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| NCT ID | NCT04008030 |
| Title | A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC) (CheckMate 8HW) |
| Acronym | CheckMate 8HW |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | Bristol-Myers Squibb |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | TUR | ROU | NOR | NLD | ITA | IRL | GRC | GBR | FRA | ESP | DNK | DEU | CZE | CAN | BRA | BEL | AUT | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Local Institution - 0059 | Los Angeles | California | 90033 | United States | Details | |
| Local Institution - 0130 | Sacramento | California | 95817 | United States | Details | |
| Local Institution - 0103 | Denver | Colorado | 80218 | United States | Details | |
| Local Institution - 0119 | Arlington Heights | Illinois | 60005 | United States | Details | |
| Local Institution - 0060 | New York | New York | 10065 | United States | Details | |
| Local Institution - 0105 | Portland | Oregon | 97227 | United States | Details | |
| Local Institution - 0121 | Pittsburgh | Pennsylvania | 15232 | United States | Details | |
| Local Institution - 0106 | Dallas | Texas | 75246 | United States | Details | |
| Local Institution - 0104 | Roanoke | Virginia | 24014 | United States | Details | |
| Local Institution - 0073 | Ciudad Autonoma Beunos Aires | Buenos Aires | 1431 | Argentina | Details | |
| Local Institution - 0074 | Viedma | RIO Negro | 8500 | Argentina | Details | |
| Local Institution - 0084 | Buenos Aires | 1093 | Argentina | Details | ||
| Local Institution - 0100 | Caba | 1199 | Argentina | Details | ||
| Local Institution - 0072 | Caba | 1426 | Argentina | Details | ||
| Local Institution - 0019 | Westmead | New South Wales | 2145 | Australia | Details | |
| Local Institution - 0053 | Woolloongabba | Queensland | 4102 | Australia | Details | |
| Local Institution - 0018 | Elizabeth Vale | South Australia | 5112 | Australia | Details | |
| Local Institution - 0041 | Clayton | Victoria | 3168 | Australia | Details | |
| Local Institution - 0017 | Heidelberg | Victoria | 3084 | Australia | Details | |
| Local Institution - 0064 | Graz | 8036 | Austria | Details | ||
| Local Institution - 0068 | Linz | 4010 | Austria | Details | ||
| Local Institution - 0120 | Salzburg | 5020 | Austria | Details | ||
| Local Institution - 0067 | Wiener Neustadt | 2700 | Austria | Details | ||
| Local Institution - 0065 | Wien | 1090 | Austria | Details | ||
| Local Institution - 0045 | Bonheiden | Antwerpen | 2820 | Belgium | Details | |
| Local Institution - 0025 | Anderlecht | Bruxelles-Capitale, Région De | 1070 | Belgium | Details | |
| Local Institution - 0024 | Leuven | 3000 | Belgium | Details | ||
| Local Institution - 0096 | Ipatinga | Minas Gerais | 35160-158 | Brazil | Details | |
| Local Institution - 0200 | Natal | RIO Grande DO Norte | 59075-740 | Brazil | Details | |
| Local Institution - 0192 | Porto Alegre | RIO Grande DO SUL | 91350-200 | Brazil | Details | |
| Local Institution - 0102 | Barretos | Sao Paulo | 14780-070 | Brazil | Details | |
| Local Institution - 0095 | Sao Paulo | São Paulo | 01509-010 | Brazil | Details | |
| Local Institution - 0094 | São José do Rio Preto | São Paulo | 15090000 | Brazil | Details | |
| Local Institution - 0199 | Rio de Janeiro | 20231-050 | Brazil | Details | ||
| Local Institution - 0193 | São Paulo | 01246-000 | Brazil | Details | ||
| Local Institution - 0011 | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| Local Institution - 0039 | Vancouver | British Columbia | V5Z 4E6 | Canada | Details | |
| Local Institution - 0013 | Toronto | Ontario | M5G 1X5 | Canada | Details | |
| Local Institution - 0016 | Montreal | Quebec | H2X 3E4 | Canada | Details | |
| Local Institution - 0015 | Sherbrooke | Quebec | J1H 5N4 | Canada | Details | |
| Local Institution - 0071 | Santiago | Metropolitana | 7500921 | Chile | Details | |
| Local Institution - 0069 | Santiago | Metropolitana | 8320000 | Chile | Details | |
| Local Institution - 0070 | Independencia | Santiago | Chile | Details | ||
| Local Institution - 0146 | Hefei | Anhui | 230061 | China | Details | |
| Local Institution | Fuzhou | Fujian | 350001 | China | Details | |
| Local Institution - 0163 | Xiamen | Fujian | 361003 | China | Details | |
| Local Institution - 0207 | Zhangzhou | Fujian | 363000 | China | Details | |
| Local Institution - 0211 | Lanzhou | Gansu | 730030 | China | Details | |
| Local Institution - 0158 | Foshan | Guangdong | 528000 | China | Details | |
| Local Institution - 0167 | Guangzhou | Guangdong | 510080 | China | Details | |
| Local Institution - 0153 | Guangzhou | Guangdong | 510095 | China | Details | |
| Local Institution - 0149 | Guangzhou | Guangdong | 510655 | China | Details | |
| Local Institution - 0160 | Nanning | Guangxi | 530000 | China | Details | |
| Local Institution - 0196 | Nanning | Guangxi | 530021 | China | Details | |
| Local Institution - 0180 | Harbin | Heilongjiang | 150040 | China | Details | |
| Local Institution - 0181 | Zhengzhou | Henan | 450052 | China | Details | |
| Local Institution - 0197 | Changsha | Hunan | 410013 | China | Details | |
| Local Institution - 0145 | Changzhou | Jiangsu | 213003 | China | Details | |
| Local Institution - 0151 | Nanchang | Jiangxi | 330006 | China | Details | |
| Local Institution - 0164 | Changchun | Jilin | 130021 | China | Details | |
| Local Institution - 0162 | Shenyang | Liaoning | 110042 | China | Details | |
| Local Institution - 0188 | Xi'an | Shaanxi | 710126 | China | Details | |
| Local Institution - 0210 | Jinan | Shandong | 250117 | China | Details | |
| Local Institution - 0212 | Linyi | Shandong | 276001 | China | Details | |
| Local Institution - 0154 | Qingdao | Shandong | 266061 | China | Details | |
| Local Institution - 0165 | Yantai | Shandong | 264000 | China | Details | |
| Local Institution - 0143 | Shanghai | Shanghai | 200080 | China | Details | |
| Local Institution - 0131 | Shanghai | Shanghai | 200120 | China | Details | |
| Local Institution - 0221 | Shanghai | Shanghai | 200131 | China | Details | |
| Local Institution - 0195 | Kunming | Yunnan | 650106 | China | Details | |
| Local Institution - 0137 | Hangzhou | Zhejiang | 310009 | China | Details | |
| Local Institution - 0206 | Ningbo | Zhejiang | 315041 | China | Details | |
| Local Institution - 0087 | Brno | 656 53 | Czechia | Details | ||
| Local Institution - 0085 | Hradec Kralove | 500 05 | Czechia | Details | ||
| Local Institution - 0088 | Novy Jicin | 741 01 | Czechia | Details | ||
| Local Institution - 0086 | Olomouc | 779 00 | Czechia | Details | ||
| Local Institution - 0038 | Herlev | 2730 | Denmark | Details | ||
| Local Institution - 0036 | Vejle | 7100 | Denmark | Details | ||
| Local Institution - 0176 | Limoges | Haute-Vienne | 87042 | France | Details | |
| Local Institution - 0138 | Lille | Nord | 59000 | France | Details | |
| Local Institution - 0186 | Bayonne | 64109 | France | Details | ||
| Local Institution - 0028 | Besancon Cedex | 25030 | France | Details | ||
| Local Institution - 0029 | Lyon Cedex 08 | 69373 | France | Details | ||
| Local Institution - 0183 | Lyon | 69008 | France | Details | ||
| Local Institution - 0066 | Marseille | 13005 | France | Details | ||
| Local Institution - 0030 | Montpellier | 34298 | France | Details | ||
| Local Institution - 0032 | Nantes | 44093 | France | Details | ||
| Local Institution - 0027 | Paris | 75012 | France | Details | ||
| Local Institution - 0061 | Pessac Cedex | 33604 | France | Details | ||
| Local Institution - 0031 | Poitiers | 86000 | France | Details | ||
| Local Institution - 0184 | Strasbourg | 67200 | France | Details | ||
| Local Institution - 0040 | Toulouse | 31059 | France | Details | ||
| Local Institution - 0042 | Dresden | 01307 | Germany | Details | ||
| Local Institution - 0007 | Essen | 45122 | Germany | Details | ||
| Local Institution - 0043 | Hamburg | 20249 | Germany | Details | ||
| Local Institution - 0117 | Hamburg | 22763 | Germany | Details | ||
| Local Institution - 0008 | Hannover | 30625 | Germany | Details | ||
| Local Institution - 0009 | Heidelberg | 69120 | Germany | Details | ||
| Local Institution - 0044 | Marburg | 35043 | Germany | Details | ||
| Local Institution - 0010 | Munich | 81377 | Germany | Details | ||
| Local Institution - 0222 | Athens | 11525 | Greece | Details | ||
| Local Institution - 0123 | Athens | 11528 | Greece | Details | ||
| Local Institution - 0125 | Heraklion | 71110 | Greece | Details | ||
| Local Institution - 0124 | Holargos | 15562 | Greece | Details | ||
| Local Institution - 0126 | Ioannina | 45500 | Greece | Details | ||
| Local Institution - 0091 | Dublin 8 | Dublin | Ireland | Details | ||
| Local Institution - 0022 | Dublin | Ireland | Details | |||
| Local Institution - 0026 | Limerick | V94 F858 | Ireland | Details | ||
| Local Institution - 0055 | Catania | 95122 | Italy | Details | ||
| Local Institution - 0003 | Genova | 16132 | Italy | Details | ||
| Local Institution - 0001 | Milan | 20162 | Italy | Details | ||
| Local Institution - 0004 | Napoli | 80131 | Italy | Details | ||
| Local Institution - 0002 | Padova | 35128 | Italy | Details | ||
| Local Institution - 0054 | Roma | 00168 | Italy | Details | ||
| Local Institution - 0109 | Nagoya-shi | Aichi | 4648681 | Japan | Details | |
| Local Institution - 0112 | Chiba-shi | Chiba | 260-8717 | Japan | Details | |
| Local Institution - 0107 | Kashiwa-shi | Chiba | 2778577 | Japan | Details | |
| Local Institution - 0132 | Matsuyama | Ehime | 791-0280 | Japan | Details | |
| Local Institution - 0116 | Fukuoka-shi | Fukuoka | 8111395 | Japan | Details | |
| Local Institution - 0174 | Sapporo-shi | Hokkaido | 0608648 | Japan | Details | |
| Local Institution - 0128 | Kanazawa-city | Ishikawa | 9208641 | Japan | Details | |
| Local Institution - 0111 | Kawasaki | Kanagawa | 216-8511 | Japan | Details | |
| Local Institution - 0175 | Yokohama | Kanagawa | 241-8515 | Japan | Details | |
| Local Institution - 0133 | Kumamoto-shi | Kumamoto | 8608556 | Japan | Details | |
| Local Institution - 0189 | Osaki | Miyagi | 9896183 | Japan | Details | |
| Local Institution - 0177 | Kurashiki | Okayama | 7108602 | Japan | Details | |
| Local Institution - 0115 | Suita-shi | Osaka | 565-0871 | Japan | Details | |
| Local Institution - 0187 | Hidaka | Saitama | 350-1298 | Japan | Details | |
| Local Institution - 0110 | Kitaadachigun | Saitama | 362-0806 | Japan | Details | |
| Local Institution - 0108 | Sunto-gun | Shizuoka | 4118777 | Japan | Details | |
| Local Institution - 0118 | Chuo-ku | Tokyo | 1040045 | Japan | Details | |
| Local Institution - 0113 | Koto-ku | Tokyo | 135-8550 | Japan | Details | |
| Local Institution - 0129 | Minato-ku | Tokyo | 1058470 | Japan | Details | |
| Local Institution - 0114 | Osaka | 540-0006 | Japan | Details | ||
| Local Institution - 0052 | Amsterdam | Noord-Holland | 1066 CX | Netherlands | Details | |
| Local Institution - 0051 | Amsterdam | Noord-Holland | 1081 HV | Netherlands | Details | |
| Local Institution - 0050 | Utrecht | 3584 CX | Netherlands | Details | ||
| Local Institution - 0033 | Bergen | 5021 | Norway | Details | ||
| Local Institution - 0034 | Lorenskog | 1478 | Norway | Details | ||
| Local Institution - 0035 | Oslo | 0450 | Norway | Details | ||
| Local Institution - 0058 | Rio Piedras | 00935 | Puerto Rico | Details | ||
| Local Institution - 0076 | Cluj-Napoca | Cluj | 400015 | Romania | Details | |
| Local Institution - 0081 | Craiova | Dolj | 200542 | Romania | Details | |
| Local Institution - 0168 | Brasov | 002200 | Romania | Details | ||
| Local Institution - 0080 | Bucharest | 022328 | Romania | Details | ||
| Local Institution - 0205 | Iași | 700483 | Romania | Details | ||
| Local Institution - 0089 | Suceava | 720237 | Romania | Details | ||
| Local Institution - 0056 | Badalona | Barcelona [Barcelona] | 08916 | Spain | Details | |
| Local Institution - 0173 | A Coruna | 15006 | Spain | Details | ||
| Local Institution - 0006 | Barcelona | 08035 | Spain | Details | ||
| Local Institution - 0005 | Madrid | 28041 | Spain | Details | ||
| Local Institution - 0172 | Malaga | 29010 | Spain | Details | ||
| Local Institution - 0063 | Sevilla | 41013 | Spain | Details | ||
| Local Institution - 0171 | Valencia | 46014 | Spain | Details | ||
| Local Institution - 0092 | Adana | 01060 | Turkey | Details | ||
| Local Institution - 0101 | Istanbul | 34300 | Turkey | Details | ||
| Local Institution - 0127 | London | EC1A 7BE | United Kingdom | Details | ||
| Local Institution - 0049 | Oxford | OX3 7LE | United Kingdom | Details |