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NCT ID NCT04191096
Title Efficacy and Safety of Pembrolizumab (MK-3475) Plus Enzalutamide Plus Androgen Deprivation Therapy (ADT) Versus Placebo Plus Enzalutamide Plus ADT in Participants With Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) (MK-3475-991/KEYNOTE-991)
Recruitment Active, not recruiting
Gender male
Phase Phase III
Variant Requirements No
Sponsors Merck Sharp & Dohme Corp.
Indications
Therapies
Age Groups: adult | senior
Covered Countries USA | TUR | POL | NZL | NLD | ITA | ISR | IRL | GBR | FRA | FIN | ESP | DNK | DEU | CHE | CAN | BRA | AUT | AUS

Facility Status City State Zip Country Details
Alaska Clinical Research Center ( Site 0274) Anchorage Alaska 99503 United States Details
Providence Alaska Medical Center ( Site 0276) Anchorage Alaska 99508 United States Details
City of Hope Medical Center ( Site 0217) Duarte California 91010 United States Details
UCLA Hematology/Oncology - Santa Monica ( Site 0241) Los Angeles California 90404 United States Details
University of Colorado, Anschutz Cancer Pavilion ( Site 0236) Aurora Colorado 80045 United States Details
Hartford HealthCare Medical Group ( Site 0212) Manchester Connecticut 06042 United States Details
Smilow Cancer Center at Yale-New Haven ( Site 0250) New Haven Connecticut 06510 United States Details
Sibley Memorial Hospital ( Site 0275) Washington District of Columbia 20016 United States Details
Winship Cancer Institute of Emory University ( Site 0209) Atlanta Georgia 30322-1013 United States Details
The University of Chicago ( Site 0264) Chicago Illinois 60637 United States Details
Springfield Clinic [Springfield, IL] ( Site 0240) Springfield Illinois 62702 United States Details
Cotton-O'Neil Cancer Center ( Site 0228) Topeka Kansas 66606 United States Details
The Sidney Kimmel Comprehensive Cancer Center ( Site 0204) Baltimore Maryland 21287 United States Details
St. Vincent Frontier Cancer Center-Research ( Site 0213) Billings Montana 59102 United States Details
Comprehensive Cancer Centers of Nevada ( Site 0269) Las Vegas Nevada 89169 United States Details
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0270) New York New York 10016 United States Details
Weill Cornell Medical College ( Site 0263) New York New York 10065 United States Details
Associated Medical Professionals of NY ( Site 0251) Syracuse New York 13210 United States Details
Duke University ( Site 0206) Durham North Carolina 27710 United States Details
Tri-State Urologic Services PSC, Inc. ( Site 0253) Cincinnati Ohio 45212 United States Details
MidLantic Urology ( Site 0273) Bala-Cynwyd Pennsylvania 19004 United States Details
Ralph H. Johnson VA Center ( Site 0256) Charleston South Carolina 29401 United States Details
Carolina Urologic Research Center ( Site 0259) Myrtle Beach South Carolina 29572 United States Details
Urology Associates [Nashville, TN] ( Site 0233) Nashville Tennessee 37209 United States Details
Inova Health System ( Site 0205) Fairfax Virginia 22031 United States Details
Urology of Virginia ( Site 0224) Virginia Beach Virginia 23462 United States Details
Seattle Cancer Care Alliance ( Site 0258) Seattle Washington 98109 United States Details
Chris OBrien Lifehouse ( Site 0300) Camperdown New South Wales 2050 Australia Details
Port Macquarie Base Hospital ( Site 0301) Port Macquarie New South Wales 2444 Australia Details
Riverina Cancer Care Center ( Site 0302) Wagga Wagga New South Wales 2650 Australia Details
Gallipoli Medical Research Foundation ( Site 0309) Greenslopes Queensland 4120 Australia Details
John Flynn Hospital & Medical Centre ( Site 0308) Tugun Queensland 4224 Australia Details
Box Hill Hospital ( Site 0304) Box Hill Victoria 3128 Australia Details
Monash Health ( Site 0305) Clayton Victoria 3168 Australia Details
Peter MacCallum Cancer Centre ( Site 0306) Melbourne Victoria 3000 Australia Details
Fiona Stanley Hospital ( Site 0311) Murdoch Western Australia 6150 Australia Details
Ordensklinikum Linz GmbH Elisabethinen ( Site 0901) Linz Oberosterreich 4020 Austria Details
Landeskrankenhaus Salzburg - Universitatklinikum der PMU ( Site 0900) Salzburg 5020 Austria Details
Krankenhaus der Barmherzigen Brüder Wien ( Site 0904) Wien 1020 Austria Details
Medizinische Universitaet Wien ( Site 0903) Wien 1090 Austria Details
Oncocentro Ceara ( Site 2309) Fortaleza Ceara 60135-237 Brazil Details
Instituto de Cancer e Transplante de Curitiba ICTR ( Site 2306) Curitiba Parana 80510-130 Brazil Details
Hospital Sao Vicente de Paulo ( Site 2303) Passo Fundo Rio Grande Do Sul 99010-080 Brazil Details
Hospital de Clinicas de Porto Alegre ( Site 2304) Porto Alegre Rio Grande Do Sul 90035-903 Brazil Details
Clinica de Oncologia Reichow ( Site 2308) Blumenau Santa Catarina 89010-340 Brazil Details
Fundacao Dr Amaral Carvalho ( Site 2302) Jau Sao Paulo 17210-120 Brazil Details
Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 2305) Sao Paulo 01246-000 Brazil Details
The Ottawa Hospital ( Site 0100) Ottawa Ontario K1H 8L6 Canada Details
Niagara Health System - St. Catharines ( Site 0107) St. Catharines Ontario L2S 0A9 Canada Details
CISSS de la Monteregie-Centre ( Site 0105) Greenfield Park Quebec J4V 2H1 Canada Details
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0109) Montreal Quebec H2X 3E4 Canada Details
CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0106) Montreal Quebec H3T 1M5 Canada Details
CHUQ-Univ Laval-Hotel Dieu de Quebec ( Site 0101) Quebec G1R 2J6 Canada Details
Centro Investigación del Cáncer James Lind ( Site 2401) Temuco Araucania 4780000 Chile Details
IC La Serena Research ( Site 2406) La Serena Coquimbo 1720430 Chile Details
Clinica Universidad Catolica del Maule ( Site 2407) Talca Maule 3465584 Chile Details
Clinica Alemana ( Site 2408) Santiago Region M. De Santiago 7650568 Chile Details
Pontificia Universidad Catolica de Chile ( Site 2402) Santiago Region M. De Santiago 8330032 Chile Details
Sociedad Medica Aren y Bachero Limitada ( Site 2403) Santiago Region M. De Santiago 8420383 Chile Details
Oncocentro ( Site 2400) Vina del Mar Valparaiso 2520598 Chile Details
Peking University First Hospital ( Site 0800) Beijing Beijing 100034 China Details
Zhejiang Provincial People's Hospital ( Site 0809) Hangzhou Zhejiang 310014 China Details
The First Affiliated Hospital of Wenzhou Medical University ( Site 0834) Wenzhou Zhejiang 325000 China Details
Institucion Prestadora de Servicios de Salud Clinica de la Costa LTDA ( Site 2504) Barranquilla Atlantico 080020 Colombia Details
Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 2509) Valledupar Cesar 200001 Colombia Details
Administradora Country SA - Clinica del Country ( Site 2507) Bogota Distrito Capital De Bogota 110221 Colombia Details
Instituto Nacional de Cancerologia E.S.E ( Site 2506) Bogota Distrito Capital De Bogota 110321 Colombia Details
Hemato Oncologos ( Site 2503) Cali Valle Del Cauca 760042 Colombia Details
Rigshospitalet ( Site 1005) Copenhagen Hovedstaden 2100 Denmark Details
Herlev og Gentofte Hospital. ( Site 1004) Herlev Hovedstaden 2730 Denmark Details
Aalborg Universitetshospital ( Site 1000) Aalborg Nordjylland 9000 Denmark Details
Odense Universitetshospital ( Site 1003) Odense Syddanmark 5000 Denmark Details
Vejle Sygehus ( Site 1002) Vejle Syddanmark 7100 Denmark Details
Keski-Suomen keskussairaala ( Site 1017) Jyvaskyla Mellersta Finland 40620 Finland Details
Tampereen yliopistollinen sairaala ( Site 1022) Tampere Pirkanmaa 33520 Finland Details
HYKS ( Site 1020) Helsinki Varsinais-Suomi 00290 Finland Details
TYKS T-sairaala Syopatautien pkl ( Site 1019) Turku Varsinais-Suomi 20521 Finland Details
Centre Leon-Berard ( Site 1110) Lyon Auvergne 69373 France Details
Institut de cancérologie Strasbourg Europe (ICANS) ( Site 1114) Strasbourg Bas-Rhin 67200 France Details
CHU de Brest -Site Hopital Morvan ( Site 1103) Brest Bretagne 29200 France Details
Centre Georges Francois Leclerc ( Site 1112) Dijon Cote-d Or 21079 France Details
CHU-Jean Minjoz ( Site 1101) Besancon Doubs 25000 France Details
Institut Bergonie ( Site 1104) Bordeaux Gironde 33076 France Details
Hopital Foch ( Site 1105) Suresnes Hauts-de-Seine 92151 France Details
C.H.R.U. de Rennes. Hopital de Pontchaillou ( Site 1117) Rennes Ille-et-Vilaine 35033 France Details
Institut Jean Godinot-Clinical Research Unit ( Site 1118) Reims Marne 51726 France Details
Centre D Oncologie de Gentilly ( Site 1107) Nancy Meurthe-et-Moselle 54100 France Details
Centre Bourgogne ( Site 1119) Lille Nord-Pas-de-Calais 59000 France Details
Hospices Civils de Lyon Centre Hospitalier Lyon Sud ( Site 1102) Pierre Benite Rhone 69310 France Details
Hopital Henri Mondor ( Site 1116) Creteil Val-de-Marne 94010 France Details
Universitaetsklinikum Freiburg ( Site 1200) Freiburg Baden-Wurttemberg 79106 Germany Details
Klinikum der Universitaet Muenchen - Grosshadern ( Site 1210) Muenchen Bayern 81377 Germany Details
Klinikum Rechts der Isar ( Site 1206) Munchen Bayern 81675 Germany Details
Klinikum Nuernberg Nord ( Site 1213) Nurnberg Bayern 90419 Germany Details
Staedtisches Klinikum Braunschweig gGmbH ( Site 1217) Braunschweig Niedersachsen 38126 Germany Details
Universitaetsklinikum Magdeburg A.o.R. ( Site 1211) Magdeburg Sachsen-Anhalt 39120 Germany Details
Universitaetsklinikum der Technischen Universitaet Dresden ( Site 1204) Dresden Sachsen 01307 Germany Details
Charite Universitaetsmedizin Berlin ( Site 1201) Berlin 10117 Germany Details
Universitaetsklinikum Hamburg-Eppendorf ( Site 1212) Hamburg 20246 Germany Details
Cork University Hospital ( Site 1304) Cork T12 DC4A Ireland Details
Beaumont Hospital ( Site 1302) Dublin 00009 Ireland Details
Tallaght University Hospital ( Site 1301) Dublin D24 NR0A Ireland Details
St Vincents University Hospital ( Site 1300) Dublin DO4 YN63 Ireland Details
University Hospital Limerick ( Site 1305) Limerick V94 F858 Ireland Details
University Hospital Waterford ( Site 1303) Waterford X91 ER8E Ireland Details
Rambam Medical Center ( Site 1400) Haifa 3109601 Israel Details
Hadassah Ein Kerem Medical Center ( Site 1404) Jerusalem 9112001 Israel Details
Meir Medical Center ( Site 1401) Kfar Saba 4428164 Israel Details
Rabin Medical Center ( Site 1402) Petach Tikva 4941492 Israel Details
Sourasky Medical Center ( Site 1403) Tel Aviv 6423906 Israel Details
Assaf Harofeh Medical Center ( Site 1405) Zerifin 70300 Israel Details
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori ( Site 1503) Meldola Emilia-Romagna 47014 Italy Details
Istituto Clinico Humanitas Research Hospital ( Site 1500) Rozzano Lombardia 20089 Italy Details
Centro Di Riferimento Oncologico ( Site 1511) Aviano Pordenone 33081 Italy Details
IRCCS Giovanni Paolo II. Ospedale Oncologico ( Site 1509) Bari 70124 Italy Details
Azienda Ospedaliera Cannizzaro ( Site 1501) Catania 95126 Italy Details
Istituto Nazionale dei Tumori ( Site 1510) Milano 20133 Italy Details
Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1508) Napoli 80131 Italy Details
Fondazione Policlinico Universitario A. Gemelli ( Site 1512) Roma 00168 Italy Details
Azienda Ospedaliera Santa Maria ( Site 1502) Terni 05100 Italy Details
A.O. Verona-Ospedale Civile Maggiore Borgo-Trento ( Site 1504) Verona 37126 Italy Details
Toho University Sakura Medical Center ( Site 0732) Sakura Chiba 285-8741 Japan Details
Ehime University Hospital ( Site 0745) Toon Ehime 791-0295 Japan Details
Sapporo Medical University Hospital ( Site 0730) Sapporo Hokkaido 060-8543 Japan Details
Kitasato University Hospital ( Site 0734) Sagamihara Kanagawa 252-0375 Japan Details
Yokohama City University Medical Center ( Site 0735) Yokohama Kanagawa 232-0024 Japan Details
Nara Medical University Hospital ( Site 0744) Kashihara Nara 634-8522 Japan Details
Kindai University Hospital ( Site 0743) Osakasayama Osaka 589-8511 Japan Details
Osaka University Hospital ( Site 0742) Suita Osaka 565-0871 Japan Details
Saitama Medical University International Medical Center ( Site 0737) Hidaka Saitama 350-1298 Japan Details
Dokkyo Medical University Saitama Medical Center ( Site 0736) Koshigaya Saitama 343-8555 Japan Details
Hamamatsu University Hospital ( Site 0748) Hamamatsu Shizuoka 431-3192 Japan Details
Yamaguchi University Hospital ( Site 0746) Ube Yamaguchi 755-8505 Japan Details
Chiba Cancer Center ( Site 0733) Chiba 260-8717 Japan Details
Harasanshin Hospital ( Site 0747) Fukuoka 812-0033 Japan Details
Nagano Municipal Hospital ( Site 0731) Nagano 381-8551 Japan Details
Osaka City University Hospital ( Site 0741) Osaka 545-8586 Japan Details
Toranomon Hospital ( Site 0740) Tokyo 105-8470 Japan Details
Nippon Medical School Hospital ( Site 0738) Tokyo 113-8603 Japan Details
Tokyo Women's Medical University Hospital ( Site 0739) Tokyo 162-8666 Japan Details
Chonnam National University Hwasun Hospital ( Site 0406) Jeollanam-do Jeonranamdo 58128 Korea, Republic of Details
National Cancer Center ( Site 0400) Gyeonggi-do Kyonggi-do 10408 Korea, Republic of Details
Seoul National University Bundang Hospital ( Site 0401) Seongnam-si Kyonggi-do 13620 Korea, Republic of Details
Kyungpook National University Chilgok Hospital ( Site 0404) Daegu Taegu-Kwangyokshi 41404 Korea, Republic of Details
Seoul National University Hospital ( Site 0405) Seoul 03080 Korea, Republic of Details
Severance Hospital Yonsei University Health System ( Site 0402) Seoul 03722 Korea, Republic of Details
Asan Medical Center ( Site 0403) Seoul 05505 Korea, Republic of Details
Hospital San Lucas Cardiologica del Sureste ( Site 2606) Tuxtla Gutierrez Chiapas 29090 Mexico Details
Hospital Civil de Guadalajara Fray Antonio Alcalde ( Site 2607) Guadalajara Jalisco 44280 Mexico Details
Centro Estatal de Cancerologia de Chihuahua ( Site 2608) Chihuahua 31000 Mexico Details
Grupo Medico Camino SC ( Site 2613) Mexico City 03310 Mexico Details
Centro Oncologico Internacional. SEDNA ( Site 2609) Mexico City 04700 Mexico Details
Boca Raton Clinical Research QTO ( Site 2611) Queretaro 76070 Mexico Details
Radboud University Medical Center ( Site 1606) Nijmegen Gelderland 6500 HB Netherlands Details
Antoni van Leeuwenhoek Ziekenhuis ( Site 1603) Amsterdam Noord-Holland 1066 CX Netherlands Details
Vrije Universiteit Medisch Centrum ( Site 1601) Amsterdam Noord-Holland 1081 HV Netherlands Details
Isala Klinieken, Locatie Sophia ( Site 1604) Zwolle Overijssel 8025 AB Netherlands Details
Meander Medisch Centrum ( Site 1602) Amersfoort Utrecht 3813 TZ Netherlands Details
Franciscus Gasthuis en Vlietland ( Site 1605) Schiedam Zuid-Holland 3118 JH Netherlands Details
St. Antonius Ziekenhuis ( Site 1600) Utrecht 3543 AZ Netherlands Details
Auckland City Hospital ( Site 0321) Auckland 1023 New Zealand Details
Hospital Nacional Carlos Alberto Seguin Escobedo ESSALUD ( Site 2700) Arequipa Ariqipa 04001 Peru Details
Clinica Peruano Americana S.A. ( Site 2702) Trujillo La Libertad 13011 Peru Details
Hospital Nacional Guillermo Almenara Irigoyen ( Site 2708) Lima 15033 Peru Details
Instituto de Oncologia y Radioterapia Clinica Ricardo Palma ( Site 2706) Lima 15036 Peru Details
Hospital Militar Central [Lima, Peru] ( Site 2704) Lima 15076 Peru Details
Szpital Uniwersytecki nr 1 im. Dr. Antoniego Jurasza w Bydgoszczy ( Site 1720) Bydgoszcz Kujawsko-pomorskie 85-094 Poland Details
Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 1716) Bydgoszcz Kujawsko-pomorskie 85-796 Poland Details
Nasz Lekarz Przychodnie Medyczne ( Site 1718) Torun Kujawsko-pomorskie 87-100 Poland Details
Szpital Uniwersytecki w Krakowie ( Site 1707) Krakow Malopolskie 30-688 Poland Details
Radomskie Centrum Onkologii ( Site 1701) Radom Mazowieckie 26-600 Poland Details
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1700) Przemysl Podkarpackie 37-700 Poland Details
Wojewodzki Szpital Specjalistyczny nr 4 w Bytomiu ( Site 1717) Bytom Slaskie 41-902 Poland Details
Szpital Kliniczny im. Przemienienia Panskiego Uniwersytetu Medycznego im. K. Marcinkowskiego w Pozna Poznan Wielkopolskie 61-848 Poland Details
Szpital Wojewodzki im. Mikolaja Kopernika ( Site 1709) Koszalin Zachodniopomorskie 75-581 Poland Details
Twoja Przychodnia - Szczeciskie Centrum Medyczne ( Site 1721) Szczecin Zachodniopomorskie 71-434 Poland Details
Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 1810) Krasnoyarsk Krasnoyarskiy Kray 660133 Russian Federation Details
SBIH City clinical hospital named after D.D. Pletniov ( Site 1813) Moscow Moskva 105077 Russian Federation Details
Russian Scientific Center of Roentgenoradiology ( Site 1800) Moscow Moskva 117997 Russian Federation Details
Volga District Medical Center Federal Medical and Biological Agency ( Site 1805) Nizhny Novgorod Nizhegorodskaya Oblast 603074 Russian Federation Details
Omsk Clinical Oncology Dispensary ( Site 1809) Omsk Omskaya Oblast 644013 Russian Federation Details
Instituto Catalan de Oncologia - ICO ( Site 1901) Hospitalet de Llobregat Barcelona 08908 Spain Details
Hospital Josep Trueta ( Site 1900) Girona Gerona 17007 Spain Details
Hospital Universitario Lucus Augusti ( Site 1905) Lugo 27003 Spain Details
Hospital Universitario Ramon y Cajal ( Site 1902) Madrid 28034 Spain Details
Hospital Clinico San Carlos ( Site 1906) Madrid 28040 Spain Details
Hospital 12 de Octubre de Madrid ( Site 1903) Madrid 28041 Spain Details
Hospital Virgen de la Macarena ( Site 1904) Sevilla 41071 Spain Details
Kantonsspital Graubuenden ( Site 2003) Chur Grisons 7000 Switzerland Details
Kantonsspital St. Gallen ( Site 2000) St. Gallen Sankt Gallen 9007 Switzerland Details
CHUV (centre hospitalier universitaire vaudois) ( Site 2002) Lausanne Vaud 1011 Switzerland Details
Universitaetsspital Zuerich ( Site 2001) Zuerich Zurich 8091 Switzerland Details
Kaohsiung Chang Gung Memorial Hospital ( Site 0504) Kaohsiung 83301 Taiwan Details
National Cheng Kung University Hospital ( Site 0503) Tainan 70457 Taiwan Details
National Taiwan University Hospital ( Site 0500) Taipei 100 Taiwan Details
Taipei Veterans General Hospital ( Site 0501) Taipei 11217 Taiwan Details
Chang Gung Medical Foundation. Linkou ( Site 0502) Taoyuan 333 Taiwan Details
Chulalongkorn Hospital, Medical Oncology Unit ( Site 0600) Bangkok Krung Thep Maha Nakhon 10330 Thailand Details
Ramathibodi Hospital. ( Site 0601) Bangkok Krung Thep Maha Nakhon 10400 Thailand Details
Faculty of Medicine Siriraj Hospital ( Site 0602) Bangkok Krung Thep Maha Nakhon 10700 Thailand Details
Srinagarind Hospital ( Site 0604) Khon Kaen 40002 Thailand Details
Acibadem Adana Hastanesi ( Site 2106) Adana 01130 Turkey Details
Ankara Universitesi Tip Fakultesi. ( Site 2101) Ankara 06100 Turkey Details
Hacettepe Universitesi Tıp Fakultesi ( Site 2105) Ankara 06230 Turkey Details
Ankara Sehir Hastanesi ( Site 2103) Ankara 06800 Turkey Details
Istanbul Uni. Cerrahpasa Tip Fakultesi ( Site 2100) Istanbul 34098 Turkey Details
Ege University Medical Faculty Tulay Aktas Oncology Hospital ( Site 2102) Izmir 35100 Turkey Details
Konya Necmettin Erbakan University Medical Faculty ( Site 2104) Konya 42080 Turkey Details
Aberdeen Royal Infirmary ( Site 1315) Aberdeen Aberdeen City AB25 2ZN United Kingdom Details
Royal Cornwall Hospitals NHS Trust ( Site 1317) Truro Cornwall TR1 3LJ United Kingdom Details
University College London Hospitals NHS Foundation Trust ( Site 1320) London London, City Of NW1 2BU United Kingdom Details
Royal Marsden NHS Foundation Trust ( Site 1318) London London, City Of SW3 6JJ United Kingdom Details
Velindre Cancer Centre Hospital ( Site 1322) Cardiff CF14 2TL United Kingdom Details
*Shaded cells indicate that there was no data available from clinicaltrials.gov for the field