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| NCT ID | NCT04210115 |
| Title | Study of Pembrolizumab (MK-3475) Versus Placebo in Participants With Esophageal Carcinoma Who Are Receiving Chemotherapy and Radiation Therapy (MK-3475-975/KEYNOTE-975) |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Merck Sharp & Dohme Corp. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | ROU | ITA | HUN | GBR | FRA | EST | DNK | DEU | CZE | CAN | BRA | BEL | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| MemorialCare Health System - Long Beach Medical Center-Oncology ( Site 0691) | Long Beach | California | 90806 | United States | Details | |
| Columbus Regional Research Institute ( Site 0047) | Columbus | Georgia | 31904 | United States | Details | |
| University of Kansas Cancer Center ( Site 0023) | Westwood | Kansas | 66205 | United States | Details | |
| Cancer Center of Kansas ( Site 0058) | Wichita | Kansas | 67214 | United States | Details | |
| University Medical Center ( Site 0035) | New Orleans | Louisiana | 70112 | United States | Details | |
| Greater Baltimore Medical Center ( Site 0031) | Baltimore | Maryland | 21204 | United States | Details | |
| Dana Farber Cancer Center ( Site 0034) | Boston | Massachusetts | 02215 | United States | Details | |
| Henry Ford Hospital ( Site 0685) | Detroit | Michigan | 48202 | United States | Details | |
| University of Missouri ( Site 0688) | Columbia | Missouri | 65212 | United States | Details | |
| Renown Regional Medical Center ( Site 0706) | Reno | Nevada | 89502 | United States | Details | |
| Rutgers Cancer Institute of New Jersey ( Site 0695) | New Brunswick | New Jersey | 08903 | United States | Details | |
| Weill Cornell Medical College ( Site 0053) | New York | New York | 10065 | United States | Details | |
| Stephenson Cancer Center ( Site 0044) | Oklahoma City | Oklahoma | 73104 | United States | Details | |
| Oregon Health & Science University Center for Health & Healing 2- CHH2 ( Site 0060) | Portland | Oregon | 97239 | United States | Details | |
| Allegheny Health Network ( Site 0042) | Pittsburgh | Pennsylvania | 15212 | United States | Details | |
| Thompson Cancer Survival Center ( Site 0696) | Knoxville | Tennessee | 37916 | United States | Details | |
| Utah Cancer Specialists ( Site 0697) | Salt Lake City | Utah | 84106 | United States | Details | |
| Cancer Care Northwest - Spokane Valley ( Site 0036) | Spokane Valley | Washington | 99216 | United States | Details | |
| University of Wisconsin Hospital and Clinics ( Site 0033) | Madison | Wisconsin | 53792 | United States | Details | |
| Instituto Medico Alexander Fleming ( Site 0063) | Buenos Aires | Caba | C1426ANZ | Argentina | Details | |
| Fundacion Favaloro ( Site 0061) | Ciudad de Buenos Aires | Caba | C1093AAS | Argentina | Details | |
| Hospital Municipal de Gastroenterologia Dr. Bonorino Udaondo ( Site 0066) | Buenos Aires | C1264AAA | Argentina | Details | ||
| CEMIC ( Site 0064) | Buenos Aires | C1431FWO | Argentina | Details | ||
| UCL Saint Luc ( Site 0162) | Brussels | Bruxelles-Capitale, Region De | 1200 | Belgium | Details | |
| UZ Gent ( Site 0163) | Gent | Oost-Vlaanderen | 9000 | Belgium | Details | |
| UZ Leuven ( Site 0161) | Leuven | Vlaams-Brabant | 3000 | Belgium | Details | |
| AZ Delta ( Site 0165) | Roeselare | West-Vlaanderen | 8800 | Belgium | Details | |
| ONCOSITE - Centro de Pesquisa Clinica em Oncologia ( Site 0088) | Ijui | Rio Grande Do Sul | 98700-000 | Brazil | Details | |
| Hospital Nossa Senhora da Conceicao ( Site 0087) | Porto Alegre | Rio Grande Do Sul | 91350-200 | Brazil | Details | |
| Clinica de Oncologia Reichow ( Site 0085) | Blumenau | Santa Catarina | 89010-340 | Brazil | Details | |
| Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0081) | Sao Paulo | 01246-000 | Brazil | Details | ||
| Cross Cancer Institute ( Site 0010) | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| CancerCare Manitoba ( Site 0002) | Winnipeg | Manitoba | R3E 0V9 | Canada | Details | |
| The Ottawa Hospital - Cancer Care ( Site 0008) | Ottawa | Ontario | K1H 8L6 | Canada | Details | |
| Sunnybrook Research Institute ( Site 0012) | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| Princess Margaret Cancer Centre ( Site 0011) | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0005) | Montreal | Quebec | H2X 0A9 | Canada | Details | |
| Centro Investigación del Cáncer James Lind ( Site 0106) | Temuco | Araucania | 4800827 | Chile | Details | |
| Centro de Investigacion y desarrollo Oncologico SpA - CIDO SpA ( Site 0103) | Temuco | Araucania | 4810218 | Chile | Details | |
| Hospital Regional de Concepcion ( Site 0105) | Concepcion | Biobio | 4070038 | Chile | Details | |
| Centro de Cancer Nuestra Senora de la Esperanza ( Site 0104) | Santiago | Region M. De Santiago | 8330024 | Chile | Details | |
| Anhui Provincial Hospital-Oncology Radiotherapy Department ( Site 0531) | Hefei | Anhui | 230071 | China | Details | |
| The 900th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army ( Si | Fuzhou | Fujian | 350025 | China | Details | |
| The First Affiliated Hospital of Xiamen University ( Site 0538) | Xiamen | Fujian | 361003 | China | Details | |
| Hubei Cancer Hospital ( Site 0514) | Wuhan | Hubei | 430079 | China | Details | |
| Hunan Cancer Hospital ( Site 0515) | Changsha | Hunan | 410006 | China | Details | |
| Huai an First People s Hospital ( Site 0526) | Huai An | Jiangsu | 223001 | China | Details | |
| Jiangsu Cancer Hospital ( Site 0519) | Nanjing | Jiangsu | 210000 | China | Details | |
| The Affiliated Hospital of Xuzhou Medical University ( Site 0522) | Xuzhou | Jiangsu | 221002 | China | Details | |
| Affiliated Hospital of Jiangsu University ( Site 0524) | Zhenjiang | Jiangsu | 212000 | China | Details | |
| Jiangxi Cancer Hospital ( Site 0512) | Nanchang | Jiangxi | 330029 | China | Details | |
| Shanghai Chest Hospital ( Site 0503) | Shangai | Shanghai | 200030 | China | Details | |
| Shanghai Chest Hospital ( Site 0501) | Shanghai | Shanghai | 200030 | China | Details | |
| Zhongshan Hospital Fudan University ( Site 0502) | Shanghai | Shanghai | 200032 | China | Details | |
| Sichuan Cancer Hospital ( Site 0527) | Chengdu | Sichuan | 610041 | China | Details | |
| Tianjin Medical University Cancer Institute & Hospital ( Site 0505) | Tianjin | Tianjin | 300060 | China | Details | |
| Hangzhou First People's Hospital ( Site 0530) | Hangzhou | Zhejiang | 310002 | China | Details | |
| Sir Run Run Shaw Hospital ( Site 0523) | Hangzhou | Zhejiang | 310018 | China | Details | |
| Zhejiang Cancer Hospital ( Site 0529) | Hangzhou | Zhejiang | 310022 | China | Details | |
| Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0721) | Brno | Brno-mesto | 656 53 | Czechia | Details | |
| Fakultni nemocnice Ostrava-Klinika onkologicka ( Site 0719) | Ostrava | Moravskoslezsky Kraj | 708 52 | Czechia | Details | |
| Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 0720) | Olomouc | Olomoucky Kraj | 779 00 | Czechia | Details | |
| Fakultni nemocnice v Motole-Onkologicka klinika 2. LF UK a FN Motol ( Site 0718) | Praha | Praha 5 | 150 06 | Czechia | Details | |
| Rigshospitalet ( Site 0199) | Copenhagen | Hovedstaden | 2100 | Denmark | Details | |
| Odense Universitetshospital ( Site 0200) | Odense | Syddanmark | 5000 | Denmark | Details | |
| SA Pohja-Eesti Regionaalhaigla ( Site 0201) | Tallinn | Harjumaa | 13419 | Estonia | Details | |
| SA Tartu Ulikooli Kliinikum ( Site 0202) | Tartu | Tartumaa | 50406 | Estonia | Details | |
| Institut De Cancerologie De Lorraine ( Site 0222) | Vandoeuvre les Nancy | Ain | 54519 | France | Details | |
| Centre Francois Baclesse ( Site 0236) | Caen | Calvados | 14075 | France | Details | |
| Centre Georges Francois Leclerc ( Site 0223) | Dijon | Cote-d Or | 21079 | France | Details | |
| CHU Limoges Hopital Dupuytren ( Site 0225) | Limoges | Haute-Vienne | 87042 | France | Details | |
| Institut Curie - Centre Rene Huguenin ( Site 0237) | Saint-Cloud | Hauts-de-Seine | 92210 | France | Details | |
| Institut Jean Godinot ( Site 0238) | Reims | Marne | 51726 CEDEX | France | Details | |
| CHU Hotel Dieu Nantes ( Site 0230) | Nantes | Pays-de-la-Loire | 44093 | France | Details | |
| Institut Sainte Catherine ( Site 0228) | Avignon | Provence-Alpes-Cote-d Azur | 84918 | France | Details | |
| CHU Amiens Picardie Site Sud Amiens ( Site 0235) | Amiens | Somme | 80054 | France | Details | |
| CHD Vendee ( Site 0227) | La Roche sur Yon | Vendee | 85925 | France | Details | |
| Marienhospital Stuttgart Vincenz von Paul Kliniken gGmbH ( Site 0253) | Stuttgart | Baden-Wurttemberg | 70199 | Germany | Details | |
| Universitaetsklinikum Koeln ( Site 0251) | Koeln | Nordrhein-Westfalen | 50937 | Germany | Details | |
| Universitaetsklinikum Muenster ( Site 0248) | Muenster | Nordrhein-Westfalen | 48149 | Germany | Details | |
| Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz ( Site 0247) | Mainz | Rheinland-Pfalz | 55131 | Germany | Details | |
| Charite Campus Virchow Klinikum ( Site 0250) | Berlin | 13353 | Germany | Details | ||
| Facharztzentrum Eppendorf ( Site 0242) | Hamburg | 20249 | Germany | Details | ||
| Centro de Investigaciones Clinicas de Latinoamerica S.A. - CELAN ( Site 0122) | Guatemala | 01010 | Guatemala | Details | ||
| Gastrosoluciones ( Site 0126) | Guatemala | 01010 | Guatemala | Details | ||
| Oncomedica ( Site 0125) | Guatemala | 01010 | Guatemala | Details | ||
| Grupo Medico Angeles ( Site 0121) | Guatemala | 01015 | Guatemala | Details | ||
| Medi-K Cayala ( Site 0124) | Guatemala | 01016 | Guatemala | Details | ||
| Centro Medico Integral De Cancerología (CEMIC) ( Site 0123) | Quetzaltenango | 09002 | Guatemala | Details | ||
| Pamela Youde Nethersole Eastern Hospital ( Site 0543) | Hong Kong | Hong Kong | Details | |||
| Princess Margaret Hospital. ( Site 0542) | Hong Kong | Hong Kong | Details | |||
| Queen Mary Hospital ( Site 0541) | Pokfulam | Hong Kong | Details | |||
| Pecsi Tudomanyegyetem AOK ( Site 0265) | Pecs | Baranya | 7624 | Hungary | Details | |
| Bekes Megyei Kozponti Korhaz - Pandy Kalman Tagkorhaza ( Site 0262) | Gyula | Bekes | 5700 | Hungary | Details | |
| Orszagos Onkologiai Intezet ( Site 0263) | Budapest | 1122 | Hungary | Details | ||
| Debreceni Egyetem Klinikai Kozpont ( Site 0261) | Debrecen | 4032 | Hungary | Details | ||
| Fondazione IRCCS Policlinico San Matteo-Oncology ( Site 0300) | Pavia | Lombardia | 27100 | Italy | Details | |
| IRCCS Policlinico San Donato ( Site 0295) | San Donato Milanese | Milano | 20097 | Italy | Details | |
| Azienda Ospedaliero Universitaria Pisana - Presidio Santa Chiara ( Site 0294) | Pisa | Toscana | 56126 | Italy | Details | |
| ASST Papa Giovanni XXIII ( Site 0296) | Bergamo | 24127 | Italy | Details | ||
| Azienda Socio Sanitaria Territoriale di Cremona ( Site 0299) | Cremona | 26100 | Italy | Details | ||
| Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 0292) | Milano | 20133 | Italy | Details | ||
| Istituto Nazionale Tumori IRCCS Fondazione Pascale-SC Oncologia Clinica Sperimentale Addome ( Site 0 | Napoli | 80131 | Italy | Details | ||
| IRCCS Istituto Oncologico Veneto ( Site 0298) | Padova | 35128 | Italy | Details | ||
| Policlinico Universitario A. Gemelli ( Site 0297) | Roma | 00168 | Italy | Details | ||
| Aichi Cancer Center Hospital ( Site 0563) | Nagoya | Aichi | 464-8681 | Japan | Details | |
| National Cancer Center Hospital East ( Site 0562) | Kashiwa | Chiba | 2778577 | Japan | Details | |
| Kanagawa Cancer Center ( Site 0565) | Yokohama | Kanagawa | 241-8515 | Japan | Details | |
| Saitama Cancer Center ( Site 0564) | Kitaadachi-gun | Saitama | 362-0806 | Japan | Details | |
| Shizuoka Cancer Center Hospital and Research Institute ( Site 0566) | Sunto-gun | Shizuoka | 411-8777 | Japan | Details | |
| National Cancer Center Hospital ( Site 0561) | Tokyo | 104-0045 | Japan | Details | ||
| Chonnam National University Hwasun Hospital ( Site 0625) | Hwasun Gun | Jeonranamdo | 58128 | Korea, Republic of | Details | |
| National Cancer Center ( Site 0626) | Goyang-si | Kyonggi-do | 10408 | Korea, Republic of | Details | |
| Asan Medical Center ( Site 0623) | Songpagu | Seoul | 05505 | Korea, Republic of | Details | |
| Severance Hospital Yonsei University Health System ( Site 0624) | Seoul | 03722 | Korea, Republic of | Details | ||
| Samsung Medical Center ( Site 0622) | Seoul | 06351 | Korea, Republic of | Details | ||
| Korea University Guro Hospital ( Site 0621) | Seoul | 08308 | Korea, Republic of | Details | ||
| Cryptex Investigación Clínica S.A. de C.V. ( Site 0729) | Cuauhtémoc, Ciudad De México | Distrito Federal | 06100 | Mexico | Details | |
| CENTRO HEMATO ONCOLOGICO PRIVADO-CHOP ( Site 0728) | Toluca de Lerdo | 50120 | Mexico | Details | ||
| Instituto Nacional de Enfermedades Neoplasicas ( Site 0141) | Lima | Muni Metro De Lima | Lima 34 | Peru | Details | |
| Detecta Clínica ( Site 0146) | Surquillo | Muni Metro De Lima | 15038 | Peru | Details | |
| Hospital Nacional Arzobispo Loayza ( Site 0143) | Lima | 15082 | Peru | Details | ||
| Clinica San Gabriel ( Site 0142) | Lima | 15087 | Peru | Details | ||
| Baguio General Hospital and Medical Center ( Site 0603) | Baguio City | Benguet | 2600 | Philippines | Details | |
| Cebu Doctors University Hospital ( Site 0604) | Cebu City | Cebu | 6000 | Philippines | Details | |
| The Medical City-Iloilo ( Site 0602) | Iloilo City | Iloilo | 5000 | Philippines | Details | |
| St. Luke s Medical Center ( Site 0601) | Quezon | National Capital Region | 1102 | Philippines | Details | |
| Hospital Beatriz Angelo ( Site 0374) | Loures | Lisboa | 2674-514 | Portugal | Details | |
| Inst. Portugues de Oncologia de Lisboa Francisco Gentil EPE ( Site 0372) | Lisboa | 1099-023 | Portugal | Details | ||
| Hospital da Luz ( Site 0373) | Lisboa | 1500 650 | Portugal | Details | ||
| CHLN Hospital Santa Maria ( Site 0376) | Lisboa | 1649-035 | Portugal | Details | ||
| Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 0371) | Porto | 4200-072 | Portugal | Details | ||
| MedEuropa Bucuresti - Centru de Radioterapie-Oncology ( Site 0400) | București | Bucuresti | 022343 | Romania | Details | |
| Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 0392) | Cluj-Napoca | Cluj | 400015 | Romania | Details | |
| S.C. Radiotherapy Center Cluj S.R.L ( Site 0391) | Cluj-Napoca | Cluj | 407280 | Romania | Details | |
| Ovidius Clinical Hospital OCH-Oncology and Hematology ( Site 0393) | Ovidiu | Constanta | 905900 | Romania | Details | |
| S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 0394) | Craiova | Dolj | 200542 | Romania | Details | |
| Centrul Medical Topmed ( Site 0398) | Targu-Mures | Mures | 540156 | Romania | Details | |
| S.C.Focus Lab Plus S.R.L ( Site 0395) | Bucuresti | 022548 | Romania | Details | ||
| GBUZ Republican Clinical Oncological Dispensary-Antitumor drug therapy department ( Site 0430) | Ufa | Baskortostan, Respublika | 450054 | Russian Federation | Details | |
| Kaluga Regional Clinical Oncology Center ( Site 0424) | Kaluga | Kaluzskaja Oblast | 248007 | Russian Federation | Details | |
| Main Military Clinical Hospital n.a. N.N.Burdenko ( Site 0421) | Moscow | Moskva | 105229 | Russian Federation | Details | |
| FSAI Treatment and Rehabilitation Centre of the MoH and SD of RF ( Site 0429) | Moscow | Moskva | 125367 | Russian Federation | Details | |
| SBHI Samara Regional Clinical Oncology Dispensary ( Site 0420) | Samara | Samarskaya Oblast | 443031 | Russian Federation | Details | |
| Pavlov First Saint Petersburg State Medical University ( Site 0426) | St. Petersburg | Sankt-Peterburg | 197022 | Russian Federation | Details | |
| Medical institute named after Berezin Sergey ( Site 0417) | St. Petersburg | Sankt-Peterburg | 197758 | Russian Federation | Details | |
| Sverdlovsk Regional Oncology Hospital ( Site 0411) | Ekaterinburg | Sverdlovskaya Oblast | 620036 | Russian Federation | Details | |
| Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 0412) | Kazan | Tatarstan, Respublika | 420029 | Russian Federation | Details | |
| Chang Gung Med Foundation. Kaohsiung Branch ( Site 0643) | Kaohsiung | 833 | Taiwan | Details | ||
| China Medical University Hospital ( Site 0646) | Taichung | 40447 | Taiwan | Details | ||
| Taichung Veterans General Hospital-Radiation Oncology ( Site 0647) | Taichung | 407 | Taiwan | Details | ||
| National Cheng Kung University Hospital ( Site 0645) | Tainan | 70457 | Taiwan | Details | ||
| National Taiwan University Hospital ( Site 0641) | Taipei | 10002 | Taiwan | Details | ||
| Koo Foundation Sun Yat-Sen Cancer Center ( Site 0644) | Taipei | 11259 | Taiwan | Details | ||
| Chang Gung Medical Foundation. Linkou ( Site 0642) | Taoyuan | 33305 | Taiwan | Details | ||
| Istanbul University Cerrahpasa Medical Faculty ( Site 0452) | Istambul | Istanbul | 34098 | Turkey | Details | |
| Memorial Ankara Hastanesi ( Site 0461) | Ankara | 06520 | Turkey | Details | ||
| Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 0451) | Istanbul | 34722 | Turkey | Details | ||
| Ege Universitesi Tip Fakultesi ( Site 0457) | Izmir | 35040 | Turkey | Details | ||
| Izmir Katip Celebi Universitesi Ataturk Egitim ve Arastirma Hastanesi ( Site 0458) | Izmir | 35360 | Turkey | Details | ||
| Aberdeen Royal Infirmary ( Site 0474) | Aberdeen | Aberdeen City | AB25 2ZN | United Kingdom | Details | |
| Cambridge University Hospitals NHS Trust ( Site 0477) | Cambridge | Cambridgeshire | CB2 0QQ | United Kingdom | Details | |
| Royal Free Hospital ( Site 0702) | London | England | NW32QG | United Kingdom | Details | |
| ROYAL MARSDEN HOSPITAL (CHELSEA) ( Site 0283) | London | London, City Of | SW3 6JJ | United Kingdom | Details | |
| Hammersmith Hospital-Medical Oncology ( Site 0471) | London | London, City Of | W12 OHS | United Kingdom | Details | |
| Nottingham University Hospitals NHS Trust ( Site 0476) | Nottingham | Nottinghamshire | NG5 1PB | United Kingdom | Details | |
| Royal Marsden Hospital (Sutton) ( Site 0281) | Sutton | Surrey | SM2 5PT | United Kingdom | Details | |
| University College Hospital NHS Foundation Trust ( Site 0701) | London | Worcestershire | NW1 2PG | United Kingdom | Details | |
| The Christie NHS Foundation Trust ( Site 0282) | Manchester | M20 4BX | United Kingdom | Details | ||
| Mount Vernon Hospital ( Site 0478) | Northwood | HA6 2RN | United Kingdom | Details |