Institution - 005-125 | McKinney | Texas | 75071 | United States | Details | |
| Local Institution - 005-126 | Dallas | Texas | 75246 | United States | Details | |
| Local Institution - 005-127 | Minneapolis | Minnesota | 55404 | United States | Details | |
| Local Institution - 005-128 | Dallas | Texas | 75203 | United States | Details | |
| Local Institution - 005-129 | Dallas | Texas | 75231 | United States | Details | |
| Local Institution - 005-134 | Austin | Texas | 78745 | United States | Details | |
| Local Institution - 005-136 | Vancouver | Washington | 98684 | United States | Details | |
| Local Institution - 005-137 | Nashville | Tennessee | 37203 | United States | Details | |
| Local Institution - 005-137A | Dickson | Tennessee | 37055 | United States | Details | |
| Local Institution - 005-137B | Dickson | Tennessee | 37055 | United States | Details | |
| Local Institution - 005-137C | Dickson | Tennessee | 37055 | United States | Details | |
| Local Institution - 005-137D | Dickson | Tennessee | 37055 | United States | Details | |
| Local Institution - 005-137E | Dickson | Tennessee | 37055 | United States | Details | |
| Local Institution - 005-137F | Dickson | Tennessee | 37055 | United States | Details | |
| Local Institution - 005-137G | Dickson | Tennessee | 37055 | United States | Details | |
| Local Institution - 005-137H | Dickson | Tennessee | 37055 | United States | Details | |
| Local Institution - 005-137I | Dickson | Tennessee | 37055 | United States | Details | |
| Local Institution - 005-137J | Dickson | Tennessee | 37055 | United States | Details | |
| Local Institution - 005-137K | Dickson | Tennessee | 37055 | United States | Details | |
| Local Institution - 005-137L | Dickson | Tennessee | 37055 | United States | Details | |
| Local Institution - 005-137M | Hendersonville | Tennessee | 37075 | United States | Details | |
| Local Institution - 005-142 | Florham Park | New Jersey | 07932 | United States | Details | |
| Local Institution - 005-144 | Charlottesville | Virginia | 22903 | United States | Details | |
| Local Institution - 005-146 | Atlanta | Georgia | 30318 | United States | Details | |
| Local Institution - 005-150 | Lafayette | Indiana | 47904 | United States | Details | |
| Local Institution - 005-151 | Chicago | Illinois | 60625-3645 | United States | Details | |
| Local Institution - 005-152 | Henderson | Nevada | 89074 | United States | Details | |
| Local Institution - 005-153 | Louisville | Kentucky | 40241 | United States | Details | |
| Local Institution - 005-154 | West Palm Beach | Florida | 33401 | United States | Details | |
| Local Institution - 005-159 | Saint Louis Park | Minnesota | 55426-5000 | United States | Details | |
| Local Institution - 005-163 | Little Silver | New Jersey | 07739 | United States | Details | |
| Local Institution - 005-164 | Birmingham | Alabama | 35243 | United States | Details | |
| Local Institution - 005-169 | Westwood | Kansas | 66205 | United States | Details | |
| Local Institution - 005-171 | Fresno | California | 93720 | United States | Details | |
| Local Institution - 005-174 | Jonesboro | Arkansas | 72401 | United States | Details | |
| Local Institution - 005-176 | San Marcos | California | 92069 | United States | Details | |
| Local Institution - 005-177 | Redlands | California | 92373 | United States | Details | |
| Local Institution - 005-178 | Rockville | Maryland | 20850-6535 | United States | Details | |
| Local Institution - 005-181 | Columbus | Ohio | 43210 | United States | Details | |
| Local Institution - 005-182 | Lake Success | New York | 11042 | United States | Details | |
| Local Institution - 005-185 | Los Angeles | California | 90095 | United States | Details | |
| Local Institution - 005-186 | Philadelphia | Pennsylvania | 19111 | United States | Details | |
| Local Institution - 005-187 | Spokane | Washington | 99218 | United States | Details | |
| Local Institution - 005-191 | Coeur d'Alene | Idaho | 83814 | United States | Details | |
| Local Institution - 005-192 | Torrance | California | 90505 | United States | Details | |
| Local Institution - 005-195 | Memphis | Tennessee | 38120 | United States | Details | |
| Local Institution - 005-196 | Canton | Ohio | 44708 | United States | Details | |
| Local Institution - 005-198 | Niles | Illinois | 60714 | United States | Details | |
| Local Institution - 005-200 | Charleroi | 6000 | Belgium | Details | ||
| Local Institution - 005-201 | Brasschaat | 2930 | Belgium | Details | ||
| Local Institution - 005-202 | Gent | 9000 | Belgium | Details | ||
| Local Institution - 005-204 | Ronse | 9600 | Belgium | Details | ||
| Local Institution - 005-205 | Roeselare | 8800 | Belgium | Details | ||
| Local Institution - 005-206 | Edegem | 2650 | Belgium | Details | ||
| Local Institution - 005-207 | Gent | 9000 | Belgium | Details | ||
| Local Institution - 005-250 | Moncton | New Brunswick | E1C 6Z8 | Canada | Details | |
| Local Institution - 005-251 | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| Local Institution - 005-252 | Hamilton | Ontario | L8V 5C2 | Canada | Details | |
| Local Institution - 005-255 | Montreal | Quebec | H3A 0G4 | Canada | Details | |
| Local Institution - 005-257 | Windsor | Ontario | N8W 2X3 | Canada | Details | |
| Local Institution - 005-258 | Quebec | G1V 4G5 | Canada | Details | ||
| Local Institution - 005-259 | Calgary | Alberta | T2N 4N2 | Canada | Details | |
| Local Institution - 005-301 | Marseille | 13009 | France | Details | ||
| Local Institution - 005-302 | Paris | 75018 | France | Details | ||
| Local Institution - 005-303 | Dijon cedex | 21079 | France | Details | ||
| Local Institution - 005-304 | Villejuif | 94805 | France | Details | ||
| Local Institution - 005-305 | Strasbourg | 67200 | France | Details | ||
| Local Institution - 005-306 | Mulhouse | 68100 | France | Details | ||
| Local Institution - 005-307 | Brest | 29200 | France | Details | ||
| Local Institution - 005-308 | Limoges cedex | 87042 | France | Details | ||
| Local Institution - 005-309 | Le Mans Cedex 9 | 72037 | France | Details | ||
| Local Institution - 005-310 | Bron | 69500 | France | Details | ||
| Local Institution - 005-311 | Creteil | 94000 | France | Details | ||
| Local Institution - 005-312 | Marseille | 13015 | France | Details | ||
| Local Institution - 005-313 | Montpellier Cedex 5 | 34298 | France | Details | ||
| Local Institution - 005-314 | Rouen cedex | 76031 | France | Details | ||
| Local Institution - 005-316 | Saint Herblain | 44805 | France | Details | ||
| Local Institution - 005-317 | Lyon | 69008 | France | Details | ||
| Local Institution - 005-400 | Bad Berka | 99437 | Germany | Details | ||
| Local Institution - 005-401 | Bonn | 53127 | Germany | Details | ||
| Local Institution - 005-402 | Munchen | 81925 | Germany | Details | ||
| Local Institution - 005-403 | Gauting | 82131 | Germany | Details | ||
| Local Institution - 005-405 | Lubeck | 23538 | Germany | Details | ||
| Local Institution - 005-406 | Esslingen | 73730 | Germany | Details | ||
| Local Institution - 005-408 | Halle | 06120 | Germany | Details | ||
| Local Institution - 005-410 | Lowenstein | 74245 | Germany | Details | ||
| Local Institution - 005-411 | Immenstadt | 87509 | Germany | Details | ||
| Local Institution - 005-412 | Koln | 51109 | Germany | Details | ||
| Local Institution - 005-413 | Munchen | 81675 | Germany | Details | ||
| Local Institution - 005-414 | Mainz | 55131 | Germany | Details | ||
| Local Institution - 005-416 | Kassel | 34125 | Germany | Details | ||
| Local Institution - 005-417 | Grohansdorf | 22927 | Germany | Details | ||
| Local Institution - 005-418 | Berlin | 13125 | Germany | Details | ||
| Local Institution - 005-419 | Essen | 45136 | Germany | Details | ||
| Local Institution - 005-450 | Tatabanya | 2800 | Hungary | Details | ||
| Local Institution - 005-451 | Szombathely | 9700 | Hungary | Details | ||
| Local Institution - 005-452 | Gyor | 9023 | Hungary | Details | ||
| Local Institution - 005-453 | Farkasgyepu | 8582 | Hungary | Details | ||
| Local Institution - 005-454 | Budapest | 1083 | Hungary | Details | ||
| Local Institution - 005-455 | Budapest | 1122 | Hungary | Details | ||
| Local Institution - 005-456 | Torokbalint | 2045 | Hungary | Details | ||
| Local Institution - 005-457 | Budapest | 1121 | Hungary | Details | ||
| Local Institution - 005-500 | Afula | 1834111 | Israel | Details | ||
| Local Institution - 005-501 | Beer Yaakov | 7030000 | Israel | Details | ||
| Local Institution - 005-502 | Holon | 5822012 | Israel | Details | ||
| Local Institution - 005-504 | Beer Sheva | 84101 | Israel | Details | ||
| Local Institution - 005-505 | Zsfat | 1311001 | Israel | Details | ||
| Local Institution - 005-506 | Ramat Gan | 5265601 | Israel | Details | ||
| Local Institution - 005-507 | Jerusalem | 9103102 | Israel | Details | ||
| Local Institution - 005-600 | Parma | 43126 | Italy | Details | ||
| Local Institution - 005-602 | Bari | 70124 | Italy | Details | ||
| Local Institution - 005-603 | Catania | 95123 | Italy | Details | ||
| Local Institution - 005-604 | Napoli | 80131 | Italy | Details | ||
| Local Institution - 005-605 | Monza | 20900 | Italy | Details | ||
| Local Institution - 005-606 | Milan | 20141 | Italy | Details | ||
| Local Institution - 005-607 | Piacenza | 29100 | Italy | Details | ||
| Local Institution - 005-608 | Lecce | 73100 | Italy | Details | ||
| Local Institution - 005-609 | Pisa | 56126 | Italy | Details | ||
| Local Institution - 005-610 | Meldola | 47014 | Italy | Details | ||
| Local Institution - 005-611 | Cremona | 26100 | Italy | Details | ||
| Local Institution - 005-612 | Alessandria | 15121 | Italy | Details | ||
| Local Institution - 005-614 | Roma | 00144 | Italy | Details | ||
| Local Institution - 005-700 | s-Hertogenbosch | 5223 GZ | Netherlands | Details | ||
| Local Institution - 005-701 | Utrecht | 3543 AZ | Netherlands | Details | ||
| Local Institution - 005-702 | Groningen | 9728 NT | Netherlands | Details | ||
| Local Institution - 005-703 | Amsterdam | 1066 CX | Netherlands | Details | ||
| Local Institution - 005-705 | Rotterdam | 3045 PM | Netherlands | Details | ||
| Local Institution - 005-706 | Zwolle | 8025 AB | Netherlands | Details | ||
| Local Institution - 005-707 | Breda | 4818 CK | Netherlands | Details | ||
| Local Institution - 005-708 | Utrecht | 3584 CX | Netherlands | Details | ||
| Local Institution - 005-709 | Den Haag | 2545 AA | Netherlands | Details | ||
| Local Institution - 005-710 | Rotterdam | 3015 GD | Netherlands | Details | ||
| Local Institution - 005-711 | Amsterdam | 1081 HV | Netherlands | Details | ||
| Local Institution - 005-712 | Maastricht | 6229 HX | Netherlands | Details | ||
| Local Institution - 005-713 | Dordrecht | 3318 AT | Netherlands | Details | ||
| Local Institution - 005-714 | Nijmegen | 6525 GA | Netherlands | Details | ||
| Local Institution - 005-800 | Badalona | 08916 | Spain | Details | ||
| Local Institution - 005-801 | Malaga | 29009 | Spain | Details | ||
| Local Institution - 005-803 | Oviedo | 33011 | Spain | Details | ||
| Local Institution - 005-804 | Valencia | 46026 | Spain | Details | ||
| Local Institution - 005-805 | Jaen | 23007 | Spain | Details | ||
| Local Institution - 005-806 | Majadahonda | 28222 | Spain | Details | ||
| Local Institution - 005-807 | A Coruna | 15006 | Spain | Details | ||
| Local Institution - 005-808 | Madrid | 28006 | Spain | Details | ||
| Local Institution - 005-809 | Madrid | 28041 | Spain | Details | ||
| Local Institution - 005-810 | Barcelona | 08035 | Spain | Details | ||
| Local Institution - 005-811 | Barcelona | 08028 | Spain | Details | ||
| Local Institution - 005-812 | Lugo | 27003 | Spain | Details | ||
| Local Institution - 005-813 | Madrid | 28040 | Spain | Details | ||
| Local Institution - 005-815 | Madrid | 28040 | Spain | Details | ||
| Local Institution - 005-816 | Las Palmas de Gran Canaria | 35016 | Spain | Details | ||
| Local Institution - 005-817 | Leon | 24071 | Spain | Details | ||
| Local Institution - 005-818 | Vigo | 36312 | Spain | Details | ||
| Local Institution - 005-819 | Madrid | 28027 | Spain | Details | ||
| Local Institution - 005-821 | Madrid | 28034 | Spain | Details | ||
| Local Institution - 005-822 | Barcelona | 08003 | Spain | Details | ||
| Local Institution - 005-823 | Santiago de Compostela | 15706 | Spain | Details | ||
| Local Institution - 005-900 | London | SW3 6JJ | United Kingdom | Details | ||
| Local Institution - 005-903 | Middlesex | HA6 2RN | United Kingdom | Details | ||
| Local Institution - 005-904 | Cornwall | TR1 3LJ | United Kingdom | Details | ||
| Local Institution - 005-908 | London | NW3 2QG | United Kingdom | Details | ||
| Los Angeles Hematology Oncology Medical Group | Los Angeles | California | 90017 | United States | Details | |
| Memorial Regional Hospital | Hollywood | Florida | 33021 | United States | Details | |
| Methodist Hospital - Omaha | Omaha | Nebraska | 68114 | United States | Details | |
| Michael and Dianne Bienes Comprehensive Cancer Center | Fort Lauderdale | Florida | 33308 | United States | Details | |
| Millennium Research and Clinical Development | Houston | Texas | 77090 | United States | Details | |
| Mount Sinai Health System | Miami Beach | Florida | 33140 | United States | Details | |
| NEA Baptist Fowler Family Center for Cancer Care | Jonesboro | Arkansas | 72401 | United States | Details | |
| New England Cancer Specialists - Scarborough | Scarborough | Maine | 04074 | United States | Details | |
| New York Cancer & Blood Specialists - Port Jefferson Medical Oncology | Port Jefferson Station | New York | 11776 | United States | Details | |
| Northwest Medical Specialties - Tacoma | Tacoma | Washington | 98405 | United States | Details | |
| Oncology Consultants - Texas Medical Center | Houston | Texas | 77030 | United States | Details | |
| Orchard Healthcare Research | Skokie | Illinois | 60077 | United States | Details | |
| Ospedale di Circolo e Fondazione Macchi | Varese | 21100 | Italy | Details | ||
| Overlake Medical Center and Clinics | Bellevue | Washington | 98004 | United States | Details | |
| Palo Verde Cancer Specialists - Glendale | Glendale | Arizona | 85304 | United States | Details | |
| Providence Medical Foundation - Virginia K. Crosson Cancer Center - Fullerton | Fullerton | California | 92835 | United States | Details | |
| Providence Portland Medical Center | Portland | Oregon | 97213 | United States | Details | |
| Regional Cancer Care Associates - Sparta | Sparta | New Jersey | 07871 | United States | Details | |
| Saint Francis Cancer Treatment Center | Grand Island | Nebraska | 68803 | United States | Details | |
| Saint John Regional Hospital | Saint John | New Brunswick | E2L 4L2 | Canada | Details | |
| Saskatoon Cancer Centre | Saskatoon | Saskatchewan | S7N 4H4 | Canada | Details | |
| SCRI - Florida Cancer Specialists - North Region Research Office | Saint Petersburg | Florida | 33705 | United States | Details | |
| SCRI - Florida Cancer Specialists - Panhandle Research Office | Tallahassee | Florida | 32308 | United States | Details | |
| Sisters of Charity of Leavenworth Health St. Marys | Billings | Montana | 59102 | United States | Details | |
| Straub Medical Center | Honolulu | Hawaii | 96813 | United States | Details | |
| Texas Oncology - San Antonio Medical Center | San Antonio | Texas | 78240 | United States | Details | |
| The Center for Cancer & Blood Disorders - Fort Worth | Fort Worth | Texas | 76104 | United States | Details | |
| The Christie NHS Foundation Trust | Manchester | M20 4BX | United Kingdom | Details | ||
| The Oncology Institute of Hope & Innovation - Henderson | Henderson | Nevada | 89052 | United States | Details | |
| The Oncology Institute of Hope & Innovation - Tucson | Tucson | Arizona | 85745 | United States | Details | |
| The Royal Marsden NHS Foundation Trust | London | SW3 6JJ | United Kingdom | Details | ||
| ThedaCare Regional Cancer Center | Appleton | Wisconsin | 54911 | United States | Details | |
| Tricounty Hematology and Oncology - Massillon | Massillon | Ohio | 44646 | United States | Details | |
| University Cancer & Blood Center (UCBC) - Athens | Athens | Georgia | 30607 | United States | Details | |
| University Hospitals of Leicester NHS Trust | Leicester | LE1 5WW | United Kingdom | Details | ||
| University of California San Francisco | San Francisco | California | 94143 | United States | Details | |
| USOR - Alliance Cancer Specialists - Horsham (Abington Hematology Oncology Associates) | Horsham | Pennsylvania | 19044 | United States | Details | |
| USOR - Oncology Hematology Care - Blue Ash | Cincinnati | Ohio | 45242 | United States | Details | |
| USOR - Texas Oncology - Sugar Land | Sugar Land | Texas | 77479 | United States | Details | |
| USOR - Texas Oncology Northeast Texas - Cancer and Research Institute - Tyler | Tyler | Texas | 75702 | United States | Details | |
| USOR - Texas Oncology Northeast Texas - Denison | Denison | Texas | 75020 | United States | Details | |
| USOR - US Oncology Investigational Products Center | Irving | Texas | 75063 | United States | Details | |
| Velindre University NHS Trust | Cardiff | CF14 2TL | United Kingdom | Details | ||
| Virginia Cancer Institute - West End | Richmond | Virginia | 23229 | United States | Details | |
| Watson Clinic Cancer and Research Center | Lakeland | Florida | 33805 | United States | Details | |
| Yuma Regional Medical Center | Yuma | Arizona | 85364 | United States | Details |
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