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| NCT ID | NCT04241185 |
| Title | Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992) |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Merck Sharp & Dohme Corp. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | ROU | POL | NLD | LVA | ITA | ISR | HUN | GBR | FRA | EST | ESP | DNK | CZE | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Washington Cancer Institute at MedStar Washington Hospital Center ( Site 0041) | Washington | District of Columbia | 20010 | United States | Details | |
| Bay Pines VA Medical Center ( Site 0055) | Bay Pines | Florida | 33744 | United States | Details | |
| AdventHealth Orlando-AdventHealth Medical Group Hematology & Oncology at Orlandoc ( Site 0004) | Orlando | Florida | 32804 | United States | Details | |
| Norton Cancer Institute ( Site 0044) | Louisville | Kentucky | 40207 | United States | Details | |
| Pikeville Medical Center ( Site 0009) | Pikeville | Kentucky | 41501 | United States | Details | |
| Baltimore VA Medical Center ( Site 0054) | Baltimore | Maryland | 21201 | United States | Details | |
| Washington University ( Site 0003) | Saint Louis | Missouri | 63110 | United States | Details | |
| Summit Medical Group Cancer Center ( Site 6008) | Florham Park | New Jersey | 07932 | United States | Details | |
| John Theurer Cancer Center at Hackensack University Medical Center ( Site 0005) | Hackensack | New Jersey | 07601 | United States | Details | |
| New York Oncology Hematology P.C ( Site 0024) | Albany | New York | 12206 | United States | Details | |
| Roswell Park Cancer Institute ( Site 6009) | Buffalo | New York | 14263 | United States | Details | |
| Winthrop University Hospital ( Site 0069) | Mineola | New York | 11501 | United States | Details | |
| New York University Perlmutter Cancer Center ( Site 0001) | New York | New York | 10016 | United States | Details | |
| Fairview Hospital-Moll Cancer Center ( Site 6013) | Cleveland | Ohio | 44111 | United States | Details | |
| Cleveland Clinic Main ( Site 0062) | Cleveland | Ohio | 44195 | United States | Details | |
| Cleveland Clinic - Hillcrest Hospital-Hillcrest Hospital Cancer Center ( Site 6012) | Mayfield Heights | Ohio | 44124 | United States | Details | |
| MidLantic urology ( Site 0070) | Bala-Cynwyd | Pennsylvania | 19004 | United States | Details | |
| Saint Francis Cancer Center ( Site 0026) | Greenville | South Carolina | 29607 | United States | Details | |
| Carolina Urologic Research Center ( Site 0002) | Myrtle Beach | South Carolina | 29572 | United States | Details | |
| Urology San Antonio Research ( Site 6010) | San Antonio | Texas | 78229 | United States | Details | |
| Inova Schar Cancer Institute ( Site 6006) | Fairfax | Virginia | 22031 | United States | Details | |
| West Virginia University - Charleston Area Medical Center ( Site 6003) | Charleston | West Virginia | 25304 | United States | Details | |
| Froedtert and Medical College of Wisconsin ( Site 0022) | Milwaukee | Wisconsin | 53226 | United States | Details | |
| Liverpool Hospital ( Site 0220) | Liverpool | New South Wales | 2170 | Australia | Details | |
| GenesisCare North Shore ( Site 0217) | St Leonards | New South Wales | 2065 | Australia | Details | |
| Monash Medical Centre ( Site 0216) | Clayton | Victoria | 3168 | Australia | Details | |
| Austin Health ( Site 0218) | Heidelberg | Victoria | 3084 | Australia | Details | |
| Sir Charles Gairdner Hospital ( Site 0223) | Nedlands | Western Australia | 6009 | Australia | Details | |
| Oncocentro Valdivia ( Site 7055) | Valdivia | Los Rios | 5112129 | Chile | Details | |
| FALP ( Site 7056) | Santiago | Region M. De Santiago | 7500921 | Chile | Details | |
| Bradfordhill-Clinical Area ( Site 7051) | Santiago | Region M. De Santiago | 8420383 | Chile | Details | |
| ONCOCENTRO APYS-ACEREY ( Site 7054) | Viña del Mar | Valparaiso | 2520598 | Chile | Details | |
| Bradford Hill Norte ( Site 7052) | Antofagasta | 1240000 | Chile | Details | ||
| Fakultni nemocnice Olomouc ( Site 0559) | Olomouc | 77900 | Czechia | Details | ||
| 2. LF UK a FN Motol ( Site 0555) | Praha 5 | 150 06 | Czechia | Details | ||
| Nemocnice Na Bulovce ( Site 0556) | Praha 8 | 180 81 | Czechia | Details | ||
| Herlev og Gentofte Hospital. ( Site 0401) | Herlev | Hovedstaden | 2730 | Denmark | Details | |
| Odense Universitetshospital ( Site 0403) | Odense | Syddanmark | 5000 | Denmark | Details | |
| North Estonia Medical Centre Foundation ( Site 0081) | Tallin | Harjumaa | 13419 | Estonia | Details | |
| Tartu University Hospital ( Site 0079) | Tartu | Tartumaa | 51014 | Estonia | Details | |
| Institut Sainte Catherine ( Site 0121) | Avignon | Provence-Alpes-Cote-d Azur | 84918 | France | Details | |
| CHU Amiens Picardie Site Sud Amiens ( Site 0123) | Amiens | Somme | 80000 | France | Details | |
| Institut Curie ( Site 0112) | Paris | 75005 | France | Details | ||
| A.P.H. Paris. Hopital Bichat Claude Bernard ( Site 0115) | Paris | 75018 | France | Details | ||
| Centro de Investigaciones Clinicas de Latinoamerica S.A. - CELAN ( Site 0146) | Guatemala | 01010 | Guatemala | Details | ||
| Oncomedica ( Site 0145) | Guatemala | 01010 | Guatemala | Details | ||
| Grupo Medico Angeles ( Site 0143) | Guatemala | 01015 | Guatemala | Details | ||
| Medi-K Cayala ( Site 0142) | Guatemala | 01016 | Guatemala | Details | ||
| Centro Medico Integral De Cancerología (CEMIC) ( Site 0144) | Quetzaltenango | 09002 | Guatemala | Details | ||
| BAZ Megyei Korhaz. Klinikai Onkologia es Sugarterapias Centrum ( Site 0092) | Miskolc | Borsod-Abauj-Zemplen | 3526 | Hungary | Details | |
| Petz Aladar Megyei Oktato Korhaz ( Site 0099) | Gyor | Gyor-Moson-Sopron | 9024 | Hungary | Details | |
| Egeszsegugyi Tudomanyos Tanacs Klinikai Farmakologiai Etikai Bizottsaga ( Site 0095) | Budapest | 1051 | Hungary | Details | ||
| Debreceni Egyetem Klinikai Kozpont ( Site 0097) | Debrecen | 4032 | Hungary | Details | ||
| Somogy Megyei Kaposi Mor Oktato Korhaz ( Site 0091) | Kaposvar | 7400 | Hungary | Details | ||
| Soroka Medical Center-Oncology ( Site 7031) | Be'er Sheva | 8400000 | Israel | Details | ||
| Rambam Health Care Campus-Oncology Division ( Site 0088) | Haifa | 3109601 | Israel | Details | ||
| Hadassah Medical Center. Ein Kerem ( Site 0086) | Jerusalem | 9112001 | Israel | Details | ||
| Rabin Medical Center ( Site 7032) | Petah Tikva | 4941 492 | Israel | Details | ||
| Chaim Sheba Medical Center ( Site 0087) | Ramat Gan | 5262000 | Israel | Details | ||
| Sourasky Medical Center ( Site 0089) | Tel Aviv | 6423906 | Israel | Details | ||
| Fondazione Policlinico Universitario Campus Bio-Medico-Radiation Oncology ( Site 7041) | Roma | Lazio | 00128 | Italy | Details | |
| Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 0186) | Milano | Lombardia | 20133 | Italy | Details | |
| IRCCS Giovanni Paolo II. Ospedale Oncologico ( Site 0193) | Bari | Puglia | 70124 | Italy | Details | |
| AOU Careggi ( Site 0191) | Firenze | 50134 | Italy | Details | ||
| Ospedale Civile di Macerata ( Site 0190) | Macerata | 62100 | Italy | Details | ||
| Ospedale San Raffaele ( Site 0194) | Milano | 20132 | Italy | Details | ||
| Azienda Ospedaliero - Universitaria Policlinico di Modena ( Site 0188) | Modena | 41124 | Italy | Details | ||
| Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 0192) | Napoli | 80131 | Italy | Details | ||
| Hirosaki University Hospital ( Site 0602) | Hirosaki | Aomori | 036-8563 | Japan | Details | |
| University of Tsukuba Hospital ( Site 0605) | Tsukuba | Ibaraki | 305-8576 | Japan | Details | |
| Osaka Medical and Pharmaceutical University Hospital ( Site 0604) | Takatsuki | Osaka | 5698686 | Japan | Details | |
| Nagasaki University Hospital ( Site 0600) | Nagasaki | 852-8501 | Japan | Details | ||
| Institute of Science Tokyo Hospital ( Site 0601) | Tokyo | 113-8519 | Japan | Details | ||
| Tokyo Metropolitan Komagome Hospital ( Site 0606) | Tokyo | 113-8677 | Japan | Details | ||
| National Cancer Center ( Site 0202) | Gyeonggi-do | Kyonggi-do | 10408 | Korea, Republic of | Details | |
| Seoul National University Bundang Hospital ( Site 0204) | Seongnam-si | Kyonggi-do | 13620 | Korea, Republic of | Details | |
| Asan Medical Center ( Site 0200) | Songpagu | Seoul | 05505 | Korea, Republic of | Details | |
| Chungnam National University Hospital ( Site 0203) | Daejeon | Taejon-Kwangyokshi | 35015 | Korea, Republic of | Details | |
| Korea University Anam Hospital ( Site 0205) | Seoul | 02841 | Korea, Republic of | Details | ||
| Severance Hospital Yonsei University Health System ( Site 0201) | Seoul | 03722 | Korea, Republic of | Details | ||
| Pauls Stradins Clinical University Hospital ( Site 0073) | Riga | LV1002 | Latvia | Details | ||
| Hospital Universiti Sains Malaysia ( Site 0237) | Kubang Kerian | Kelantan | 16150 | Malaysia | Details | |
| Hospital Pulau Pinang ( Site 0239) | Penang | Pulau Pinang | 10990 | Malaysia | Details | |
| Hospital Kuala Lumpur ( Site 0238) | Kuala Lumpur | 50586 | Malaysia | Details | ||
| University Malaya Medical Centre ( Site 0236) | Kuala Lumpur | 59100 | Malaysia | Details | ||
| Netherlands Cancer Institute (NKI) ( Site 0183) | Amsterdam | Noord-Holland | 1066 CX | Netherlands | Details | |
| Erasmus MC ( Site 0182) | Rotterdam | Zuid-Holland | 3015 GD | Netherlands | Details | |
| Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie ( Site 0153) | Krakow | Malopolskie | 31-826 | Poland | Details | |
| Mazowiecki Szpital Wojewódzki w Siedlcach ( Site 0154) | Siedlce | Mazowieckie | 08-110 | Poland | Details | |
| Szpital Wojewodzki im. Mikolaja Kopernika ( Site 0152) | Koszalin | Zachodniopomorskie | 75-581 | Poland | Details | |
| Unidade Local de Saude Loures-Odivelas - Hospital Beatriz Angelo ( Site 0303) | Loures | Lisboa | 2674-514 | Portugal | Details | |
| Centro Hospitalar e Universitario de Coimbra ( Site 0306) | Coimbra | 3000-075 | Portugal | Details | ||
| Unidade Local de Saude Lisboa Ocidental - Hospital de São Francisco Xavier ( Site 0302) | Lisboa | 1449-005 | Portugal | Details | ||
| Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 0305) | Lisboa | 1649-035 | Portugal | Details | ||
| Advance Urology and Laparoscopic Center ( Site 0281) | Ponce | 00716 | Puerto Rico | Details | ||
| PAN American Center Oncologic ( Site 0280) | San Juan, Rio Piedras | 00935 | Puerto Rico | Details | ||
| Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 0249) | Cluj Napoca | Cluj | 400015 | Romania | Details | |
| S.C. Radiotherapy Center Cluj S.R.L ( Site 0252) | Cluj-Napoca | Cluj | 407280 | Romania | Details | |
| S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 0248) | Craiova | Dolj | 200542 | Romania | Details | |
| Policlinica Oncomed SRL ( Site 0254) | Timisoara | Timis | 300239 | Romania | Details | |
| MEMORIAL HEALTHCARE INTERNATIONAL S.R.L. ( Site 0253) | Bucuresti | 013812 | Romania | Details | ||
| Institutul Oncologic-Oncologie Medicala ( Site 0256) | Cluj | 400015 | Romania | Details | ||
| Institutul Regional de Oncologie Iasi ( Site 0255) | Iasi | 700483 | Romania | Details | ||
| Instituto Catalan de Oncologia - ICO ( Site 0103) | L Hospitalet De Llobregat | Barcelona | 08908 | Spain | Details | |
| Hospital La Fe de Valencia ( Site 0105) | Valencia | Valenciana, Comunitat | 46026 | Spain | Details | |
| HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Medical Oncology ( Site 0106) | Sevilla | 41013 | Spain | Details | ||
| University of Health Sciences,Gulhane School of Medicine-Oncology ( Site 0509) | Ankara | 06010 | Turkey | Details | ||
| Ankara Universitesi Tip Fakultesi. ( Site 0502) | Ankara | 06100 | Turkey | Details | ||
| Istanbul Uni. Cerrahpasa Tip Fakultesi ( Site 0501) | Istanbul | 34098 | Turkey | Details | ||
| T.C. Saglik Bakanligi Turkiye Kamu Hastaneleri Kurumu - Baki-Istanbul Bakirkoy Sadi Konuk Training ( | Istanbul | 34147 | Turkey | Details | ||
| Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 0504) | Istanbul | 34722 | Turkey | Details | ||
| Ege University Medical Faculty ( Site 0508) | Izmir | 35100 | Turkey | Details | ||
| Karadeniz Teknik Universitesi Tip Fakultesi ( Site 0503) | Trabzon | 61080 | Turkey | Details | ||
| Clinical oncology dispensary of Dnipro ( Site 0133) | Dnipro | Dnipropetrovska Oblast | 49055 | Ukraine | Details | |
| Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 0139) | Kharkiv | Kharkivska Oblast | 61024 | Ukraine | Details | |
| MNPE Regional Center of Oncology ( Site 0134) | Kharkiv | Kharkivska Oblast | 61070 | Ukraine | Details | |
| Ukranian Center of TomoTherapy ( Site 0140) | Kropyvnytskiy | Kirovohradska Oblast | 25011 | Ukraine | Details | |
| SNPE National Cancer Institute ( Site 0136) | Kyiv | Kyivska Oblast | 03022 | Ukraine | Details | |
| Kyiv City Clinical Oncology Center ( Site 0135) | Kyiv | 03115 | Ukraine | Details | ||
| Betsi Cadwaladr University Health Board ( Site 0447) | Rhyl | Denbighshire | LL18 5UJ | United Kingdom | Details | |
| South Devon Healthcare Foundation Trust. Torbay Hospital ( Site 0444) | Torquay | Devon | TQ2 7AA | United Kingdom | Details | |
| Royal Preston Hospital ( Site 0449) | Preston | Lancashire | PR2 9HT | United Kingdom | Details | |
| University College London Hospitals NHS Foundation Trust ( Site 0445) | London | London, City Of | NW1 2PG | United Kingdom | Details | |
| The Royal Marsden NHS Foundation Trust. ( Site 0442) | London | London, City Of | SW3 6JJ | United Kingdom | Details | |
| Nottingham University Hospital NHS Trust ( Site 0250) | Nottingham | Nottinghamshire | NG5 1PB | United Kingdom | Details | |
| Darlington Memorial Hospital NHS Trust ( Site 0446) | Darlington | DL3 6HX | United Kingdom | Details |