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| NCT ID | NCT03976375 |
| Title | Efficacy and Safety of Pembrolizumab (MK-3475) With Lenvatinib (E7080/MK-7902) vs. Docetaxel in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC) and Progressive Disease (PD) After Platinum Doublet Chemotherapy and Immunotherapy (MK-7902-008/E7080-G000-316/LEAP-008) |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Merck Sharp & Dohme Corp. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | ITA | ISR | HUN | GRC | GBR | FRA | ESP | DEU | CAN | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Comprehensive Blood & Cancer Center [Bakersfield, CA] ( Site 1604) | Bakersfield | California | 93309 | United States | Details | |
| Cancer Specialists of North Florida - Fleming Island ( Site 1675) | Fleming Island | Florida | 32003 | United States | Details | |
| Mid-Florida Cancer Centers ( Site 1611) | Orange City | Florida | 32763 | United States | Details | |
| University of Kentucky School of Medicine & Hospitals ( Site 1621) | Lexington | Kentucky | 40536 | United States | Details | |
| Hematology Oncology Clinic ( Site 1680) | Baton Rouge | Louisiana | 70809 | United States | Details | |
| Harry & Jeanette Weinberg Cancer Institute ( Site 1626) | Baltimore | Maryland | 21237 | United States | Details | |
| Medstar Good Samaritan Hospital ( Site 1625) | Baltimore | Maryland | 21239 | United States | Details | |
| Massachusetts General Hospital ( Site 1622) | Boston | Massachusetts | 02114 | United States | Details | |
| MGH - North Shore Cancer Center ( Site 1668) | Danvers | Massachusetts | 01923 | United States | Details | |
| The Mass General Cancer Center at Newton-Wellesley ( Site 1692) | Newton | Massachusetts | 02462 | United States | Details | |
| University of Massachusetts Medical School ( Site 1693) | Worcester | Massachusetts | 01655 | United States | Details | |
| Billings Clinic ( Site 1631) | Billings | Montana | 59101 | United States | Details | |
| Bozeman Health Deaconness Cancer Center ( Site 1632) | Bozeman | Montana | 59715 | United States | Details | |
| Memorial Sloan-Kettering Cancer Center At Basking Ridge ( Site 1664) | Basking Ridge | New Jersey | 07920 | United States | Details | |
| Memorial Sloan-Kettering Cancer Center at Middletown ( Site 1665) | Middletown | New Jersey | 07748 | United States | Details | |
| Memorial Sloan-Kettering Cancer Center at Montvale ( Site 1667) | Montvale | New Jersey | 07645 | United States | Details | |
| Memorial Sloan-Kettering Cancer Center at Commack ( Site 1662) | Commack | New York | 11725 | United States | Details | |
| Memorial Sloan-Kettering Cancer Center at West Harrison ( Site 1666) | Harrison | New York | 10604 | United States | Details | |
| Memorial Sloan-Kettering Cancer Center ( Site 1661) | New York | New York | 10065 | United States | Details | |
| New York Cancer and Blood Specialists ( Site 1696) | Port Jefferson Station | New York | 11776 | United States | Details | |
| University of Rochester ( Site 1638) | Rochester | New York | 14642 | United States | Details | |
| Memorial Sloan Kettering Cancer Center - Nassau ( Site 1670) | Uniondale | New York | 11553 | United States | Details | |
| TriHealth Cancer Institute ( Site 1672) | Cincinnati | Ohio | 45220 | United States | Details | |
| MetroHealth Medical Center ( Site 1694) | Cleveland | Ohio | 44109 | United States | Details | |
| Kaiser Permanente Center for Health Research-Kaiser Permanente Medical Center ( Site 1644) | Portland | Oregon | 97227 | United States | Details | |
| Fox Chase Cancer Center ( Site 1647) | Philadelphia | Pennsylvania | 19111 | United States | Details | |
| Thompson Cancer Survival Center ( Site 1695) | Knoxville | Tennessee | 37916 | United States | Details | |
| Millenium Physicians ( Site 1690) | Houston | Texas | 77090 | United States | Details | |
| Instituto de Investigaciones Metabolicas ( Site 2004) | Caba | Buenos Aires | C1012AAR | Argentina | Details | |
| Hospital Britanico de Buenos Aires ( Site 2002) | Buenos Aires | Caba | C1280AEB | Argentina | Details | |
| Sanatorio Parque ( Site 2005) | Rosario | Santa Fe | S2000DSV | Argentina | Details | |
| Hospital Aleman ( Site 2000) | Buenos Aires | C1118AAT | Argentina | Details | ||
| CEMIC ( Site 2003) | Buenos Aires | C1431FWO | Argentina | Details | ||
| Blacktown Hospital ( Site 0004) | Blacktown | New South Wales | 2148 | Australia | Details | |
| Port Macquarie Base Hospital ( Site 0003) | Port Macquarie | New South Wales | 2444 | Australia | Details | |
| Westmead Hospital ( Site 0005) | Westmead | New South Wales | 2145 | Australia | Details | |
| Southern Medical Day Care Centre ( Site 0001) | Wollongong | New South Wales | 2500 | Australia | Details | |
| Princess Alexandra Hospital - Division of Cancer Services ( Site 0002) | Woolloongabba | Queensland | 4102 | Australia | Details | |
| Calvary Central Districts Hospital ( Site 0007) | Elizabeth Vale | South Australia | 5112 | Australia | Details | |
| Bendigo Cancer Centre ( Site 0008) | Bendigo | Victoria | 3552 | Australia | Details | |
| CancerCare Manitoba ( Site 1504) | Winnipeg | Manitoba | R3E 0V9 | Canada | Details | |
| Kingston Health Sciences Centre ( Site 1503) | Kingston | Ontario | K7L 2V7 | Canada | Details | |
| London Regional Cancer Program - London HSC ( Site 1505) | London | Ontario | N6A 5W9 | Canada | Details | |
| Princess Margaret Cancer Centre ( Site 1502) | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 1501) | Montreal | Quebec | H3T 1M5 | Canada | Details | |
| CHUQ-Univ Laval-Hotel Dieu de Quebec ( Site 1514) | Quebec | G1R 2J6 | Canada | Details | ||
| Rodrigo Botero SAS ( Site 1300) | Medellin | Antioquia | 050030 | Colombia | Details | |
| Clinica de la Costa Ltda. ( Site 1309) | Barranquilla | Atlantico | 080020 | Colombia | Details | |
| Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 1305) | Valledupar | Cesar | 200001 | Colombia | Details | |
| Oncomedica S.A. ( Site 1302) | Monteria | Cordoba | 230001 | Colombia | Details | |
| Administradora Country SA - Clinica del Country ( Site 1307) | Bogota | Distrito Capital De Bogota | 110221 | Colombia | Details | |
| Clinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 1304) | Bogota | Distrito Capital De Bogota | 110311 | Colombia | Details | |
| Centro Medico Imbanaco de Cali S.A ( Site 1301) | Cali | Valle Del Cauca | 760042 | Colombia | Details | |
| CHU Caen Service de Pneumologie ( Site 0401) | Caen | Calvados | 14033 | France | Details | |
| HIA Percy-Clamart ( Site 0411) | Clamart | Hauts-de-Seine | 92140 | France | Details | |
| ICO Centre Paul Papin ( Site 0412) | Angers | Maine-et-Loire | 49100 | France | Details | |
| Clinique Ambroise Pare ( Site 0402) | Beuvry | Pas-de-Calais | 62660 | France | Details | |
| Centre Hospitalier General - Avignon ( Site 0407) | Avignon | Provence-Alpes-Cote-d Azur | 84000 | France | Details | |
| Centre Hospitalier Le Mans ( Site 0406) | Le Mans | Sarthe | 72037 | France | Details | |
| Institut Curie ( Site 0400) | Paris | 75005 | France | Details | ||
| Hopital Europeen Georges Pompidou ( Site 0408) | Paris | 75015 | France | Details | ||
| Thoraxklinik Heidelberg gGmbH am Universitaetsklinikum Heidelberg ( Site 0501) | Heidelberg | Baden-Wurttemberg | 69126 | Germany | Details | |
| Evangelisches Krankenhaus Hamm gGmbH ( Site 0504) | Hamm | Nordrhein-Westfalen | 59063 | Germany | Details | |
| SRH Wald-Klinikum Gera GmbH ( Site 0503) | Gera | Thuringen | 07548 | Germany | Details | |
| Vivantes Klinikum Spandau ( Site 0505) | Berlin | 13585 | Germany | Details | ||
| General Hospital of Chest Diseases "Sotiria" ( Site 1703) | Athens | Attiki | 115 27 | Greece | Details | |
| Metropolitan Hospital-4th Oncology Dept ( Site 1700) | Athens | Attiki | 185 47 | Greece | Details | |
| University Hospital of Ioannina ( Site 1701) | Ioannina | 455 00 | Greece | Details | ||
| European Interbalkan Medical Center ( Site 1704) | Thessaloniki | 570 01 | Greece | Details | ||
| Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Oktatókórház ( Site 0601) | Miskolc | Borsod-Abauj-Zemplen | 3526 | Hungary | Details | |
| Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz ( Site 0606) | Szekesfehervar | Fejer | 8000 | Hungary | Details | |
| Petz Aladar Megyei Oktato Korhaz ( Site 0609) | Gyor | Gyor-Moson-Sopron | 9024 | Hungary | Details | |
| Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 0610) | Szolnok | Jasz-Nagykun-Szolnok | 5004 | Hungary | Details | |
| Tudogyogyintezet Torokbalint ( Site 0602) | Torokbalint | Pest | 2045 | Hungary | Details | |
| Veszprem Megyei Tudogyogyintezet ( Site 0607) | Farkasgyepu | Veszprem | 8582 | Hungary | Details | |
| Semmelweis Egyetem.. ( Site 0604) | Budapest | 1083 | Hungary | Details | ||
| Orszagos Koranyi Pulmonologiai Intezet ( Site 0603) | Budapest | 1121 | Hungary | Details | ||
| Orszagos Koranyi Pulmonologiai Intezet ( Site 0608) | Budapest | 1121 | Hungary | Details | ||
| Soroka Medical Center ( Site 0701) | Beer Sheva | 8410101 | Israel | Details | ||
| Rambam Medical Center ( Site 0703) | Haifa | 3525408 | Israel | Details | ||
| Shaare Zedek Medical Center-Oncology ( Site 0706) | Jerusalem | 9013102 | Israel | Details | ||
| Meir Medical Center ( Site 0702) | Kfar-Saba | 4428132 | Israel | Details | ||
| Rabin Medical Center ( Site 0700) | Petah Tikva | 4941492 | Israel | Details | ||
| Chaim Sheba Medical Center ( Site 0704) | Ramat Gan | 5262000 | Israel | Details | ||
| Sourasky Medical Center (Ichilov) - Oncology Clinic ( Site 0705) | Tel Aviv | 6423906 | Israel | Details | ||
| Ospedale San Gerardo - ASST Monza ( Site 0804) | Monza | Monza E Brianza | 20900 | Italy | Details | |
| Istittuto Nazionale dei Tumori Regina Elena IRCCS - IFO ( Site 0807) | Rome | Roma | 00144 | Italy | Details | |
| A.O. Ospedali Riuniti Villa Sofia - Cervello P.O. Villa Sofia ( Site 0810) | Palermo | Sicilia | 90146 | Italy | Details | |
| Ospedale San Luigi Gonzaga ( Site 0802) | Orbassano | Torino | 10043 | Italy | Details | |
| Azienda Ospedaliera San Giuseppe Moscati ( Site 0809) | Avellino | 83100 | Italy | Details | ||
| IRCCS Giovanni Paolo II. Ospedale Oncologico ( Site 0808) | Bari | 70124 | Italy | Details | ||
| AOU Policlinico Vittorio Emanuele ( Site 0811) | Catania | 95123 | Italy | Details | ||
| Istituto Nazionale dei Tumori ( Site 0806) | Milano | 20133 | Italy | Details | ||
| Policlinico San Matteo - Fondazione IRCCS ( Site 0812) | Pavia | 27100 | Italy | Details | ||
| Azienda Ospedaliera di Perugia ( Site 0805) | Perugia | 06132 | Italy | Details | ||
| Kanagawa Cardiovascular and Respiratory Center ( Site 0105) | Yokohama | Kanagawa | 236-0051 | Japan | Details | |
| Sendai Kousei Hospital ( Site 0107) | Sendai | Miyagi | 980-0873 | Japan | Details | |
| Kansai Medical University Hospital ( Site 0104) | Hirakata | Osaka | 573-1191 | Japan | Details | |
| Chiba University Hospital ( Site 0106) | Chiba | 260-8677 | Japan | Details | ||
| Niigata Cancer Center Hospital ( Site 0101) | Niigata | 951-8566 | Japan | Details | ||
| National Cancer Center Hospital ( Site 0103) | Tokyo | 104-0045 | Japan | Details | ||
| The Cancer Institute Hospital of JFCR ( Site 0100) | Tokyo | 135-8550 | Japan | Details | ||
| Chungbuk National University Hospital ( Site 0201) | Cheongju si | Chungbuk | 28644 | Korea, Republic of | Details | |
| Seoul National University Bundang Hospital ( Site 0204) | Seongnam-si | Kyonggi-do | 13620 | Korea, Republic of | Details | |
| Asan Medical Center ( Site 0203) | Songpagu | Seoul | 05505 | Korea, Republic of | Details | |
| Severance Hospital Yonsei University Health System ( Site 0202) | Seoul | 03722 | Korea, Republic of | Details | ||
| Centro Hospitalar Lisboa Norte E.P.E. - Hospital Pulido Valente ( Site 1801) | Lisboa | 1769-001 | Portugal | Details | ||
| Hospital CUF Porto ( Site 1802) | Porto | 4100-180 | Portugal | Details | ||
| Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 1800) | Porto | 4200-072 | Portugal | Details | ||
| Hematology and Oncology Institute ( Site 2105) | Manati | 00674 | Puerto Rico | Details | ||
| Ad-Vance Medical Research LLC ( Site 2103) | Ponce | 00717 | Puerto Rico | Details | ||
| Puerto Rico Medical Research Center LLC ( Site 2101) | San Juan | 00918 | Puerto Rico | Details | ||
| GBUZ Republican Clinical Oncological Dispensary ( Site 0922) | Ufa | Baskortostan, Respublika | 450054 | Russian Federation | Details | |
| Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 0918) | Krasnoyarsk | Krasnoyarskiy Kray | 660133 | Russian Federation | Details | |
| Main Military Clinical Hospital n.a. N.N.Burdenko ( Site 0905) | Moscow | Moskva | 105094 | Russian Federation | Details | |
| Central Clinical Hospital of the Administration of the President ( Site 0910) | Moscow | Moskva | 121359 | Russian Federation | Details | |
| Budgetary Healthcare Institution of Omsk Region Clinical Oncology Dispensary-Chemotherapy #1 ( Site | Omsk | Omskaya Oblast | 644013 | Russian Federation | Details | |
| SPb SBHI City Clinical Oncological Dispensary ( Site 0901) | Saint Petersburg | Sankt-Peterburg | 198255 | Russian Federation | Details | |
| Railway Hospital of OJSC ( Site 0907) | Saint-Petersburg | Sankt-Peterburg | 195271 | Russian Federation | Details | |
| Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 0903) | Saint-Petersburg | Sankt-Peterburg | 197758 | Russian Federation | Details | |
| GBUZ SPb CRPCstmc(o) ( Site 0921) | Sankt- Peterburg | Sankt-Peterburg | 197758 | Russian Federation | Details | |
| Pavlov First Saint Petersburg State Medical University ( Site 0917) | St. Petersburg | Sankt-Peterburg | 197022 | Russian Federation | Details | |
| Hospital Central de Asturias ( Site 1002) | Oviedo | Asturias | 33011 | Spain | Details | |
| Consorci Hospitalari Mataro ( Site 1008) | Mataro | Barcelona | 08304 | Spain | Details | |
| Hospital Universitario Marques de Valdecilla ( Site 1003) | Santander | Cantabria | 39008 | Spain | Details | |
| Hospital Universitario Insular de Gran Canaria ( Site 1011) | Las Palmas de Gran Canaria | Las Palmas | 35001 | Spain | Details | |
| Hospital Universitario Puerta de Hierro ( Site 1007) | Majadahonda | Madrid | 28222 | Spain | Details | |
| Hospital Universitario Quiron Madrid ( Site 1012) | Pozuelo de Alarcon | Madrid | 28223 | Spain | Details | |
| Hospital Clinico de Valencia ( Site 1010) | Valencia | Valenciana, Comunitat | 46010 | Spain | Details | |
| Hospital Universitari Vall d Hebron ( Site 1004) | Barcelona | 08035 | Spain | Details | ||
| Hospital Ciudad de Jaen ( Site 1000) | Jaen | 23007 | Spain | Details | ||
| Hospital Universitario Fundacion Jimenez Diaz ( Site 1005) | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario 12 de Octubre ( Site 1006) | Madrid | 28041 | Spain | Details | ||
| Hull & East Yorkshire NHS Trust. Castle Hill Hospital ( Site 1108) | Cottingham | East Riding Of Yorkshire | HU16 5JQ | United Kingdom | Details | |
| Nottingham City Hospital Campus ( Site 1105) | Nottingham | England | NG5 1PB | United Kingdom | Details | |
| Leicester Royal Infirmary ( Site 1110) | Leicester | Leicestershire | LE1 5WW | United Kingdom | Details | |
| North Middlesex University Hospital NHS Trust ( Site 1109) | London | London, City Of | N18 1QX | United Kingdom | Details | |
| Guy s and St Thomas Hospital NHS Foundation Trust ( Site 1102) | London | London, City Of | SE1 9RT | United Kingdom | Details | |
| Mount Vernon Cancer Centre ( Site 1107) | Northwood | London, City Of | HA6 2RN | United Kingdom | Details | |
| Aberdeen Royal Infirmary ( Site 1114) | Aberdeen | Scotland | AB25 2ZN | United Kingdom | Details | |
| University Hospital Coventry and Warwickshire NHS Trust ( Site 1112) | Coventry | Warwickshire | CV2 2DX | United Kingdom | Details | |
| Birmingham Heartlands Hospital ( Site 1103) | Birmingham | B9 5SS | United Kingdom | Details | ||
| St James s University Hospital ( Site 1106) | Leeds | LS9 7TF | United Kingdom | Details |