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| NCT ID | NCT04008030 |
| Title | A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC) (CheckMate 8HW) |
| Acronym | CheckMate 8HW |
| Recruitment | Recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Bristol-Myers Squibb |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | TUR | ROU | NOR | NLD | ITA | IRL | GRC | GBR | FRA | ESP | DNK | DEU | CZE | CAN | BRA | BEL | AUT | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Banner MD Anderson Cancer Center | WITHDRAWN | Gilbert | Arizona | 85234 | United States | Details |
| Local Institution - 0059 | COMPLETED | Los Angeles | California | 90033 | United States | Details |
| Local Institution - 0130 | ACTIVE_NOT_RECRUITING | Sacramento | California | 95817 | United States | Details |
| Local Institution - 0103 | ACTIVE_NOT_RECRUITING | Denver | Colorado | 80218 | United States | Details |
| Local Institution | WITHDRAWN | Miami | Florida | 33136 | United States | Details |
| Local Institution | WITHDRAWN | Marietta | Georgia | 30060 | United States | Details |
| Local Institution - 0119 | COMPLETED | Arlington Heights | Illinois | 60005 | United States | Details |
| Local Institution - 0060 | ACTIVE_NOT_RECRUITING | New York | New York | 10065 | United States | Details |
| Local Institution - 0105 | COMPLETED | Portland | Oregon | 97227 | United States | Details |
| Local Institution | WITHDRAWN | Philadelphia | Pennsylvania | 19104 | United States | Details |
| Local Institution - 0121 | COMPLETED | Pittsburgh | Pennsylvania | 15232 | United States | Details |
| Local Institution - 0106 | COMPLETED | Dallas | Texas | 75246 | United States | Details |
| Local Institution | WITHDRAWN | Fort Worth | Texas | 76104 | United States | Details |
| Local Institution - 0104 | ACTIVE_NOT_RECRUITING | Roanoke | Virginia | 24014 | United States | Details |
| Local Institution - 0073 | ACTIVE_NOT_RECRUITING | Ciudad Autonoma Beunos Aires | Buenos Aires | 1431 | Argentina | Details |
| Local Institution - 0074 | COMPLETED | Viedma | RIO Negro | 8500 | Argentina | Details |
| Local Institution - 0084 | ACTIVE_NOT_RECRUITING | Buenos Aires | 1093 | Argentina | Details | |
| Local Institution - 0100 | ACTIVE_NOT_RECRUITING | Caba | 1199 | Argentina | Details | |
| Local Institution - 0072 | ACTIVE_NOT_RECRUITING | Caba | 1426 | Argentina | Details | |
| Local Institution - 0019 | ACTIVE_NOT_RECRUITING | Westmead | New South Wales | 2145 | Australia | Details |
| Local Institution - 0053 | ACTIVE_NOT_RECRUITING | Woolloongabba | Queensland | 4102 | Australia | Details |
| Local Institution - 0018 | ACTIVE_NOT_RECRUITING | Elizabeth Vale | South Australia | 5112 | Australia | Details |
| Local Institution - 0041 | ACTIVE_NOT_RECRUITING | Clayton | Victoria | 3168 | Australia | Details |
| Local Institution - 0017 | ACTIVE_NOT_RECRUITING | Heidelberg | Victoria | 3084 | Australia | Details |
| Local Institution - 0064 | ACTIVE_NOT_RECRUITING | Graz | 8036 | Austria | Details | |
| Local Institution - 0068 | ACTIVE_NOT_RECRUITING | Linz | 4010 | Austria | Details | |
| Local Institution - 0120 | ACTIVE_NOT_RECRUITING | Salzburg | 5020 | Austria | Details | |
| Local Institution - 0067 | ACTIVE_NOT_RECRUITING | Wiener Neustadt | 2700 | Austria | Details | |
| Local Institution - 0065 | ACTIVE_NOT_RECRUITING | Wien | 1090 | Austria | Details | |
| Local Institution - 0045 | ACTIVE_NOT_RECRUITING | Bonheiden | Antwerpen | 2820 | Belgium | Details |
| Local Institution - 0025 | ACTIVE_NOT_RECRUITING | Anderlecht | Bruxelles-Capitale, Région De | 1070 | Belgium | Details |
| Local Institution | WITHDRAWN | Brussel | 1090 | Belgium | Details | |
| Local Institution - 0024 | ACTIVE_NOT_RECRUITING | Leuven | 3000 | Belgium | Details | |
| Local Institution - 0096 | ACTIVE_NOT_RECRUITING | Ipatinga | Minas Gerais | 35160-158 | Brazil | Details |
| Local Institution - 0200 | COMPLETED | Natal | RIO Grande DO Norte | 59075-740 | Brazil | Details |
| Local Institution - 0097 | WITHDRAWN | Porto Alegre | Rio Grande Do Sul | 90610-000 | Brazil | Details |
| Local Institution - 0192 | ACTIVE_NOT_RECRUITING | Porto Alegre | RIO Grande DO SUL | 91350-200 | Brazil | Details |
| Local Institution - 0102 | ACTIVE_NOT_RECRUITING | Barretos | Sao Paulo | 14780-070 | Brazil | Details |
| Local Institution - 0095 | ACTIVE_NOT_RECRUITING | Sao Paulo | São Paulo | 01509-010 | Brazil | Details |
| Local Institution - 0094 | ACTIVE_NOT_RECRUITING | São José do Rio Preto | São Paulo | 15090000 | Brazil | Details |
| Local Institution - 0199 | COMPLETED | Rio de Janeiro | 20231-050 | Brazil | Details | |
| Local Institution - 0193 | ACTIVE_NOT_RECRUITING | São Paulo | 01246-000 | Brazil | Details | |
| Local Institution - 0011 | COMPLETED | Edmonton | Alberta | T6G 1Z2 | Canada | Details |
| Local Institution - 0039 | COMPLETED | Vancouver | British Columbia | V5Z 4E6 | Canada | Details |
| Local Institution | WITHDRAWN | Halifax | Nova Scotia | B3H 2Y9 | Canada | Details |
| Local Institution - 0013 | COMPLETED | Toronto | Ontario | M5G 1X5 | Canada | Details |
| Local Institution - 0016 | ACTIVE_NOT_RECRUITING | Montreal | Quebec | H2X 3E4 | Canada | Details |
| Local Institution - 0015 | COMPLETED | Sherbrooke | Quebec | J1H 5N4 | Canada | Details |
| Local Institution | WITHDRAWN | Quebec | G1R 2J6 | Canada | Details | |
| Local Institution - 0071 | ACTIVE_NOT_RECRUITING | Santiago | Metropolitana | 7500921 | Chile | Details |
| Local Institution - 0069 | ACTIVE_NOT_RECRUITING | Santiago | Metropolitana | 8320000 | Chile | Details |
| Local Institution - 0070 | COMPLETED | Independencia | Santiago | Chile | Details | |
| Local Institution - 0146 | COMPLETED | Hefei | Anhui | 230061 | China | Details |
| Local Institution | NOT_YET_RECRUITING | Fuzhou | Fujian | 350001 | China | Details |
| The First Affiliated hospital of Xiamen University | RECRUITING | Xiamen | Fujian | 361003 | China | Details |
| Zhangzhou Municipal Hospital of Fujian Province | RECRUITING | Zhangzhou | Fujian | 363000 | China | Details |
| Lanzhou university second hospital | RECRUITING | Lanzhou | Gansu | 730030 | China | Details |
| The First People's Hospital of Foshan | RECRUITING | Foshan | Guangdong | 528000 | China | Details |
| Local Institution - 0194 | WITHDRAWN | Guangzhou | Guangdong | 510030 | China | Details |
| Local Institution - 0167 | RECRUITING | Guangzhou | Guangdong | 510080 | China | Details |
| Local Institution - 0153 | COMPLETED | Guangzhou | Guangdong | 510095 | China | Details |
| The Sixth Affiliated Hospital of Sun Yat-sen University | RECRUITING | Guangzhou | Guangdong | 510655 | China | Details |
| The people's hospital of Guangxi Zhuang autonomous region | RECRUITING | Nanning | Guangxi | 530000 | China | Details |
| Guangxi Medical University Affiliated Tumor Hospital | RECRUITING | Nanning | Guangxi | 530021 | China | Details |
| Harbin Medical University Cancer Hospital | RECRUITING | Harbin | Heilongjiang | 150040 | China | Details |
| The First Affiliated Hospital of Zhengzhou University | RECRUITING | Zhengzhou | Henan | 450052 | China | Details |
| Hunan Cancer Hospital | RECRUITING | Changsha | Hunan | 410013 | China | Details |
| The First People's Hospital of Changzhou | RECRUITING | Changzhou | Jiangsu | 213003 | China | Details |
| The 1st Affiliate Hospital Of Nanchang University | RECRUITING | Nanchang | Jiangxi | 330006 | China | Details |
| The 1st Hospital Of Jilin University | RECRUITING | Changchun | Jilin | 130021 | China | Details |
| Liaoning Cancer Hospital and Institute | RECRUITING | Shenyang | Liaoning | 110042 | China | Details |
| Local Institution - 0188 | COMPLETED | Xi'an | Shaanxi | 710126 | China | Details |
| Shandong Cancer Hospital | RECRUITING | Jinan | Shandong | 250117 | China | Details |
| Local Institution - 0212 | RECRUITING | Linyi | Shandong | 276034 | China | Details |
| Local Institution - 0154 | RECRUITING | Qingdao | Shandong | 266061 | China | Details |
| Local Institution - 0165 | COMPLETED | Yantai | Shandong | 264000 | China | Details |
| Local Institution - 0143 | COMPLETED | Shanghai | Shanghai | 200080 | China | Details |
| Shanghai East Hospital | RECRUITING | Shanghai | Shanghai | 200120 | China | Details |
| Shanghai GoBroad Cancer Hospital China Pharmaceutical University | RECRUITING | Shanghai | Shanghai | 200131 | China | Details |
| Yunnan Province Cancer Hospital | RECRUITING | Kunming | Yunnan | 650106 | China | Details |
| The 2nd Affiliated Hospital Of Z.U.S.M | RECRUITING | Hangzhou | Zhejiang | 310009 | China | Details |
| Local Institution - 0206 | RECRUITING | Ningbo | Zhejiang | 315041 | China | Details |
| Local Institution - 0087 | ACTIVE_NOT_RECRUITING | Brno | 656 53 | Czechia | Details | |
| Local Institution - 0085 | ACTIVE_NOT_RECRUITING | Hradec Kralove | 500 05 | Czechia | Details | |
| Local Institution - 0088 | COMPLETED | Novy Jicin | 741 01 | Czechia | Details | |
| Local Institution - 0086 | ACTIVE_NOT_RECRUITING | Olomouc | 779 00 | Czechia | Details | |
| Local Institution - 0038 | ACTIVE_NOT_RECRUITING | Herlev | 2730 | Denmark | Details | |
| Local Institution | WITHDRAWN | Odense | 5000 | Denmark | Details | |
| Local Institution - 0036 | ACTIVE_NOT_RECRUITING | Vejle | 7100 | Denmark | Details | |
| Local Institution - 0176 | ACTIVE_NOT_RECRUITING | Limoges | Haute-Vienne | 87042 | France | Details |
| Local Institution - 0138 | ACTIVE_NOT_RECRUITING | Lille | Nord | 59000 | France | Details |
| Local Institution - 0186 | COMPLETED | Bayonne | 64109 | France | Details | |
| Local Institution - 0028 | ACTIVE_NOT_RECRUITING | Besancon Cedex | 25030 | France | Details | |
| Local Institution - 0029 | ACTIVE_NOT_RECRUITING | Lyon Cedex 08 | 69373 | France | Details | |
| Local Institution - 0183 | COMPLETED | Lyon | 69008 | France | Details | |
| Local Institution - 0066 | ACTIVE_NOT_RECRUITING | Marseille | 13005 | France | Details | |
| Local Institution - 0030 | ACTIVE_NOT_RECRUITING | Montpellier | 34298 | France | Details | |
| Local Institution - 0032 | ACTIVE_NOT_RECRUITING | Nantes | 44093 | France | Details | |
| Local Institution - 0027 | ACTIVE_NOT_RECRUITING | Paris | 75012 | France | Details | |
| Local Institution - 0061 | ACTIVE_NOT_RECRUITING | Pessac Cedex | 33604 | France | Details | |
| Local Institution - 0031 | ACTIVE_NOT_RECRUITING | Poitiers | 86000 | France | Details | |
| Local Institution | WITHDRAWN | Rouen | 76000 | France | Details | |
| Local Institution - 0184 | COMPLETED | Strasbourg | 67200 | France | Details | |
| Local Institution - 0040 | ACTIVE_NOT_RECRUITING | Toulouse | 31059 | France | Details | |
| Local Institution - 0042 | ACTIVE_NOT_RECRUITING | Dresden | 01307 | Germany | Details | |
| Local Institution - 0007 | ACTIVE_NOT_RECRUITING | Essen | 45122 | Germany | Details | |
| Local Institution - 0043 | ACTIVE_NOT_RECRUITING | Hamburg | 20249 | Germany | Details | |
| Local Institution - 0117 | ACTIVE_NOT_RECRUITING | Hamburg | 22763 | Germany | Details | |
| Local Institution - 0008 | ACTIVE_NOT_RECRUITING | Hannover | 30625 | Germany | Details | |
| Local Institution - 0009 | ACTIVE_NOT_RECRUITING | Heidelberg | 69120 | Germany | Details | |
| Local Institution - 0044 | ACTIVE_NOT_RECRUITING | Marburg | 35043 | Germany | Details | |
| Local Institution - 0010 | ACTIVE_NOT_RECRUITING | Munich | 81377 | Germany | Details | |
| Local Institution - 0222 | NOT_YET_RECRUITING | Athens | Attikí (Region) | 115 25 | Greece | Details |
| Local Institution - 0123 | ACTIVE_NOT_RECRUITING | Athens | 11528 | Greece | Details | |
| Local Institution - 0125 | COMPLETED | Heraklion | 71110 | Greece | Details | |
| Local Institution - 0124 | ACTIVE_NOT_RECRUITING | Holargos | 15562 | Greece | Details | |
| Local Institution - 0126 | COMPLETED | Ioannina | 45500 | Greece | Details | |
| Local Institution - 0091 | COMPLETED | Dublin 8 | Dublin | Ireland | Details | |
| Local Institution - 0022 | COMPLETED | Dublin | Ireland | Details | ||
| Local Institution - 0026 | COMPLETED | Limerick | V94 F858 | Ireland | Details | |
| Local Institution - 0055 | ACTIVE_NOT_RECRUITING | Catania | 95122 | Italy | Details | |
| Local Institution - 0003 | COMPLETED | Genova | 16132 | Italy | Details | |
| Local Institution - 0001 | ACTIVE_NOT_RECRUITING | Milan | 20162 | Italy | Details | |
| Local Institution - 0004 | COMPLETED | Napoli | 80131 | Italy | Details | |
| Local Institution - 0002 | ACTIVE_NOT_RECRUITING | Padova | 35128 | Italy | Details | |
| Local Institution - 0054 | ACTIVE_NOT_RECRUITING | Roma | 00168 | Italy | Details | |
| Local Institution - 0109 | ACTIVE_NOT_RECRUITING | Nagoya-shi | Aichi | 4648681 | Japan | Details |
| Local Institution - 0112 | ACTIVE_NOT_RECRUITING | Chiba-shi | Chiba | 260-8717 | Japan | Details |
| Local Institution - 0107 | ACTIVE_NOT_RECRUITING | Kashiwa-shi | Chiba | 2778577 | Japan | Details |
| Local Institution - 0132 | ACTIVE_NOT_RECRUITING | Matsuyama | Ehime | 791-0280 | Japan | Details |
| Local Institution - 0116 | ACTIVE_NOT_RECRUITING | Fukuoka-shi | Fukuoka | 8111395 | Japan | Details |
| Local Institution - 0174 | COMPLETED | Sapporo-shi | Hokkaido | 0608648 | Japan | Details |
| Local Institution - 0128 | ACTIVE_NOT_RECRUITING | Kanazawa-city | Ishikawa | 9208641 | Japan | Details |
| Local Institution - 0111 | ACTIVE_NOT_RECRUITING | Kawasaki-shi | Kanagawa | 2168511 | Japan | Details |
| Local Institution - 0175 | ACTIVE_NOT_RECRUITING | Yokohama | Kanagawa | 241-8515 | Japan | Details |
| Local Institution - 0133 | ACTIVE_NOT_RECRUITING | Kumamoto-shi | Kumamoto | 8608556 | Japan | Details |
| Local Institution - 0189 | ACTIVE_NOT_RECRUITING | Osaki | Miyagi | 9896183 | Japan | Details |
| Local Institution - 0177 | ACTIVE_NOT_RECRUITING | Kurashiki | Okayama | 7108602 | Japan | Details |
| Local Institution - 0115 | ACTIVE_NOT_RECRUITING | Suita-shi | Osaka | 565-0871 | Japan | Details |
| Local Institution - 0187 | ACTIVE_NOT_RECRUITING | Hidaka | Saitama | 350-1298 | Japan | Details |
| Local Institution - 0110 | ACTIVE_NOT_RECRUITING | Kitaadachigun | Saitama | 362-0806 | Japan | Details |
| Local Institution - 0108 | ACTIVE_NOT_RECRUITING | Sunto-gun | Shizuoka | 4118777 | Japan | Details |
| Local Institution - 0118 | ACTIVE_NOT_RECRUITING | Chuo-ku | Tokyo | 1040045 | Japan | Details |
| Local Institution - 0113 | ACTIVE_NOT_RECRUITING | Koto-ku | Tokyo | 135-8550 | Japan | Details |
| Local Institution - 0129 | ACTIVE_NOT_RECRUITING | Minato-ku | Tokyo | 1058470 | Japan | Details |
| Local Institution - 0114 | ACTIVE_NOT_RECRUITING | Osaka | 540-0006 | Japan | Details | |
| Local Institution - 0052 | ACTIVE_NOT_RECRUITING | Amsterdam | Noord-Holland | 1066 CX | Netherlands | Details |
| Local Institution - 0051 | ACTIVE_NOT_RECRUITING | Amsterdam | Noord-Holland | 1081 HV | Netherlands | Details |
| Local Institution - 0050 | ACTIVE_NOT_RECRUITING | Utrecht | 3584 CX | Netherlands | Details | |
| Local Institution - 0033 | ACTIVE_NOT_RECRUITING | Bergen | 5021 | Norway | Details | |
| Local Institution - 0034 | COMPLETED | Lorenskog | 1478 | Norway | Details | |
| Local Institution - 0035 | ACTIVE_NOT_RECRUITING | Oslo | 0450 | Norway | Details | |
| Local Institution - 0058 | ACTIVE_NOT_RECRUITING | Rio Piedras | 00935 | Puerto Rico | Details | |
| Local Institution - 0076 | ACTIVE_NOT_RECRUITING | Cluj-Napoca | Cluj | 400015 | Romania | Details |
| Local Institution - 0081 | ACTIVE_NOT_RECRUITING | Craiova | Dolj | 200542 | Romania | Details |
| Local Institution - 0168 | COMPLETED | Brasov | 002200 | Romania | Details | |
| Local Institution - 0080 | ACTIVE_NOT_RECRUITING | Bucharest | 022328 | Romania | Details | |
| Local Institution - 0075 | WITHDRAWN | Constanta | 900591 | Romania | Details | |
| Local Institution - 0205 | COMPLETED | Iași | 700483 | Romania | Details | |
| Local Institution - 0089 | ACTIVE_NOT_RECRUITING | Suceava | 720237 | Romania | Details | |
| Local Institution - 0056 | ACTIVE_NOT_RECRUITING | Badalona | Barcelona [Barcelona] | 08916 | Spain | Details |
| Local Institution - 0173 | ACTIVE_NOT_RECRUITING | A Coruna | 15006 | Spain | Details | |
| Local Institution - 0006 | ACTIVE_NOT_RECRUITING | Barcelona | 08035 | Spain | Details | |
| Local Institution | WITHDRAWN | Madrid | 28034 | Spain | Details | |
| Local Institution - 0005 | ACTIVE_NOT_RECRUITING | Madrid | 28041 | Spain | Details | |
| Local Institution - 0172 | ACTIVE_NOT_RECRUITING | Malaga | 29010 | Spain | Details | |
| Local Institution - 0063 | ACTIVE_NOT_RECRUITING | Sevilla | 41013 | Spain | Details | |
| Local Institution - 0171 | ACTIVE_NOT_RECRUITING | Valencia | 46014 | Spain | Details | |
| Local Institution - 0092 | ACTIVE_NOT_RECRUITING | Adana | 01060 | Turkey | Details | |
| Local Institution - 0101 | ACTIVE_NOT_RECRUITING | Istanbul | 34300 | Turkey | Details | |
| Local Institution | WITHDRAWN | London | Greater London | SE1 9RY | United Kingdom | Details |
| Local Institution | WITHDRAWN | Leeds | Yorkshire | LS9 7TF | United Kingdom | Details |
| Local Institution - 0127 | ACTIVE_NOT_RECRUITING | London | EC1A 7BE | United Kingdom | Details | |
| Local Institution - 0049 | ACTIVE_NOT_RECRUITING | Oxford | OX3 7LE | United Kingdom | Details |