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| NCT ID | NCT04191499 |
| Title | A Study Evaluating the Efficacy and Safety of Inavolisib + Palbociclib + Fulvestrant vs Placebo + Palbociclib + Fulvestrant in Patients With PIK3CA-Mutant, Hormone Receptor-Positive, Her2-Negative, Locally Advanced or Metastatic Breast Cancer (INAVO120) |
| Acronym | INAVO120 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase II |
| Variant Requirements | Yes |
| Sponsors | Hoffmann-La Roche |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | POL | NZL | ITA | HUN | GRC | GBR | FRA | ESP | DNK | DEU | CAN | BRA | BEL | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Beverly Hills Cancer Center | Beverly Hills | California | 90211 | United States | Details | |
| Winship Cancer Institute of Emory University | Atlanta | Georgia | 30329 | United States | Details | |
| Massachusetts General Hospital. | Boston | Massachusetts | 02114 | United States | Details | |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | United States | Details | |
| Wake Forest University Baptist Medical Center | Winston-Salem | North Carolina | 27157 | United States | Details | |
| Sarah Cannon Research Institute / Tennessee Oncology | Chattanooga | Tennessee | 37404 | United States | Details | |
| Sarah Cannon Research Institute / Tennessee Oncology | Nashville | Tennessee | 37203 | United States | Details | |
| Texas Oncology - Central South | Austin | Texas | 78731 | United States | Details | |
| Texas Tech University Health Sciences Center; Department of Internal Medicine | El Paso | Texas | 79905 | United States | Details | |
| Texas Oncology - Northeast Texas | Tyler | Texas | 75702 | United States | Details | |
| Northwest Medical Specialties | Tacoma | Washington | 98405 | United States | Details | |
| Fundación CENIT para la Investigación en Neurociencias | Buenos Aires | C1125ABD | Argentina | Details | ||
| Centro Oncologico Korben; Oncology | Ciudad Autonoma Buenos Aires | C1426AGE | Argentina | Details | ||
| Hosp Provincial D. Centenarios; Oncology Dept | Rosario | S2002KDS | Argentina | Details | ||
| Macquarie University Hospital | Macquarie Park | New South Wales | 2113 | Australia | Details | |
| Westmead Hospital; Medical Oncology and Pallative Care | Westmead | New South Wales | 2145 | Australia | Details | |
| Southern Medical Day Care Centre | Wollongong | New South Wales | 2500 | Australia | Details | |
| Mater Adult Hospital; Oncology | South Brisbane | Queensland | 4101 | Australia | Details | |
| Princess Alexandra Hospital; Cancer Trials Unit | Woolloongabba | Queensland | 4102 | Australia | Details | |
| Western Health | Fitzroy | Victoria | 3065 | Australia | Details | |
| Peninsula and South Eastern Haematology and Oncology Group | Frankston | Victoria | 3199 | Australia | Details | |
| UZ Leuven Gasthuisberg | Leuven | 3000 | Belgium | Details | ||
| Hospital Araujo Jorge; Departamento de Ginecologia E Mama | Goiania | GO | 74605-070 | Brazil | Details | |
| Santa Casa de Misericordia de Porto Alegre | Porto Alegre | RS | 90020-090 | Brazil | Details | |
| Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda | Sao Paulo | SP | 01317-001 | Brazil | Details | |
| Tom Baker Cancer Centre-Calgary | Calgary | Alberta | T2N 4N2 | Canada | Details | |
| London Regional Cancer Program, London Health Sciences Centre, Baines Centre | London | Ontario | N6A 4L6 | Canada | Details | |
| Ottawa Hospital | Ottawa | Ontario | K1H 8L6 | Canada | Details | |
| Princess Margaret Cancer Center | Toronto | Ontario | M5G 1Z5 | Canada | Details | |
| Hopital du Saint Sacrement | Quebec City | Quebec | G1S 4L8 | Canada | Details | |
| Beijing Cancer Hospital | Beijing | 100142 | China | Details | ||
| The First Hospital of Jilin University | Changchun City | 130021 | China | Details | ||
| West China Hospital, Sichuan University | Chengdu | 610041 | China | Details | ||
| The First Affiliated Hospital, Chongqing Medical University | Chongqing | 400016 | China | Details | ||
| Fujian Medical University Union Hospital | Fuzhou City | 350001 | China | Details | ||
| Sun Yet-sen University Cancer Center | Guangzhou City | 510663 | China | Details | ||
| Zhejiang Cancer Hospital; Zhejiang Cancer Hospital cancer department | Hangzhou City | 310022 | China | Details | ||
| Harbin Medical University Cancer Hospital | Harbin | 150081 | China | Details | ||
| Jiangsu Province Hospital (the First Affiliated Hospital With Nanjing Medical University) | Nanjing City | 210029 | China | Details | ||
| Fudan University Shanghai Cancer Center; Medical Oncology | Shanghai City | 201315 | China | Details | ||
| Hebei Medical University Fourth Hospital;(Tumor Hospital of Hebei Province) | Shijiazhuang | 050035 | China | Details | ||
| Tianjin Cancer Hospital | Tianjin | 300060 | China | Details | ||
| Union Hospital Tongji Medical College Huazhong University of Science and Technology | Wuhan City | 430023 | China | Details | ||
| Hubei Cancer Hospital | Wuhan | 430079 | China | Details | ||
| First Affiliated Hospital of Medical College of Xi'an Jiaotong University | Xi'an | 710061 | China | Details | ||
| Henan Cancer Hospital | Zhengzhou | 450008 | China | Details | ||
| Vejle Sygehus; Onkologisk Afdeling | Vejle | 7100 | Denmark | Details | ||
| Centre Jean Perrin Centre Regional de Lutte Contre Le Cancer D auvergne | Clermont-ferrand | 63003 | France | Details | ||
| Centre Georges Francois Leclerc; Oncologie 3 | Dijon | 21079 | France | Details | ||
| Centre Oscar Lambret; Senologie | Lille | 59020 | France | Details | ||
| Hopital Dupuytren; Oncologie Medicale | Limoges | 87042 | France | Details | ||
| Hopital Prive Jean Mermoz; Cancerologie | Lyon | 69373 | France | Details | ||
| Institut régional du Cancer Montpellier | Montpellier | 34298 | France | Details | ||
| Institut Universitaire du Cancer de Toulouse-Oncopole | Toulouse | 31059 | France | Details | ||
| Acad. F. Todua Medical Center | Tbilisi | 0112 | Georgia | Details | ||
| Israel-Georgian Medical Research Clinic Healthycore | Tbilisi | 0112 | Georgia | Details | ||
| Cancer Research Centre | Tbilisi | 0159 | Georgia | Details | ||
| Tbilisi Oncology Dispensary | Tbilisi | 0159 | Georgia | Details | ||
| Multiprofile Clinic Consilium Medulla | Tbilisi | 0186 | Georgia | Details | ||
| S Khechinashvili University Clinic Ltd | Tbilisi | 179 | Georgia | Details | ||
| Ambulantes Tumorzentrum Spandau; Dres. Benno Mohr und Uwe Peters | Berlin | 13581 | Germany | Details | ||
| Klinikum Essen-Mitte Ev. Huyssens-Stiftung / Knappschafts GmbH; Klinik für Senologie / Brustzentrum | Essen | 45136 | Germany | Details | ||
| Nationales Centrum für Tumorerkrankungen (NCT) ; Gyn. Onk. Frauenklinik; Uniklinikum Heidelberg | Heidelberg | 69120 | Germany | Details | ||
| Universitätsklinikum Mannheim; Frauenklinik | Mannheim | 68167 | Germany | Details | ||
| Klinikum Mutterhaus der Borromaeerinnen gGmbH; Haematologie/Onkologie | Trier | 54290 | Germany | Details | ||
| Universitätsfrauenklinik Ulm; Abteilung Gynäkologie | Ulm | 89075 | Germany | Details | ||
| Anticancer Hospital Ag. Savas ; 2Nd Dept. of Oncology - Internal Medicine | Athens | 115 22 | Greece | Details | ||
| Univ General Hosp Heraklion; Medical Oncology | Heraklion | 711 10 | Greece | Details | ||
| Euromedical General Clinic of Thessaloniki; Oncology Department | Thessaloniki | 546 45 | Greece | Details | ||
| Queen Mary Hospital; Dept of Medicine | Hong Kong | Hong Kong | Details | |||
| Prince of Wales Hospital; Department of Clinical Onocology | Shatin | Hong Kong | Details | |||
| Orszagos Onkologiai Intezet; B Belgyogyaszati Osztaly | Budapest | 1122 | Hungary | Details | ||
| Uzsoki Utcai Korhaz; Onkoradiológiai Osztály | Budapest | 1145 | Hungary | Details | ||
| Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet; Megyei Onkologiai Kozpont | Szolnok | 5004 | Hungary | Details | ||
| Azienda Ospedaliera Universitaria Federico II | Napoli | Campania | 80131 | Italy | Details | |
| A.O. Universitaria Di Parma | Parma | Emilia-Romagna | 43100 | Italy | Details | |
| Irccs Centro Di Riferimento Oncologico (CRO) | Aviano | Friuli-Venezia Giulia | 33081 | Italy | Details | |
| Az. Osp. Spedali Civili; Divisione Di Oncologia - Iii Medicina | Brescia | Lombardia | 25123 | Italy | Details | |
| Fondazione IRCCS Istituto Nazionale dei Tumori | Milano | Lombardia | 20133 | Italy | Details | |
| Ospedale Santa Maria Annunziata; Oncologia | Bagno a Ripoli | Toscana | 50012 | Italy | Details | |
| Azienda Ospedaliero Universitaria Pisana; Unita Operativa Oncologia Medica 2 | Pisa | Toscana | 56126 | Italy | Details | |
| IOV - Istituto Oncologico Veneto - IRCCS; Oncologia Medica II | Padova | Veneto | 35128 | Italy | Details | |
| Pusan National University Hospital | Busan | 602-739 | Korea, Republic of | Details | ||
| Kyungpook National University Medical Center | Daegu | 41404 | Korea, Republic of | Details | ||
| National Cancer Center | Goyang-si | 10408 | Korea, Republic of | Details | ||
| Seoul National University Bundang Hospital | Seongnam-si | 463-707 | Korea, Republic of | Details | ||
| Korea University Anam Hospital | Seoul | 02841 | Korea, Republic of | Details | ||
| Seoul National University Hospital | Seoul | 03080 | Korea, Republic of | Details | ||
| Severance Hospital, Yonsei University Health System | Seoul | 03722 | Korea, Republic of | Details | ||
| Asan Medical Center | Seoul | 05505 | Korea, Republic of | Details | ||
| Gangnam Severance Hospital | Seoul | 06273 | Korea, Republic of | Details | ||
| Samsung Medical Center | Seoul | 06351 | Korea, Republic of | Details | ||
| Ewha Womans University Mokdong Hospital | Seoul | 07985 | Korea, Republic of | Details | ||
| National Cancer Institute IKN | Putrajaya | Federal Territory OF Putrajaya | 62250 | Malaysia | Details | |
| Hospital Sultan Ismail; Oncology | Johor Bahru | Johor | 81100 | Malaysia | Details | |
| Sarawak General Hospital; Department of Radiotherapy, Oncology and Palliative care | Sarawak | 93586 | Malaysia | Details | ||
| Palmerston North Hospital; Regional Cancer Treatment Service | Palmerston North | 4442 | New Zealand | Details | ||
| Narodowy Instytut Onkologii Odzia? w Gliwicach; Centrum Diagnostyki i Leczenia Chorób Piersi | Gliwice | 44-102 | Poland | Details | ||
| Przychodnia Lekarska KOMED, Roman Karaszewski | Konin | 62-500 | Poland | Details | ||
| Opolskie Centrum Onkologii; Onkologia Kliniczna z Odcinkiem Dziennym | Opole | 45-061 | Poland | Details | ||
| Lecznice Citomed Sp. z o.o. | Torun | 87-100 | Poland | Details | ||
| Narodowy Inst.Onkologii im.Sklodowskiej-Curie Panstw.Inst.Bad; Klinika Nowtw.Piersi i Chir.Rekonstr | Warszawa | 02-781 | Poland | Details | ||
| Centro Clinico Champalimaud; Oncologia Medica | Lisboa | 1400-038 | Portugal | Details | ||
| IPO do Porto; Servico de Oncologia Medica | Porto | 4200-072 | Portugal | Details | ||
| Moscow Clinical Scientific Center | Moscow | Moskovskaja Oblast | 111123 | Russian Federation | Details | |
| Blokhin Cancer Research Center; Out-Patients Dept | Moscow | Moskovskaja Oblast | 115552 | Russian Federation | Details | |
| MEDSI Clinical Hospital on Pyatnitsky Highway; Department of antitumor drug therapy | Moscow | Moskovskaja Oblast | 143422 | Russian Federation | Details | |
| LLC Medscan | Moskva | Moskovskaja Oblast | 119421 | Russian Federation | Details | |
| Clinical Hospital Lapino (LLC Haven) | Yudino | Moskovskaja Oblast | 143081 | Russian Federation | Details | |
| Medical Clinic "AB Medical group" | Sankt-peterburg | Sankt Petersburg | 196006 | Russian Federation | Details | |
| Volgograd Regional Clinical Oncology Dispensary | Volgograd | 400138 | Russian Federation | Details | ||
| Regional Clinical Oncology Hospital | Yaroslavl | 150040 | Russian Federation | Details | ||
| National University Hospital; National University Cancer Institute, Singapore (NCIS) | Singapore | 119228 | Singapore | Details | ||
| National Cancer Centre; Medical Oncology | Singapore | 168583 | Singapore | Details | ||
| Hospital General Universitario de Elche; Servicio de Oncologia | Elche | Alicante | 03203 | Spain | Details | |
| Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia | Badalona | Barcelona | 08916 | Spain | Details | |
| Hospital Universitario Puerta de Hierro; Servicio de Oncologia | Majadahonda | Madrid | 28222 | Spain | Details | |
| Clinica Universitaria de Navarra; Servicio de Oncologia | Pamplona | Navarra | 31008 | Spain | Details | |
| Hospital Universitario de Canarias;servicio de Oncologia | La Laguna | Tenerife | 38320 | Spain | Details | |
| Hospital del Mar; Servicio de Oncologia | Barcelona | 08003 | Spain | Details | ||
| Vall d?Hebron Institute of Oncology (VHIO), Barcelona | Barcelona | 08035 | Spain | Details | ||
| Hospital Clinic de Barcelona. Unidad de Nuevas Terapias;Oncology Department | Barcelona | 08036 | Spain | Details | ||
| Insituto Catalán de Oncologia (ICO) | Barcelona | 08907 | Spain | Details | ||
| Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia | Jaen | 23007 | Spain | Details | ||
| Hospital General Universitario Gregorio Marañon; Servicio de Oncologia | Madrid | 28009 | Spain | Details | ||
| Clinica Universidad de Navarra-Madrid | Madrid | 28027 | Spain | Details | ||
| Hospital Clinico San Carlos; Servicio de Oncologia | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario 12 de Octubre; Servicio de Oncologia | Madrid | 28041 | Spain | Details | ||
| Hospital Universitario Virgen Macarena; Servicio de Oncologia | Sevilla | 41009 | Spain | Details | ||
| Instituto Valenciano Oncologia; Oncologia Medica | Valencia | 46009 | Spain | Details | ||
| Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia | Valencia | 46010 | Spain | Details | ||
| Kaohsiung Medical Uni Chung-Ho Hospital; Dept of Surgery | Kaohsiung | 807 | Taiwan | Details | ||
| Chi-Mei Medical Centre; Hematology & Oncology | Tainan | 710 | Taiwan | Details | ||
| Koo Foundation Sun Yat-Sen Cancer Center; Hemato-Oncology | Taipei City | 11259 | Taiwan | Details | ||
| VETERANS GENERAL HOSPITAL; Department of General Surgery | Taipei | 00112 | Taiwan | Details | ||
| National Taiwan Uni Hospital; General Surgery | Taipei | 100 | Taiwan | Details | ||
| Tri-Service General Hospital, Division of General Surgery | Taipei | 114 | Taiwan | Details | ||
| Ramathibodi Hospital; Dept of Med.-Div. of Med. Onc | Bangkok | 10400 | Thailand | Details | ||
| Maharaj Nakorn Chiang Mai Hospital; Department of Surgery/Head Neck and Breast Unit; Clinical Trial | Chiang Mai | 50200 | Thailand | Details | ||
| Chulabhorn Hospital; Medical Oncology | Lak Si | 10210 | Thailand | Details | ||
| Songklanagarind Hospital; Department of Oncology | Songkhla | 90110 | Thailand | Details | ||
| Adana Baskent University Hospital; Medical Oncology | Adana | 01120 | Turkey | Details | ||
| Gulhane Training and Research Hospital | Ankara | 06010 | Turkey | Details | ||
| Ege University Medical Faculty; Medical Oncology Department | Bornova, ?zm?r | 35100 | Turkey | Details | ||
| Istanbul University Cerrahpasa Faculty of Medicine | Istanbul | 34098 | Turkey | Details | ||
| Prof. Dr. Cemil Tascioglu City Hospital; Med Onc | Istanbul | 34384 | Turkey | Details | ||
| SI Institute of general&urgent surgery n/a Zaytseva V.T NAMSU; Purulent Surgery department | Kharkiv | Kharkiv Governorate | 61018 | Ukraine | Details | |
| Municipal Institution SubCarpathian Clinical Oncological Centre; Surgical department#2 | Ivano-Frankivsk | KIEV Governorate | 76018 | Ukraine | Details | |
| Uzhhorod Central City Clinical Hospital | Uzhhorod | KIEV Governorate | 88000 | Ukraine | Details | |
| City Clinical Hospital #4 | Dnipropetrovsk | 49102 | Ukraine | Details | ||
| ME Kryviy Rih Oncology Dispensary of Dnipropetrovs?k Regional Council; Chemotherapy Department | Kryvyi Rih | 50048 | Ukraine | Details | ||
| Kyiv City Clinical Oncological Center | Kyiv | 03115 | Ukraine | Details | ||
| RCI Sumy Regional Clinical Oncological Dispensary | Sumy | 40005 | Ukraine | Details | ||
| Princess Alexandra Hospital; Oncology Department | Harlow | CM20 1QX | United Kingdom | Details | ||
| Barts Health NHS Trust; Cancer Research Delivery Group | London | EC1A 7BE | United Kingdom | Details | ||
| St Georges University Hospitals NHS Foundation Trust | London | SW17 0RE | United Kingdom | Details | ||
| Churchill Hospital; Department of Oncology | Oxford | OX3 7LE | United Kingdom | Details | ||
| Peterborough City Hospital, Edith Cavell Campus; Oncology Department | Peterborough | PE3 9GZ | United Kingdom | Details | ||
| Derriford Hospital | Plymouth | PL6 8BT | United Kingdom | Details |